Synthesis and characterization of biodegradable and thermosensitive polymeric micelles with covalently bound doxorubicin-glucuronide prodrug via click chemistry

Bioconjugate Chemistry

Volumn 22, Issue 12, 2011, Pages 2519-2530

  Talelli, M ^a   Morita, K ^a   Rijcken, C J F ^a,d   Aben, R W M ^b   Lammers, T ^a,c   Scheeren, H W ^b   Van Nostrum, C F ^a   Storm, G ^a   Hennink, W E ^a  

^a UTRECHT UNIVERSITY   (Netherlands)

^b RADBOUD UNIVERSITY NIJMEGEN   (Netherlands)

^c RWTH AACHEN UNIVERSITY   (Germany)

^d Crystal Delivery BV   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

BIODEGRADABLE POLYMERS; BLOCK COPOLYMERS; CONTROLLED DRUG DELIVERY; ENZYMES; FUNCTIONAL POLYMERS; MOTION PICTURE EXPERTS GROUP STANDARDS; POLYETHYLENE GLYCOLS; SYNTHESIS (CHEMICAL); TARGETED DRUG DELIVERY;

ANTHRACYCLINES; CLICK CHEMISTRY; COVALENTLY BOUND; DOXORUBICIN; GLUCURONIDASE; GLUCURONIDES; IN-VITRO; PRODRUGS; SYNTHESIS AND CHARACTERIZATIONS; THERMOSENSITIVE POLYMERIC MICELLES;

MICELLES;

2 AZIDOETHANOL; 2 AZIDOETHYL METHACRYLATE; ALCOHOL DERIVATIVE; ANTINEOPLASTIC AGENT; BETA GLUCURONIDASE; COPOLYMER; DOXORUBICIN GLUCURONIDE PRODRUG; METHACRYLIC ACID DERIVATIVE; POLY(ETHYLENE GLYCOL) B POLY[ N (2 HYDROXYPROPYL)METHACRYLAMIDE LACTATE]; PRODRUG; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIODEGRADABILITY; CHEMICAL STRUCTURE; CLICK CHEMISTRY; COVALENT BOND; CRITICAL MICELLE TEMPERATURE; DRUG CYTOTOXICITY; DRUG DELIVERY SYSTEM; DRUG SYNTHESIS; HEAT SENSITIVITY; IN VITRO STUDY; INCUBATION TEMPERATURE; INFRARED SPECTROSCOPY; LIGHT SCATTERING; MICELLE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTON NUCLEAR MAGNETIC RESONANCE; TEMPERATURE;

EID: 84555220701     PISSN: 10431802     EISSN: 15204812     Source Type: Journal    
DOI: 10.1021/bc2003499     Document Type: Article

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