Solution Structure of Ectodomains of the Insulin Receptor Family: The Ectodomain of the Type 1 Insulin-Like Growth Factor Receptor Displays Asymmetry of Ligand Binding Accompanied by Limited Conformational Change

Journal of Molecular Biology

Volumn 394, Issue 5, 2009, Pages 878-892

  Whitten, Andrew E ^a,b   Smith, Brian J ^c   Menting, John G ^c   Margetts, Mai B ^c   McKern, Neil M ^d   Lovrecz, George O ^d   Adams, Timothy E ^d   Richards, Kim ^d   Bentley, John D ^d   Trewhella, Jill ^b   Ward, Colin W ^c   Lawrence, Michael C ^c  

^a AUSTRALIAN NUCLEAR SCIENCE AND TECHNOLOGY ORGANISATION   (Australia)

^b UNIVERSITY OF SYDNEY   (Australia)

^c WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH   (Australia)

^d CSIRO   (Australia)

Author keywords

insulin receptor; insulin like growth factor 1; negative cooperativity; small angle X ray scattering; Type 1 insulin like growth factor receptor

Indexed keywords

INSULIN RECEPTOR; SOMATOMEDIN C RECEPTOR;

ANIMAL CELL; ARTICLE; CHO CELL; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; FEMALE; LIGAND BINDING; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN STRUCTURE; SIGNAL TRANSDUCTION; STOICHIOMETRY; X RAY CRYSTALLOGRAPHY;

EID: 70449632130     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2009.10.011     Document Type: Article

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