Molecular dynamics structures of peptide nucleic acid DNA hybrid in the wild-type and mutated alleles of Ki-ras proto-oncogene: Stereochemical rationale for the low affinity of PNA in the presence of an A...C mismatch

FEBS Journal

Volumn 272, Issue 16, 2005, Pages 4055-4070

  Rathinavelan, Thenmalarchelvi ^b   Yathindra, Narayanarao ^a  

^a ITPB   (India)

^b NONE

Author keywords

Enthalpy entropy contribution; Fluctuating A...C mismatch hydrogen bond; Mismatch containing PNA DNA hybrid; Point mutation

Indexed keywords

DNA HYBRID; PEPTIDE NUCLEIC ACID; PYRIMIDINE; WATER;

ALLELE; AMINO ACID SEQUENCE; ARTICLE; BASE MISPAIRING; CODON; DNA CONFORMATION; DNA STRUCTURE; ENTHALPY; ENTROPY; GENE MUTATION; HYDROGEN BOND; MISMATCH REPAIR; MOLECULAR DYNAMICS; MOLECULAR INTERACTION; ONCOGENE RAS; POINT MUTATION; PRIORITY JOURNAL; PROTEIN STABILITY; PROTO ONCOGENE; SIMULATION; STEREOCHEMISTRY; WILD TYPE;

ALLELES; BASE PAIR MISMATCH; BASE SEQUENCE; DNA; GENES, RAS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PEPTIDE NUCLEIC ACIDS; POINT MUTATION; STEREOISOMERISM;

EID: 23844553816     PISSN: 1742464X     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1742-4658.2005.04817.x     Document Type: Article

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