Human ROBO1 is cleaved by metalloproteinases and γ-secretase and migrates to the nucleus in cancer cells

FEBS Letters

Volumn 584, Issue 13, 2010, Pages 2909-2915

  Seki, Motoaki ^a   Watanabe, Akira ^a   Enomoto, Satoshi ^a   Kawamura, Takeshi ^a   Ito, Hirotaka ^a   Kodama, Tatsuhiko ^a   Hamakubo, Takao ^a   Aburatani, Hiroyuki ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

Secretase; Metalloproteinase; Regulated intramembrane proteolysis; ROBO1

Indexed keywords

GAMMA SECRETASE; GAMMA SECRETASE INHIBITOR; L 685458; METALLOPROTEINASE; METALLOPROTEINASE INHIBITOR; ROUNDABOUT RECEPTOR; ROUNDABOUT RECEPTOR 1; TAPI 1; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; CANCER CELL CULTURE; CARBOXY TERMINAL SEQUENCE; CELL NUCLEUS; CONTROLLED STUDY; HUMAN; HUMAN CELL; LIQUID CHROMATOGRAPHY; LIVER CELL CARCINOMA; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN TRANSPORT; TANDEM MASS SPECTROMETRY;

AMINO ACID SEQUENCE; AMYLOID PRECURSOR PROTEIN SECRETASES; CARBAMATES; CELL NUCLEUS; DIPEPTIDES; HEP G2 CELLS; HUMANS; HYDROXAMIC ACIDS; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; LEUPEPTINS; METALLOPROTEASES; MOLECULAR SEQUENCE DATA; NERVE TISSUE PROTEINS; RECEPTORS, IMMUNOLOGIC; SEQUENCE HOMOLOGY, AMINO ACID; TANDEM MASS SPECTROMETRY;

EID: 77953725797     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2010.05.009     Document Type: Article

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