Orally Active, Antimetastatic, Nontoxic Diphenyl Ether-Derived Carbamoylphosphonate Matrix Metalloproteinase Inhibitors

ChemMedChem

Volumn 6, Issue 8, 2011, Pages 1471-1477

  Frant, Julia ^a   Veerendhar, Ainelly ^a   Chernilovsky, Tamir ^a   Nedvetzki, Shlomo ^b   Vaksman, Olga ^a   Hoffman, Amnon ^a   Breuer, Eli ^a   Reich, Reuven ^a  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^b BIOLINERX LTD   (Israel)

Author keywords

Antitumor agents; Drug design; Enzymes; Inhibitors; Medicinal chemistry; Phosphonates

Indexed keywords

ANTIMETASTATIC AGENT; CARBAMOYLPHOSPHONATE 2; CARBAMOYLPHOSPHONATE 5; CARBAMOYLPHOSPHONATE 6; COLLAGENASE 3; GELATINASE A; GELATINASE B; MACROPHAGE ELASTASE; MARIMASTAT; MATRIX METALLOPROTEINASE INHIBITOR; PHOSPHONIC ACID DERIVATIVE; TUMOR NECROSIS FACTOR ALPHA CONVERTING ENZYME; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DISEASE MODEL; DRUG BIOAVAILABILITY; DRUG DISTRIBUTION; DRUG POTENCY; ENZYME INHIBITION; IC 50; IN VITRO STUDY; IN VIVO STUDY; INHIBITION KINETICS; LUNG METASTASIS; MALE; MAXIMUM PLASMA CONCENTRATION; MELANOMA; METASTASIS INHIBITION; MOUSE; MUSCULOSKELETAL DISEASE; MUSCULOSKELETAL SYNDROME; NONHUMAN; PRIORITY JOURNAL; RAT; TIME TO MAXIMUM PLASMA CONCENTRATION;

ADMINISTRATION, ORAL; ANIMALS; ANTINEOPLASTIC AGENTS; ENZYME INHIBITORS; MATRIX METALLOPROTEINASES; MELANOMA, EXPERIMENTAL; MICE; PHENYL ETHERS; PHOSPHONIC ACIDS; PROTEIN ISOFORMS; RATS;

EID: 79960694567     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.201100153     Document Type: Article

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