A new class of aggregation inhibitor of amyloid-β peptide based on an O-acyl isopeptide

Bioorganic and Medicinal Chemistry

Volumn 21, Issue 21, 2013, Pages 6323-6327

  Kawashima, Hiroyuki ^a   Sohma, Youhei ^a,b   Nakanishi, Tomoya ^a   Kitamura, Hitomi ^a   Mukai, Hidehito ^a,c   Yamashita, Masayuki ^a   Akaji, Kenichi ^a   Kiso, Yoshiaki ^a,c  

^a KYOTO PHARMACEUTICAL UNIVERSITY   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c NAGAHAMA INSTITUTE OF BIO SCIENCE AND TECHNOLOGY   (Japan)

Author keywords

Aggregation; Alzheimer; Amyloid; Inhibitor; Isopeptide

Indexed keywords

ALANINE; AMIDE; AMYLOID BETA PROTEIN[1-42]; AMYLOID BETA PROTEIN[1-42] AGGREGATION INHIBITOR; ESTER DERIVATIVE; GLYCINE; N METHYLAMIDE; O ACYLISOPEPTIDE; PEPTIDE DERIVATIVE; PROTEIN INHIBITOR; SERINE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL BOND; DRUG STABILITY; FIBER; PH; PROTEIN AGGREGATION; PROTEIN MODIFICATION;

AD; AGGREGATION; ALZHEIMER; ALZHEIMER'S DISEASE; AMYLOID; AMYLOID Β PEPTIDE; AΒ; CARBOXYFLUORESCEIN; DIC; DIMETHYL SULFOXIDE; DMF; DMSO; FAM; HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY; HOBT; HPLC; INHIBITOR; ISOPEPTIDE; KDA; KILODALTON OF MASS; MALDI; MASS SPECTROMETRY; MATRIX-ASSISTED LASER DESORPTION IONIZATION; MS; N,N-DIMETHYLFORMAMIDE; N,N′-DIISOPROPYLCARBODIIMIDE; N-HYDROXYBENZOTRIAZOLE; NDGA; NORDIHYDROGUAIARETIC ACID; TFA; TIME OF FLIGHT; TOF; TRIFLUROACETIC ACID; ULTRA-VIOLET; UV;

AMINO ACID SEQUENCE; AMYLOID BETA-PEPTIDES; ESTERS; FLUORESCENCE POLARIZATION; MICROSCOPY, ATOMIC FORCE; MOLECULAR SEQUENCE DATA; PEPTIDE FRAGMENTS; PEPTIDES; PROTEIN BINDING;

EID: 84885174978     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2013.08.062     Document Type: Article

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