Natural product vindoline stimulates insulin secretion and efficiently ameliorates glucose homeostasis in diabetic murine models

Journal of Ethnopharmacology

Volumn 150, Issue 1, 2013, Pages 285-297

  Yao, Xin Gang ^a   Chen, Fanglei ^a   Li, Ping ^a   Quan, Lingling ^b   Chen, Jing ^a   Yu, Liang ^a   Ding, Hong ^a   Li, Chenjing ^a   Chen, Lili ^a   Gao, Zhaobing ^a   Wan, Ping ^b   Hu, Lihong ^a   Jiang, Hualiang ^a   Shen, Xu ^a  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

^b SHANGHAI NORMAL UNIVERSITY   (China)

Author keywords

cell dysfunction; Glucose stimulated insulin secretion; Type 2 diabetes; Vindoline

Indexed keywords

CYTOKINE; GLUCOSE; HEMOGLOBIN A1C; INSULIN; POTASSIUM CHANNEL KV2.1; STREPTOZOCIN; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; VINDOLINE; VOLTAGE GATED POTASSIUM CHANNEL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIDIABETIC ACTIVITY; APOPTOSIS; ARTICLE; BODY WEIGHT; CATHARANTHUS ROSEUS; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DIABETES MELLITUS; ENZYME LINKED IMMUNOSORBENT ASSAY; GLUCOSE BLOOD LEVEL; GLUCOSE HOMEOSTASIS; IN VIVO STUDY; INSULIN BLOOD LEVEL; INSULIN RELEASE; INSULINOMA; MALE; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; ORAL GLUCOSE TOLERANCE TEST; PANCREAS ISLET; PANCREAS ISLET BETA CELL; RAT; STREPTOZOCIN DIABETES;

CATHARANTHUS ROSEUS; MURINAE; MUS; RATTUS;

CATHARANTHUS ROSEUS; CATHARANTHUS ROSEUS (L). DON; FORSKOLIN; FSK; GLUCOSE-STIMULATED INSULIN SECRETION; GLY; GLYBENCLAMIDE; GLYCATED HEMOGLOBIN; GSIS; HBA(1C); HFD; HIGH-FAT DIET; LAME; LINOLEIC ACID METHYL ESTER.; OGTT; ORAL GLUCOSE TOLERANCE TEST; PLASMA TRIGLYCERIDE; STREPTOZOTOCIN; STZ; TEA; TETRAETHYLAMMONIUM CHLORIDE; TG; TYPE 2 DIABETES; VINDOLINE; Β-CELL DYSFUNCTION;

ANIMALS; APOCYNACEAE; APOPTOSIS; CELL LINE, TUMOR; CELLS, CULTURED; CHO CELLS; CRICETULUS; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, TYPE 2; GLUCOSE; GLUCOSE TOLERANCE TEST; HEK293 CELLS; HEMOGLOBIN A, GLYCOSYLATED; HOMEOSTASIS; HUMANS; HYPOGLYCEMIC AGENTS; INSULIN; ISLETS OF LANGERHANS; MICE; MICE, INBRED C57BL; POTASSIUM CHANNEL BLOCKERS; VINBLASTINE;

EID: 84885428171     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2013.08.043     Document Type: Article

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