Solid phase synthesis of 2,6-disubstituted-4(3H)-pyrimidinones targeting HIV-1 reverse transcriptase

Tetrahedron Letters

Volumn 39, Issue 20, 1998, Pages 3307-3310

  Nizi, Emanuela ^a   Botta, Maurizio ^a   Corelli, Federico ^a   Manetti, Fabrizio ^a   Messina, Flavía ^a   Maga, Giovanni ^b  

^a UNIVERSITY OF SIENA   (Italy)

^b Ist Genet Biochim ed E   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

PYRIMIDINE DERIVATIVE;

ACYLATION; ARTICLE; CHEMICAL STRUCTURE; MOLECULAR MODEL; PROTON NUCLEAR MAGNETIC RESONANCE; STEREOSPECIFICITY; SYNTHESIS;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 0032516263     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(97)84377-8     Document Type: Article

References (16)

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3. 3. Botta, M.; Saladino, R.; Gentile, G.; Summa, V.; Nicoletti, R.; Verri, A.; Focher, F.; Spadari, S. Tetrahedron 1994, 50, 3603.
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6. 5. Results to be published.
7. 6. (a) Botta, M.; Saladino, R.; Delle Monache, G.; Gentile, G.; Nicoletti, R. Heterocycles 1996, 43, 1687 and references cited therein.
8. (b) Botta, M.; Saladino, R.; Anzini, M.; Corelli, F. Nucleosides Nucleotides 1994, 13, 1769.
9. 7. Botta, M.; Saladino, R.; Occhinero, F.; Nicoletti, R. Trends in Organic Chemistry 1995, 5, 57.
10. 8. Botta, M.; Occhinero, F.; Saladino, R.; Crestini, C.; Nicoletti, R. Tetrahedron Letters 1997, 38, 8249.
11. 9. Bergeron, R.J.; McManis, J.S. J. Org. Chem. 1987, 52, 1700.
12. 10. Delle Monache, G.; Botta, B.; Delle Monache, F.; Espinal, R.; De Bonnevaux, S.C.; De Luca, C.; Botta, M.; Corelli, F.; Carmignani, M. J. Med. Chem. 1993, 36, 2956.
13. 1H NMR spectroscopy. All the new compounds gave satisfactory (±0.4% of the theoretical values) elementary analyses, with the exception of 5 (not analyzed).
14. 12. Aryes, J.T.; Mann, C.K. Polymer Lett. (Part B) 1965, 3, 505.
15. 13. All the other compounds resulted to be less active than 1b. Full description of their biological evaluation will be reported elsewhere.
16. 14. Nizi, E. Doctorate Thesis, University of Siena, October 1997.