-
1
-
-
0043026915
-
Beta-cell apoptosis in the pathogenesis of human type 2 diabetes mellitus
-
Leonardi O, Mints G, Hussain MA: Beta-cell apoptosis in the pathogenesis of human type 2 diabetes mellitus. Eur J Endocrinol 149:99-102, 2003
-
(2003)
Eur J Endocrinol
, vol.149
, pp. 99-102
-
-
Leonardi, O.1
Mints, G.2
Hussain, M.A.3
-
2
-
-
1842844414
-
Decreased beta-cell mass in diabetes: Significance, mechanisms and therapeutic implications
-
Donath MY, Halban PA: Decreased beta-cell mass in diabetes: significance, mechanisms and therapeutic implications. Diabetologia 47:581-589, 2004
-
(2004)
Diabetologia
, vol.47
, pp. 581-589
-
-
Donath, M.Y.1
Halban, P.A.2
-
3
-
-
0442305381
-
Apoptotic signal transduction pathways in diabetes
-
Mandrup-Poulsen T: Apoptotic signal transduction pathways in diabetes. Biochem Pharmacol 66:1433-1440, 2003
-
(2003)
Biochem Pharmacol
, vol.66
, pp. 1433-1440
-
-
Mandrup-Poulsen, T.1
-
4
-
-
0037219411
-
β-Cell deficit and increased β-cell apoptosis in humans with type 2 diabetes
-
Butler AE, Janson J, Bonner-Weir S, Ritzel R, Rizza RA, Butler PC: β-Cell deficit and increased β-cell apoptosis in humans with type 2 diabetes. Diabetes 52:102-110, 2003
-
(2003)
Diabetes
, vol.52
, pp. 102-110
-
-
Butler, A.E.1
Janson, J.2
Bonner-Weir, S.3
Ritzel, R.4
Rizza, R.A.5
Butler, P.C.6
-
5
-
-
0021895206
-
Gelsolin, a Ca2+-dependent actin-binding protein in a hamster insulin-secreting cell line
-
Nelson TY, Boyd AE III: Gelsolin, a Ca2+-dependent actin-binding protein in a hamster insulin-secreting cell line. J Clin Invest 75:1015-1022, 1985
-
(1985)
J Clin Invest
, vol.75
, pp. 1015-1022
-
-
Nelson, T.Y.1
Boyd III, A.E.2
-
6
-
-
33745201223
-
Regulation of pancreatic beta-cell insulin secretion by actin cytoskeleton remodelling: Role of gelsolin and cooperation with the MAPK signalling pathway
-
Tomas A, Yermen B, Min L, Pessin JE, Halban PA: Regulation of pancreatic beta-cell insulin secretion by actin cytoskeleton remodelling: role of gelsolin and cooperation with the MAPK signalling pathway. J Cell Sci 119:2156-2167, 2006
-
(2006)
J Cell Sci
, vol.119
, pp. 2156-2167
-
-
Tomas, A.1
Yermen, B.2
Min, L.3
Pessin, J.E.4
Halban, P.A.5
-
7
-
-
0032966363
-
Functions of gelsolin: Motility, signaling, apoptosis, cancer
-
Kwiatkowski DJ: Functions of gelsolin: motility, signaling, apoptosis, cancer. Curr Opin Cell Biol 11:103-108, 1999
-
(1999)
Curr Opin Cell Biol
, vol.11
, pp. 103-108
-
-
Kwiatkowski, D.J.1
-
8
-
-
0001027292
-
Gelsolin, a multifunctional actin regulatory protein
-
Sun HQ, Yamamoto M, Mejillano M, Yin HL: Gelsolin, a multifunctional actin regulatory protein. J Biol Chem 274:33179-33182, 1999
-
(1999)
J Biol Chem
, vol.274
, pp. 33179-33182
-
-
Sun, H.Q.1
Yamamoto, M.2
Mejillano, M.3
Yin, H.L.4
-
9
-
-
0141761142
-
The gelsolin family of actin regulatory proteins: Modular structures, versatile functions
-
McGough AM, Staiger CJ, Min JK, Simonetti KD: The gelsolin family of actin regulatory proteins: modular structures, versatile functions. FEBS Lett 552:75-81, 2003
-
(2003)
FEBS Lett
, vol.552
, pp. 75-81
-
-
McGough, A.M.1
Staiger, C.J.2
Min, J.K.3
Simonetti, K.D.4
-
10
-
-
9744264059
-
Gelsolin superfamily proteins: Key regulators of cellular functions
-
Silacci P, Mazzolai L, Gauci C, Stergiopulos N, Yin HL, Hayoz D: Gelsolin superfamily proteins: key regulators of cellular functions. Cell Mol Life Sci 61:2614-2623, 2004
-
(2004)
Cell Mol Life Sci
, vol.61
, pp. 2614-2623
-
-
Silacci, P.1
Mazzolai, L.2
Gauci, C.3
Stergiopulos, N.4
Yin, H.L.5
Hayoz, D.6
-
11
-
-
4444227992
-
Apoptosis induced by interferon-alpha and antagonized by EGF is regulated by caspase-3-mediated cleavage of gelsolin in human epidermoid cancer cells
-
Boccellino M, Giuberti G, Quagliuolo L, Marra M, D'Alessandro AM, Fujita H, Giovane A, Abbruzzese A, Caraglia M: Apoptosis induced by interferon-alpha and antagonized by EGF is regulated by caspase-3-mediated cleavage of gelsolin in human epidermoid cancer cells. J Cell Physiol 201:71-83, 2004
-
(2004)
J Cell Physiol
, vol.201
, pp. 71-83
-
-
Boccellino, M.1
Giuberti, G.2
Quagliuolo, L.3
Marra, M.4
D'Alessandro, A.M.5
Fujita, H.6
Giovane, A.7
Abbruzzese, A.8
Caraglia, M.9
-
12
-
-
0032426430
-
Caspase-3-induced gelsolin fragmentation contributes to actin cytoskeletal collapse, nucleolysis, and apoptosis of vascular smooth muscle cells exposed to proinflammatory cytokines
-
Geng YJ, Azuma T, Tang JX, Hartwig JH, Muszynski M, Wu Q, Libby P, Kwiatkowski DJ: Caspase-3-induced gelsolin fragmentation contributes to actin cytoskeletal collapse, nucleolysis, and apoptosis of vascular smooth muscle cells exposed to proinflammatory cytokines. Eur J Cell Biol 77:294-302, 1998
-
(1998)
Eur J Cell Biol
, vol.77
, pp. 294-302
-
-
Geng, Y.J.1
Azuma, T.2
Tang, J.X.3
Hartwig, J.H.4
Muszynski, M.5
Wu, Q.6
Libby, P.7
Kwiatkowski, D.J.8
-
13
-
-
0030820875
-
Caspase-3-generated fragment of gelsolin: Effector of morphological change in apoptosis
-
Kothakota S, Azuma T, Reinhard C, Klippel A, Tang J, Chu K, McGarry TJ, Kirschner MW, Koths K, Kwiatkowski DJ, Williams LT: Caspase-3-generated fragment of gelsolin: effector of morphological change in apoptosis. Science 278:294-298, 1997
-
(1997)
Science
, vol.278
, pp. 294-298
-
-
Kothakota, S.1
Azuma, T.2
Reinhard, C.3
Klippel, A.4
Tang, J.5
Chu, K.6
McGarry, T.J.7
Kirschner, M.W.8
Koths, K.9
Kwiatkowski, D.J.10
Williams, L.T.11
-
14
-
-
0030829514
-
Inhibition of apoptosis by the actin-regulatory protein gelsolin
-
Ohtsu M, Sakai N, Fujita H, Kashiwagi M, Gasa S, Shimizu S, Eguchi Y, Tsujimoto Y, Sakiyama Y, Kobayashi K, Kuzumaki N: Inhibition of apoptosis by the actin-regulatory protein gelsolin. EMBO J 16:4650-4656, 1997
-
(1997)
EMBO J
, vol.16
, pp. 4650-4656
-
-
Ohtsu, M.1
Sakai, N.2
Fujita, H.3
Kashiwagi, M.4
Gasa, S.5
Shimizu, S.6
Eguchi, Y.7
Tsujimoto, Y.8
Sakiyama, Y.9
Kobayashi, K.10
Kuzumaki, N.11
-
15
-
-
0034635549
-
Gelsolin in complex with phosphatidylinositol 4,5-bisphosphate inhibits caspase-3 and -9 to retard apoptotic progression
-
Azuma T, Koths K, Flanagan L, Kwiatkowski D: Gelsolin in complex with phosphatidylinositol 4,5-bisphosphate inhibits caspase-3 and -9 to retard apoptotic progression. J Biol Chem 275:3761-3766, 2000
-
(2000)
J Biol Chem
, vol.275
, pp. 3761-3766
-
-
Azuma, T.1
Koths, K.2
Flanagan, L.3
Kwiatkowski, D.4
-
16
-
-
0032555262
-
A cloning method for caspase substrates that uses the yeast two-hybrid system: Cloning of the antiapoptotic gene gelsolin
-
Kamada S, Kusano H, Fujita H, Ohtsu M, Koya RC, Kuzumaki N, Tsujimoto Y: A cloning method for caspase substrates that uses the yeast two-hybrid system: cloning of the antiapoptotic gene gelsolin. Proc Natl Acad Sci U S A 95:8532-8537, 1998
-
(1998)
Proc Natl Acad Sci U S A
, vol.95
, pp. 8532-8537
-
-
Kamada, S.1
Kusano, H.2
Fujita, H.3
Ohtsu, M.4
Koya, R.C.5
Kuzumaki, N.6
Tsujimoto, Y.7
-
17
-
-
0034685808
-
Gelsolin inhibits apoptosis by blocking mitochondrial membrane potential loss and cytochrome c release
-
Koya RC, Fujita H, Shimizu S, Ohtsu M, Takimoto M, Tsujimoto Y, Kuzumaki N: Gelsolin inhibits apoptosis by blocking mitochondrial membrane potential loss and cytochrome c release. J Biol Chem 275:15343-15349, 2000
-
(2000)
J Biol Chem
, vol.275
, pp. 15343-15349
-
-
Koya, R.C.1
Fujita, H.2
Shimizu, S.3
Ohtsu, M.4
Takimoto, M.5
Tsujimoto, Y.6
Kuzumaki, N.7
-
18
-
-
0034609764
-
Human gelsolin prevents apoptosis by inhibiting apoptotic mitochondrial changes via closing VDAC
-
Kusano H, Shimizu S, Koya RC, Fujita H, Kamada S, Kuzumaki N, Tsujimoto Y: Human gelsolin prevents apoptosis by inhibiting apoptotic mitochondrial changes via closing VDAC. Oncogene 19:4807-4814, 2000
-
(2000)
Oncogene
, vol.19
, pp. 4807-4814
-
-
Kusano, H.1
Shimizu, S.2
Koya, R.C.3
Fujita, H.4
Kamada, S.5
Kuzumaki, N.6
Tsujimoto, Y.7
-
19
-
-
0032959847
-
Neuroprotective effects of gelsolin during murine stroke
-
Endres M, Fink K, Zhu J, Stagliano NE, Bondada V, Geddes JW, Azuma T, Mattson MP, Kwiatkowski DJ, Moskowitz MA: Neuroprotective effects of gelsolin during murine stroke. J Clin Invest 103:347-354, 1999
-
(1999)
J Clin Invest
, vol.103
, pp. 347-354
-
-
Endres, M.1
Fink, K.2
Zhu, J.3
Stagliano, N.E.4
Bondada, V.5
Geddes, J.W.6
Azuma, T.7
Mattson, M.P.8
Kwiatkowski, D.J.9
Moskowitz, M.A.10
-
20
-
-
10744231936
-
Neuronal gelsolin prevents apoptosis by enhancing actin depolymerization
-
Harms C, Bosel J, Lautenschlager M, Harms U, Braun JS, Hortnagl H, Dirnagl U, Kwiatkowski DJ, Fink K, Endres M: Neuronal gelsolin prevents apoptosis by enhancing actin depolymerization. Mol Cell Neurosci 25:69-82, 2004
-
(2004)
Mol Cell Neurosci
, vol.25
, pp. 69-82
-
-
Harms, C.1
Bosel, J.2
Lautenschlager, M.3
Harms, U.4
Braun, J.S.5
Hortnagl, H.6
Dirnagl, U.7
Kwiatkowski, D.J.8
Fink, K.9
Endres, M.10
-
21
-
-
33644639878
-
Anti-apoptotic function of gelsolin in fas antibody-induced liver failure in vivo
-
Leifeld L, Fink K, Debska G, Fielenbach M, Schmitz V, Sauerbruch T, Spengler U: Anti-apoptotic function of gelsolin in fas antibody-induced liver failure in vivo. Am J Pathol 168:778-785, 2006
-
(2006)
Am J Pathol
, vol.168
, pp. 778-785
-
-
Leifeld, L.1
Fink, K.2
Debska, G.3
Fielenbach, M.4
Schmitz, V.5
Sauerbruch, T.6
Spengler, U.7
-
22
-
-
0037390423
-
Differential gene expression in well-regulated and dysregulated pancreatic beta-cell (MIN6) sublines
-
Lilla V, Webb G, Rickenbach K, Maturana A, Steiner DF, Halban PA, Irminger JC: Differential gene expression in well-regulated and dysregulated pancreatic beta-cell (MIN6) sublines. Endocrinology 144:1368-1379, 2003
-
(2003)
Endocrinology
, vol.144
, pp. 1368-1379
-
-
Lilla, V.1
Webb, G.2
Rickenbach, K.3
Maturana, A.4
Steiner, D.F.5
Halban, P.A.6
Irminger, J.C.7
-
23
-
-
0014315154
-
Guinea pig anti-insulin serum: Adjuvant effect of H. pertussis vaccine
-
Wright PH, Makulu DR, Posey IJ: Guinea pig anti-insulin serum: adjuvant effect of H. pertussis vaccine. Diabetes 17:513-516, 1968
-
(1968)
Diabetes
, vol.17
, pp. 513-516
-
-
Wright, P.H.1
Makulu, D.R.2
Posey, I.J.3
-
24
-
-
0026648674
-
Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation
-
Gavrieli Y, Sherman Y, Ben-Sasson SA: Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J Cell Biol 119:493-501, 1992
-
(1992)
J Cell Biol
, vol.119
, pp. 493-501
-
-
Gavrieli, Y.1
Sherman, Y.2
Ben-Sasson, S.A.3
-
25
-
-
0025637049
-
Differences in aggregation properties and levels of the neural cell adhesion molecule (NCAM) between islet cell types
-
Rouiller DG, Cirulli V, Halban PA: Differences in aggregation properties and levels of the neural cell adhesion molecule (NCAM) between islet cell types. Exp Cell Res 191:305-312, 1990
-
(1990)
Exp Cell Res
, vol.191
, pp. 305-312
-
-
Rouiller, D.G.1
Cirulli, V.2
Halban, P.A.3
-
26
-
-
0033606891
-
Imaging Ca2+ concentration changes at the secretory vesicle surface with a recombinant targeted cameleon
-
Emmanouilidou E, Teschemacher AG, Pouli AE, Nicholls LI, Seward EP, Rutter GA: Imaging Ca2+ concentration changes at the secretory vesicle surface with a recombinant targeted cameleon. Curr Biol 9:915-918, 1999
-
(1999)
Curr Biol
, vol.9
, pp. 915-918
-
-
Emmanouilidou, E.1
Teschemacher, A.G.2
Pouli, A.E.3
Nicholls, L.I.4
Seward, E.P.5
Rutter, G.A.6
-
27
-
-
20444363538
-
Beta-cells in type 2 diabetes: A loss of function and mass
-
Maedler K, Donath MY: Beta-cells in type 2 diabetes: a loss of function and mass. Horm Res 62 (Suppl. 3):67-73, 2004
-
(2004)
Horm Res
, vol.62
, Issue.SUPPL. 3
, pp. 67-73
-
-
Maedler, K.1
Donath, M.Y.2
-
28
-
-
0024588255
-
Gelsolin modulation in epithelial and stromal cells of mammary carcinoma
-
Chaponnier C, Gabbiani G: Gelsolin modulation in epithelial and stromal cells of mammary carcinoma. Am J Pathol 134:597-603, 1989
-
(1989)
Am J Pathol
, vol.134
, pp. 597-603
-
-
Chaponnier, C.1
Gabbiani, G.2
-
29
-
-
6344265234
-
Pioglitazone and sodium salicylate protect human beta-cells against apoptosis and impaired function induced by glucose and interleukin-1beta
-
Zeender E, Maedler K, Bosco D, Berney T, Donath MY, Halban PA: Pioglitazone and sodium salicylate protect human beta-cells against apoptosis and impaired function induced by glucose and interleukin-1beta. J Clin Endocrinol Metab 89:5059-5066, 2004
-
(2004)
J Clin Endocrinol Metab
, vol.89
, pp. 5059-5066
-
-
Zeender, E.1
Maedler, K.2
Bosco, D.3
Berney, T.4
Donath, M.Y.5
Halban, P.A.6
-
30
-
-
0345171412
-
Prolonged culture in low glucose induces apoptosis of rat pancreatic beta-cells through induction of c-myc
-
Van de Casteele M, Kefas BA, Cai Y, Heimberg H, Scott DK, Henquin JC, Pipeleers D, Jonas JC: Prolonged culture in low glucose induces apoptosis of rat pancreatic beta-cells through induction of c-myc. Biochem Biophys Res Commun 312:937-944, 2003
-
(2003)
Biochem Biophys Res Commun
, vol.312
, pp. 937-944
-
-
Van de Casteele, M.1
Kefas, B.A.2
Cai, Y.3
Heimberg, H.4
Scott, D.K.5
Henquin, J.C.6
Pipeleers, D.7
Jonas, J.C.8
-
32
-
-
0031771385
-
Altered bcl-2 and bax expression and intracellular Ca2+ signaling in apoptosis of pancreatic cells and the impairment of glucose-induced insulin secretion
-
Mizuno N, Yoshitomi H, Ishida H, Kuromi H, Kawaki J, Seino Y, Seino S: Altered bcl-2 and bax expression and intracellular Ca2+ signaling in apoptosis of pancreatic cells and the impairment of glucose-induced insulin secretion. Endocrinology 139:1429-1439, 1998
-
(1998)
Endocrinology
, vol.139
, pp. 1429-1439
-
-
Mizuno, N.1
Yoshitomi, H.2
Ishida, H.3
Kuromi, H.4
Kawaki, J.5
Seino, Y.6
Seino, S.7
-
33
-
-
0035856952
-
Beta-cell death during progression to diabetes
-
Mathis D, Vence L, Benoist C: Beta-cell death during progression to diabetes. Nature 414:792-798, 2001
-
(2001)
Nature
, vol.414
, pp. 792-798
-
-
Mathis, D.1
Vence, L.2
Benoist, C.3
-
34
-
-
0344142396
-
Emerging roles of caspase-3 in apoptosis
-
Porter AG, Janicke RU: Emerging roles of caspase-3 in apoptosis. Cell Death Differ 6:99-104, 1999
-
(1999)
Cell Death Differ
, vol.6
, pp. 99-104
-
-
Porter, A.G.1
Janicke, R.U.2
-
35
-
-
4344619325
-
Oncogenic Ras promotes butyrate-induced apoptosis through inhibition of gelsolin expression
-
Klampfer L, Huang J, Sasazuki T, Shirasawa S, Augenlicht L: Oncogenic Ras promotes butyrate-induced apoptosis through inhibition of gelsolin expression. J Biol Chem 279:36680-36688, 2004
-
(2004)
J Biol Chem
, vol.279
, pp. 36680-36688
-
-
Klampfer, L.1
Huang, J.2
Sasazuki, T.3
Shirasawa, S.4
Augenlicht, L.5
-
36
-
-
20544464657
-
Oncogenic Ras increases sensitivity of colon cancer cells to 5-FU-induced apoptosis
-
Klampfer L, Swaby LA, Huang J, Sasazuki T, Shirasawa S, Augenlicht L: Oncogenic Ras increases sensitivity of colon cancer cells to 5-FU-induced apoptosis. Oncogene 24:3932-3941, 2005
-
(2005)
Oncogene
, vol.24
, pp. 3932-3941
-
-
Klampfer, L.1
Swaby, L.A.2
Huang, J.3
Sasazuki, T.4
Shirasawa, S.5
Augenlicht, L.6
-
37
-
-
0034210210
-
Failure of gelsolin overexpression to regulate lymphocyte apoptosis
-
Posey SC, Martelli MP, Azuma T, Kwiatkowski DJ, Bierer BE: Failure of gelsolin overexpression to regulate lymphocyte apoptosis. Blood 95:3483-3488, 2000
-
(2000)
Blood
, vol.95
, pp. 3483-3488
-
-
Posey, S.C.1
Martelli, M.P.2
Azuma, T.3
Kwiatkowski, D.J.4
Bierer, B.E.5
-
38
-
-
12344323484
-
Type 2 diabetes: A matter of beta-cell life and death?
-
Rhodes CJ: Type 2 diabetes: a matter of beta-cell life and death? Science 307:380-384, 2005
-
(2005)
Science
, vol.307
, pp. 380-384
-
-
Rhodes, C.J.1
-
39
-
-
0033969520
-
Importance of cell-matrix interactions in rat islet β-cell secretion in vitro: Role of α6β1 integrin
-
Bosco D, Meda P, Halban PA, Rouiller DG: Importance of cell-matrix interactions in rat islet β-cell secretion in vitro: role of α6β1 integrin. Diabetes 49:233-243, 2000
-
(2000)
Diabetes
, vol.49
, pp. 233-243
-
-
Bosco, D.1
Meda, P.2
Halban, P.A.3
Rouiller, D.G.4
-
40
-
-
3242786441
-
Extracellular matrix protects pancreatic β-cells against apoptosis: Role of short- and long-term signaling pathways
-
Hammar E, Parnaud G, Bosco D, Perriraz N, Maedler K, Donath M, Rouiller DG, Halban PA: Extracellular matrix protects pancreatic β-cells against apoptosis: role of short- and long-term signaling pathways. Diabetes 53:2034-2041, 2004
-
(2004)
Diabetes
, vol.53
, pp. 2034-2041
-
-
Hammar, E.1
Parnaud, G.2
Bosco, D.3
Perriraz, N.4
Maedler, K.5
Donath, M.6
Rouiller, D.G.7
Halban, P.A.8
|