-
1
-
-
79959517565
-
Human fatty liver disease: old questions and new insights
-
Cohen JC, Horton JD, Hobbs HH, (2011) Human fatty liver disease: old questions and new insights. Science 332: 1519-1523.
-
(2011)
Science
, vol.332
, pp. 1519-1523
-
-
Cohen, J.C.1
Horton, J.D.2
Hobbs, H.H.3
-
2
-
-
0037373008
-
Liver-specific disruption of PPARgamma in leptin-deficient mice improves fatty liver but aggravates diabetic phenotypes
-
Matsusue K, Haluzik M, Lambert G, Yim SH, Gavrilova O, et al. (2003) Liver-specific disruption of PPARgamma in leptin-deficient mice improves fatty liver but aggravates diabetic phenotypes. J Clin Invest 111: 737-747.
-
(2003)
J Clin Invest
, vol.111
, pp. 737-747
-
-
Matsusue, K.1
Haluzik, M.2
Lambert, G.3
Yim, S.H.4
Gavrilova, O.5
-
3
-
-
50949107027
-
Consequences of lipid droplet coat protein downregulation in liver cells: abnormal lipid droplet metabolism and induction of insulin resistance
-
Bell M, Wang H, Chen H, McLenithan JC, Gong DW, et al. (2008) Consequences of lipid droplet coat protein downregulation in liver cells: abnormal lipid droplet metabolism and induction of insulin resistance. Diabetes 57: 2037-2045.
-
(2008)
Diabetes
, vol.57
, pp. 2037-2045
-
-
Bell, M.1
Wang, H.2
Chen, H.3
McLenithan, J.C.4
Gong, D.W.5
-
4
-
-
44949130214
-
Fat-specific protein 27 regulates storage of triacylglycerol
-
Keller P, Petrie JT, De Rose P, Gerin I, Wright WS, et al. (2008) Fat-specific protein 27 regulates storage of triacylglycerol. J Biol Chem 283: 14355-14365.
-
(2008)
J Biol Chem
, vol.283
, pp. 14355-14365
-
-
Keller, P.1
Petrie, J.T.2
De Rose, P.3
Gerin, I.4
Wright, W.S.5
-
5
-
-
77649224298
-
A physiological role for fat specific protein 27/cell death-inducing DFF45-like effector C in adipose and liver
-
Matsusue K, (2010) A physiological role for fat specific protein 27/cell death-inducing DFF45-like effector C in adipose and liver. Biol Pharm Bull 33: 346-350.
-
(2010)
Biol Pharm Bull
, vol.33
, pp. 346-350
-
-
Matsusue, K.1
-
6
-
-
36348940037
-
Fat-specific protein 27, a novel lipid droplet protein that enhances triglyceride storage
-
Puri V, Konda S, Ranjit S, Aouadi M, Chawla A, et al. (2007) Fat-specific protein 27, a novel lipid droplet protein that enhances triglyceride storage. J Biol Chem 282: 34213-34218.
-
(2007)
J Biol Chem
, vol.282
, pp. 34213-34218
-
-
Puri, V.1
Konda, S.2
Ranjit, S.3
Aouadi, M.4
Chawla, A.5
-
7
-
-
8744267532
-
Proteomic analysis of proteins associated with lipid droplets of basal and lipolytically stimulated 3T3-L1 adipocytes
-
Brasaemle DL, Dolios G, Shapiro L, Wang R, (2004) Proteomic analysis of proteins associated with lipid droplets of basal and lipolytically stimulated 3T3-L1 adipocytes. J Biol Chem 279: 46835-46842.
-
(2004)
J Biol Chem
, vol.279
, pp. 46835-46842
-
-
Brasaemle, D.L.1
Dolios, G.2
Shapiro, L.3
Wang, R.4
-
8
-
-
33646168160
-
Lipid droplets: a unified view of a dynamic organelle
-
Martin S, Parton RG, (2006) Lipid droplets: a unified view of a dynamic organelle. Nat Rev Mol Cell Biol 7: 373-378.
-
(2006)
Nat Rev Mol Cell Biol
, vol.7
, pp. 373-378
-
-
Martin, S.1
Parton, R.G.2
-
9
-
-
70450220107
-
Partial lipodystrophy and insulin resistant diabetes in a patient with a homozygous nonsense mutation in CIDEC
-
Rubio-Cabezas O, Puri V, Murano I, Saudek V, Semple RK, et al. (2009) Partial lipodystrophy and insulin resistant diabetes in a patient with a homozygous nonsense mutation in CIDEC. EMBO Mol Med 1: 280-287.
-
(2009)
EMBO Mol Med
, vol.1
, pp. 280-287
-
-
Rubio-Cabezas, O.1
Puri, V.2
Murano, I.3
Saudek, V.4
Semple, R.K.5
-
11
-
-
48749103552
-
FSP27 contributes to efficient energy storage in murine white adipocytes by promoting the formation of unilocular lipid droplets
-
Nishino N, Tamori Y, Tateya S, Kawaguchi T, Shibakusa T, et al. (2008) FSP27 contributes to efficient energy storage in murine white adipocytes by promoting the formation of unilocular lipid droplets. J Clin Invest 118: 2808-2821.
-
(2008)
J Clin Invest
, vol.118
, pp. 2808-2821
-
-
Nishino, N.1
Tamori, Y.2
Tateya, S.3
Kawaguchi, T.4
Shibakusa, T.5
-
12
-
-
37249062585
-
RNAi screens reveal novel metabolic regulators: RIP140, MAP4k4 and the lipid droplet associated fat specific protein (FSP) 27
-
Puri V, Virbasius JV, Guilherme A, Czech MP, (2008) RNAi screens reveal novel metabolic regulators: RIP140, MAP4k4 and the lipid droplet associated fat specific protein (FSP) 27. Acta Physiol (Oxf) 192: 103-115.
-
(2008)
Acta Physiol (Oxf)
, vol.192
, pp. 103-115
-
-
Puri, V.1
Virbasius, J.V.2
Guilherme, A.3
Czech, M.P.4
-
13
-
-
72249118392
-
Functional analysis of FSP27 protein regions for lipid droplet localization, caspase-dependent apoptosis, and dimerization with CIDEA
-
Liu K, Zhou S, Kim JY, Tillison K, Majors D, et al. (2009) Functional analysis of FSP27 protein regions for lipid droplet localization, caspase-dependent apoptosis, and dimerization with CIDEA. Am J Physiol Endocrinol Metab 297: E1395-1413.
-
(2009)
Am J Physiol Endocrinol Metab
, vol.297
-
-
Liu, K.1
Zhou, S.2
Kim, J.Y.3
Tillison, K.4
Majors, D.5
-
14
-
-
41449098953
-
Hepatic steatosis in leptin-deficient mice is promoted by the PPARgamma target gene Fsp27
-
Matsusue K, Kusakabe T, Noguchi T, Takiguchi S, Suzuki T, et al. (2008) Hepatic steatosis in leptin-deficient mice is promoted by the PPARgamma target gene Fsp27. Cell Metab 7: 302-311.
-
(2008)
Cell Metab
, vol.7
, pp. 302-311
-
-
Matsusue, K.1
Kusakabe, T.2
Noguchi, T.3
Takiguchi, S.4
Suzuki, T.5
-
15
-
-
84861447098
-
Hepatic peroxisome proliferator-activated receptor-{gamma}-fat-specific protein 27 pathway contributes to obesity-related hypertension via afferent vagal signals
-
Uno K, Yamada T, Ishigaki Y, Imai J, Hasegawa Y, et al. (2011) Hepatic peroxisome proliferator-activated receptor-{gamma}-fat-specific protein 27 pathway contributes to obesity-related hypertension via afferent vagal signals. Eur Heart J.
-
(2011)
Eur Heart J
-
-
Uno, K.1
Yamada, T.2
Ishigaki, Y.3
Imai, J.4
Hasegawa, Y.5
-
16
-
-
0036293873
-
PPARs: transcription factors controlling lipid and lipoprotein metabolism
-
Bocher V, Pineda-Torra I, Fruchart JC, Staels B, (2002) PPARs: transcription factors controlling lipid and lipoprotein metabolism. Ann N Y Acad Sci 967: 7-18.
-
(2002)
Ann N Y Acad Sci
, vol.967
, pp. 7-18
-
-
Bocher, V.1
Pineda-Torra, I.2
Fruchart, J.C.3
Staels, B.4
-
17
-
-
0036007024
-
C/EBPalpha induces adipogenesis through PPARgamma: a unified pathway
-
Rosen ED, Hsu CH, Wang X, Sakai S, Freeman MW, et al. (2002) C/EBPalpha induces adipogenesis through PPARgamma: a unified pathway. Genes Dev 16: 22-26.
-
(2002)
Genes Dev
, vol.16
, pp. 22-26
-
-
Rosen, E.D.1
Hsu, C.H.2
Wang, X.3
Sakai, S.4
Freeman, M.W.5
-
18
-
-
20044380758
-
The link between nutritional status and insulin sensitivity is dependent on the adipocyte-specific peroxisome proliferator-activated receptor-gamma2 isoform
-
Medina-Gomez G, Virtue S, Lelliott C, Boiani R, Campbell M, et al. (2005) The link between nutritional status and insulin sensitivity is dependent on the adipocyte-specific peroxisome proliferator-activated receptor-gamma2 isoform. Diabetes 54: 1706-1716.
-
(2005)
Diabetes
, vol.54
, pp. 1706-1716
-
-
Medina-Gomez, G.1
Virtue, S.2
Lelliott, C.3
Boiani, R.4
Campbell, M.5
-
19
-
-
79955868038
-
An increase in liver PPARgamma2 is an initial event to induce fatty liver in response to a diet high in butter: PPARgamma2 knockdown improves fatty liver induced by high-saturated fat
-
Yamazaki T, Shiraishi S, Kishimoto K, Miura S, Ezaki O, (2010) An increase in liver PPARgamma2 is an initial event to induce fatty liver in response to a diet high in butter: PPARgamma2 knockdown improves fatty liver induced by high-saturated fat. J Nutr Biochem 22: 543-553.
-
(2010)
J Nutr Biochem
, vol.22
, pp. 543-553
-
-
Yamazaki, T.1
Shiraishi, S.2
Kishimoto, K.3
Miura, S.4
Ezaki, O.5
-
22
-
-
33645218590
-
Regulation of leptin synthesis and secretion before birth: implications for the early programming of adult obesity
-
McMillen IC, Edwards LJ, Duffield J, Muhlhausler BS, (2006) Regulation of leptin synthesis and secretion before birth: implications for the early programming of adult obesity. Reproduction 131: 415-427.
-
(2006)
Reproduction
, vol.131
, pp. 415-427
-
-
McMillen, I.C.1
Edwards, L.J.2
Duffield, J.3
Muhlhausler, B.S.4
-
23
-
-
34249787641
-
Prenatal and postnatal pathways to obesity: different underlying mechanisms, different metabolic outcomes
-
Thompson NM, Norman AM, Donkin SS, Shankar RR, Vickers MH, et al. (2007) Prenatal and postnatal pathways to obesity: different underlying mechanisms, different metabolic outcomes. Endocrinology 148: 2345-2354.
-
(2007)
Endocrinology
, vol.148
, pp. 2345-2354
-
-
Thompson, N.M.1
Norman, A.M.2
Donkin, S.S.3
Shankar, R.R.4
Vickers, M.H.5
-
24
-
-
33748328554
-
Metabolic imprinting: critical impact of the perinatal environment on the regulation of energy homeostasis
-
Levin BE, (2006) Metabolic imprinting: critical impact of the perinatal environment on the regulation of energy homeostasis. Philos Trans R Soc Lond B Biol Sci 361: 1107-1121.
-
(2006)
Philos Trans R Soc Lond B Biol Sci
, vol.361
, pp. 1107-1121
-
-
Levin, B.E.1
-
25
-
-
0034219349
-
The obesity epidemic: metabolic imprinting on genetically susceptible neural circuits
-
Levin BE, (2000) The obesity epidemic: metabolic imprinting on genetically susceptible neural circuits. Obes Res 8: 342-347.
-
(2000)
Obes Res
, vol.8
, pp. 342-347
-
-
Levin, B.E.1
-
26
-
-
60349113479
-
Maternal nutritional history predicts obesity in adult offspring independent of postnatal diet
-
Howie GJ, Sloboda DM, Kamal T, Vickers MH, (2009) Maternal nutritional history predicts obesity in adult offspring independent of postnatal diet. J Physiol 587: 905-915.
-
(2009)
J Physiol
, vol.587
, pp. 905-915
-
-
Howie, G.J.1
Sloboda, D.M.2
Kamal, T.3
Vickers, M.H.4
-
27
-
-
77952420159
-
Maternal obesity during pregnancy and lactation programs the development of offspring non-alcoholic fatty liver disease in mice
-
Oben JA, Mouralidarane A, Samuelsson AM, Matthews PJ, Morgan ML, et al. (2010) Maternal obesity during pregnancy and lactation programs the development of offspring non-alcoholic fatty liver disease in mice. J Hepatol 52: 913-920.
-
(2010)
J Hepatol
, vol.52
, pp. 913-920
-
-
Oben, J.A.1
Mouralidarane, A.2
Samuelsson, A.M.3
Matthews, P.J.4
Morgan, M.L.5
-
28
-
-
77949873038
-
Maternal obesity programmes offspring development of non-alcoholic fatty pancreas disease
-
Oben JA, Patel T, Mouralidarane A, Samuelsson AM, Matthews P, et al. (2010) Maternal obesity programmes offspring development of non-alcoholic fatty pancreas disease. Biochem Biophys Res Commun 394: 24-28.
-
(2010)
Biochem Biophys Res Commun
, vol.394
, pp. 24-28
-
-
Oben, J.A.1
Patel, T.2
Mouralidarane, A.3
Samuelsson, A.M.4
Matthews, P.5
-
29
-
-
78650756700
-
Suboptimal maternal nutrition, during early fetal liver development, promotes lipid accumulation in the liver of obese offspring
-
Hyatt MA, Gardner DS, Sebert S, Wilson V, Davidson N, et al. (2011) Suboptimal maternal nutrition, during early fetal liver development, promotes lipid accumulation in the liver of obese offspring. Reproduction 141: 119-126.
-
(2011)
Reproduction
, vol.141
, pp. 119-126
-
-
Hyatt, M.A.1
Gardner, D.S.2
Sebert, S.3
Wilson, V.4
Davidson, N.5
-
30
-
-
79954573165
-
Chronic high-fat diet drives postnatal epigenetic regulation of mu-opioid receptor in the brain
-
Vucetic Z, Kimmel J, Reyes TM, (2011) Chronic high-fat diet drives postnatal epigenetic regulation of mu-opioid receptor in the brain. Neuropsychopharmacology 36: 1199-1206.
-
(2011)
Neuropsychopharmacology
, vol.36
, pp. 1199-1206
-
-
Vucetic, Z.1
Kimmel, J.2
Reyes, T.M.3
-
31
-
-
77957258099
-
Maternal high-fat diet alters methylation and gene expression of dopamine and opioid-related genes
-
Vucetic Z, Kimmel J, Totoki K, Hollenbeck E, Reyes TM, (2010) Maternal high-fat diet alters methylation and gene expression of dopamine and opioid-related genes. Endocrinology 151: 4756-4764.
-
(2010)
Endocrinology
, vol.151
, pp. 4756-4764
-
-
Vucetic, Z.1
Kimmel, J.2
Totoki, K.3
Hollenbeck, E.4
Reyes, T.M.5
-
32
-
-
0033771545
-
Metabolic imprinting on genetically predisposed neural circuits perpetuates obesity
-
Levin BE, (2000) Metabolic imprinting on genetically predisposed neural circuits perpetuates obesity. Nutrition 16: 909-915.
-
(2000)
Nutrition
, vol.16
, pp. 909-915
-
-
Levin, B.E.1
-
33
-
-
64949167434
-
Synergy of nature and nurture in the development of childhood obesity
-
Levin BE, (2009) Synergy of nature and nurture in the development of childhood obesity. Int J Obes (Lond) 33Suppl 1: S53-56.
-
(2009)
Int J Obes (Lond)
, vol.33
-
-
Levin, B.E.1
-
34
-
-
0016682724
-
Integration of amino acid biosynthesis into the cell cycle of Saccharomyces cerevisiae
-
Wolfner M, Yep D, Messenguy F, Fink GR, (1975) Integration of amino acid biosynthesis into the cell cycle of Saccharomyces cerevisiae. J Mol Biol 96: 273-290.
-
(1975)
J Mol Biol
, vol.96
, pp. 273-290
-
-
Wolfner, M.1
Yep, D.2
Messenguy, F.3
Fink, G.R.4
-
35
-
-
0026556814
-
Phosphorylation of initiation factor 2 alpha by protein kinase GCN2 mediates gene-specific translational control of GCN4 in yeast
-
Dever TE, Feng L, Wek RC, Cigan AM, Donahue TF, et al. (1992) Phosphorylation of initiation factor 2 alpha by protein kinase GCN2 mediates gene-specific translational control of GCN4 in yeast. Cell 68: 585-596.
-
(1992)
Cell
, vol.68
, pp. 585-596
-
-
Dever, T.E.1
Feng, L.2
Wek, R.C.3
Cigan, A.M.4
Donahue, T.F.5
-
36
-
-
0024381444
-
Juxtaposition of domains homologous to protein kinases and histidyl-tRNA synthetases in GCN2 protein suggests a mechanism for coupling GCN4 expression to amino acid availability
-
Wek RC, Jackson BM, Hinnebusch AG, (1989) Juxtaposition of domains homologous to protein kinases and histidyl-tRNA synthetases in GCN2 protein suggests a mechanism for coupling GCN4 expression to amino acid availability. Proc Natl Acad Sci U S A 86: 4579-4583.
-
(1989)
Proc Natl Acad Sci U S A
, vol.86
, pp. 4579-4583
-
-
Wek, R.C.1
Jackson, B.M.2
Hinnebusch, A.G.3
-
37
-
-
0036771638
-
The GCN2 eIF2alpha kinase is required for adaptation to amino acid deprivation in mice
-
Zhang P, McGrath BC, Reinert J, Olsen DS, Lei L, et al. (2002) The GCN2 eIF2alpha kinase is required for adaptation to amino acid deprivation in mice. Mol Cell Biol 22: 6681-6688.
-
(2002)
Mol Cell Biol
, vol.22
, pp. 6681-6688
-
-
Zhang, P.1
McGrath, B.C.2
Reinert, J.3
Olsen, D.S.4
Lei, L.5
-
38
-
-
20144374658
-
Uncharged tRNA and sensing of amino acid deficiency in mammalian piriform cortex
-
Hao S, Sharp JW, Ross-Inta CM, McDaniel BJ, Anthony TG, et al. (2005) Uncharged tRNA and sensing of amino acid deficiency in mammalian piriform cortex. Science 307: 1776-1778.
-
(2005)
Science
, vol.307
, pp. 1776-1778
-
-
Hao, S.1
Sharp, J.W.2
Ross-Inta, C.M.3
McDaniel, B.J.4
Anthony, T.G.5
-
39
-
-
20144387009
-
The GCN2 kinase biases feeding behavior to maintain amino acid homeostasis in omnivores
-
Maurin AC, Jousse C, Averous J, Parry L, Bruhat A, et al. (2005) The GCN2 kinase biases feeding behavior to maintain amino acid homeostasis in omnivores. Cell Metab 1: 273-277.
-
(2005)
Cell Metab
, vol.1
, pp. 273-277
-
-
Maurin, A.C.1
Jousse, C.2
Averous, J.3
Parry, L.4
Bruhat, A.5
-
40
-
-
33846602706
-
The GCN2 eIF2alpha kinase regulates fatty-acid homeostasis in the liver during deprivation of an essential amino acid
-
Guo F, Cavener DR, (2007) The GCN2 eIF2alpha kinase regulates fatty-acid homeostasis in the liver during deprivation of an essential amino acid. Cell Metab 5: 103-114.
-
(2007)
Cell Metab
, vol.5
, pp. 103-114
-
-
Guo, F.1
Cavener, D.R.2
-
41
-
-
70449158340
-
A simple method for the isolation and purification of total lipides from animal tissues
-
Folch J, Lees M, Sloane Stanley GH, (1957) A simple method for the isolation and purification of total lipides from animal tissues. J Biol Chem 226: 497-509.
-
(1957)
J Biol Chem
, vol.226
, pp. 497-509
-
-
Folch, J.1
Lees, M.2
Sloane Stanley, G.H.3
-
42
-
-
27844553841
-
Hepatic peroxisomal fatty acid beta-oxidation is regulated by liver X receptor alpha
-
Hu T, Foxworthy P, Siesky A, Ficorilli JV, Gao H, et al. (2005) Hepatic peroxisomal fatty acid beta-oxidation is regulated by liver X receptor alpha. Endocrinology 146: 5380-5387.
-
(2005)
Endocrinology
, vol.146
, pp. 5380-5387
-
-
Hu, T.1
Foxworthy, P.2
Siesky, A.3
Ficorilli, J.V.4
Gao, H.5
-
43
-
-
0019742075
-
Assay of peroxisomal beta-oxidation of fatty acids
-
Lazarow PB, (1981) Assay of peroxisomal beta-oxidation of fatty acids. Methods Enzymol 72: 315-319.
-
(1981)
Methods Enzymol
, vol.72
, pp. 315-319
-
-
Lazarow, P.B.1
-
44
-
-
33747119058
-
Optimized conditions for measuring lipolysis in murine primary adipocytes
-
Viswanadha S, Londos C, (2006) Optimized conditions for measuring lipolysis in murine primary adipocytes. J Lipid Res 47: 1859-1864.
-
(2006)
J Lipid Res
, vol.47
, pp. 1859-1864
-
-
Viswanadha, S.1
Londos, C.2
-
45
-
-
0036710326
-
Intracranial administration of transforming growth factor-beta3 increases fat oxidation in rats
-
Yamazaki H, Arai M, Matsumura S, Inoue K, Fushiki T, (2002) Intracranial administration of transforming growth factor-beta3 increases fat oxidation in rats. Am J Physiol Endocrinol Metab 283: E536-544.
-
(2002)
Am J Physiol Endocrinol Metab
, vol.283
-
-
Yamazaki, H.1
Arai, M.2
Matsumura, S.3
Inoue, K.4
Fushiki, T.5
-
46
-
-
67649418447
-
Histone methylation regulator PTIP is required for PPARgamma and C/EBPalpha expression and adipogenesis
-
Cho YW, Hong S, Jin Q, Wang L, Lee JE, et al. (2009) Histone methylation regulator PTIP is required for PPARgamma and C/EBPalpha expression and adipogenesis. Cell Metab 10: 27-39.
-
(2009)
Cell Metab
, vol.10
, pp. 27-39
-
-
Cho, Y.W.1
Hong, S.2
Jin, Q.3
Wang, L.4
Lee, J.E.5
-
47
-
-
0025081078
-
The fetal and infant origins of adult disease
-
Barker DJ, (1990) The fetal and infant origins of adult disease. BMJ 301: 1111.
-
(1990)
BMJ
, vol.301
, pp. 1111
-
-
Barker, D.J.1
-
48
-
-
4344650450
-
Prenatal programming of postnatal obesity: fetal nutrition and the regulation of leptin synthesis and secretion before birth
-
McMillen IC, Muhlhausler BS, Duffield JA, Yuen BS, (2004) Prenatal programming of postnatal obesity: fetal nutrition and the regulation of leptin synthesis and secretion before birth. Proc Nutr Soc 63: 405-412.
-
(2004)
Proc Nutr Soc
, vol.63
, pp. 405-412
-
-
McMillen, I.C.1
Muhlhausler, B.S.2
Duffield, J.A.3
Yuen, B.S.4
-
49
-
-
32644436318
-
Liver triglyceride secretion and lipid oxidative metabolism are rapidly altered by leptin in vivo
-
Huang W, Dedousis N, Bandi A, Lopaschuk GD, O'Doherty RM, (2006) Liver triglyceride secretion and lipid oxidative metabolism are rapidly altered by leptin in vivo. Endocrinology 147: 1480-1487.
-
(2006)
Endocrinology
, vol.147
, pp. 1480-1487
-
-
Huang, W.1
Dedousis, N.2
Bandi, A.3
Lopaschuk, G.D.4
O'Doherty, R.M.5
-
50
-
-
79959364257
-
Loss of mitogen-activated protein kinase phosphatase-1 protects from hepatic steatosis by repression of cell death-inducing DNA fragmentation factor A (DFFA)-like effector C (CIDEC)/fat-specific protein 27
-
Flach RJ, Qin H, Zhang L, Bennett AM, (2011) Loss of mitogen-activated protein kinase phosphatase-1 protects from hepatic steatosis by repression of cell death-inducing DNA fragmentation factor A (DFFA)-like effector C (CIDEC)/fat-specific protein 27. J Biol Chem 286: 22195-22202.
-
(2011)
J Biol Chem
, vol.286
, pp. 22195-22202
-
-
Flach, R.J.1
Qin, H.2
Zhang, L.3
Bennett, A.M.4
-
51
-
-
77953868236
-
Lipid-induced insulin resistance: unravelling the mechanism
-
Samuel VT, Petersen KF, Shulman GI, (2010) Lipid-induced insulin resistance: unravelling the mechanism. Lancet 375: 2267-2277.
-
(2010)
Lancet
, vol.375
, pp. 2267-2277
-
-
Samuel, V.T.1
Petersen, K.F.2
Shulman, G.I.3
-
52
-
-
41649112075
-
Assessment of fat-specific protein 27 in the adipocyte lineage suggests a dual role for FSP27 in adipocyte metabolism and cell death
-
Kim JY, Liu K, Zhou S, Tillison K, Wu Y, et al. (2008) Assessment of fat-specific protein 27 in the adipocyte lineage suggests a dual role for FSP27 in adipocyte metabolism and cell death. Am J Physiol Endocrinol Metab 294: E654-667.
-
(2008)
Am J Physiol Endocrinol Metab
, vol.294
-
-
Kim, J.Y.1
Liu, K.2
Zhou, S.3
Tillison, K.4
Wu, Y.5
-
53
-
-
0029016829
-
An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma)
-
Lehmann JM, Moore LB, Smith-Oliver TA, Wilkison WO, Willson TM, et al. (1995) An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma). J Biol Chem 270: 12953-12956.
-
(1995)
J Biol Chem
, vol.270
, pp. 12953-12956
-
-
Lehmann, J.M.1
Moore, L.B.2
Smith-Oliver, T.A.3
Wilkison, W.O.4
Willson, T.M.5
-
54
-
-
79960110157
-
The transcription factor cyclic AMP-responsive element-binding protein H regulates triglyceride metabolism
-
Lee JH, Giannikopoulos P, Duncan SA, Wang J, Johansen CT, et al. (2011) The transcription factor cyclic AMP-responsive element-binding protein H regulates triglyceride metabolism. Nat Med 17: 812-815.
-
(2011)
Nat Med
, vol.17
, pp. 812-815
-
-
Lee, J.H.1
Giannikopoulos, P.2
Duncan, S.A.3
Wang, J.4
Johansen, C.T.5
-
55
-
-
84872149680
-
Epigenetic mechanisms involved in developmental nutritional programming
-
Gabory A, Attig L, Junien C, (2011) Epigenetic mechanisms involved in developmental nutritional programming. World J Diabetes 2: 164-175.
-
(2011)
World J Diabetes
, vol.2
, pp. 164-175
-
-
Gabory, A.1
Attig, L.2
Junien, C.3
-
56
-
-
77956260872
-
Chromatin structure and gene expression programs of human embryonic and induced pluripotent stem cells
-
Guenther MG, Frampton GM, Soldner F, Hockemeyer D, Mitalipova M, et al. (2010) Chromatin structure and gene expression programs of human embryonic and induced pluripotent stem cells. Cell Stem Cell 7: 249-257.
-
(2010)
Cell Stem Cell
, vol.7
, pp. 249-257
-
-
Guenther, M.G.1
Frampton, G.M.2
Soldner, F.3
Hockemeyer, D.4
Mitalipova, M.5
-
57
-
-
34247636362
-
PPAR gamma 2 prevents lipotoxicity by controlling adipose tissue expandability and peripheral lipid metabolism
-
Medina-Gomez G, Gray SL, Yetukuri L, Shimomura K, Virtue S, et al. (2007) PPAR gamma 2 prevents lipotoxicity by controlling adipose tissue expandability and peripheral lipid metabolism. PLoS Genet 3: e64.
-
(2007)
PLoS Genet
, vol.3
-
-
Medina-Gomez, G.1
Gray, S.L.2
Yetukuri, L.3
Shimomura, K.4
Virtue, S.5
-
58
-
-
24144445901
-
Translational control of hippocampal synaptic plasticity and memory by the eIF2alpha kinase GCN2
-
Costa-Mattioli M, Gobert D, Harding H, Herdy B, Azzi M, et al. (2005) Translational control of hippocampal synaptic plasticity and memory by the eIF2alpha kinase GCN2. Nature 436: 1166-1173.
-
(2005)
Nature
, vol.436
, pp. 1166-1173
-
-
Costa-Mattioli, M.1
Gobert, D.2
Harding, H.3
Herdy, B.4
Azzi, M.5
-
59
-
-
0029006391
-
The histidyl-tRNA synthetase-related sequence in the eIF-2 alpha protein kinase GCN2 interacts with tRNA and is required for activation in response to starvation for different amino acids
-
Wek SA, Zhu S, Wek RC, (1995) The histidyl-tRNA synthetase-related sequence in the eIF-2 alpha protein kinase GCN2 interacts with tRNA and is required for activation in response to starvation for different amino acids. Mol Cell Biol 15: 4497-4506.
-
(1995)
Mol Cell Biol
, vol.15
, pp. 4497-4506
-
-
Wek, S.A.1
Zhu, S.2
Wek, R.C.3
-
60
-
-
33646152751
-
Antiviral effect of the mammalian translation initiation factor 2alpha kinase GCN2 against RNA viruses
-
Berlanga JJ, Ventoso I, Harding HP, Deng J, Ron D, et al. (2006) Antiviral effect of the mammalian translation initiation factor 2alpha kinase GCN2 against RNA viruses. Embo J 25: 1730-1740.
-
(2006)
Embo J
, vol.25
, pp. 1730-1740
-
-
Berlanga, J.J.1
Ventoso, I.2
Harding, H.P.3
Deng, J.4
Ron, D.5
-
61
-
-
0037031145
-
Activation of GCN2 in UV-irradiated cells inhibits translation
-
Deng J, Harding HP, Raught B, Gingras AC, Berlanga JJ, et al. (2002) Activation of GCN2 in UV-irradiated cells inhibits translation. Curr Biol 12: 1279-1286.
-
(2002)
Curr Biol
, vol.12
, pp. 1279-1286
-
-
Deng, J.1
Harding, H.P.2
Raught, B.3
Gingras, A.C.4
Berlanga, J.J.5
-
62
-
-
33846622807
-
An afferent vagal nerve pathway links hepatic PPARalpha activation to glucocorticoid-induced insulin resistance and hypertension
-
Bernal-Mizrachi C, Xiaozhong L, Yin L, Knutsen RH, Howard MJ, et al. (2007) An afferent vagal nerve pathway links hepatic PPARalpha activation to glucocorticoid-induced insulin resistance and hypertension. Cell Metab 5: 91-102.
-
(2007)
Cell Metab
, vol.5
, pp. 91-102
-
-
Bernal-Mizrachi, C.1
Xiaozhong, L.2
Yin, L.3
Knutsen, R.H.4
Howard, M.J.5
-
63
-
-
16244388931
-
Hypothalamic sensing of circulating fatty acids is required for glucose homeostasis
-
Lam TK, Pocai A, Gutierrez-Juarez R, Obici S, Bryan J, et al. (2005) Hypothalamic sensing of circulating fatty acids is required for glucose homeostasis. Nat Med 11: 320-327.
-
(2005)
Nat Med
, vol.11
, pp. 320-327
-
-
Lam, T.K.1
Pocai, A.2
Gutierrez-Juarez, R.3
Obici, S.4
Bryan, J.5
-
64
-
-
84861408932
-
Hepatic peroxisome proliferator-activated receptor-gamma-fat-specific protein 27 pathway contributes to obesity-related hypertension via afferent vagal signals
-
Uno K, Yamada T, Ishigaki Y, Imai J, Hasegawa Y, et al. (2012) Hepatic peroxisome proliferator-activated receptor-gamma-fat-specific protein 27 pathway contributes to obesity-related hypertension via afferent vagal signals. Eur Heart J 33: 1279-1289.
-
(2012)
Eur Heart J
, vol.33
, pp. 1279-1289
-
-
Uno, K.1
Yamada, T.2
Ishigaki, Y.3
Imai, J.4
Hasegawa, Y.5
-
65
-
-
0026772772
-
Type 2 (non-insulin-dependent) diabetes mellitus: the thrifty phenotype hypothesis
-
Hales CN, Barker DJ, (1992) Type 2 (non-insulin-dependent) diabetes mellitus: the thrifty phenotype hypothesis. Diabetologia 35: 595-601.
-
(1992)
Diabetologia
, vol.35
, pp. 595-601
-
-
Hales, C.N.1
Barker, D.J.2
|