Metabolism of 2,2′,3,3′,6,6′-hexachlorobiphenyl (PCB 136) atropisomers in tissue slices from phenobarbital or dexamethasone-induced rats is sex-dependent

Xenobiotica

Volumn 43, Issue 11, 2013, Pages 933-947

  Wu, Xianai ^a   Kania Korwel, Izabela ^a   Chen, Hao ^b   Stamou, Marianna ^b   Dammanahalli, Karigowda J ^a   Duffel, Michael ^a   Lein, Pamela J ^b   Lehmler, Hans Joachim ^a  

^a UNIVERSITY OF IOWA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Atropisomeric enrichment; Cytochrome P450 enzymes; Sex differences

Indexed keywords

CYP2S1; CYP4X1; CYTOCHROME P450; CYTOCHROME P450 1A2; CYTOCHROME P450 2B1; CYTOCHROME P450 3A2; DEXAMETHASONE; HEXACHLOROBIPHENYL; PCB 136; PHENOBARBITAL; UNCLASSIFIED DRUG;

ADULT ANIMAL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHIRALITY; CONTROLLED STUDY; ENANTIOSELECTIVITY; ENZYME INDUCTION; FEMALE; ISOMER; LIVER MICROSOME METABOLISM; LIVER SLICE; MALE; METABOLITE; NEUROTOXICITY; NONHUMAN; SEX DIFFERENCE;

AGING; ANIMALS; ANIMALS, NEWBORN; CELL SURVIVAL; CYTOCHROME P-450 ENZYME SYSTEM; DEXAMETHASONE; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HIPPOCAMPUS; HYDROXYLATION; LIVER; MALE; PHENOBARBITAL; POLYCHLORINATED BIPHENYLS; RATS; RATS, SPRAGUE-DAWLEY; SEX CHARACTERISTICS; STEREOISOMERISM; TISSUE SURVIVAL;

EID: 84885142046     PISSN: 00498254     EISSN: 13665928     Source Type: Journal    
DOI: 10.3109/00498254.2013.785626     Document Type: Article

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