메뉴 건너뛰기




Volumn 155, Issue 2, 2011, Pages 200-210

New pharmaceutical applications for macromolecular binders

Author keywords

Chelators; Cyclodextrins; Nanomedicine; Polymeric binders; Polymeric drugs

Indexed keywords

BINDING PROPERTIES; BIOLOGICAL RESPONSE; CHELATORS; ILLUSTRATIVE EXAMPLES; LARGER SUBSTRATES; MACROMOLECULAR BINDERS; MACROMOLECULAR DRUGS; MULTIVALENT BINDING; NANOMEDICINES; PHARMACEUTICAL APPLICATIONS; POLYMERIC BINDER; POLYMERIC DRUGS;

EID: 80054098915     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2011.04.027     Document Type: Conference Paper
Times cited : (31)

References (118)
  • 1
    • 77955175216 scopus 로고    scopus 로고
    • Strategies in the design of nanoparticles for therapeutic applications
    • R.A. Petros, and J.M. DeSimone Strategies in the design of nanoparticles for therapeutic applications Nat. Rev. Drug Discov. 9 2010 615 627
    • (2010) Nat. Rev. Drug Discov. , vol.9 , pp. 615-627
    • Petros, R.A.1    Desimone, J.M.2
  • 2
    • 36849067019 scopus 로고    scopus 로고
    • Nanocarriers as an emerging platform for cancer therapy
    • DOI 10.1038/nnano.2007.387, PII NNANO2007387
    • D. Peer, J.M. Karp, S. Hong, O.C. Farokhzad, R. Margalit, and R. Langer Nanocarriers as an emerging platform for cancer therapy Nat. Nanotechnol. 2 2007 751 760 (Pubitemid 350223348)
    • (2007) Nature Nanotechnology , vol.2 , Issue.12 , pp. 751-760
    • Peer, D.1    Karp, J.M.2    Hong, S.3    Farokhzad, O.C.4    Margalit, R.5    Langer, R.6
  • 3
    • 33747840618 scopus 로고    scopus 로고
    • Polymer conjugates as anticancer nanomedicines
    • DOI 10.1038/nrc1958, PII NRC1958
    • R. Duncan Polymer conjugates as anticancer nanomedicines Nat. Rev. Cancer 6 2006 688 701 (Pubitemid 44286001)
    • (2006) Nature Reviews Cancer , vol.6 , Issue.9 , pp. 688-701
    • Duncan, R.1
  • 4
    • 0038387390 scopus 로고    scopus 로고
    • The dawning era of polymer therapeutics
    • DOI 10.1038/nrd1088
    • R. Duncan The dawning era of polymer therapeutics Nat. Rev. Drug Discov. 2 2003 347 360 (Pubitemid 37361705)
    • (2003) Nature Reviews Drug Discovery , vol.2 , Issue.5 , pp. 347-360
    • Duncan, R.1
  • 5
    • 34548529080 scopus 로고    scopus 로고
    • Polymer therapeutics
    • K.L. Kiick Polymer therapeutics Science 317 2007 1182 1183
    • (2007) Science , vol.317 , pp. 1182-1183
    • Kiick, K.L.1
  • 6
    • 0032076568 scopus 로고    scopus 로고
    • A trivalent system from vancomycin-D-Ala-D-Ala with higher affinity than avidin-biotin
    • DOI 10.1126/science.280.5364.708
    • J. Rao, J. Lahiri, L. Isaacs, R.M. Weis, and G.M. Whitesides A trivalent system from Vancomycin-D-Ala-D-Ala with higher affinity than avidin-biotin Science 280 1998 708 711 (Pubitemid 28243338)
    • (1998) Science , vol.280 , Issue.5364 , pp. 708-711
    • Rao, J.1    Lahiri, J.2    Isaacs, L.3    Weis, R.M.4    Whitesides, G.M.5
  • 7
    • 0032476812 scopus 로고    scopus 로고
    • Polyvalent interactions in biological systems: Implications for design and use of multivalent ligands and inhibitors
    • M. Mammen, S.-K. Choi, and G.M. Whitesides Polyvalent interactions in biological systems: implications for design and use of multivalent ligands and inhibitors Angew. Chem. Int. Ed. Engl. 37 1998 2754 2794 (Pubitemid 29008561)
    • (1998) Angewandte Chemie - International Edition , vol.37 , Issue.20 , pp. 2754-2794
    • Mammen, M.1    Choi, S.-K.2    Whitesides, G.M.3
  • 8
    • 72449134369 scopus 로고    scopus 로고
    • Cyclodextrin-based polymeric materials: Synthesis, properties, and pharmaceutical/biomedical applications
    • F. van de Manakker, T. Vermonden, C.F. van Nostrum, and W.E. Hennink Cyclodextrin-based polymeric materials: synthesis, properties, and pharmaceutical/biomedical applications Biomacromolecules 10 2009 3157 3175
    • (2009) Biomacromolecules , vol.10 , pp. 3157-3175
    • Van De Manakker, F.1    Vermonden, T.2    Van Nostrum, C.F.3    Hennink, W.E.4
  • 9
    • 79954453230 scopus 로고    scopus 로고
    • Cyclodextrin functionalized polymers as drug delivery systems
    • J.W. Zhou, and H. Ritter Cyclodextrin functionalized polymers as drug delivery systems Polym. Chem. 1 2010 1552 1559
    • (2010) Polym. Chem. , vol.1 , pp. 1552-1559
    • Zhou, J.W.1    Ritter, H.2
  • 10
    • 0037011939 scopus 로고    scopus 로고
    • Inter-receptor communication through arrays of bacterial chemoreceptors
    • J.E. Gestwicki, and L.L. Kiessling Inter-receptor communication through arrays of bacterial chemoreceptors Nature 415 2002 81 82
    • (2002) Nature , vol.415 , pp. 81-82
    • Gestwicki, J.E.1    Kiessling, L.L.2
  • 11
    • 0029094342 scopus 로고
    • Activation of a G protein complex by aggregation of beta-1,4- galactosyltransferase on the surface of sperm
    • X. Gong, D. Dubois, D. Miller, and B. Shur Activation of a G protein complex by aggregation of beta-1,4-galactosyltransferase on the surface of sperm Science 269 1995 1718 1721
    • (1995) Science , vol.269 , pp. 1718-1721
    • Gong, X.1    Dubois, D.2    Miller, D.3    Shur, B.4
  • 13
    • 23844451374 scopus 로고    scopus 로고
    • The convergence of synthetic organic and polymer chemistries
    • DOI 10.1126/science.1109778
    • C.J. Hawker, and K.L. Wooley The convergence of synthetic organic and polymer chemistries Science 309 2005 1200 1205 (Pubitemid 41170906)
    • (2005) Science , vol.309 , Issue.5738 , pp. 1200-1205
    • Hawker, C.J.1    Wooley, K.L.2
  • 14
    • 33845407170 scopus 로고    scopus 로고
    • Molecularly imprinted polymers for the recognition of proteins: The state of the art
    • DOI 10.1016/j.bios.2006.06.023, PII S0956566306002958
    • A. Bossi, F. Bonini, A.P.F. Turner, and S.A. Piletsky Molecularly imprinted polymers for the recognition of proteins: The state of the art Biosens. Bioelectron. 22 2007 1131 1137 (Pubitemid 44894899)
    • (2007) Biosensors and Bioelectronics , vol.22 , Issue.6 , pp. 1131-1137
    • Bossi, A.1    Bonini, F.2    Turner, A.P.F.3    Piletsky, S.A.4
  • 15
    • 43049083390 scopus 로고    scopus 로고
    • Molecularly imprinted polymers with specific recognition for macromolecules and proteins
    • DOI 10.1016/j.progpolymsci.2007.09.004, PII S0079670007001141
    • N.M. Bergmann, and N.A. Peppas Molecularly imprinted polymers with specific recognition for macromolecules and proteins Prog. Polym. Sci. 33 2008 271 288 (Pubitemid 351625301)
    • (2008) Progress in Polymer Science (Oxford) , vol.33 , Issue.3 , pp. 271-288
    • Bergmann, N.M.1    Peppas, N.A.2
  • 16
    • 77958549246 scopus 로고    scopus 로고
    • Damned if you do, damned if you don't: Potassium binding resins in hyperkalemia
    • M. Watson, K.C. Abbott, and C.M. Yuan Damned if you do, damned if you don't: potassium binding resins in hyperkalemia Clin. J. Am. Soc. Nephrol. 5 2010 1723 1726
    • (2010) Clin. J. Am. Soc. Nephrol. , vol.5 , pp. 1723-1726
    • Watson, M.1    Abbott, K.C.2    Yuan, C.M.3
  • 17
    • 78049372352 scopus 로고    scopus 로고
    • Sevelamer carbonate for the treatment of hyperphosphatemia in patients with kidney failure (CKD III-V)
    • P. Biggar, and M. Ketteler Sevelamer carbonate for the treatment of hyperphosphatemia in patients with kidney failure (CKD III-V) Expert Opin. Pharmacother. 11 2010 2739 2750
    • (2010) Expert Opin. Pharmacother. , vol.11 , pp. 2739-2750
    • Biggar, P.1    Ketteler, M.2
  • 18
    • 56449096123 scopus 로고    scopus 로고
    • In vitro chelating, cytotoxicity, and blood compatibility of degradable poly(ethylene glycol)-based macromolecular iron chelators
    • N.A.A. Rossi, I. Mustafa, J.K. Jackson, H.M. Burt, S.A. Horte, M.D. Scott, and J.N. Kizhakkedathu In vitro chelating, cytotoxicity, and blood compatibility of degradable poly(ethylene glycol)-based macromolecular iron chelators Biomaterials 30 2009 638 648
    • (2009) Biomaterials , vol.30 , pp. 638-648
    • Rossi, N.A.A.1    Mustafa, I.2    Jackson, J.K.3    Burt, H.M.4    Horte, S.A.5    Scott, M.D.6    Kizhakkedathu, J.N.7
  • 19
    • 77955412648 scopus 로고    scopus 로고
    • Synthesis and characterization of a triazine dendrimer that sequesters iron(III) using 12 desferrioxamine B groups
    • J. Lim, V.J. Venditto, and E.E. Simanek Synthesis and characterization of a triazine dendrimer that sequesters iron(III) using 12 desferrioxamine B groups Bioorg. Med. Chem. 18 2010 5749 5753
    • (2010) Bioorg. Med. Chem. , vol.18 , pp. 5749-5753
    • Lim, J.1    Venditto, V.J.2    Simanek, E.E.3
  • 20
    • 44449129418 scopus 로고    scopus 로고
    • Synthesis and iron(III)-chelating properties of novel 3-hydroxypyridin-4-one hexadentate ligand-containing copolymers
    • DOI 10.1021/bm701122u
    • T. Zhou, X.L. Kong, Z.D. Liu, D.Y. Liu, and R.C. Hider Synthesis and iron(III)-chelating properties of novel 3-hydroxypyridin-4-one hexadentate ligand-containing copolymers Biomacromolecules 9 2008 1372 1380 (Pubitemid 351757114)
    • (2008) Biomacromolecules , vol.9 , Issue.5 , pp. 1372-1380
    • Zhou, T.1    Kong, X.L.2    Liu, Z.D.3    Liu, D.Y.4    Hider, R.C.5
  • 21
    • 73349138621 scopus 로고    scopus 로고
    • Cyclodextrin overcomes deficient lysosome-to-endoplasmic reticulum transport of cholesterol in Niemann-Pick type C cells
    • L. Abi-Mosleh, R.E. Infante, A. Radhakrishnan, J.L. Goldstein, and M.S. Brown Cyclodextrin overcomes deficient lysosome-to-endoplasmic reticulum transport of cholesterol in Niemann-Pick type C cells Proc. Natl. Acad. Sci. USA 106 2009 19316 19321
    • (2009) Proc. Natl. Acad. Sci. USA , vol.106 , pp. 19316-19321
    • Abi-Mosleh, L.1    Infante, R.E.2    Radhakrishnan, A.3    Goldstein, J.L.4    Brown, M.S.5
  • 22
    • 0036009879 scopus 로고    scopus 로고
    • 2-O-substituted cyclodextrins as reversal agents for the neuromuscular blocker rocuronium bromide
    • DOI 10.1016/S0968-0896(02)00026-3, PII S0968089602000263
    • G.J. Tarver, S.J.A. Grove, K. Buchanan, A. Bom, A. Cooke, S.J. Rutherford, and M.-Q. Zhang 2-O-substituted cyclodextrins as reversal agents for the neuromuscular blocker rocuronium bromide Bioorg. Med. Chem. 10 2002 1819 1827 (Pubitemid 34286374)
    • (2002) Bioorganic and Medicinal Chemistry , vol.10 , Issue.6 , pp. 1819-1827
    • Tarver, G.J.1    Grove, S.J.A.2    Buchanan, K.3    Bom, A.4    Cooke, A.5    Rutherford, S.J.6    Zhang, M.-Q.7
  • 24
    • 14344252278 scopus 로고    scopus 로고
    • Aromatic-aromatic interaction of amitriptyline: Implication of overdosed drug detoxification
    • DOI 10.1002/jps.20256
    • D.-W. Lee, J. Flint, T. Morey, D. Dennis, R. Partch, and R. Baney Aromatic-aromatic interaction of amitriptyline: implication of overdosed drug detoxification J. Pharm. Sci. 94 2005 373 381 (Pubitemid 40293333)
    • (2005) Journal of Pharmaceutical Sciences , vol.94 , Issue.2 , pp. 373-381
    • Lee, D.-W.1    Flint, J.2    Morey, T.3    Dennis, D.4    Partch, R.5    Baney, R.6
  • 25
    • 59349085748 scopus 로고    scopus 로고
    • Toxin-binding treatment for Clostridium difficile: A review including reports of studies with tolevamer
    • K. Weiss Toxin-binding treatment for Clostridium difficile: a review including reports of studies with tolevamer Int. J. Antimicrob. Agents 33 2009 4 7
    • (2009) Int. J. Antimicrob. Agents , vol.33 , pp. 4-7
    • Weiss, K.1
  • 27
    • 0037442497 scopus 로고    scopus 로고
    • Assessment in mice of the therapeutic potential of tailored, multivalent Shiga toxin carbohydrate ligands
    • DOI 10.1086/373996
    • G.L. Mulvey, P. Marcato, P.I. Kitov, J. Sadowska, D.R. Bundle, and G.D. Armstrong Assessment in mice of the therapeutic potential of tailored, multivalent shiga toxin carbohydrate ligands J. Infect. Dis. 187 2003 640 649 (Pubitemid 36250028)
    • (2003) Journal of Infectious Diseases , vol.187 , Issue.4 , pp. 640-649
    • Mulvey, G.L.1    Marcato, P.2    Kitov, P.I.3    Sadowska, J.4    Bundle, D.R.5    Armstrong, G.D.6
  • 31
    • 33746318195 scopus 로고    scopus 로고
    • Synthesis of polyvalent inhibitors of controlled molecular weight: Structure-activity relationship for inhibitors of anthrax toxin
    • DOI 10.1021/bm060210p
    • K.V. Gujraty, A. Joshi, A. Saraph, V. Poon, J. Mogridge, and R.S. Kane Synthesis of polyvalent inhibitors of controlled molecular weight: structure-activity relationship for inhibitors of anthrax toxin Biomacromolecules 7 2006 2082 2085 (Pubitemid 44103346)
    • (2006) Biomacromolecules , vol.7 , Issue.7 , pp. 2082-2085
    • Gujraty, K.V.1    Joshi, A.2    Saraph, A.3    Poon, V.4    Mogridge, J.5    Kane, R.S.6
  • 32
    • 33748993435 scopus 로고    scopus 로고
    • Synthesis of potent inhibitors of anthrax toxin based on poly-L-glutamic acid
    • DOI 10.1021/bc060042y
    • A. Joshi, A. Saraph, V. Poon, J. Mogridge, and R.S. Kane Synthesis of potent inhibitors of anthrax toxin based on poly-L-glutamic acid Bioconjug. Chem. 17 2006 1265 1269 (Pubitemid 44455336)
    • (2006) Bioconjugate Chemistry , vol.17 , Issue.5 , pp. 1265-1269
    • Joshi, A.1    Saraph, A.2    Poon, V.3    Mogridge, J.4    Kane, R.S.5
  • 33
    • 77953081554 scopus 로고    scopus 로고
    • The influence of poly-N-[(2,2-dimethyl-1,3-dioxolane)methyl]acrylamide on fibrin polymerization, cross-linking and clot structure
    • B.F.L. Lai, Y. Zou, D.E. Brooks, and J.N. Kizhakkedathu The influence of poly-N-[(2,2-dimethyl-1,3-dioxolane)methyl]acrylamide on fibrin polymerization, cross-linking and clot structure Biomaterials 31 2010 5749 5758
    • (2010) Biomaterials , vol.31 , pp. 5749-5758
    • Lai, B.F.L.1    Zou, Y.2    Brooks, D.E.3    Kizhakkedathu, J.N.4
  • 35
    • 0037025441 scopus 로고    scopus 로고
    • Synthesis and anti-influenza evaluation of polyvalent sialidase inhibitors bearing 4-guanidino-Neu5Ac2en derivatives
    • DOI 10.1016/S0960-894X(02)00330-X, PII S0960894X0200330X
    • T. Honda, S. Yoshida, M. Arai, T. Masuda, and M. Yamashita Synthesis and anti-influenza evaluation of polyvalent sialidase inhibitors bearing 4-guanidino-Neu5Ac2en derivatives Bioorg. Med. Chem. Lett. 12 2002 1929 1932 (Pubitemid 34756451)
    • (2002) Bioorganic and Medicinal Chemistry Letters , vol.12 , Issue.15 , pp. 1929-1932
    • Honda, T.1    Yoshida, S.2    Arai, M.3    Masuda, T.4    Yamashita, M.5
  • 39
    • 0032811377 scopus 로고    scopus 로고
    • Bacteria targeted by human natural antibodies using α-gal conjugated receptor-specific glycopolymers
    • DOI 10.1016/S0968-0896(99)00099-1, PII S0968089699000991
    • J. Li, S. Zacharek, X. Chen, J. Wang, W. Zhang, A. Janczuk, and P.G. Wang Bacteria targeted by human natural antibodies using α-Gal conjugated receptor-specific glycopolymers Bioorg. Med. Chem. 7 1999 1549 1558 (Pubitemid 29347121)
    • (1999) Bioorganic and Medicinal Chemistry , vol.7 , Issue.8 , pp. 1549-1558
    • Li, J.1    Zacharek, S.2    Chen, X.3    Wang, J.4    Zhang, W.5    Janczuk, A.6    Wang, P.G.7
  • 41
    • 76649140507 scopus 로고    scopus 로고
    • Drug-free macromolecular therapeutics: Induction of apoptosis by coiled-coil-mediated cross-linking of antigens on the cell surface
    • K. Wu, J. Liu, R.N. Johnson, J. Yang, and J. Kopeček Drug-free macromolecular therapeutics: induction of apoptosis by coiled-coil-mediated cross-linking of antigens on the cell surface Angew. Chem. Int. Ed. Engl. 49 2010 1451 1455
    • (2010) Angew. Chem. Int. Ed. Engl. , vol.49 , pp. 1451-1455
    • Wu, K.1    Liu, J.2    Johnson, R.N.3    Yang, J.4    Kopeček, J.5
  • 42
    • 70349782154 scopus 로고    scopus 로고
    • Binding mechanisms in supramolecular complexes
    • H.-J. Schneider Binding mechanisms in supramolecular complexes Angew. Chem. Int. Ed. Engl. 48 2009 3924 3977
    • (2009) Angew. Chem. Int. Ed. Engl. , vol.48 , pp. 3924-3977
    • Schneider, H.-J.1
  • 43
    • 33745228759 scopus 로고    scopus 로고
    • Phosphate binders: New products and challenges
    • DOI 10.1111/j.1542-4758.2006.00100.x
    • A. Bellasi, L. Kooienga, and G.A. Block Phosphate binders: new products and challenges Hemodial. Int. 10 2006 225 234 (Pubitemid 43923204)
    • (2006) Hemodialysis International , vol.10 , Issue.3 , pp. 225-234
    • Bellasi, A.1    Kooienga, L.2    Block, G.A.3
  • 48
    • 0000025295 scopus 로고    scopus 로고
    • Principles and recent developments in chelation treatment of metal intoxication
    • O. Andersen Principles and recent developments in chelation treatment of metal intoxication Chem. Rev. 99 1999 2683 2710
    • (1999) Chem. Rev. , vol.99 , pp. 2683-2710
    • Andersen, O.1
  • 49
    • 61849129297 scopus 로고    scopus 로고
    • Heavy metal induced oxidative stress and its possible reversal by chelation therapy
    • S.J.S. Flora, M. Mittal, and A. Mehta Heavy metal induced oxidative stress and its possible reversal by chelation therapy Indian J. Med. Res. 128 2008 501 523
    • (2008) Indian J. Med. Res. , vol.128 , pp. 501-523
    • Flora, S.J.S.1    Mittal, M.2    Mehta, A.3
  • 50
    • 0020958872 scopus 로고
    • Chelating agents and cadmium toxicity: Problems and prospects
    • G.F. Nordberg Chelating agents and cadmium toxicity: problems and prospects Environ. Health Perspect. 54 1984 213 218 (Pubitemid 14094123)
    • (1983) Environmental Health Perspectives , vol.54 , pp. 213-218
    • Nordberg, G.F.1
  • 51
    • 61849118442 scopus 로고    scopus 로고
    • Cadmium and its adverse effects on human health
    • A. Bernard Cadmium and its adverse effects on human health Indian J. Med. Res. 128 2008 557 564
    • (2008) Indian J. Med. Res. , vol.128 , pp. 557-564
    • Bernard, A.1
  • 52
    • 0028337034 scopus 로고
    • Distribution and tissue uptake of poly(ethylene glycol) with different molecular weights after intravenous administration to mice
    • DOI 10.1002/jps.2600830432
    • T. Yamaoka Distribution and tissue uptake of poly(ethylene glycol) with different molecular weights after intravenous administration to mice J. Pharm. Sci. 83 1994 601 606 (Pubitemid 24222392)
    • (1994) Journal of Pharmaceutical Sciences , vol.83 , Issue.4 , pp. 601-606
    • Yamaoka, T.1    Tabata, Y.2    Ikada, Y.3
  • 53
    • 0141789795 scopus 로고    scopus 로고
    • Interaction of metal ions with caffeine and theophylline: Stability and structural features
    • S. Nafisi, S.A. Sadjadi, S.S. Zadeh, and M. Damerchelli Interaction of metal ions with caffeine and theophylline: stability and structural features J. Biomol. Struct. Dyn. 21 2003 289 296
    • (2003) J. Biomol. Struct. Dyn. , vol.21 , pp. 289-296
    • Nafisi, S.1    Sadjadi, S.A.2    Zadeh, S.S.3    Damerchelli, M.4
  • 54
    • 61349201499 scopus 로고    scopus 로고
    • Pharmacokinetics and biodistribution of N-isopropylacrylamide copolymers for the design of pH-sensitive liposomes
    • N. Bertrand, J.G. Fleischer, K.M. Wasan, and J.C. Leroux Pharmacokinetics and biodistribution of N-isopropylacrylamide copolymers for the design of pH-sensitive liposomes Biomaterials 30 2009 2598 2605
    • (2009) Biomaterials , vol.30 , pp. 2598-2605
    • Bertrand, N.1    Fleischer, J.G.2    Wasan, K.M.3    Leroux, J.C.4
  • 55
    • 57649224047 scopus 로고    scopus 로고
    • Colesevelam improves glycemic control and lipid management in inadequately controlled type 2 diabetes mellitus
    • K. Tziomalos, V.G. Athyros, and D.P. Mikhailidis Colesevelam improves glycemic control and lipid management in inadequately controlled type 2 diabetes mellitus Nat. Clin. Pract. Endocrinol. Metab. 5 2009 16 17
    • (2009) Nat. Clin. Pract. Endocrinol. Metab. , vol.5 , pp. 16-17
    • Tziomalos, K.1    Athyros, V.G.2    Mikhailidis, D.P.3
  • 56
    • 67649206289 scopus 로고    scopus 로고
    • A review of bile acid sequestrants: Potential mechanism(s) for glucose-lowering effects in type 2 diabetes mellitus
    • B. Staels A review of bile acid sequestrants: potential mechanism(s) for glucose-lowering effects in type 2 diabetes mellitus Postgrad. Med. 121 2009 25 30
    • (2009) Postgrad. Med. , vol.121 , pp. 25-30
    • Staels, B.1
  • 58
    • 26244449246 scopus 로고    scopus 로고
    • First human exposure of Org 25969, a novel agent to reverse the action of rocuronium bromide
    • DOI 10.1097/00000542-200510000-00007
    • F. Gijsenbergh, S. Ramael, N. Houwing, and T. van Iersel First human exposure of Org 25969, a novel agent to reverse the action of rocuronium bromide Anesthesiology 103 2005 695 703 (Pubitemid 41415517)
    • (2005) Anesthesiology , vol.103 , Issue.4 , pp. 695-703
    • Gijsenbergh, F.1    Ramael, S.2    Houwing, N.3    Van Iersel, T.4
  • 61
    • 31144448393 scopus 로고    scopus 로고
    • Org 25969 (sugammadex), a selective relaxant binding agent for antagonism of prolonged rocuronium-induced neuromuscular block
    • DOI 10.1093/bja/aei314
    • M. Shields, M. Giovanelli, R. Mirakhur, I. Moppett, J. Adams, and Y. Hermens Org 25969 (sugammadex), a selective relaxant binding agent for antagonism of prolonged rocuronium-induced neuromuscular block Br. J. Anaesth. 96 2006 36 43 (Pubitemid 43124528)
    • (2006) British Journal of Anaesthesia , vol.96 , Issue.1 , pp. 36-43
    • Shields, M.1    Giovannelli, M.2    Mirakhur, R.K.3    Moppett, I.4    Adams, J.5    Hermens, Y.6
  • 62
    • 33847235862 scopus 로고    scopus 로고
    • Sugammadex: Another milestone in clinical neuromuscular pharmacology
    • DOI 10.1213/01.ane.0000244594.63318.fc, PII 0000053920070300000026
    • M. Naguib Sugammadex: another milestone in clinical neuromuscular pharmacology Anesth. Analg. 104 2007 575 581 (Pubitemid 46331731)
    • (2007) Anesthesia and Analgesia , vol.104 , Issue.3 , pp. 575-581
    • Naguib, M.1
  • 63
    • 33847229811 scopus 로고    scopus 로고
    • Emergency use of sugammadex after failure of standard reversal drugs
    • A. Lenz, G. Hill, and P.F. White Emergency use of sugammadex after failure of standard reversal drugs Anesth. Analg. 104 2007 585 586
    • (2007) Anesth. Analg. , vol.104 , pp. 585-586
    • Lenz, A.1    Hill, G.2    White, P.F.3
  • 64
    • 60549084168 scopus 로고    scopus 로고
    • Reversal of defective lysosomal transport in NPC disease ameliorates liver dysfunction and neurodegeneration in the npc1-/- mouse
    • B. Liu, S.D. Turley, D.K. Burns, A.M. Miller, J.J. Repa, and J.M. Dietschy Reversal of defective lysosomal transport in NPC disease ameliorates liver dysfunction and neurodegeneration in the npc1-/- mouse Proc. Natl. Acad. Sci. USA 106 2009 2377 2382
    • (2009) Proc. Natl. Acad. Sci. USA , vol.106 , pp. 2377-2382
    • Liu, B.1    Turley, S.D.2    Burns, D.K.3    Miller, A.M.4    Repa, J.J.5    Dietschy, J.M.6
  • 65
    • 77950402392 scopus 로고    scopus 로고
    • Endocytosis of β-cyclodextrins is responsible for cholesterol reduction in Niemann-Pick type C mutant cells
    • A.I. Rosenbaum, G. Zhang, J.D. Warren, and F.R. Maxfield Endocytosis of β-cyclodextrins is responsible for cholesterol reduction in Niemann-Pick type C mutant cells Proc. Natl. Acad. Sci. USA 107 2010 5477 5482
    • (2010) Proc. Natl. Acad. Sci. USA , vol.107 , pp. 5477-5482
    • Rosenbaum, A.I.1    Zhang, G.2    Warren, J.D.3    Maxfield, F.R.4
  • 66
    • 0034603154 scopus 로고    scopus 로고
    • Adaptive recognition by nucleic acid aptamers
    • DOI 10.1126/science.287.5454.820
    • T. Hermann, and D.J. Patel Biochemistry - Adaptive recognition by nucleic acid aptamers Science 287 2000 820 825 (Pubitemid 30084318)
    • (2000) Science , vol.287 , Issue.5454 , pp. 820-825
    • Hermann, T.1    Patel, D.J.2
  • 68
  • 69
    • 33845388596 scopus 로고    scopus 로고
    • First-in-human experience of an antidote-controlled anticoagulant using RNA aptamer technology: A phase 1a pharmacodynamic evaluation of a drug-antidote pair for the controlled regulation of factor IXa activity
    • DOI 10.1161/CIRCULATIONAHA.106.668434, PII 0000301720061205000012
    • C.K. Dyke, S.R. Steinhubl, N.S. Kleiman, R.O. Cannon, L.G. Aberle, M. Lin, S.K. Myles, C. Melloni, R.A. Harrington, J.H. Alexander, R.C. Becker, and C.P. Rusconi First-in-human experience of an antidote-controlled anticoagulant using RNA aptamer technology: a phase 1a pharmacodynamic evaluation of a drug-antidote pair for the controlled regulation of factor IXa activity Circulation 114 2006 2490 2497 (Pubitemid 44901522)
    • (2006) Circulation , vol.114 , Issue.23 , pp. 2490-2497
    • Dyke, C.K.1    Steinhubl, S.R.2    Kleiman, N.S.3    Cannon, R.O.4    Aberle, L.G.5    Lin, M.6    Myles, S.K.7    Melloni, C.8    Harrington, R.A.9    Alexander, J.H.10    Becker, R.C.11    Rusconi, C.P.12
  • 72
    • 3042855154 scopus 로고    scopus 로고
    • Toxin binding of tolevamer, a polyanionic drug that protects against antibiotic-associated diarrhea
    • DOI 10.1529/biophysj.104.041277
    • W. Braunlin, Q. Xu, P. Hook, R. Fitzpatrick, J.D. Klinger, R. Burrier, and C.B. Kurtz Toxin binding of tolevamer, a polyanionic drug that protects against antibiotic-associated diarrhea Biophys. J. 87 2004 534 539 (Pubitemid 38880106)
    • (2004) Biophysical Journal , vol.87 , Issue.1 , pp. 534-539
    • Braunlin, W.1    Xu, Q.2    Hook, P.3    Fitzpatrick, R.4    Klinger, J.D.5    Burrier, R.6    Kurtz, C.B.7
  • 73
    • 0028358924 scopus 로고
    • Oligosaccharide sequences attached to an inert support (SYNSORB) as potential therapy for antibiotic-associated diarrhea and pseudomembranous colitis
    • L.D. Heerze, M.A. Kelm, J.A. Talbot, and G.D. Armstrong Oligosaccharide sequences attached to an inert support (SYNSORB) as potential therapy for antibiotic-associated diarrhea and pseudomembranous colitis J. Infect. Dis. 169 1994 1291 1296 (Pubitemid 24164593)
    • (1994) Journal of Infectious Diseases , vol.169 , Issue.6 , pp. 1291-1296
    • Heerze, L.D.1    Kelm, M.A.2    Talbot, J.A.3    Armstrong, G.D.4
  • 75
    • 0034628502 scopus 로고    scopus 로고
    • Shiga-like toxins are neutralized by tailored multivalent carbohydrate ligands
    • DOI 10.1038/35001095
    • P.I. Kitov, J.M. Sadowska, G. Mulvey, G.D. Armstrong, H. Ling, N.S. Pannu, R.J. Read, and D.R. Bundle Shiga-like toxins are neutralized by tailored multivalent carbohydrate ligands Nature 403 2000 669 672 (Pubitemid 30104009)
    • (2000) Nature , vol.403 , Issue.6770 , pp. 669-672
    • Kitov, P.I.1    Sadowska, J.M.2    Mulvey, G.3    Armstrong, G.D.4    Ling, H.5    Pannu, N.S.6    Read, R.J.7    Bundle, D.R.8
  • 76
    • 44949249151 scopus 로고    scopus 로고
    • A new formulation of tolevamer, a novel nonantibiotic polymer, is safe and well-tolerated in healthy volunteers: A randomized phase I trial
    • DOI 10.1111/j.1365-2125.2008.03151.x
    • J. Peppe, A. Porzio, and D.M. Davidson A new formulation of tolevamer, a novel nonantibiotic polymer, is safe and well-tolerated in healthy volunteers: a randomized phase I trial Br. J. Clin. Pharmacol. 66 2008 102 109 (Pubitemid 351822150)
    • (2008) British Journal of Clinical Pharmacology , vol.66 , Issue.1 , pp. 102-109
    • Peppe, J.1    Porzio, A.2    Davidson, D.M.3
  • 77
    • 0018278995 scopus 로고
    • Anion-exchange resins in antibiotics-associated colitis
    • C. TeWen, B.O. Andrew, and G.B. John Anion-exchange resins in antibiotics-associated colitis Lancet 312 1978 258 259
    • (1978) Lancet , vol.312 , pp. 258-259
    • Tewen, C.1    Andrew, B.O.2    John, G.B.3
  • 79
    • 0018844685 scopus 로고
    • Binding of Clostridium difficile cytotoxin and vancomycin by anion-exchange resins
    • N.S. Taylor, and J.G. Bartlett Binding of Clostridium difficile cytotoxin and vancomycin by anion-exchange resins J. Infect. Dis. 141 1980 92 97 (Pubitemid 10133840)
    • (1980) Journal of Infectious Diseases , vol.141 , Issue.1 , pp. 92-97
    • Taylor, N.S.1    Bartlett, J.G.2
  • 81
    • 33845486226 scopus 로고    scopus 로고
    • Tolevamer, a novel toxin-binding polymer: Overview of preclinical pharmacology and physicochemical properties
    • R.H. Barker Jr., R. Dagher, D.M. Davidson, and J.K. Marquis Tolevamer, a novel toxin-binding polymer: overview of preclinical pharmacology and physicochemical properties Aliment. Pharmacol. Ther. 24 2006 10
    • (2006) Aliment. Pharmacol. Ther. , vol.24 , pp. 10
    • Barker, Jr.R.H.1    Dagher, R.2    Davidson, D.M.3    Marquis, J.K.4
  • 83
    • 0026078094 scopus 로고
    • Toxin A of Clostridium difficile binds to the human carbohydrate antigens I, X, and y
    • K.D. Tucker, and T.D. Wilkins Toxin A of Clostridium difficile binds to the human carbohydrate antigens I, X, and Y Infect. Immun. 59 1991 73 78
    • (1991) Infect. Immun. , vol.59 , pp. 73-78
    • Tucker, K.D.1    Wilkins, T.D.2
  • 84
    • 0030017761 scopus 로고    scopus 로고
    • A receptor decoy inhibits the enterotoxic effects of Clostridium difficile toxin A in rat ileum
    • DOI 10.1053/gast.1996.v111.pm8690209
    • I. Castagliuolo, J.T. LaMont, B. Qiu, S.T. Nikulasson, and C. Pothoulakis A receptor decoy inhibits the enterotoxic effects of Clostridium difficile toxin A in rat ileum Gastroenterology 111 1996 433 438 (Pubitemid 26256732)
    • (1996) Gastroenterology , vol.111 , Issue.2 , pp. 433-438
    • Castagliuolo, I.1    LaMont, J.T.2    Qiu, B.3    Nikulasson, S.T.4    Pothoulakis, C.5
  • 88
    • 0036715684 scopus 로고    scopus 로고
    • Coeliac disease: Dissecting a complex inflammatory disorder
    • DOI 10.1038/nri885
    • L.M. Sollid Coeliac disease: dissecting a complex inflammatory disorder Nat. Rev. Immunol. 2 2002 647 655 (Pubitemid 37328722)
    • (2002) Nature Reviews Immunology , vol.2 , Issue.9 , pp. 647-655
    • Sollid, L.M.1
  • 89
    • 78649893491 scopus 로고    scopus 로고
    • Prevention measures and exploratory pharmacological treatments of celiac disease
    • M. Pinier, G. Fuhrmann, E. Verdu, and J.-C. Leroux Prevention measures and exploratory pharmacological treatments of celiac disease Am. J. Gastroenterol. 105 2010 2551 2561
    • (2010) Am. J. Gastroenterol. , vol.105 , pp. 2551-2561
    • Pinier, M.1    Fuhrmann, G.2    Verdu, E.3    Leroux, J.-C.4
  • 90
    • 34547494627 scopus 로고    scopus 로고
    • Combination Enzyme Therapy for Gastric Digestion of Dietary Gluten in Patients With Celiac Sprue
    • DOI 10.1053/j.gastro.2007.05.028, PII S0016508507010104
    • J. Gass, M.T. Bethune, M. Siegel, A. Spencer, and C. Khosla Combination enzyme therapy for gastric digestion of dietary gluten in patients with celiac sprue Gastroenterology 133 2007 472 480 (Pubitemid 47187353)
    • (2007) Gastroenterology , vol.133 , Issue.2 , pp. 472-480
    • Gass, J.1    Bethune, M.T.2    Siegel, M.3    Spencer, A.4    Khosla, C.5
  • 91
    • 34547852241 scopus 로고    scopus 로고
    • The safety, tolerance, pharmacokinetic and pharmacodynamic effects of single doses of AT-1001 in coeliac disease subjects: A proof of concept study
    • DOI 10.1111/j.1365-2036.2007.03413.x
    • B.M. Paterson, K.M. Lammers, M.C. Arrieta, A. Fasano, and J.B. Meddings The safety, tolerance, pharmacokinetic and pharmacodynamic effects of single doses of AT-1001 in coeliac disease subjects: a proof of concept study Aliment. Pharmacol. Ther. 26 2007 757 766 (Pubitemid 47246202)
    • (2007) Alimentary Pharmacology and Therapeutics , vol.26 , Issue.5 , pp. 757-766
    • Paterson, B.M.1    Lammers, K.M.2    Arrieta, M.C.3    Fasano, A.4    Meddings, J.B.5
  • 92
    • 33845501601 scopus 로고    scopus 로고
    • Structure-activity relationship analysis of the selective inhibition of transglutaminase 2 by dihydroisoxazoles
    • DOI 10.1021/jm060839a
    • R.E. Watts, M. Siegel, and C. Khosla Structure-activity relationship analysis of the selective inhibition of transglutaminase 2 by dihydroisoxazoles J. Med. Chem. 49 2006 7493 7501 (Pubitemid 44913408)
    • (2006) Journal of Medicinal Chemistry , vol.49 , Issue.25 , pp. 7493-7501
    • Watts, R.E.1    Siegel, M.2    Khosla, C.3
  • 93
    • 33244472849 scopus 로고    scopus 로고
    • Inhibition of HLA-DQ2-mediated antigen presentation by analogues of a high affinity 33-residue peptide from α2-gliadin
    • DOI 10.1021/ja056423o
    • J. Xia, M. Siegel, E. Bergseng, L.M. Sollid, and C. Khosla Inhibition of HLA-DQ2-mediated antigen presentation by analogues of a high affinity 33-residue peptide from alpha2-gliadin J. Am. Chem. Soc. 128 2006 1859 1867 (Pubitemid 43277324)
    • (2006) Journal of the American Chemical Society , vol.128 , Issue.6 , pp. 1859-1867
    • Xia, J.1    Siegel, M.2    Bergseng, E.3    Sollid, L.M.4    Khosla, C.5
  • 94
    • 72949112576 scopus 로고    scopus 로고
    • Immune tolerance induced by peptide immunotherapy in an HLA DQ2-dependent mouse model of gluten immunity
    • L.K. Catherine, D. James, C. Zhenjun, P.A. Robert, and M. James Immune tolerance induced by peptide immunotherapy in an HLA DQ2-dependent mouse model of gluten immunity Gastroenterology 136 2009 A-57
    • (2009) Gastroenterology , vol.136 , pp. 57
    • Catherine, L.K.1    James, D.2    Zhenjun, C.3    Robert, P.A.4    James, M.5
  • 95
    • 59949097490 scopus 로고    scopus 로고
    • Interaction of α-gliadin with poly(HEMA-co-SS): Structural characterization and biological implication
    • L. Liang, M. Pinier, J.-C. Leroux, and M. Subirade Interaction of α-gliadin with poly(HEMA-co-SS): structural characterization and biological implication Biopolymers 91 2009 169 178
    • (2009) Biopolymers , vol.91 , pp. 169-178
    • Liang, L.1    Pinier, M.2    Leroux, J.-C.3    Subirade, M.4
  • 96
    • 77951962866 scopus 로고    scopus 로고
    • Interaction of α-gliadin with polyanions: Design considerations for sequestrants used in supportive treatment of celiac disease
    • L. Liang, M. Pinier, J.-C. Leroux, and M. Subirade Interaction of α-gliadin with polyanions: design considerations for sequestrants used in supportive treatment of celiac disease Biopolymers 93 2010 418 428
    • (2010) Biopolymers , vol.93 , pp. 418-428
    • Liang, L.1    Pinier, M.2    Leroux, J.-C.3    Subirade, M.4
  • 97
    • 0031002854 scopus 로고    scopus 로고
    • Generation and in situ evaluation of libraries of poly(acrylic acid) presenting sialosides as side chains as polyvalent inhibitors of influenza- mediated hemagglutination
    • DOI 10.1021/ja963519x
    • S.-K. Choi, M. Mammen, and G.M. Whitesides Generation and in situ evaluation of libraries of poly(acrylic acid) presenting sialosides as side chains as polyvalent inhibitors of influenza-mediated hemagglutination J. Am. Chem. Soc. 119 1997 4103 4111 (Pubitemid 27239958)
    • (1997) Journal of the American Chemical Society , vol.119 , Issue.18 , pp. 4103-4111
    • Choi, S.-K.1    Mammen, M.2    Whitesides, G.M.3
  • 98
    • 27744509732 scopus 로고    scopus 로고
    • Evaluation of dendrimer SPL7013, a lead microbicide candidate against herpes simplex viruses
    • DOI 10.1016/j.antiviral.2005.08.004, PII S0166354205001749
    • E. Gong, B. Matthews, T. McCarthy, J. Chu, G. Holan, J. Raff, and S. Sacks Evaluation of dendrimer SPL7013, a lead microbicide candidate against herpes simplex viruses Antiviral Res. 68 2005 139 146 (Pubitemid 41612458)
    • (2005) Antiviral Research , vol.68 , Issue.3 , pp. 139-146
    • Gong, E.1    Matthews, B.2    McCarthy, T.3    Chu, J.4    Holan, G.5    Raff, J.6    Sacks, S.7
  • 100
    • 66749127854 scopus 로고    scopus 로고
    • Isolation of sulfated galactan from Codium fragile and its antiviral effect
    • Y. Ohta, J.-B. Lee, K. Hayashi, and T. Hayashi Isolation of sulfated galactan from Codium fragile and its antiviral effect Biol. Pharm. Bull. 32 2009 892 898
    • (2009) Biol. Pharm. Bull. , vol.32 , pp. 892-898
    • Ohta, Y.1    Lee, J.-B.2    Hayashi, K.3    Hayashi, T.4
  • 102
    • 76249114922 scopus 로고    scopus 로고
    • Multivalent benzoboroxole functionalized polymers as gp120 glycan targeted microbicide entry inhibitors
    • J.I. Jay, B.E. Lai, D.G. Myszka, A. Mahalingam, K. Langheinrich, D.F. Katz, and P.F. Kiser Multivalent benzoboroxole functionalized polymers as gp120 glycan targeted microbicide entry inhibitors Mol. Pharm. 7 2009 116 129
    • (2009) Mol. Pharm. , vol.7 , pp. 116-129
    • Jay, J.I.1    Lai, B.E.2    Myszka, D.G.3    Mahalingam, A.4    Langheinrich, K.5    Katz, D.F.6    Kiser, P.F.7
  • 103
    • 0029994114 scopus 로고    scopus 로고
    • Polyacrylamides bearing pendant α-sialoside groups strongly inhibit agglutination of erythrocytes by influenza virus: The strong inhibition reflects enhanced binding through cooperative polyvalent interactions
    • DOI 10.1021/ja953729u
    • G.B. Sigal, M. Mammen, G. Dahmann, and G.M. Whitesides Polyacrylamides bearing pendant α-sialoside groups strongly inhibit agglutination of erythrocytes by influenza virus: the strong inhibition reflects enhanced binding through cooperative polyvalent interactions J. Am. Chem. Soc. 118 1996 3789 3800 (Pubitemid 26168538)
    • (1996) Journal of the American Chemical Society , vol.118 , Issue.16 , pp. 3789-3800
    • Sigal, G.B.1    Mammen, M.2    Dahmann, G.3    Whitesides, G.M.4
  • 104
    • 38949198100 scopus 로고    scopus 로고
    • VivaGel™ (SPL7013): A candidate dendrimer-microbicide for the prevention of HIV and HSV infection
    • R. Rupp, S.L. Rosenthal, and L.R. Stanberry VivaGel™ (SPL7013): A candidate dendrimer-microbicide for the prevention of HIV and HSV infection Int. J. Med. 2 2007 561 566
    • (2007) Int. J. Med. , vol.2 , pp. 561-566
    • Rupp, R.1    Rosenthal, S.L.2    Stanberry, L.R.3
  • 107
    • 0037165196 scopus 로고    scopus 로고
    • Antimicrobial peptides of multicellular organisms
    • DOI 10.1038/415389a
    • M. Zasloff Antimicrobial peptides of multicellular organisms Nature 415 2002 389 395 (Pubitemid 34100944)
    • (2002) Nature , vol.415 , Issue.6870 , pp. 389-395
    • Zasloff, M.1
  • 108
    • 6344244516 scopus 로고    scopus 로고
    • Pseudomonas aeruginosa-induced infection and degradation of human wound fluid and skin proteins ex vivo are eradicated by a synthetic cationic polymer
    • DOI 10.1093/jac/dkh407
    • M. Werthen, M. Davoudi, A. Sonesson, D. Nitsche, M. Mörgelin, K. Blom, and A. Schmidtchen Pseudomonas aeruginosa-induced infection and degradation of human wound fluid and skin proteins ex vivo are eradicated by a synthetic cationic polymer J. Antimicrob. Chemother. 54 2004 772 779 (Pubitemid 39386730)
    • (2004) Journal of Antimicrobial Chemotherapy , vol.54 , Issue.4 , pp. 772-779
    • Werthen, M.1    Davoudi, M.2    Sonesson, A.3    Nitsche, D.P.4    Morgelin, M.5    Blom, K.6    Schmidtchen, A.7
  • 109
    • 0036470752 scopus 로고    scopus 로고
    • Poly(styrene-alt-maleic anhydride)-4-aminophenol conjugate: Synthesis and antibacterial activity
    • J.H. Jeong, Y.S. Byoun, and Y.S. Lee Poly(styrene-alt-maleic anhydride)-4-aminophenol conjugate: synthesis and antibacterial activity React. Funct. Polym. 50 2002 257 263
    • (2002) React. Funct. Polym. , vol.50 , pp. 257-263
    • Jeong, J.H.1    Byoun, Y.S.2    Lee, Y.S.3
  • 112
    • 77955139276 scopus 로고    scopus 로고
    • Fluorescent mannose-functionalized hyperbranched poly(amido amine)s: Synthesis and interaction with E. Coli
    • W. Yang, C.-Y. Pan, M.-D. Luo, and H.-B. Zhang Fluorescent mannose-functionalized hyperbranched poly(amido amine)s: synthesis and interaction with E. Coli Biomacromolecules 11 2010 1840 1846
    • (2010) Biomacromolecules , vol.11 , pp. 1840-1846
    • Yang, W.1    Pan, C.-Y.2    Luo, M.-D.3    Zhang, H.-B.4
  • 113
    • 70349925268 scopus 로고    scopus 로고
    • A supramolecular polymer as a self-assembling polyvalent scaffold
    • M.K. Müller, and L. Brunsweld A supramolecular polymer as a self-assembling polyvalent scaffold Angew. Chem. Int. Ed. Engl. 48 2009 2921 2924
    • (2009) Angew. Chem. Int. Ed. Engl. , vol.48 , pp. 2921-2924
    • Müller, M.K.1    Brunsweld, L.2
  • 115
    • 0344256483 scopus 로고    scopus 로고
    • Leukocyte and endothelial cell adhesion molecules as targets for therapeutic interventions in inflammatory disease
    • DOI 10.1016/j.tips.2003.10.004
    • H. Ulbrich, E.E. Eriksson, and L. Lindbom Leukocyte and endothelial cell adhesion molecules as targets for therapeutic interventions in inflammatory disease Trends Pharmacol. Sci. 24 2003 640 647 (Pubitemid 37494786)
    • (2003) Trends in Pharmacological Sciences , vol.24 , Issue.12 , pp. 640-647
    • Ulbrich, H.1    Eriksson, E.E.2    Lindbom, L.3
  • 116
    • 35948988152 scopus 로고    scopus 로고
    • Injectable nanocarriers for biodetoxification
    • J.C. Leroux Injectable nanocarriers for biodetoxification Nat. Nanotechnol. 2 2007 679 684
    • (2007) Nat. Nanotechnol. , vol.2 , pp. 679-684
    • Leroux, J.C.1
  • 117
    • 78650737398 scopus 로고    scopus 로고
    • Transmembrane pH-gradient liposomes to treat cardiovascular drug intoxication
    • N. Bertrand, C. Bouvet, P. Moreau, and J.C. Leroux Transmembrane pH-gradient liposomes to treat cardiovascular drug intoxication ACS Nano 4 2010 7552 7558
    • (2010) ACS Nano , vol.4 , pp. 7552-7558
    • Bertrand, N.1    Bouvet, C.2    Moreau, P.3    Leroux, J.C.4
  • 118
    • 70349999917 scopus 로고    scopus 로고
    • Polymeric carriers: Preclinical safety and the regulatory implications for design and development of polymer therapeutics
    • R. Gaspar, and R. Duncan Polymeric carriers: preclinical safety and the regulatory implications for design and development of polymer therapeutics Adv. Drug Deliv. Rev. 61 2009 1220 1231
    • (2009) Adv. Drug Deliv. Rev. , vol.61 , pp. 1220-1231
    • Gaspar, R.1    Duncan, R.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.