Mastering tricyclic ring systems for desirable functional cannabinoid activity

European Journal of Medicinal Chemistry

Volumn 69, Issue , 2013, Pages 881-907

  Petrov, Ravil R ^a   Knight, Lindsay ^b   Chen, Shao Rui ^c   Wager Miller, Jim ^b   McDaniel, Steven W ^a   Diaz, Fanny ^a   Barth, Francis ^d   Pan, Hui Lin ^c   Mackie, Ken ^b   Cavasotto, Claudio N ^e   Diaz, Philippe ^a  

^a UNIVERSITY OF MONTANA   (United States)

^b INDIANA UNIVERSITY   (United States)

^c UNIVERSITY OF TEXAS   (United States)

^d SANOFI   (France)

^e Partner Institute of the Max Planck Society ^*  (Argentina)

Author keywords

Cannabinoid; Carbazole; CB1; CB2; GPCR; Neuropathic pain

Indexed keywords

(9 PENTYL 9H CARBAZOL 3 YL)(PIPERIDIN 1 YL)METHANONE; 3 [3 (PIPERIDINE 1 CARBONYL) 9H CARBAZOL 9 YL]PROPYL(1,1 DIOXO THIOMORPHOLINO) 4 CARBOXYLATE; 9 (3 METHOXYPROPYL) 9H (CARBAZOL 3 YL)(PIPERIDIN 1 YL)METHANONE; ANALGESIC AGENT; CANNABINOID; CANNABINOID 1 RECEPTOR; CANNABINOID 1 RECEPTOR AGONIST; CANNABINOID 2 RECEPTOR; CANNABINOID 2 RECEPTOR AGONIST; CARBAZOLE DERIVATIVE; GAMMA CARBOLINE DERIVATIVE; N (2,2 DIMETHYLPROPYL) 9 PENTYL 9H PYRIDO[3,4 B]INDOLE 3 CARBOXAMIDE; N [3 [3 (PIPERIDINE 1 CARBONYL) 9H CARBAZOL 9 YL]PROPYL]METHANESULFONAMIDE; PIPERIDIN 1 YL[9 (PYRIDIN 4 YLMETHYL) 9H CARBAZOL 3 YL]METHANONE; RADIOLIGAND; UNCLASSIFIED DRUG;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; DRUG EFFECT; DRUG INHIBITION; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SELECTIVITY; HUMAN; IN VITRO STUDY; IN VIVO STUDY; INTERNALIZATION; MALE; NEUROPATHIC PAIN; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

BOVINE SERUM ALBUMIN; BSA; CANNABINOID; CANNABINOID RECEPTOR 1; CANNABINOID RECEPTOR 2; CARBAZOLE; CB1; CB2; EC(50); EDTA; ETHYLENEDIAMINETETRAACETIC ACID; GPCR; GTP; GUANOSINE-5′-TRIPHOSPHATE; HALF MAXIMAL EFFECTIVE CONCENTRATION; HCB1; HCB2; HUMAN CB1; HUMAN CB2; IC(50); MEDIAN INHIBITION CONCENTRATION; NEUROPATHIC PAIN; VZAFOXSCFBBHKO-UHFFFAOYSA-N;

ANIMALS; CARBAZOLES; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; NEURALGIA; RATS; RECEPTOR, CANNABINOID, CB1; RECEPTOR, CANNABINOID, CB2; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84885348455     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2013.09.038     Document Type: Article

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