Effects of hypoxanthine substitution in peptide nucleic acids targeting KRAS2 oncogenic mRNA molecules: Theory and experiment

Journal of Physical Chemistry B

Volumn 117, Issue 39, 2013, Pages 11584-11595

  Sanders, Jeffrey M ^a   Wampole, Matthew E ^a   Chen, Chang Po ^a   Sethi, Dalip ^a,e   Singh, Amrita ^a   Dupradeau, François Yves ^b   Wang, Fan ^b   Gray, Brian D ^c   Thakur, Mathew L ^a,d   Wickstrom, Eric ^a,d  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

^b UNIVERSITÉ DE PICARDIE JULES VERNE   (France)

^c MOLECULAR TARGETING TECHNOLOGIES INC   (United States)

^d THOMAS JEFFERSON UNIVERSITY   (United States)

^e Fortis Memorial Research Institute   (India)

Author keywords

[No Author keywords available]

Indexed keywords

DISEASES; MOLECULAR DYNAMICS; PEPTIDES; POSITIVE IONS; RNA;

FREE-ENERGY CALCULATIONS; GENETIC DISORDERS; MOLECULAR DYNAMICS SIMULATIONS; MRNA MOLECULES; PEPTIDE NUCLEIC ACID; SINGLE-BASE MISMATCH; THERMAL MELTING; WATSON-CRICK BASE PAIRS;

AROMATIC COMPOUNDS;

ADENINE; GUANINE; HYPOXANTHINE; KRAS PROTEIN, HUMAN; MESSENGER RNA; ONCOPROTEIN; PEPTIDE NUCLEIC ACID; RAS PROTEIN; URACIL;

ALGORITHM; ARTICLE; BASE PAIRING; CHEMICAL STRUCTURE; CHEMISTRY; CIRCULAR DICHROISM; DNA DENATURATION; GENETICS; HUMAN; MOLECULAR DYNAMICS; POINT MUTATION; SYNTHESIS; TRANSITION TEMPERATURE; VALIDATION STUDY;

ADENINE; ALGORITHMS; BASE PAIRING; CIRCULAR DICHROISM; GUANINE; HUMANS; HYPOXANTHINE; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; NUCLEIC ACID DENATURATION; PEPTIDE NUCLEIC ACIDS; POINT MUTATION; PROTO-ONCOGENE PROTEINS; RAS PROTEINS; RNA, MESSENGER; TRANSITION TEMPERATURE; URACIL;

EID: 84885120124     PISSN: 15206106     EISSN: 15205207     Source Type: Journal    
DOI: 10.1021/jp4064966     Document Type: Article

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