Contribution of iNOS/sGC/PKG pathway, COX-2, CYP4A1, and gp91 phox to the protective effect of 5,14-HEDGE, a 20-HETE mimetic, against vasodilation, hypotension, tachycardia, and inflammation in a rat model of septic shock

Nitric Oxide - Biology and Chemistry

Volumn 33, Issue , 2013, Pages 18-41

  Tunctan, Bahar ^a   Korkmaz, Belma ^a   Sari, Ayse Nihal ^a   Kacan, Meltem ^a   Unsal, Demet ^a   Serin, Mehmet Sami ^a   Buharalioglu, C Kemal ^a   Sahan Firat, Seyhan ^a   Cuez, Tuba ^a   Schunck, Wolf Hagen ^b   Manthati, Vijaya L ^c   Falck, John R ^c   Malik, Kafait U ^d  

^a MERSIN UNIVERSITY   (Turkey)

^b MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^c UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^d UNIVERSITY OF TENNESSEE COLLEGE OF MEDICINE   (United States)

Author keywords

COX 2; CYP4A1; Endotoxin; Hypotension; INOS sGC PKG pathway

Indexed keywords

20 HYDROXYICOSATETRAENOIC ACID; 3 NITROTYROSINE; ARACHIDONIC ACID; CYCLIC GMP; CYCLIC GMP DEPENDENT PROTEIN KINASE; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYTOCHROME P450 4A1; GLYCINE DERIVATIVE; GUANYLATE CYCLASE; HEAT SHOCK PROTEIN 90; INDUCIBLE NITRIC OXIDE SYNTHASE; LIPOPOLYSACCHARIDE; MESSENGER RNA; N (20 HYDROXYEICOSA 5,14 DIENOYL)GLYCINE; PEROXYNITRITE; PROSTAGLANDIN E2; PROSTANOID; PROTEIN P47; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 2; UNCLASSIFIED DRUG; VASOCONSTRICTOR AGENT; VASODILATOR STIMULATED PHOSPHOPROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; ENDOTOXEMIA; ENZYME ACTIVITY; HEART RATE; HYPOTENSION; INFLAMMATION; KIDNEY MICROSOME; MEAN ARTERIAL PRESSURE; METABOLITE; MORTALITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SEPTIC SHOCK; TACHYCARDIA; VASODILATATION;

MUS; RATTUS;

1,3-PBIT; 20-HEDE; 20-HETE; 20-HYDROXYEICOSA-6(Z),15(Z)-DIENOIC ACID; 20-HYDROXYEICOSATETRAENOIC ACID; 5,14-HEDGE; AA; ARACHIDONIC ACID; CDNA; CGMP; COMPLEMENTARY DEOXYRIBONUCLEIC ACID; COX; COX-2; CYCLIC GUANOSINE MONOPHOSPHATE; CYCLOOXYGENASE; CYCTOCHROME P450; CYP; CYP4A1; EET; ELISA; ENDOTHELIAL NITRIC OXIDE SYNTHASE; ENDOTOXIN; ENOS; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPOXYEICOSATRIENOIC ACID; ERK; EXTRACELLULAR SIGNAL-REGULATED KINASE; GP91(PHOX)/NOX2; HEART RATE; HEAT SHOCK PROTEIN; HR; HSP; HYPOTENSION; I.P.; IKK; IL; INDUCIBLE NITRIC OXIDE SYNTHASE; INHIBITOR OF ΚB; INOS; INOS/SGC/PKG PATHWAY; INTERLEUKIN; INTRAPERITONEALLY; IΚB; IΚB KINASE; LIPOPOLYSACCHARIDE; LPS; MAP; MAPK; MEAN ARTERIAL PRESSURE; MEK; MESSENGER RIBONUCLEIC ACID; MITOGEN-ACTIVATED PROTEIN KINASE; MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1; MRNA; N-[20-HYDROXYEICOSA-5(Z),14(Z)-DIENOYL]GLYCINE; NADPH; NF-ΚB; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; NITRIC OXIDE; NO; NUCLEAR FACTOR-ΚB; P-VASP; PG; PHENYLENE-1,3-BIS(ETHANE-2-ISOTHIOUREA) DIHYDROBROMIDE; PHOSPHORYLATED VASODILATOR STIMULATED PHOSPHOPROTEIN; PKG; PROSTAGLANDIN; PROTEIN KINASE G; REVERSE TRANSCRIPTION-POLYMERASE CHAIN REACTION; RT-PCR; S.C.; SEH; SGC; SOLUBLE EPOXIDE HYDROLASE; SOLUBLE GUANYLYL CYCLASE; SUBCUTANEOUSLY; TNF; TUMOR NECROSIS FACTOR; VASODILATOR STIMULATED PHOSPHOPROTEIN; VASP;

ANIMALS; CELL ADHESION MOLECULES; CYCLIC GMP-DEPENDENT PROTEIN KINASES; CYCLOOXYGENASE 2; CYTOCHROME P-450 ENZYME SYSTEM; DISEASE MODELS, ANIMAL; GUANYLATE CYCLASE; HSP90 HEAT-SHOCK PROTEINS; HYDROXYEICOSATETRAENOIC ACIDS; LIPOPEPTIDES; LIPOPOLYSACCHARIDES; MALE; MEMBRANE GLYCOPROTEINS; MICROFILAMENT PROTEINS; NADPH OXIDASE; NITRIC OXIDE SYNTHASE TYPE II; ORGAN SPECIFICITY; PEROXYNITROUS ACID; PHOSPHOPROTEINS; PROTECTIVE AGENTS; RANDOM ALLOCATION; RATS; RATS, WISTAR; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RNA, MESSENGER; SHOCK, SEPTIC; SIGNAL TRANSDUCTION;

EID: 84885109307     PISSN: 10898603     EISSN: 10898611     Source Type: Journal    
DOI: 10.1016/j.niox.2013.05.001     Document Type: Article

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