Protein kinase A regulates cholinergic gene expression in PC12 cells: REST4 silences the silencing activity of neuron-restrictive silencer factor/REST

Molecular and Cellular Biology

Volumn 19, Issue 10, 1999, Pages 6788-6795

  Shimojo, Masahito ^a   Paquette, Alice J ^b   Anderson, David J ^b   Hersh, Louis B ^a  

^a UNIVERSITY OF KENTUCKY   (United States)

^b CALIFORNIA INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACYLTRANSFERASE; CHOLINE ACETYLTRANSFERASE; CYCLIC AMP DEPENDENT PROTEIN KINASE;

ANIMAL CELL; ARTICLE; CHOLINERGIC ACTIVITY; CONTROLLED STUDY; ENZYME REGULATION; GENE EXPRESSION REGULATION; GENE LOCATION; GENE LOCUS; NONHUMAN; PRIORITY JOURNAL; RAT; SILENCER GENE; TRANSCRIPTION REGULATION;

ANIMALIA;

EID: 0032875467     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.19.10.6788     Document Type: Article

References (31)

1. Bejanin, S., R. Cervini, J. Mallet, and S. Berrard. 1994. A unique gene organization for two cholinergic markers, choline acetyltransferase and a putative vesicular transporter of acetylcholine. J. Biol. Chem. 269:21944-21947.
2. Berrard, S., H. Varoqui, R. Cervini, M. Israel, J. Mallet, and M. F. Diebler. 1995. Coregulation of two embedded gene products, choline acetyltransferase and the vesicular acetylcholine transporter. J. Neurochem. 65:939-942.
3. Berse, B., and J. K. Blusztajn. 1995. Coordinated up-regulation of choline acetyltransferase and vesicular acetylcholine transporter gene expression by the retinoic acid receptor α, cAMP, and leukemia inhibitory factor/ciliary neurotrophic factor signaling pathways in a murine septal cell line. J. Biol. Chem. 270:22101-22104.
4. Cassano, S., A. Gallo, V. Buccigrossi, A. Porcellini, R. Cerillo, M. E. Gottesman, and E. V. Avvedimento. 1996. Membrane localization of cAMP-dependent protein kinase amplifies cAMP signaling to the nucleus in PC12 cells. J. Biol. Chem. 271:29870-29875.
5. Cervini, R., L. Houhou, P.-F. Pradat, S. Bejanin, J. Mallet, and S. Berrard. 1995. Specific vesicular acetylcholine transporter promoters lie within the first intron of the rat choline acetyltransferase gene. J. Biol. Chem. 270: 24654-24657.
6. Chen, Z.-F., A. J. Paquette, and D. J. Anderson. 1998 NRSF/REST is required in vivo for repression of multiple neuronal target genes during embryogenesis. Nat. Genet. 20:136-142.
7. Chong, J. A., J. Tapia-Ramirez, S. Kim, J. J. Toledo-Aral, Y. Zheng, M. C. Boutros, Y. M. Altshuller, M. A. Frohman, S. D. Kraner, and G. Mandel. 1995. REST: a mammalian silencer protein that restricts sodium channel gene expression to neurons. Cell 80:949-957.
8. Correll, L. A., T. A. Woodford, J. D. Corbin, P. L. Mellon, and G. S. McKnight. 1989. Functional characterization of cAMP-binding mutations in type I protein kinase. J. Biol. Chem. 264:16672-16678.
9. Erickson, J. D., H. Varoqui, M. K. Schafer, W. Modi, M. F. Diebler, E. Weihe, J. Rand, L. E. Eiden, T. I. Bonner, and T. B. Usdin. 1994. Functional identification of a vesicular acetylcholine transporter and its expression from a "cholinergic" gene locus. J. Biol. Chem. 269:21929-21932.
10. Ginty, D. D., D. Glowacka, C. DeFranco, and J. A. Wagner. 1991. Nerve growth factor-induced neuronal differentiation after dominant repression of both type I and type II cAMP-dependent protein kinase activities. J. Biol. Chem. 266:15325-15333.
11. Hersh, L. B. 1992. Induction of choline acetyltransferase in the neuroblastoma x glioma cell line NG108-15. Neurochem. Res. 17:1063-1067.
12. Inoue, H., Y. P. Li, J. A. Wagner, and L. B. Hersh. 1995. Expression of the choline acetyltransferase gene depends on protein kinase A activity. J. Neurochem. 64:985-990.
13. Kallunki, P., S. Jenkinson, G. M. Edelman, and F. S. Jones. 1995. Silencer elements modulate the expression of the gene for the neuron-glia cell adhesion molecule, Ng-CAM. J. Biol. Chem. 270:21291-21298.
14. Kengaku, M., H. Misawa, and T. Deguchi. 1993. Multiple mRNA species of choline acetyltransferase from rat spinal cord. Mol. Brain Res. 18:71-76.
15. Li, L., T. Suzuki, N. Mori, and P. Greengard. 1993. Identification of a functional silencer element involved in neuron-specific expression of the synapsin I gene. Proc. Natl. Acad. Sci. USA 90:1460-1464.
16. Lonnerberg, P., C. J. Schoenherr, D. J. Anderson, and C. F. Ibanez. 1996. Cell type-specific regulation of choline acetyltransferase gene expression. Role of the neuron-restrictive silencer element and cholinergic-specific enhancer sequences. J. Biol. Chem. 271:33358-33365.
17. Mieda, M., T. Haga, and D. W. Saffen. 1997. Expression of the rat m4 muscarinic acetylcholine receptor gene is regulated by the neuron-restrictive silencer element/repressor element 1. J. Biol. Chem. 272:5854-5860.
18. Misawa, H., K. Ishii, and T. Deguchi. 1992. Gene expression of mouse choline acetyltransferase. Alternative splicing and identification of a highly active promoter region. J. Biol. Chem. 267:20392-20399.
19. Misawa, H., R. Takahashi, and T. Deguchi. 1995. Coordinate expression of vesicular acetylcholine transporter and choline acetyltransferase in sympathetic superior cervical neurons. Neuroreport 6:965-968.
20. + channel genes binds a factor present in nonneuronal cells but not in neuronal cells. Neuron 9:45-54.
21. Palm, K., N. Belluardo, M. Metsis, and T. Timmusk. 1998. Neuronal expression of zinc finger transcription factor REST/NRSF/XBR gene. J. Neurosci. 18:1280-1296.
22. Roth, M. B., A. M. Zahler, and J. A. Stolk. 1991. A conserved family of nuclear phosphoproteins localized to sites of polymerase II transcription. J. Cell Biol. 115:587-596.
23. Sahara, S., K. Sato, H. Kaise, K. Mori, A. Sato, M. Aoto, A. A. Tokmakov, and Y. Fukami. 1996. Biochemical evidence for the interaction of regulatory subunit of cAMP-dependent protein kinase with IDA (inter-DFG-APE) region of catalytic subunit. FEBS Lett. 384:138-142.
24. Schoenherr, C. J., and D. J. Anderson. 1995. The neuron-restrictive silencer factor (NRSF): a coordinate represser of multiple neuron-specific genes. Science 267:1360-1363.
25. Shimojo, M., D. Wu, and L. B. Hersh. 1998. The cholinergic gene locus is coordinately regulated by protein kinase A II in PC12 cells. J. Neurochem. 71:1118-1126.
26. Tapia-Ramirez, J., B. J. Eggen, M. J. Peral-Kubio, J. J. Toledo-Aral, and G. Mandel. 1997. A single zinc finger motif in the silencing factor REST represses the neural-specific type II sodium channel promoter. Proc. Natl. Acad. Sci. USA 94:1177-1182.
27. Thiel, G., M. Lietz, and M. Cramer. 1998. Biological activity and modular structure of RE-1-silencing transcription factor (REST), a represser of neuronal genes. J. Biol. Chem. 273:26891-26899.
28. Towbin, H., T. Staehelin, and J. Gordon. 1979. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc. Natl. Acad. Sci. USA 76:4350-4354.
29. Van Buskirk, R., T. Corcoran, and J. A. Wagner. 1985. Clonal variants of PC12 pheochromocytoma cells with defects in cAMP-dependent protein kinases induce ornithine decarboxylase in response to nerve growth factor but not to adenosine agonists. Mol. Cell. Biol. 5:1984-1992.
30. Wu, D., and L. B. Hersh. 1994. Choline acetyltransferase: celebrating its fiftieth year. J. Neurochem. 62:1653-1663.
31. Zhao, Y., and L. B. Hersh. Unpublished data.