The impact of sperm DNA damage in assisted conception and beyond: Recent advances in diagnosis and treatment

Reproductive BioMedicine Online

Volumn 27, Issue 4, 2013, Pages 325-337

  Lewis, Sheena E M ^a   Aitken, R John ^b   Conner, Sarah J ^c   De Iuliis, Geoffry ^b   Evenson, Donald P ^d   Henkel, Ralph ^e   Giwercman G, Aleksander ^f,g   Gharagozloo, Parviz ^h  

^a QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

^b UNIVERSITY OF NEWCASTLE   (Australia)

^c UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^d SCSA Diagnostics   (United States)

^e UNIVERSITY OF THE WESTERN CAPE   (South Africa)

^f LUND UNIVERSITY   (Sweden)

^g LUND UNIVERSITY HOSPITAL   (Sweden)

^h CELLOXESS LLC   (United States)

Author keywords

Antioxidant therapy; Assisted reproduction; DNA fragmentation; Male infertility; Oxidized bases; Spermatozoa

Indexed keywords

ALPHA TOCOPHEROL; ANTIOXIDANT; BIOLOGICAL MARKER; HYALURONIC ACID;

ANTIOXIDANT ACTIVITY; BIREFRINGENCE; CHILDHOOD DISEASE; CHROMATIN STRUCTURE; CLINICAL EFFECTIVENESS; COMET ASSAY; DIAGNOSTIC TEST; DNA ADDUCT; DNA DAMAGE; DNA DETERMINATION; DRUG EFFICACY; DRUG FORMULATION; DRUG SAFETY; FERTILIZATION; FERTILIZATION IN VITRO; GERM LINE; HALO TEST; HUMAN; INFERTILITY THERAPY; INTRACYTOPLASMIC MORPHOLOGICALLY SELECTED SPERM INJECTION; INTRACYTOPLASMIC SPERM INJECTION; INTRAUTERINE INSEMINATION; LABORATORY TEST; MALE GENITAL SYSTEM; MALE INFERTILITY; MASS SPECTROMETRY; MEDICAL DECISION MAKING; NICK END LABELING; NONHUMAN; OUTCOME ASSESSMENT; OXIDATIVE STRESS; PREDICTIVE VALUE; PREGNANCY RATE; PROSTATE CANCER; REVIEW; SEMEN ANALYSIS; SEMINAL PLASMA; SPERM; SPERM CHROMATIN DISPERSION TEST; SPERM CHROMATIN STRUCTURE ASSAY; SPERMATOZOON COUNT; SPERMATOZOON DENSITY; SPERMATOZOON MOTILITY; SPONTANEOUS ABORTION;

ANTIOXIDANT THERAPY; ASSISTED REPRODUCTION; DNA FRAGMENTATION; MALE INFERTILITY; OXIDIZED BASES; SPERMATOZOA;

ANTIOXIDANTS; BIOLOGICAL MARKERS; CHROMATIN; COMET ASSAY; DNA ADDUCTS; DNA DAMAGE; FEMALE; HUMANS; IN SITU NICK-END LABELING; INFERTILITY, MALE; MALE; PREGNANCY; SEMEN ANALYSIS; SPERMATOZOA;

EID: 84885191376     PISSN: 14726483     EISSN: 14726491     Source Type: Journal    
DOI: 10.1016/j.rbmo.2013.06.014     Document Type: Review

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