Spermatogenesis and mutagenicity of environmental hazards: Extrapolation of genetic risk from mouse to man

Andrologia

Volumn 32, Issue 4-5, 2000, Pages 233-237

  Adler, I D ^a  

^a INSTITUTE OF EPIDEMIOLOGY   (Germany)

Author keywords

Chemical mutagens; Genetic risk; Mouse; Spermatogenesis

Indexed keywords

1,3 BUTADIENE; MUTAGENIC AGENT;

CHROMOSOME; CHROMOSOME TRANSLOCATION; CONFERENCE PAPER; CYTOGENETICS; ENVIRONMENT; GENE; GENE MUTATION; GENETIC RISK; GERM CELL; HAZARD; HUMAN; MUTAGENICITY; NONHUMAN; PROGENY;

ANIMALS; BUTADIENES; DRUG EVALUATION, PRECLINICAL; ENVIRONMENTAL POLLUTANTS; HUMANS; MALE; MICE; MUTAGENS; RISK FACTORS; SPECIES SPECIFICITY; SPERMATOGENESIS; SPERMATOZOA; TRANSLOCATION, GENETIC;

EID: 0033806422     PISSN: 03034569     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1439-0272.2000.00390.x     Document Type: Conference Paper

References (26)

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2. Male germ cell cytogenetics
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5. Dose-response study for 1,3-butadiene-induced dominant lethal mutations and heritable translocations in germ cells of male mice
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7. Chemically induced mutations in mice
8. Comparison of the mutagenic effect of chemicals and ionizing radiation in the spermatogenic cells of mice
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10. Comparison of radiation- and chemicallyinduced dominant lethal mutations in mice
11. Dominant lethal mutations in male mice
12. Methods to estimate genetic risk
13. Differential spermatogenic response of mice to the induction of dominant lethal mutations by n-propyl methanesulfonate and iso-propyl methanesulfonate
14. Response of mouse spermatogonial stem cells to x-ray induction of heritable reciprocal translocations
15. Gene and chromosome mutation after large fractionated or unfractionated radiation doses to mouse spermatogonia
16. Initial depletion and subsequent recovery of spermatogonia of the mouse after 20 R of gamma-rays and 100, 300 and 600 R of x-rays
17. Effects of 25 R of x-rays at 10 days of age on oocyte numbers and fertility of female mice
18. Genetic effects of 1,3-butadiene and associated risk for heritable damage
19. Chemotherapy induces transient sex chromosomal and autosomal aneuploidy in human sperm
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21. Genetic effects of radiation in mammals
22. Mutation frequencies in female mice and the estimation of genetic hazards of radiation in women
23. Specific locus test shows ethylnitrosourea to be the most potent mutagen in the mouse
24. Models and assumptions underlying genetic risk assessment
25. Biological effect monitoring in industrial workers from the Czech Republic exposed to low levels of butadiene