메뉴 건너뛰기




Volumn 169, Issue 3, 2013, Pages 329-335

Simply mixing with poly(ethylene glycol) enhances the fraction of the active chemical form of antitumor drugs of camptothecin family

Author keywords

10 Hydrocamptothecin (HCPT); Anticancer; Camptothecin (CPT); Drug material interaction; Poly(ethylene glycol) (PEG); Topotecan (TPT)

Indexed keywords

BODY FLUIDS; CARBOXYLATION; ESTERS; ETHYLENE GLYCOL; MIXING; POLYOLS;

EID: 84885182945     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2012.12.004     Document Type: Article
Times cited : (32)

References (49)
  • 1
    • 84861749627 scopus 로고    scopus 로고
    • State of the art in PEGylation: The great versatility achieved after forty years of research
    • G. Pasut, F.M. Veronese, State of the art in PEGylation: the great versatility achieved after forty years of research, J. Control. Release 161 (2012) 461-472.
    • (2012) J. Control. Release , vol.161 , pp. 461-472
    • Pasut, G.1    Veronese, F.M.2
  • 3
    • 1942434691 scopus 로고    scopus 로고
    • Development of Clinical Dosage Forms for a Poorly Water Soluble Drug I: Application of Polyethylene Glycol-Polysorbate 80 Solid Dispersion Carrier System
    • DOI 10.1002/jps.20044
    • R.M. Dannenfelser, H. He, Y. Joshi, S. Bateman, A.T.M. Serajuddin, Development of clinical dosage forms for a poorly water soluble drug I: application of polyethylene glycol-polysorbate 80 solid dispersion carrier system, J. Pharm. Sci. 93 (2004) 1165-1175. (Pubitemid 38529690)
    • (2004) Journal of Pharmaceutical Sciences , vol.93 , Issue.5 , pp. 1165-1175
    • Dannenfelser, R.-M.1    He, H.2    Joshi, Y.3    Bateman, S.4    Serajuddin, A.T.M.5
  • 4
    • 84857363579 scopus 로고    scopus 로고
    • A poly(ethylene glycol)-based surfactant for formulation of drug-loaded mucus penetrating particles
    • O. Mert, S.K. Lai, L. Ensign, M. Yang, Y.Y. Wang, J. Wood, J. Hanes, A poly(ethylene glycol)-based surfactant for formulation of drug-loaded mucus penetrating particles, J. Control. Release 157 (2012) 455-460.
    • (2012) J. Control. Release , vol.157 , pp. 455-460
    • Mert, O.1    Lai, S.K.2    Ensign, L.3    Yang, M.4    Wang, Y.Y.5    Wood, J.6    Hanes, J.7
  • 5
    • 0001319478 scopus 로고    scopus 로고
    • Biodegradable block copolymers as injectable drug-delivery systems
    • DOI 10.1038/42218
    • B. Jeong, Y.H. Bae, D.S. Lee, S.W. Kim, Biodegradable block copolymers as injectable drug-delivery systems, Nature 388 (1997) 860-862. (Pubitemid 27377054)
    • (1997) Nature , vol.388 , Issue.6645 , pp. 860-862
    • Jeong, B.1    Bae, Y.H.2    Lee, D.S.3    Kim, S.W.4
  • 6
    • 84861584761 scopus 로고    scopus 로고
    • Polymersomes for drug delivery: Design, formation and characterization
    • J.S. Lee, J. Feijen, Polymersomes for drug delivery: design, formation and characterization, J. Control. Release 161 (2012) 473-483.
    • (2012) J. Control. Release , vol.161 , pp. 473-483
    • Lee, J.S.1    Feijen, J.2
  • 7
    • 84555220701 scopus 로고    scopus 로고
    • Synthesis and characterization of biodegradable and thermosensitive polymeric micelles with covalently bound doxorubicin-glucuronide prodrug via click chemistry
    • M. Talelli, K. Morita, C.J.F. Rijcken, R.W.M. Aben, T. Lammers, H.W. Scheeren, C.F. van Nostrum, G. Storm, W.E. Hennink, Synthesis and characterization of biodegradable and thermosensitive polymeric micelles with covalently bound doxorubicin-glucuronide prodrug via click chemistry, Bioconjug. Chem. 22 (2011) 2519-2530.
    • (2011) Bioconjug. Chem. , vol.22 , pp. 2519-2530
    • Talelli, M.1    Morita, K.2    Rijcken, C.J.F.3    Aben, R.W.M.4    Lammers, T.5    Scheeren, H.W.6    Van Nostrum, C.F.7    Storm, G.8    Hennink, W.E.9
  • 8
    • 84863338345 scopus 로고    scopus 로고
    • Precise control of intracellular drug release and anti-tumor activity of biodegradable micellar drugs via reduction-sensitive shell-shedding
    • W. Wang, H.L. Sun, F.H. Meng, S.B. Ma, H.Y. Liu, Z.Y. Zhong, Precise control of intracellular drug release and anti-tumor activity of biodegradable micellar drugs via reduction-sensitive shell-shedding, Soft Matter 8 (2012) 3949-3956.
    • (2012) Soft Matter , vol.8 , pp. 3949-3956
    • Wang, W.1    Sun, H.L.2    Meng, F.H.3    Ma, S.B.4    Liu, H.Y.5    Zhong, Z.Y.6
  • 9
    • 80053334176 scopus 로고    scopus 로고
    • PH-responsive polymeric micelle based on PEG-poly(beta-amino ester)/(amido amine) as intelligent vehicle for magnetic resonance imaging in detection of cerebral ischemic area
    • G.H. Gao, J.W. Lee, M.K. Nguyen, G.H. Im, J. Yang, H. Heo, P. Jeon, T.G. Park, J.H. Lee, D.S. Lee, pH-responsive polymeric micelle based on PEG-poly(beta-amino ester)/(amido amine) as intelligent vehicle for magnetic resonance imaging in detection of cerebral ischemic area, J. Control. Release 155 (2011) 11-17.
    • (2011) J. Control. Release , vol.155 , pp. 11-17
    • Gao, G.H.1    Lee, J.W.2    Nguyen, M.K.3    Im, G.H.4    Yang, J.5    Heo, H.6    Jeon, P.7    Park, T.G.8    Lee, J.H.9    Lee, D.S.10
  • 10
    • 84860850040 scopus 로고    scopus 로고
    • Low-molecular-weight methylcellulose-based thermo-reversible gel/pluronic micelle combination system for local and sustained docetaxel delivery
    • J.K. Kim, Y.W. Won, K.S. Lim, Y.H. Kim, Low-molecular-weight methylcellulose-based thermo-reversible gel/pluronic micelle combination system for local and sustained docetaxel delivery, Pharm. Res. 29 (2012) 525-534.
    • (2012) Pharm. Res. , vol.29 , pp. 525-534
    • Kim, J.K.1    Won, Y.W.2    Lim, K.S.3    Kim, Y.H.4
  • 11
    • 21744462392 scopus 로고    scopus 로고
    • A novel microgel and associated post-fabrication encapsulation technique of proteins
    • DOI 10.1016/j.jconrel.2005.04.001, PII S0168365905001653
    • Y. Zhang, W. Zhu, B.B. Wang, J.D. Ding, Anovel microgel and associated post-fabrication encapsulation technique of proteins, J. Control. Release 105 (2005) 260-268. (Pubitemid 40941991)
    • (2005) Journal of Controlled Release , vol.105 , Issue.3 , pp. 260-268
    • Zhang, Y.1    Zhu, W.2    Wang, B.3    Ding, J.4
  • 12
    • 47749146197 scopus 로고    scopus 로고
    • Injectable hydrogels as unique biomedical materials
    • L. Yu, J.D. Ding, Injectable hydrogels as unique biomedical materials, Chem. Soc. Rev. 37 (2008) 1473-1481.
    • (2008) Chem. Soc. Rev. , vol.37 , pp. 1473-1481
    • Yu, L.1    Ding, J.D.2
  • 14
    • 79955771707 scopus 로고    scopus 로고
    • Biodegradable and thermoreversible PCLA-PEG-PCLA hydrogel as a barrier for prevention of post-operative adhesion
    • Z. Zhang, J. Ni, L. Chen, L. Yu, J.W. Xu, J.D. Ding, Biodegradable and thermoreversible PCLA-PEG-PCLA hydrogel as a barrier for prevention of post-operative adhesion, Biomaterials 32 (2011) 4725-4736.
    • (2011) Biomaterials , vol.32 , pp. 4725-4736
    • Zhang, Z.1    Ni, J.2    Chen, L.3    Yu, L.4    Xu, J.W.5    Ding, J.D.6
  • 15
    • 84862837839 scopus 로고    scopus 로고
    • The effect of culture conditions on the adipogenic and osteogenic inductionsofmesenchymal stem cellson micropatterned surfaces
    • R. Peng, X. Yao, B. Cao, J. Tang, J.D. Ding, The effect of culture conditions on the adipogenic and osteogenic inductionsofmesenchymal stem cellson micropatterned surfaces, Biomaterials 33 (2012) 6008-6019.
    • (2012) Biomaterials , vol.33 , pp. 6008-6019
    • Peng, R.1    Yao, X.2    Cao, B.3    Tang, J.4    Ding, J.D.5
  • 16
    • 7144248725 scopus 로고
    • Plant antitumor agents. I. Isolation and structure of camptothecin a novel alkaloidal leukemia and tumor inhibitor from camptotheca acuminata
    • M.E. Wall, M.C. Wani, C.E. Cook, K.H. Palmer, A.T. McPhail, G.A. Sim, Plant antitumor agents. I. Isolation and structure of camptothecin a novel alkaloidal leukemia and tumor inhibitor from camptotheca acuminata, J. Am. Chem. Soc. 88 (1966) 3888-3890.
    • (1966) J. Am. Chem. Soc. , vol.88 , pp. 3888-3890
    • Wall, M.E.1    Wani, M.C.2    Cook, C.E.3    Palmer, K.H.4    McPhail, A.T.5    Sim, G.A.6
  • 17
    • 33749034730 scopus 로고    scopus 로고
    • Topoisomerase I inhibitors: Camptothecins and beyond
    • DOI 10.1038/nrc1977, PII NRC1977
    • Y. Pommier, Topoisomerase I inhibitors: camptothecins and beyond, Nat. Rev. Cancer 6 (2006) 789-802. (Pubitemid 44450467)
    • (2006) Nature Reviews Cancer , vol.6 , Issue.10 , pp. 789-802
    • Pommier, Y.1
  • 18
    • 77950588535 scopus 로고    scopus 로고
    • Cancer therapies utilizing the camptothecins: A review of the in vivo literature
    • V.J. Venditto, E.E. Simanek, Cancer therapies utilizing the camptothecins: a review of the in vivo literature, Mol. Pharm. 7 (2010) 307-349.
    • (2010) Mol. Pharm. , vol.7 , pp. 307-349
    • Venditto, V.J.1    Simanek, E.E.2
  • 20
    • 77953287618 scopus 로고    scopus 로고
    • Prevention of in vivo lung tumor growth by prolonged local delivery of hydroxycamptothecin using poly(ester-carbonate)-collagen composites
    • J.B. Wolinsky, R. Liu, J. Walpole, L.R. Chirieac, Y.L. Colson, M.W. Grinstaff, Prevention of in vivo lung tumor growth by prolonged local delivery of hydroxycamptothecin using poly(ester-carbonate)-collagen composites, J. Control. Release 144 (2010) 280-287.
    • (2010) J. Control. Release , vol.144 , pp. 280-287
    • Wolinsky, J.B.1    Liu, R.2    Walpole, J.3    Chirieac, L.R.4    Colson, Y.L.5    Grinstaff, M.W.6
  • 21
    • 70849096524 scopus 로고    scopus 로고
    • Novel anti-tumor strategy: PEG-hydroxycamptothecin conjugate loaded transferrin-PEG-nanoparticles
    • M.H. Hong, S.J. Zhu, Y.Y. Jiang, G.T. Tang, C. Sun, C. Fang, B. Shi, Y.Y. Pei, Novel anti-tumor strategy: PEG-hydroxycamptothecin conjugate loaded transferrin-PEG-nanoparticles, J. Control. Release 141 (2010) 22-29.
    • (2010) J. Control. Release , vol.141 , pp. 22-29
    • Hong, M.H.1    Zhu, S.J.2    Jiang, Y.Y.3    Tang, G.T.4    Sun, C.5    Fang, C.6    Shi, B.7    Pei, Y.Y.8
  • 23
    • 79960096264 scopus 로고    scopus 로고
    • Preclinicalto clinical development of the novel camptothecin nanopharmaceutical CRLX101
    • S. Svenson, M. Wolfgang, J. Hwang, J. Ryan, S. Eliasof, Preclinicalto clinical development of the novel camptothecin nanopharmaceutical CRLX101, J. Control. Release 153 (2011) 49-55.
    • (2011) J. Control. Release , vol.153 , pp. 49-55
    • Svenson, S.1    Wolfgang, M.2    Hwang, J.3    Ryan, J.4    Eliasof, S.5
  • 24
    • 84857910834 scopus 로고    scopus 로고
    • Irinophore C (TM), a lipid-based nanoparticulate formulation of irinotecan, is more effective than free irinotecan when used to treat an orthotopic glioblastoma model
    • M. Verreault, D. Strutt, D. Masin, M. Anantha, D. Waterhouse, D.T. Yapp, M.B. Bally, Irinophore C (TM), a lipid-based nanoparticulate formulation of irinotecan, is more effective than free irinotecan when used to treat an orthotopic glioblastoma model, J. Control. Release 158 (2012) 34-43.
    • (2012) J. Control. Release , vol.158 , pp. 34-43
    • Verreault, M.1    Strutt, D.2    Masin, D.3    Anantha, M.4    Waterhouse, D.5    Yapp, D.T.6    Bally, M.B.7
  • 25
    • 84861691386 scopus 로고    scopus 로고
    • Characterization of PEGylated nanoliposomes co-remotely loaded with topotecan and vincristine: Relating structure and pharmacokinetics to therapeutic efficacy
    • D. Zucker, A.V. Andriyanov, A. Steiner, U. Raviv, Y. Barenholz, Characterization of PEGylated nanoliposomes co-remotely loaded with topotecan and vincristine: relating structure and pharmacokinetics to therapeutic efficacy, J. Control. Release 160 (2012) 281-289.
    • (2012) J. Control. Release , vol.160 , pp. 281-289
    • Zucker, D.1    Andriyanov, A.V.2    Steiner, A.3    Raviv, U.4    Barenholz, Y.5
  • 27
    • 0028267240 scopus 로고
    • Camptothecins: From bench research to hospital wards
    • M. Potmesil, Camptothecins - from bench research to hospital wards, Cancer Res. 54 (1994) 1431-1439. (Pubitemid 24106402)
    • (1994) Cancer Research , vol.54 , Issue.6 , pp. 1431-1439
    • Potmesil, M.1
  • 28
    • 35348914686 scopus 로고    scopus 로고
    • Relevance of extracellular and intracellular interactions of camptothecins as determinants of antitumor activity
    • DOI 10.1016/j.bcp.2007.04.027, PII S0006295207002857
    • G.L. Beretta, F. Zunino, Relevance of extracellular and intracellular interactions of camptothecins as determinants of antitumor activity, Biochem. Pharmacol. 74 (2007) 1437-1444. (Pubitemid 47575490)
    • (2007) Biochemical Pharmacology , vol.74 , Issue.10 , pp. 1437-1444
    • Beretta, G.L.1    Zunino, F.2
  • 29
    • 0028012774 scopus 로고
    • The structural basis of camptothecin interactions with human serum albumin: Impact on drug stability
    • T.G. Burke, Z.H. Mi, The structural basis of Camptothecin interactions with human serum-albumin - impact on drug stability, J. Med. Chem. 37 (1994) 40-46. (Pubitemid 24058811)
    • (1994) Journal of Medicinal Chemistry , vol.37 , Issue.1 , pp. 40-46
    • Burke, T.G.1    Mi, Z.2
  • 30
    • 3042555861 scopus 로고    scopus 로고
    • Solubilization and stabilization of camptothecin in micellar solutions of pluronic-g-poly(acrylic acid) copolymers
    • DOI 10.1016/j.jconrel.2004.04.007, PII S0168365904001889
    • R. Barreiro-Iglesias, L. Bromberg, M. Temchenko, T.A. Hatton, A. Concheiro, C. Alvarez-Lorenzo, Solubilization and stabilization of camptothecin in micellar solutions of pluronic-g-poly(acrylic acid) copolymers, J. Control. Release 97 (2004) 537-549. (Pubitemid 38802955)
    • (2004) Journal of Controlled Release , vol.97 , Issue.3 , pp. 537-549
    • Barreiro-Iglesias, R.1    Bromberg, L.2    Temchenko, M.3    Hatton, T.A.4    Concheiro, A.5    Alvarez-Lorenzo, C.6
  • 31
    • 42049121123 scopus 로고    scopus 로고
    • Hydrophobically modified glycol chitosan nanoparticles-encapsulated camptothecin enhance the drug stability and tumor targeting in cancer therapy
    • K.H. Min, K. Park, Y.S. Kim, S.M. Bae, S. Lee, H.G. Jo, R.W. Park, I.S. Kim, S.Y. Jeong, K. Kim, I.C. Kwon, Hydrophobically modified glycol chitosan nanoparticles-encapsulated camptothecin enhance the drug stability and tumor targeting in cancer therapy, J. Control. Release 127 (2008) 208-218.
    • (2008) J. Control. Release , vol.127 , pp. 208-218
    • Min, K.H.1    Park, K.2    Kim, Y.S.3    Bae, S.M.4    Lee, S.5    Jo, H.G.6    Park, R.W.7    Kim, I.S.8    Jeong, S.Y.9    Kim, K.10    Kwon, I.C.11
  • 32
    • 42049093001 scopus 로고    scopus 로고
    • In vivo antitumor activity of camptothecin incorporated in liposomes formulated with an artificial lipid and human serum albumin
    • M. Watanabe, K. Kawano, K. Toma, Y. Hattori, Y. Maitani, In vivo antitumor activity of camptothecin incorporated in liposomes formulated with an artificial lipid and human serum albumin, J. Control. Release 127 (2008) 231-238.
    • (2008) J. Control. Release , vol.127 , pp. 231-238
    • Watanabe, M.1    Kawano, K.2    Toma, K.3    Hattori, Y.4    Maitani, Y.5
  • 33
    • 40649123230 scopus 로고    scopus 로고
    • Preservation of the active lactone form of irinotecan using drug eluting beads for the treatment of colorectal cancer metastases
    • Y.Q. Tang, P.R. Czuczman, S.T. Chung, A.L. Lewis, Preservation of the active lactone form of irinotecan using drug eluting beads for the treatment of colorectal cancer metastases, J. Control. Release 127 (2008) 70-78.
    • (2008) J. Control. Release , vol.127 , pp. 70-78
    • Tang, Y.Q.1    Czuczman, P.R.2    Chung, S.T.3    Lewis, A.L.4
  • 34
    • 68549136478 scopus 로고    scopus 로고
    • Poly(omega-pentadecalactone-co-butylene-co-succinate) nanoparticles as biodegradable carriers for camptothecin delivery
    • J. Liu, Z.Z. Jiang, S.M. Zhang, W.M. Saltzman, Poly(omega- pentadecalactone-co-butylene-co-succinate) nanoparticles as biodegradable carriers for camptothecin delivery, Biomaterials 30 (2009) 5707-5719.
    • (2009) Biomaterials , vol.30 , pp. 5707-5719
    • Liu, J.1    Jiang, Z.Z.2    Zhang, S.M.3    Saltzman, W.M.4
  • 35
    • 77956011455 scopus 로고    scopus 로고
    • Nanomicelle with long-term circulation and enhanced stability of camptothecin based on MPEGylated alpha, beta-poly (l-aspartic acid)-camptothecin conjugate
    • W.L. Zhang, J. Huang, N.Q. Fan, J.H. Yu, Y.B. Liu, S.Y. Liu, D.X. Wang, Y.P. Li, Nanomicelle with long-term circulation and enhanced stability of camptothecin based on MPEGylated alpha, beta-poly (l-aspartic acid)-camptothecin conjugate, Colloid Surf B Biointerfaces 81 (2010) 297-303.
    • (2010) Colloid Surf B Biointerfaces , vol.81 , pp. 297-303
    • Zhang, W.L.1    Huang, J.2    Fan, N.Q.3    Yu, J.H.4    Liu, Y.B.5    Liu, S.Y.6    Wang, D.X.7    Li, Y.P.8
  • 36
    • 80855130910 scopus 로고    scopus 로고
    • Enhancement of the fraction of the active form of an antitumor drug topotecan via an injectable hydrogel
    • G.T. Chang, T.Y. Ci, L. Yu, J.D. Ding, Enhancement of the fraction of the active form of an antitumor drug topotecan via an injectable hydrogel, J. Control. Release 156 (2011) 21-27.
    • (2011) J. Control. Release , vol.156 , pp. 21-27
    • Chang, G.T.1    Ci, T.Y.2    Yu, L.3    Ding, J.D.4
  • 37
    • 84863197348 scopus 로고    scopus 로고
    • Fabrication of biodegradable micelles with sheddable poly(ethylene glycol) shells as the carrier of 7-ethyl-10-hydroxy-camptothecin
    • Q. Guo, P. Luo, Y. Luo, F. Du, W. Lu, S. Liu, J. Huang, J. Yu, Fabrication of biodegradable micelles with sheddable poly(ethylene glycol) shells as the carrier of 7-ethyl-10-hydroxy-camptothecin, Colloid Surf B Biointerfaces 100 (2012) 138-145.
    • (2012) Colloid Surf B Biointerfaces , vol.100 , pp. 138-145
    • Guo, Q.1    Luo, P.2    Luo, Y.3    Du, F.4    Lu, W.5    Liu, S.6    Huang, J.7    Yu, J.8
  • 39
    • 84867078413 scopus 로고    scopus 로고
    • Light-driven proton pumps of archaerhodopsin and bacteriorhodopsin and polymer-matrix composite materials of those functional proteins
    • Y.Z. Wang, D.W. Ma, Y.C. Zhao, M. Ming, J. Wu, J.D. Ding, Light-driven proton pumps of archaerhodopsin and bacteriorhodopsin and polymer-matrix composite materials of those functional proteins, Acta Polym. Sin. (2012) 698-713.
    • (2012) Acta Polym. Sin. , pp. 698-713
    • Wang, Y.Z.1    Ma, D.W.2    Zhao, Y.C.3    Ming, M.4    Wu, J.5    Ding, J.D.6
  • 40
    • 0027930186 scopus 로고
    • Differential interactions of camptothecin lactone and carboxylate forms with human blood components
    • Z.H. Mi, T.G. Burke, Differential interactions of camptothecin lactone and carboxylate forms with human blood components, Biochemistry 33 (1994) 10325-10336. (Pubitemid 24281798)
    • (1994) Biochemistry , vol.33 , Issue.34 , pp. 10325-10336
    • Mi, Z.1    Burke, T.G.2
  • 41
    • 0040730144 scopus 로고
    • Dielectric constants of some organic solvent-water mixtures at various temperatures
    • G. Akerlof, Dielectric constants of some organic solvent-water mixtures at various temperatures, J. Am. Chem. Soc. 54 (1932) 4125-4139.
    • (1932) J. Am. Chem. Soc. , vol.54 , pp. 4125-4139
    • Akerlof, G.1
  • 42
    • 82355185831 scopus 로고    scopus 로고
    • Polyethylene glycol behaves like weak organic solvent
    • A. Hirano, K. Shiraki, T. Arakawa, Polyethylene glycol behaves like weak organic solvent, Biopolymers 97 (2012) 117-122.
    • (2012) Biopolymers , vol.97 , pp. 117-122
    • Hirano, A.1    Shiraki, K.2    Arakawa, T.3
  • 43
    • 0027096415 scopus 로고
    • A kinetic and mechanistic study of the hydrolysis of camptothecin and some analogues
    • DOI 10.1002/jps.2600810718
    • J. Fassberg, V.J. Stella, A kinetic and mechanistic study of the hydrolysis of camptothecin and some analogues, J. Pharm. Sci. 81 (1992) 676-684. (Pubitemid 23006796)
    • (1992) Journal of Pharmaceutical Sciences , vol.81 , Issue.7 , pp. 676-684
    • Fassberg, J.1    Stella, V.J.2
  • 44
    • 0028835388 scopus 로고
    • Variation of acidity constants and pH values of some organic-acids in water-2-propanol mixtures with solvent composition - Effect of preferential solvation
    • E. Bosch, C. Rafols, M. Roses, Variation of acidity constants and pH values of some organic-acids in water-2-propanol mixtures with solvent composition - effect of preferential solvation, Anal. Chim. Acta 302 (1995) 109-119.
    • (1995) Anal. Chim. Acta , vol.302 , pp. 109-119
    • Bosch, E.1    Rafols, C.2    Roses, M.3
  • 46
    • 0039640319 scopus 로고
    • Interpretation of pH measurements in alcohol-water solvents
    • R.G. Bates, M. Paabo, R.A. Robinson, Interpretation of pH measurements in alcohol-water solvents, J. Phys. Chem. 67 (1963) 1833-1838.
    • (1963) J. Phys. Chem. , vol.67 , pp. 1833-1838
    • Bates, R.G.1    Paabo, M.2    Robinson, R.A.3
  • 47
    • 0033043628 scopus 로고    scopus 로고
    • The acidic microclimate in poly(lactide-co-glycolide) microspheres stabilizes camptothecins
    • A. Shenderova, T.G. Burke, S.P. Schwendeman, The acidic microclimate in poly(lactide-co-glycolide) microspheres stabilizes camptothecins, Pharm. Res. 16 (1999) 241-248.
    • (1999) Pharm. Res. , vol.16 , pp. 241-248
    • Shenderova, A.1    Burke, T.G.2    Schwendeman, S.P.3
  • 48
    • 56949105019 scopus 로고    scopus 로고
    • Recent progress in tumor pH targeting nanotechnology
    • E.S. Lee, Z.G. Gao, Y.H. Bae, Recent progress in tumor pH targeting nanotechnology, J. Control. Release 132 (2008) 164-170.
    • (2008) J. Control. Release , vol.132 , pp. 164-170
    • Lee, E.S.1    Gao, Z.G.2    Bae, Y.H.3
  • 49
    • 78349301671 scopus 로고    scopus 로고
    • N-boc-histidine-capped PLGA-PEG-PLGA as a smart polymer for drug delivery sensitive to tumor extracellular pH
    • G.T. Chang, C. Li, W.Y. Lu, J.D. Ding, N-boc-histidine-capped PLGA-PEG-PLGA as a smart polymer for drug delivery sensitive to tumor extracellular pH, Macromol. Biosci. 10 (2010) 1248-1256.
    • (2010) Macromol. Biosci. , vol.10 , pp. 1248-1256
    • Chang, G.T.1    Li, C.2    Lu, W.Y.3    Ding, J.D.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.