Mutagenesis and computer modeling studies of a GPCR conserved residue W5.43(194) in ligand recognition and signal transduction for CB2 receptor

International Immunopharmacology

Volumn 11, Issue 9, 2011, Pages 1303-1310

  Zhang, Yuxun ^a   Xie, Zhaojun ^a   Wang, Lirong ^a,b,c   Schreiter, Brielle ^a   Lazo, John S ^c,e   Gertsch, Jurg ^f   Xie, Xiang Qun ^a,b,c,d  

^a UNIVERSITY OF PITTSBURGH   (United States)

^b Library Development Center   (United States)

^c Drug Discovery Institute   (United States)

^d Departments of Computational Biology and Structural Biology   (United States)

^e UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^f UNIVERSITY OF BERN   (Switzerland)

Author keywords

Cannabinoid receptor CB2; Computer modeling; G protein coupled receptors; Ligand binding and G protein signaling; Site directed mutagenesis; Tryptophan

Indexed keywords

2,3 DIHYDRO 5 METHYL 3 (MORPHOLINOMETHYL) 6 (1 NAPHTHOYL)PYRROLO[1,2,3 DE][1,4]BENZOXAZINE; 4 (1,1 DIMETHYLHEPTYL) 1',2',3',4',5',6' HEXAHYDRO 2,3' DIHYDROXY 6' (3 HYDROXYPROPYL)BIPHENYL; 5 (4 CHLORO 3 METHYLPHENYL) 1 (4 METHYLBENZYL) N (1,3,3 TRIMETHYLBICYCLO[2.2.1]HEPTAN 2 YL) 3 PYRAZOLECARBOXAMIDE; ADENYLATE CYCLASE; CANNABINOID 2 RECEPTOR; CYCLIC AMP; FORSKOLIN; G PROTEIN COUPLED RECEPTOR;

AMINO ACID SUBSTITUTION; ARTICLE; BINDING AFFINITY; BINDING ASSAY; COMPUTER MODEL; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DRUG BINDING SITE; DRUG RECEPTOR BINDING; ENZYME ACTIVITY; HUMAN; HUMAN CELL; HYDROGEN BOND; LIGAND BINDING; MOLECULAR INTERACTION; MOLECULAR RECOGNITION; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; RECEPTOR AFFINITY; SIGNAL TRANSDUCTION; SITE DIRECTED MUTAGENESIS;

ADENYLATE CYCLASE; AMINO ACID SUBSTITUTION; BENZOXAZINES; BINDING SITES; BINDING, COMPETITIVE; BORNANES; CELL LINE, TRANSFORMED; CELL MEMBRANE; COMPUTER SIMULATION; CYCLIC AMP; CYCLOHEXANOLS; FORSKOLIN; HEK293 CELLS; HUMANS; LIGANDS; MODELS, MOLECULAR; MORPHOLINES; MUTAGENESIS, SITE-DIRECTED; NAPHTHALENES; PROTEIN BINDING; PYRAZOLES; RECEPTOR, CANNABINOID, CB2; RECEPTORS, G-PROTEIN-COUPLED; RECOMBINANT PROTEINS; SIGNAL TRANSDUCTION;

EID: 80051915393     PISSN: 15675769     EISSN: 18781705     Source Type: Journal    
DOI: 10.1016/j.intimp.2011.04.013     Document Type: Article

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