Evaluation of (Z)-2-((1-benzyl-1H-indol-3-yl)methylene)-quinuclidin-3-one analogues as novel, high affinity ligands for CB1 and CB2 cannabinoid receptors

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 7, 2013, Pages 2019-2021

  Madadi, Nikhil Reddy ^a   Penthala, Narsimha Reddy ^a   Brents, Lisa K ^b   Ford, Benjamin M ^b   Prather, Paul L ^b   Crooks, Peter A ^a  

^a UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^b UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

Author keywords

Cannabinoid ligands; CB1 receptors; CB2 receptors; N Benzyl indolequinuclidin 3 one oxime; N Benzyl indolequinuclidinol; N Benzyl indolequinuclidinone

Indexed keywords

2 [(1 BENZYL 1H INDOL 3 YL)METHYLENE]QUINUCLIDIN 3 ONE DERIVATIVE; CANNABINOID 1 RECEPTOR; CANNABINOID 2 RECEPTOR; CANNABINOID DERIVATIVE; QUINUCLIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CATALYSIS; DRUG RECEPTOR BINDING; DRUG SCREENING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; MOUSE; NONHUMAN; STRUCTURE ACTIVITY RELATION;

HUMANS; INDOLES; LIGANDS; MOLECULAR STRUCTURE; QUINUCLIDINES; RECEPTOR, CANNABINOID, CB1; RECEPTOR, CANNABINOID, CB2; STEREOISOMERISM;

EID: 84875232237     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.02.025     Document Type: Article

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