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Volumn 8, Issue 10, 2013, Pages

TLR and NKG2D Signaling Pathways Mediate CS-Induced Pulmonary Pathologies

Author keywords

[No Author keywords available]

Indexed keywords

CELL SURFACE PROTEIN; CIGARETTE SMOKE; NATURAL KILLER CELL RECEPTOR NKG2D; NUCLEIC ACID; RETINOIC ACID INDUCIBLE EARLY TRANSCRIPT 1; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 9; UNCLASSIFIED DRUG;

EID: 84885146607     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0078735     Document Type: Article
Times cited : (15)

References (40)
  • 1
    • 0035694588 scopus 로고    scopus 로고
    • Global initiative for chronic obstructive lung diseases (GOLD): time to act
    • doi:10.1183/09031936.01.0027401
    • Pauwels R, (2001) Global initiative for chronic obstructive lung diseases (GOLD): time to act. Eur Respir J 18: 901-902. doi:10.1183/09031936.01.0027401. PubMed: 11829093.
    • (2001) Eur Respir J , vol.18 , pp. 901-902
    • Pauwels, R.1
  • 2
    • 80052706801 scopus 로고    scopus 로고
    • New insights into the immunology of chronic obstructive pulmonary disease
    • doi:10.1016/S0140-6736(11)60988-4
    • Brusselle GG, Joos GF, Bracke KR, (2011) New insights into the immunology of chronic obstructive pulmonary disease. Lancet 378: 1015-1026. doi:10.1016/S0140-6736(11)60988-4. PubMed: 21907865.
    • (2011) Lancet , vol.378 , pp. 1015-1026
    • Brusselle, G.G.1    Joos, G.F.2    Bracke, K.R.3
  • 3
    • 65649102628 scopus 로고    scopus 로고
    • Sustained CTL activation by murine pulmonary epithelial cells promotes the development of COPD-like disease
    • doi:10.1172/JCI34462
    • Borchers MT, Wesselkamper SC, Curull V, Ramirez-Sarmiento A, Sánchez-Font A, et al. (2009) Sustained CTL activation by murine pulmonary epithelial cells promotes the development of COPD-like disease. J Clin Invest 119: 636-649. doi:10.1172/JCI34462. PubMed: 19197141.
    • (2009) J Clin Invest , vol.119 , pp. 636-649
    • Borchers, M.T.1    Wesselkamper, S.C.2    Curull, V.3    Ramirez-Sarmiento, A.4    Sánchez-Font, A.5
  • 4
    • 77952784713 scopus 로고    scopus 로고
    • Chronic cigarette smoke exposure primes NK cell activation in a mouse model of chronic obstructive pulmonary disease
    • doi:10.4049/jimmunol.0903654
    • Motz GT, Eppert BL, Wortham BW, Amos-Kroohs RM, Flury JL, et al. (2010) Chronic cigarette smoke exposure primes NK cell activation in a mouse model of chronic obstructive pulmonary disease. J Immunol 184: 4460-4469. doi:10.4049/jimmunol.0903654. PubMed: 20228194.
    • (2010) J Immunol , vol.184 , pp. 4460-4469
    • Motz, G.T.1    Eppert, B.L.2    Wortham, B.W.3    Amos-Kroohs, R.M.4    Flury, J.L.5
  • 5
    • 84860321233 scopus 로고    scopus 로고
    • NKG2D mediates NK cell hyperresponsiveness and influenza-induced pathologies in a mouse model of chronic obstructive pulmonary disease
    • doi:10.4049/jimmunol.1102643
    • Wortham BW, Eppert BL, Motz GT, Flury JL, Orozco-Levi M, et al. (2012) NKG2D mediates NK cell hyperresponsiveness and influenza-induced pathologies in a mouse model of chronic obstructive pulmonary disease. J Immunol 188: 4468-4475. doi:10.4049/jimmunol.1102643. PubMed: 22467655.
    • (2012) J Immunol , vol.188 , pp. 4468-4475
    • Wortham, B.W.1    Eppert, B.L.2    Motz, G.T.3    Flury, J.L.4    Orozco-Levi, M.5
  • 6
    • 77956642196 scopus 로고    scopus 로고
    • Natural killer cell education and tolerance
    • doi:10.1016/j.cell.2010.08.031
    • Orr MT, Lanier LL, (2010) Natural killer cell education and tolerance. Cell 142: 847-856. doi:10.1016/j.cell.2010.08.031. PubMed: 20850008.
    • (2010) Cell , vol.142 , pp. 847-856
    • Orr, M.T.1    Lanier, L.L.2
  • 7
    • 0142197631 scopus 로고    scopus 로고
    • Roles of the NKG2D immunoreceptor and its ligands
    • doi:10.1038/nri1199
    • Raulet DH, (2003) Roles of the NKG2D immunoreceptor and its ligands. Nat Rev Immunol 3: 781-790. doi:10.1038/nri1199. PubMed: 14523385.
    • (2003) Nat Rev Immunol , vol.3 , pp. 781-790
    • Raulet, D.H.1
  • 9
    • 31344461659 scopus 로고    scopus 로고
    • Innate immune recognition of viral infection
    • doi:10.1038/ni1303
    • Kawai T, Akira S, (2006) Innate immune recognition of viral infection. Nat Immunol 7: 131-137. doi:10.1038/ni1303. PubMed: 16424890.
    • (2006) Nat Immunol , vol.7 , pp. 131-137
    • Kawai, T.1    Akira, S.2
  • 10
    • 35348932070 scopus 로고    scopus 로고
    • Intracellular NOD-like receptors in host defense and disease
    • doi:10.1016/j.immuni.2007.10.002
    • Kanneganti TD, Lamkanfi M, Núñez G, (2007) Intracellular NOD-like receptors in host defense and disease. Immunity 27: 549-559. doi:10.1016/j.immuni.2007.10.002. PubMed: 17967410.
    • (2007) Immunity , vol.27 , pp. 549-559
    • Kanneganti, T.D.1    Lamkanfi, M.2    Núñez, G.3
  • 11
    • 34247100277 scopus 로고    scopus 로고
    • Dendritic cells prime natural killer cells by trans-presenting interleukin 15
    • doi:10.1016/j.immuni.2007.03.006
    • Lucas M, Schachterle W, Oberle K, Aichele P, Diefenbach A, (2007) Dendritic cells prime natural killer cells by trans-presenting interleukin 15. Immunity 26: 503-517. doi:10.1016/j.immuni.2007.03.006. PubMed: 17398124.
    • (2007) Immunity , vol.26 , pp. 503-517
    • Lucas, M.1    Schachterle, W.2    Oberle, K.3    Aichele, P.4    Diefenbach, A.5
  • 12
    • 0033009888 scopus 로고    scopus 로고
    • Natural killer cells in antiviral defense: function and regulation by innate cytokines
    • doi:10.1146/annurev.immunol.17.1.189
    • Biron CA, Nguyen KB, Pien GC, Cousens LP, Salazar-Mather TP, (1999) Natural killer cells in antiviral defense: function and regulation by innate cytokines. Annu Rev Immunol 17: 189-220. doi:10.1146/annurev.immunol.17.1.189. PubMed: 10358757.
    • (1999) Annu Rev Immunol , vol.17 , pp. 189-220
    • Biron, C.A.1    Nguyen, K.B.2    Pien, G.C.3    Cousens, L.P.4    Salazar-Mather, T.P.5
  • 13
    • 46849090674 scopus 로고    scopus 로고
    • Noncytotoxic functions of NK cells: direct pathogen restriction and assistance to adaptive immunity
    • doi:18523242
    • Strowig T, Brilot F, Münz C, (2008) Noncytotoxic functions of NK cells: direct pathogen restriction and assistance to adaptive immunity. J Immunol 180: 7785-7791. PubMed: 18523242.
    • (2008) J Immunol , vol.180 , pp. 7785-7791
    • Strowig, T.1    Brilot, F.2    Münz, C.3
  • 14
    • 33846597964 scopus 로고    scopus 로고
    • Opposing effects of Toll-like receptor stimulation induce autoimmunity or tolerance
    • doi:10.1016/j.it.2006.12.006
    • Ehlers M, Ravetch JV, (2007) Opposing effects of Toll-like receptor stimulation induce autoimmunity or tolerance. Trends Immunol 28: 74-79. doi:10.1016/j.it.2006.12.006. PubMed: 17197239.
    • (2007) Trends Immunol , vol.28 , pp. 74-79
    • Ehlers, M.1    Ravetch, J.V.2
  • 15
    • 57149096649 scopus 로고    scopus 로고
    • Deleterious role of TLR3 during hyperoxia-induced acute lung injury
    • doi:10.1164/rccm.200807-1020OC
    • Murray LA, Knight DA, McAlonan L, Argentieri R, Joshi A, et al. (2008) Deleterious role of TLR3 during hyperoxia-induced acute lung injury. Am J Respir Crit Care Med 178: 1227-1237. doi:10.1164/rccm.200807-1020OC. PubMed: 18849495.
    • (2008) Am J Respir Crit Care Med , vol.178 , pp. 1227-1237
    • Murray, L.A.1    Knight, D.A.2    McAlonan, L.3    Argentieri, R.4    Joshi, A.5
  • 16
    • 31344466165 scopus 로고    scopus 로고
    • The Unc93b1 mutation 3d disrupts exogenous antigen presentation and signaling via Toll-like receptors 3, 7 and 9
    • doi:10.1038/nrm1901
    • Tabeta K, Hoebe K, Janssen EM, Du X, Georgel P, et al. (2006) The Unc93b1 mutation 3d disrupts exogenous antigen presentation and signaling via Toll-like receptors 3, 7 and 9. Nat Immunol 7: 156-164. doi:10.1038/nrm1901. PubMed: 16415873.
    • (2006) Nat Immunol , vol.7 , pp. 156-164
    • Tabeta, K.1    Hoebe, K.2    Janssen, E.M.3    Du, X.4    Georgel, P.5
  • 17
    • 41549163195 scopus 로고    scopus 로고
    • NKG2D-deficient mice are defective in tumor surveillance in models of spontaneous malignancy
    • doi:10.1016/j.immuni.2008.02.016
    • Guerra N, Tan YX, Joncker NT, Choy A, Gallardo F, et al. (2008) NKG2D-deficient mice are defective in tumor surveillance in models of spontaneous malignancy. Immunity 28: 571-580. doi:10.1016/j.immuni.2008.02.016. PubMed: 18394936.
    • (2008) Immunity , vol.28 , pp. 571-580
    • Guerra, N.1    Tan, Y.X.2    Joncker, N.T.3    Choy, A.4    Gallardo, F.5
  • 18
    • 71849094775 scopus 로고    scopus 로고
    • Persistence of Lung CD8 T Cell Oligoclonal Expansions upon Smoking Cessation in a Mouse Model of Cigarette Smoke-Induced Emphysema
    • doi:19017996
    • Motz GT, Eppert BL, Sun G, Wesselkamper SC, Linke MJ, et al. (2008) Persistence of Lung CD8 T Cell Oligoclonal Expansions upon Smoking Cessation in a Mouse Model of Cigarette Smoke-Induced Emphysema. J Immunol 181: 8036-8043. PubMed: 19017996.
    • (2008) J Immunol , vol.181 , pp. 8036-8043
    • Motz, G.T.1    Eppert, B.L.2    Sun, G.3    Wesselkamper, S.C.4    Linke, M.J.5
  • 19
    • 0027524601 scopus 로고
    • Production of immortalized distal respiratory epithelial cell lines from surfactant protein C/simian virus 40 large tumor antigen transgenic mice
    • doi:10.1073/pnas.90.23.11029
    • Wikenheiser KA, Vorbroker DK, Rice WR, Clark JC, Bachurski CJ, et al. (1993) Production of immortalized distal respiratory epithelial cell lines from surfactant protein C/simian virus 40 large tumor antigen transgenic mice. Proc Natl Acad Sci U S A 90: 11029-11033. doi:10.1073/pnas.90.23.11029. PubMed: 8248207.
    • (1993) Proc Natl Acad Sci U S A , vol.90 , pp. 11029-11033
    • Wikenheiser, K.A.1    Vorbroker, D.K.2    Rice, W.R.3    Clark, J.C.4    Bachurski, C.J.5
  • 20
    • 77954722942 scopus 로고    scopus 로고
    • Chronic Cigarette Smoke Exposure Generates Pathogenic T Cells Capable of Driving COPD-like Disease in Rag2-/- Mice
    • 20133926
    • Motz GT, Eppert BL, Wesselkamper SC, Flury JL, Borchers MT, (2010) Chronic Cigarette Smoke Exposure Generates Pathogenic T Cells Capable of Driving COPD-like Disease in Rag2-/- Mice. Am J Respir Crit Care Med 181: 1223-1233. PubMed: 20133926.
    • (2010) Am J Respir Crit Care Med , vol.181 , pp. 1223-1233
    • Motz, G.T.1    Eppert, B.L.2    Wesselkamper, S.C.3    Flury, J.L.4    Borchers, M.T.5
  • 21
    • 0041508928 scopus 로고    scopus 로고
    • Aberrant lung structure, composition, and function in a murine model of Hermansky-Pudlak syndrome
    • doi:12777251
    • Lyerla TA, Rusiniak ME, Borchers M, Jahreis G, Tan J, et al. (2003) Aberrant lung structure, composition, and function in a murine model of Hermansky-Pudlak syndrome. Am J Physiol Lung Cell Mol Physiol 285: L643-L653. PubMed: 12777251.
    • (2003) Am J Physiol Lung Cell Mol Physiol , vol.285
    • Lyerla, T.A.1    Rusiniak, M.E.2    Borchers, M.3    Jahreis, G.4    Tan, J.5
  • 22
    • 84872706645 scopus 로고    scopus 로고
    • Functional characterization of T cell populations in a mouse model of chronic obstructive pulmonary disease
    • doi:10.4049/jimmunol.1202442
    • Eppert BL, Wortham BW, Flury JL, Borchers MT, (2013) Functional characterization of T cell populations in a mouse model of chronic obstructive pulmonary disease. J Immunol 190: 1331-1340. doi:10.4049/jimmunol.1202442. PubMed: 23264660.
    • (2013) J Immunol , vol.190 , pp. 1331-1340
    • Eppert, B.L.1    Wortham, B.W.2    Flury, J.L.3    Borchers, M.T.4
  • 23
    • 0842278645 scopus 로고    scopus 로고
    • Cutting edge: toll-like receptor signaling in macrophages induces ligands for the NKG2D receptor
    • doi:14764662
    • Hamerman JA, Ogasawara K, Lanier LL, (2004) Cutting edge: toll-like receptor signaling in macrophages induces ligands for the NKG2D receptor. J Immunol 172: 2001-2005. PubMed: 14764662.
    • (2004) J Immunol , vol.172 , pp. 2001-2005
    • Hamerman, J.A.1    Ogasawara, K.2    Lanier, L.L.3
  • 24
    • 1842477469 scopus 로고    scopus 로고
    • mRNA is an endogenous ligand for Toll-like receptor 3
    • doi:14729660
    • Karikó K, Ni H, Capodici J, Lamphier M, Weissman D, (2004) mRNA is an endogenous ligand for Toll-like receptor 3. J Biol Chem 279: 12542-12550. PubMed: 14729660.
    • (2004) J Biol Chem , vol.279 , pp. 12542-12550
    • Karikó, K.1    Ni, H.2    Capodici, J.3    Lamphier, M.4    Weissman, D.5
  • 25
    • 28544449709 scopus 로고    scopus 로고
    • Immune stimulation mediated by autoantigen binding sites within small nuclear RNAs involves Toll-like receptors 7 and 8
    • doi:10.1084/jem.20051696
    • Vollmer J, Tluk S, Schmitz C, Hamm S, Jurk M, et al. (2005) Immune stimulation mediated by autoantigen binding sites within small nuclear RNAs involves Toll-like receptors 7 and 8. J Exp Med 202: 1575-1585. doi:10.1084/jem.20051696. PubMed: 16330816.
    • (2005) J Exp Med , vol.202 , pp. 1575-1585
    • Vollmer, J.1    Tluk, S.2    Schmitz, C.3    Hamm, S.4    Jurk, M.5
  • 26
    • 3042548183 scopus 로고    scopus 로고
    • Toll-like receptor 9-dependent and -independent dendritic cell activation by chromatin-immunoglobulin G complexes
    • doi:10.1084/jem.20031942
    • Boulé MW, Broughton C, Mackay F, Akira S, Marshak-Rothstein A, et al. (2004) Toll-like receptor 9-dependent and-independent dendritic cell activation by chromatin-immunoglobulin G complexes. J Exp Med 199: 1631-1640. doi:10.1084/jem.20031942. PubMed: 15197227.
    • (2004) J Exp Med , vol.199 , pp. 1631-1640
    • Boulé, M.W.1    Broughton, C.2    Mackay, F.3    Akira, S.4    Marshak-Rothstein, A.5
  • 27
    • 1042269503 scopus 로고    scopus 로고
    • Innate immunity in the lung: how epithelial cells fight against respiratory pathogens
    • doi:10.1183/09031936.03.00098803
    • Bals R, Hiemstra PS, (2004) Innate immunity in the lung: how epithelial cells fight against respiratory pathogens. Eur Respir J 23: 327-333. doi:10.1183/09031936.03.00098803. PubMed: 14979512.
    • (2004) Eur Respir J , vol.23 , pp. 327-333
    • Bals, R.1    Hiemstra, P.S.2
  • 28
    • 0031722160 scopus 로고    scopus 로고
    • Tobacco smoke induces both apoptosis and necrosis in mammalian cells: differential effects of HSP70
    • 9755110
    • Vayssier M, Banzet N, François D, Bellmann K, Polla BS, (1998) Tobacco smoke induces both apoptosis and necrosis in mammalian cells: differential effects of HSP70. Am J Physiol 275: L771-L779. PubMed: 9755110.
    • (1998) Am J Physiol , vol.275
    • Vayssier, M.1    Banzet, N.2    François, D.3    Bellmann, K.4    Polla, B.S.5
  • 29
    • 33750949369 scopus 로고    scopus 로고
    • Differential effects of cigarette smoke on oxidative stress and proinflammatory cytokine release in primary human airway epithelial cells and in a variety of transformed alveolar epithelial cells
    • doi:10.1186/1465-9921-7-132
    • Kode A, Yang SR, Rahman I, (2006) Differential effects of cigarette smoke on oxidative stress and proinflammatory cytokine release in primary human airway epithelial cells and in a variety of transformed alveolar epithelial cells. Respir Res 7: 132. doi:10.1186/1465-9921-7-132. PubMed: 17062156.
    • (2006) Respir Res , vol.7 , pp. 132
    • Kode, A.1    Yang, S.R.2    Rahman, I.3
  • 30
    • 48749097634 scopus 로고    scopus 로고
    • Cigarette smoke selectively enhances viral PAMP- and virus-induced pulmonary innate immune and remodeling responses in mice
    • doi:18654661
    • Kang MJ, Lee CG, Lee JY, Dela Cruz CS, Chen ZJ, et al. (2008) Cigarette smoke selectively enhances viral PAMP- and virus-induced pulmonary innate immune and remodeling responses in mice. J Clin Invest 118: 2771-2784. PubMed: 18654661.
    • (2008) J Clin Invest , vol.118 , pp. 2771-2784
    • Kang, M.J.1    Lee, C.G.2    Lee, J.Y.3    Dela Cruz, C.S.4    Chen, Z.J.5
  • 31
    • 0034606218 scopus 로고    scopus 로고
    • Interferon gamma induction of pulmonary emphysema in the adult murine lung
    • doi:10.1084/jem.192.11.1587
    • Wang Z, Zheng T, Zhu Z, Homer RJ, Riese RJ, et al. (2000) Interferon gamma induction of pulmonary emphysema in the adult murine lung. J Exp Med 192: 1587-1600. doi:10.1084/jem.192.11.1587. PubMed: 11104801.
    • (2000) J Exp Med , vol.192 , pp. 1587-1600
    • Wang, Z.1    Zheng, T.2    Zhu, Z.3    Homer, R.J.4    Riese, R.J.5
  • 32
    • 14744295733 scopus 로고    scopus 로고
    • Increased airway epithelial and T-cell apoptosis in COPD remains despite smoking cessation
    • doi:10.1183/09031936.05.00077604
    • Hodge S, Hodge G, Holmes M, Reynolds PN, (2005) Increased airway epithelial and T-cell apoptosis in COPD remains despite smoking cessation. Eur Respir J 25: 447-454. doi:10.1183/09031936.05.00077604. PubMed: 15738287.
    • (2005) Eur Respir J , vol.25 , pp. 447-454
    • Hodge, S.1    Hodge, G.2    Holmes, M.3    Reynolds, P.N.4
  • 33
    • 0041422233 scopus 로고    scopus 로고
    • Stimulation of T cell autoreactivity by anomalous expression of NKG2D and its MIC ligands in rheumatoid arthritis
    • doi:10.1073/pnas.1632807100
    • Groh V, Bruhl A, El-Gabalawy H, Nelson JL, Spies T, (2003) Stimulation of T cell autoreactivity by anomalous expression of NKG2D and its MIC ligands in rheumatoid arthritis. Proc Natl Acad Sci U S A 100: 9452-9457. doi:10.1073/pnas.1632807100. PubMed: 12878725.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 9452-9457
    • Groh, V.1    Bruhl, A.2    El-Gabalawy, H.3    Nelson, J.L.4    Spies, T.5
  • 34
    • 36249023845 scopus 로고    scopus 로고
    • In vivo expression pattern of MICA and MICB and its relevance to auto-immunity and cancer
    • doi:10.1371/journal.pone.0000518
    • Schrambach S, Ardizzone M, Leymarie V, Sibilia J, Bahram S, (2007) In vivo expression pattern of MICA and MICB and its relevance to auto-immunity and cancer. PLOS ONE 2: e518. doi:10.1371/journal.pone.0000518. PubMed: 17565371.
    • (2007) PLOS ONE , vol.2
    • Schrambach, S.1    Ardizzone, M.2    Leymarie, V.3    Sibilia, J.4    Bahram, S.5
  • 35
    • 18744431007 scopus 로고    scopus 로고
    • Potential role of NKG2D/MHC class I-related chain A interaction in intrathymic maturation of single-positive CD8 T cells
    • doi:12902493
    • Hüe S, Monteiro RC, Berrih-Aknin S, Caillat-Zucman S, (2003) Potential role of NKG2D/MHC class I-related chain A interaction in intrathymic maturation of single-positive CD8 T cells. J Immunol 171: 1909-1917. PubMed: 12902493.
    • (2003) J Immunol , vol.171 , pp. 1909-1917
    • Hüe, S.1    Monteiro, R.C.2    Berrih-Aknin, S.3    Caillat-Zucman, S.4
  • 36
    • 2942546678 scopus 로고    scopus 로고
    • NKG2D blockade prevents autoimmune diabetes in NOD mice
    • doi:10.1016/j.immuni.2004.05.008
    • Ogasawara K, Hamerman JA, Ehrlich LR, Bour-Jordan H, Santamaria P, et al. (2004) NKG2D blockade prevents autoimmune diabetes in NOD mice. Immunity 20: 757-767. doi:10.1016/j.immuni.2004.05.008. PubMed: 15189740.
    • (2004) Immunity , vol.20 , pp. 757-767
    • Ogasawara, K.1    Hamerman, J.A.2    Ehrlich, L.R.3    Bour-Jordan, H.4    Santamaria, P.5
  • 37
    • 34250666265 scopus 로고    scopus 로고
    • NKG2D recognition mediates Toll-like receptor 3 signaling-induced breakdown of epithelial homeostasis in the small intestines of mice
    • doi:10.1073/pnas.0700822104
    • Zhou R, Wei H, Sun R, Zhang J, Tian Z, (2007) NKG2D recognition mediates Toll-like receptor 3 signaling-induced breakdown of epithelial homeostasis in the small intestines of mice. Proc Natl Acad Sci U S A 104: 7512-7515. doi:10.1073/pnas.0700822104. PubMed: 17463084.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 7512-7515
    • Zhou, R.1    Wei, H.2    Sun, R.3    Zhang, J.4    Tian, Z.5
  • 38
    • 84855163540 scopus 로고    scopus 로고
    • Intrinsic danger: activation of Toll-like receptors in rheumatoid arthritis
    • doi:10.1093/rheumatology/ker257
    • Goh FG, Midwood KS, (2012) Intrinsic danger: activation of Toll-like receptors in rheumatoid arthritis. Rheumatology (Oxford) 51: 7-23. doi:10.1093/rheumatology/ker257. PubMed: 21984766.
    • (2012) Rheumatology (Oxford) , vol.51 , pp. 7-23
    • Goh, F.G.1    Midwood, K.S.2
  • 39
    • 25444443335 scopus 로고    scopus 로고
    • RNA released from necrotic synovial fluid cells activates rheumatoid arthritis synovial fibroblasts via Toll-like receptor 3
    • doi:10.1002/art.21273
    • Brentano F, Schorr O, Gay RE, Gay S, Kyburz D, (2005) RNA released from necrotic synovial fluid cells activates rheumatoid arthritis synovial fibroblasts via Toll-like receptor 3. Arthritis Rheum 52: 2656-2665. doi:10.1002/art.21273. PubMed: 16142732.
    • (2005) Arthritis Rheum , vol.52 , pp. 2656-2665
    • Brentano, F.1    Schorr, O.2    Gay, R.E.3    Gay, S.4    Kyburz, D.5
  • 40
    • 57749177662 scopus 로고    scopus 로고
    • The role of Toll-like receptors 3 and 9 in the development of autoimmune diabetes in NOD mice
    • doi:10.1196/annals.1447.039
    • Wong FS, Hu C, Zhang L, Du W, Alexopoulou L, et al. (2008) The role of Toll-like receptors 3 and 9 in the development of autoimmune diabetes in NOD mice. Ann N Y Acad Sci 1150: 146-148. doi:10.1196/annals.1447.039. PubMed: 19120284.
    • (2008) Ann N Y Acad Sci , vol.1150 , pp. 146-148
    • Wong, F.S.1    Hu, C.2    Zhang, L.3    Du, W.4    Alexopoulou, L.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.