3-Carboxamido-5-aryl-isoxazoles as new CB2 agonists for the treatment of colitis

Bioorganic and Medicinal Chemistry

Volumn 21, Issue 17, 2013, Pages 5383-5394

  Tourteau, Aurélien ^a   Andrzejak, Virginie ^a   Body Malapel, Mathilde ^b   Lemaire, Lucas ^a   Lemoine, Amélie ^a   Mansouri, Roxane ^a   Djouina, Madjid ^b   Renault, Nicolas ^b   El Bakali, Jamal ^a   Desreumaux, Pierre ^b   Muccioli, Giulio G ^c   Lambert, Didier M ^c   Chavatte, Philippe ^b   Rigo, Benoît ^d   Leleu Chavain, Natascha ^a   Millet, Régis ^a  

^a Faculté des Sciences Pharmaceutiques et Biologiques Université de Lille   (France)

^b UNIV LILLE   (France)

^c UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

^d Ecole des Hautes Etudes d'Ingenieur   (France)

Author keywords

Cannabinoid; CB2; IBD; Isoxazoles

Indexed keywords

3 CARBOXAMIDO 5 ARYL ISOXAZOLE DERIVATIVE; CANNABINOID 2 RECEPTOR; CANNABINOID 2 RECEPTOR AGONIST; DOCUSATE SODIUM; ISOXAZOLE DERIVATIVE; N (1 ADAMANTYL) 5 (2 BUTOXYPHENYL)ISOXAZOLE 3 CARBOXAMIDE; N (1 ADAMANTYL) 5 (2 ETHOXYPHENYL)ISOXAZOLE 3 CARBOXAMIDE; N (1 ADAMANTYL) 5 (2 HEPTYLOXYPHENYL)ISOXAZOLE 3 CARBOXAMIDE; N (1 ADAMANTYL) 5 (2 HEXYLOXYPHENYL)ISOXAZOLE 3 CARBOXAMIDE; N (1 ADAMANTYL) 5 (2 METHOXYPHENYL)ISOXAZOLE 3 CARBOXAMIDE; N (1 ADAMANTYL) 5 (2 OCTOLOXYPHENYL)ISOXAZOLE 3 CARBOXAMIDE; N (1 ADAMANTYL) 5 (2 PENTYLOXYPHENYL)ISOXAZOLE 3 CARBOXAMIDE; N (1 ADAMANTYL) 5 (2 PROPOXYPHENYL)ISOXAZOLE 3 CARBOXAMIDE; N (1 ADAMANTYL) 5 PHENYLISOXAZOLE 3 CARBOXAMIDE; N (1 ADAMANTYLMETHYL) 5 PHENYLISOXAZOLE 3 CARBOXAMIDE; N (2 ADAMANTYL) 5 (2 PENTYLOXYPHENYL)ISOXAZOLE 3 CARBOXAMIDE; N (2 ADAMANTYL) 5 PHENYLISOXAZOLE 3 CARBOXAMIDE; N (3 NORADAMANTYL) 5 (2 PENTYLOXYPHENYL)ISOXAZOLE 3 CARBOXAMIDE; N (5 METHYL 1,3,4 THIADIAZOL 2 YL) 5 (2 PENTYLOXYPHENYL); N (PIPERIDIN 1 YL) 5 (2 PENTYLOXYPHENYL)ISOXAZOLE 3 CARBOXAMIDE; N BENZYL 5 (2 PENTYLOXYPHENYL)ISOXAZOLE 3 CARBOXAMIDE; N CYCLOBUTYL 5 (2 PENTYLOXYPHENYL)ISOXAZOLE 3 CARBOXAMIDE; N CYCLOHEPTYL 5 (2 PENTYLOXYPHENYL)ISOXAZOLE 3 CARBOXAMIDE; N CYCLOHEXYL 5 (2 PENTYLOXYPHENYL)ISOXAZOLE 3 CARBOXAMIDE; N CYCLOOCTYL 5 (2 PENTYLOXYPHENYL)ISOXAZOLE 3 CARBOXAMIDE; N CYCLOPENTYL 5 (2 PENTYLOXYPHENYL)ISOXAZOLE 3 CARBOXAMIDE; N CYCLOPROPYL 5 (2 PENTYLOXYPHENYL)ISOXAZOLE 3 CARBOXAMIDE; N NAPHTYL 5 (2 PENTYLOXYPHENYL)ISOXAZOLE 3 CARBOXAMIDE; N,N DIISOBUTYL 5 (2 PENTYLOXYPHENYL)ISOXAZOLE 3 CARBOXAMIDE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BIOLOGICAL ACTIVITY; CELL PROLIFERATION; COLITIS; CONTROLLED STUDY; DISEASE MODEL; DRUG CYTOTOXICITY; DRUG DESIGN; DRUG DETERMINATION; DRUG SYNTHESIS; HUMAN; HUMAN CELL; MALE; MOUSE; NONHUMAN; RECEPTOR AFFINITY; STRUCTURE ACTIVITY RELATION; TOXICITY TESTING;

CANNABINOID; CB(2); IBD; ISOXAZOLES;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CELL PROLIFERATION; COLITIS; DEXTRAN SULFATE; HT29 CELLS; HUMANS; INTERLEUKIN-1BETA; ISOXAZOLES; MALE; MICE; MICE, INBRED C57BL; PROTEIN BINDING; RECEPTOR, CANNABINOID, CB1; RECEPTOR, CANNABINOID, CB2; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84881374097     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2013.06.010     Document Type: Article

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