H2S biogenesis by human cystathionine γ-lyase leads to the novel sulfur metabolites lanthionine and homolanthionine and is responsive to the grade of hyperhomocysteinemia

Journal of Biological Chemistry

Volumn 284, Issue 17, 2009, Pages 11601-11612

  Chiku, Taurai ^a   Padovani, Dominique ^a   Zhu, Weidong ^b   Singh, Sangita ^a,b   Vitvitsky, Victor ^a   Banerjee, Ruma ^a  

^a UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

^b UNIVERSITY OF NEBRASKA LINCOLN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HOMOCYSTEINE; HYPERHOMOCYSTEINEMIA; KINETIC SIMULATION; LANTHIONINE; NERVOUS SYSTEM; RELATIVE IMPORTANCE; REPLACEMENT REACTIONS; SIGNALING MOLECULES; SYNTHASE;

ENZYMES; HYDROGEN; HYDROGEN SULFIDE; MAMMALS; MOLECULES; SULFUR;

SUBSTITUTION REACTIONS;

CYSTATHIONINE GAMMA LYASE; CYSTEINE; HOMOCYSTEINE; HOMOLANTHIONINE; HYDROGEN SULFIDE; LANTHIONINE; NITRIC OXIDE; SULFUR; UNCLASSIFIED DRUG; ALANINE; DRUG DERIVATIVE; RECOMBINANT PROTEIN; SULFIDE;

ARTICLE; BIOGENESIS; CATALYSIS; CHEMICAL REACTION KINETICS; CONTROLLED STUDY; ELIMINATION REACTION; ENZYME SUBSTRATE; HYDROGEN SULFIDE BIOGENESIS; HYPERHOMOCYSTEINEMIA; METABOLITE; PRIORITY JOURNAL; REACTION ANALYSIS; SIMULATION; CHEMICAL MODEL; CHEMISTRY; DOSE RESPONSE; HUMAN; KINETICS; MASS SPECTROMETRY; METABOLISM; PH; TEMPERATURE;

MAMMALIA;

ALANINE; CATALYSIS; CYSTATHIONINE GAMMA-LYASE; CYSTEINE; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; HYDROGEN SULFIDE; HYDROGEN-ION CONCENTRATION; HYPERHOMOCYSTEINEMIA; KINETICS; MASS SPECTROMETRY; MODELS, CHEMICAL; RECOMBINANT PROTEINS; SULFIDES; SULFUR; TEMPERATURE;

EID: 66449109703     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M808026200     Document Type: Article

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