Activation of MEK1/ERK1/2/iNOS/sGC/PKG pathway associated with peroxynitrite formation contributes to hypotension and vascular hyporeactivity in endotoxemic rats

Nitric Oxide - Biology and Chemistry

Volumn 24, Issue 3, 2011, Pages 160-172

  Korkmaz, Belma ^a   Buharalioglu, Kemal ^a   Sahan Firat, Seyhan ^a   Cuez, Tuba ^a   Tuncay Demiryurek, A ^b   Tunctan, Bahar ^a  

^a MERSIN UNIVERSITY   (Turkey)

^b GAZIANTEP UNIVERSITY   (Turkey)

Author keywords

Endotoxin; Hypotension; MEK1 ERK1 2 iNOS sGC PKG pathway; Peroxynitrite; Vascular hyporeactivity

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 1H 1,2,4 OXADIAZOLO[4,3 A]QUINOXALIN 1 ONE; 3 NITROTYROSINE; CYCLIC GMP DEPENDENT PROTEIN KINASE; GUANYLATE CYCLASE; INDUCIBLE NITRIC OXIDE SYNTHASE; KT 5823; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; PEROXYNITRITE; PHOSPHOPROTEIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENDOTHELIUM; ENDOTOXEMIA; ENZYME ACTIVITY; HYPOTENSION; MALE; MEAN ARTERIAL PRESSURE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION;

ANIMALS; AORTA, THORACIC; BLOOD PRESSURE; CYCLIC GMP-DEPENDENT PROTEIN KINASES; ENDOTOXEMIA; ENDOTOXINS; ENZYME ACTIVATION; ENZYME INHIBITORS; GUANYLATE CYCLASE; HEART RATE; HYPOTENSION; MALE; MAP KINASE KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; NITRIC OXIDE SYNTHASE TYPE II; NITRITES; NOREPINEPHRINE; OXIDATIVE STRESS; PEROXYNITROUS ACID; RATS; RATS, WISTAR; RECEPTORS, CYTOPLASMIC AND NUCLEAR; SIGNAL TRANSDUCTION; TYROSINE;

RATTUS;

EID: 79954630982     PISSN: 10898603     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.niox.2011.02.004     Document Type: Article

References (67)

1. J.E. Carré, and M. Singer Cellular energetic metabolism in sepsis: the need for a systems approach Biochim. Biophys. Acta. 1777 2008 763 771
2. D. Fernandes, and J. Assreuy Nitric oxide and vascular reactivity in sepsis Shock 30 2008 10 13
3. A.G. Tsiotou, G.H. Sakorafas, G. Anagnostopoulos, and J. Bramis Septic shock; current pathogenetic concepts from a clinical perspective Med. Sci. Monit. 11 2005 76 85
4. T.E. Grissom, S. Bina, J. Hart, and S.M. Muldoon Effect of phenlephrine-induced vascular smooth muscle contractions in endotoxin-exposed rat aortic rings Crit. Care Med. 24 1996 287 293 (Pubitemid 26065338)
5. T.M. McKenna, F.M. Martin, B. Chernow, and F.A. Briglia Vascular endothelium contributes to decreased aortic contractility in experimental sepsis Circ. Shock 19 1986 267 273 (Pubitemid 16097470)
6. T. Nakaki, Y. Otsuka, M. Nakayama, and R. Kato Endothelium-accelerated hyporesponsiveness of norepinephrine-elicited contraction of rat aorta in the presence of bacterial lipopolysaccharide Eur. J. Pharmacol. 219 1992 311 318
7. G. Julou-Schaeffer, G.A. Gray, I. Fleming, C. Schott, J.R. Parratt, and J.C. Stoclet Loss of vascular responsiveness induced by endotoxin involves L-arginine pathway Am. J. Physiol. 259 1990 H1038 H1043
8. E.A. Suba, T.M. McKenna, and T.J. Williams In vivo and in vitro effects of endotoxin on vascular responsiveness to norepinephrine and signal transduction in the rat Circ. Shock 36 1992 127 133
9. C. Thiemermann The role of the L-arginine: nitric oxide pathway in circulatory shock Adv. Pharmacol. 28 1994 45 79
10. N.S. Bryan, K. Bian, and F. Murad Discovery of the nitric oxide signaling pathway and targets for drug development Front. Biosci. 14 2009 1 18
11. Y. Gao The multiple actions of NO Pflugers Arch. 459 2010 829 839
12. J. Garthwaite New insight into the functioning of nitric oxide-receptive guanylyl cyclase: physiological and pharmacological implications Mol. Cell. Biochem. 334 2010 221 232
13. S.M. Lohmann, and U. Walter Tracking functions of cGMP-dependent protein kinases (cGK) Front. Biosci. 10 2005 1313 1328
14. M. Oelze, H. Mollnau, N. Hoffmann, A. Warnholtz, M. Bodenschatz, A. Smolenski, U. Walter, M. Skatchkov, T. Meinertz, and T. Münzel Vasodilator-stimulated phosphoprotein serine 239 phosphorylation as a sensitive monitor of defective nitric oxide/cGMP signaling and endothelial dysfunction Circ. Res. 87 2000 999 1005
15. E. Esposito, and S. Cuzzocrea Role of nitroso radicals as drug targets in circulatory shock Br. J. Pharmacol. 157 2009 494 508
16. E. Esposito, and S. Cuzzocrea Superoxide, NO, peroxynitrite and PARP in circulatory shock and inflammation Front. Biosci. 14 2009 263 296
17. P. Pacher, J.S. Beckman, and L. Liaudet Nitric oxide and peroxynitrite in health and disease Physiol. Rev. 87 2007 315 424 (Pubitemid 46217686)
18. C. Szabó, H. Ischiropoulos, and R. Radi Peroxynitrite: biochemistry, pathophysiology and development of therapeutics Nat. Rev. Drug Discov. 6 2007 662 680 (Pubitemid 47207751)
19. C. Dessy, I. Kim, C.L. Sougnez, R. Laporte, and K.G. Morgan A role for MAP kinase diffentiated smooth muscle contraction evoked by -adrenoceptor stimulation Am. J. Physiol. 275 1998 C1081 C1086
20. R.J. Hoefen, and B.C. Berk The role of MAP kinases in endothelial activation Vasc. Pharmacol. 38 2002 271 273 (Pubitemid 36398260)
21. Z.W. Hu, X.Y. Shi, R.Z. Lin, J. Chen, and B.B. Hoffman Alpha1-Adrenergic receptor stimulation of mitogenesis in human vascular smooth muscle cells: role of tyrosine protein kinases and calcium in activation of mitogen-activated protein kinase J. Pharmacol. Exp. Ther. 290 1999 28 37 (Pubitemid 29302300)
22. G.L. Johnson, and R. Lapadat Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases Science 298 2002 1911 1912 (Pubitemid 35425238)
23. S. Kwon, W.J. Lee, L.H. Fang, B. Kim, and H.Y. Ahn Mitogen-activated protein kinases partially regulate endothelin-1-induced contractions through a myosin light chain phosphorylation-independent pathway J. Vet. Med. Sci. 65 2003 225 230 (Pubitemid 41389978)
24. C. Hague, P.J. Gonzalez-Cabrera, W.B. Jeffries, and P.W. Abel Relationship between alpha(1)-adrenergic receptor-induced contraction and extracellular signal-regulated kinase activation in the bovine inferior alveolar artery J. Pharmacol. Exp. Ther. 3030 2002 403 411
25. S.W. Watts 5-Hydroxytryptamine-induced potentiation of endothelin-1- and norepinephrine-induced contraction is mitogen-activated protein kinase pathway dependent Hypertension 35 2000 244 248 (Pubitemid 30054180)
26. W. Kan, K.S. Zhao, Y. Jiang, W. Yan, Q. Huang, J. Wang, Q. Qin, X. Huang, and S. Wang Lung, spleen, and kidney are the major places for inducible nitric oxide synthase expression in endotoxic shock: role of p38 mitogen-activated protein kinase in signal transduction of inducible nitric oxide synthase expression Shock 21 2004 281 287
27. S.H. Kim, J. Kim, and R.P. Sharma Inhibition of p38 and ERK MAP kinases blocks endotoxin-induced nitric oxide production and differentially modulates cytokine expression Pharmacol. Res. 49 2004 433 439 (Pubitemid 38283863)
28. S.J. Suh, T.W. Chung, M.J. Son, S.H. Kim, T.C. Moon, K.H. Son, H.P. Kim, H.W. Chang, and C.H. Kim The naturally occurring biflavonoid, ochnaflavone, inhibits LPS-induced iNOS expression, which is mediated by ERK1/2 via NF-kappaB regulation, in RAW264.7 cells Arch. Biochem. Biophys. 447 2006 136 146
29. D. Yoshinari, I. Takeyoshi, Y. Koibuchi, K. Matsumoto, Y. Kawashima, T. Koyama, S. Ohwada, and Y. Morishita Effects of a dual inhibitor of tumor necrosis factor-alpha and interleukin-1 on lipopolysaccharide-induced lung injury in rats: involvement of the p38 mitogen-activated protein kinase pathway Crit. Care Med. 29 2001 628 634 (Pubitemid 32225308)
30. T. Yamakawa, S. Eguchi, T. Matsumoto, Y. Yamakawa, K. Numaguchi, I. Miyata, C.M. Reynolds, E.D. Motley, and T. Inagami Intracellular signaling in rat cultured vascular smooth muscle cells: roles of nuclear factor-kappaB and p38 mitogen-activated protein kinase on tumor necrosis factor-alpha production Endocrinology 140 1999 3562 3572 (Pubitemid 30645410)
31. B. Jiang, P. Brecher, and R.A. Cohen Persistent activation of nuclear factor-kappaB by interleukin-1beta and subsequent inducible NO synthase expression requires extracellular signal-regulated kinase Arterioscler. Thromb. Vasc. Biol. 21 2001 1915 1920 (Pubitemid 34219741)
32. A.M. Badger, J.N. Bradbeer, B. Votta, J.C. Lee, J.L. Adams, and D.E. Griswold Pharmacological profile of SB 203580, a selective inhibitor of cytokine suppressive binding protein/p38 kinase, in animal models of arthritis, bone resorption, endotoxin shock and immune function J. Pharmacol. Exp. Ther. 279 1996 1453 1461 (Pubitemid 27166795)
33. C. Mendez, C. Jaffray, V. Wong, K.F. Salhab, A.A. Kramer, L.C. Carey, and J.G. Norman Involvement of p38 mitogen-activated protein kinase in the induction of tolerance to hemorrhagic and endotoxic shock J. Surg. Res. 91 2000 165 170 (Pubitemid 30445592)
34. S.A. Wadsworth, D.E. Cavender, S.A. Beers, P. Lalan, P.H. Schafer, E.A. Malloy, W. Wu, B. Fahmy, G.C. Olini, J.E. Davis, J.L. Pellegrino-Gensey, M.P. Wachter, and J.J. Siekierka RWJ 67657, a potent, orally active inhibitor of p38 mitogen-activated protein kinase J. Pharmacol. Exp. Ther. 291 1999 680 687 (Pubitemid 29503541)
35. J. Branger, B. van den Blink, S. Weijer, J. Madwed, C.L. Bos, A. Gupta, C.L. Yong, S.H. Polmar, D.P. Olszyna, C.E. Hack, S.J. van Deventer, M.P. Peppelenbosch, and T. van der Poll Anti-inflammatory effects of a p38 mitogen-activated protein kinase inhibitor during human endotoxemia J. Immunol. 168 2002 4070 4077 (Pubitemid 34298414)
36. M.M. Faas, H. Moes, J.W. Fijen, A.C. Muller Kobold, J.E. Tulleken, and J.G. Zijlstra Monocyte intracellular cytokine production during human endotoxaemia with or without a second in vitro LPS challenge: effect of RWJ-67657, a p38 MAP-kinase inhibitor, on LPS-hyporesponsiveness Clin. Exp. Immunol. 127 2002 337 343 (Pubitemid 34233941)
37. J.W. Fijen, J.G. Zijlstra, P. De Boer, R. Spanjersberg, J.W. Tervaert, T.S. Van Der Werf, J.J. Ligtenberg, and J.E. Tulleken Suppression of the clinical and cytokine response to endotoxin by RWJ-67657, a p38 mitogen-activated protein-kinase inhibitor, in healthy human volunteers Clin. Exp. Immunol. 124 2001 16 20 (Pubitemid 32476930)
38. M.N. Lub-de Hooge, S. de Jong, C. Vermot-Desroches, J.E. Tulleken, E.G. de Vries, and J.G. Zijlstra Endotoxin increases plasma soluble tumor necrosis factor-related apoptosis-inducing ligand level mediated by the p38 mitogen-activated protein kinase signaling pathway Shock 22 2004 186 188 (Pubitemid 40228199)
39. Y.J. Cheng, and M. Liu Modulation of tumor necrosis factor-alpha and oxidative stress through protein kinase C and P42/44 mitogen-activated protein kinase in lead increases lipopolysaccharide-induced liver damage in rats Shock 24 2005 188 193 (Pubitemid 41105519)
40. K. Schuh, and A. Pahl Inhibition of the MAP kinase ERK protects from lipopolysaccharide-induced lung injury Biochem. Pharmacol. 77 2009 1827 1834
41. B. Tunctan, B. Korkmaz, H. Yildirim, L. Tamer, U. Atik, and C.K. Buharalioglu Increased production of nitric oxide contributes to renal oxidative stress in endotoxemic rat Am. J. Infect. Dis. 1 2005 111 115
42. B. Tunctan, B. Korkmaz, H. Yildirim, L. Tamer, U. Atik, and C. Buharalioglu Reversal of endotoxin-induced hypotension by inhibition of inducible nitric oxide synthase activity is associated with improved oxidative status in rat heart, Aorta and mesenteric artery Turkish J. Med. Sci. 36 2006 71 80
43. B. Tunctan, F.A. Yaghini, A. Estes, and K.U. Malik Inhibition by nitric oxide and cyclooxygenase of cytochrome P450 4A expression and activity contributes to endotoxin-induced hypotension in rats Nitric Oxide: Biol. Chem. 14 2006 51 57 (Pubitemid 43063508)
44. B. Korkmaz, E. Ozveren, C.K. Buharalioglu, and B. Tunctan Extracellular signal-regulated kinase (ERK12) contributes to endotoxin-induced hyporeactivity via nitric oxide and prostacyclin production in rat aorta Pharmacology 78 2006 123 128 (Pubitemid 44764027)
45. B. Tunctan, B. Korkmaz, Z.N. Dogruer, L. Tamer, U. Atik, and C.K. Buharalioglu Inhibition of extracellular signal-regulated kinase (ERK1/2) activity reverses endotoxin-induced hypotension via decreased nitric oxide production in rats Pharmacol. Res. 56 2007 56 64 (Pubitemid 46990931)
46. B. Korkmaz, K. Buharalioglu, T.A. Demiryurek, S. Sahan-Firat, T. Cuez, B. Tunctan, Activation of MEK1/ERK1/2/iNOS/sGC/PKG pathway contributes to the fall in blood pressure and vascular reactivity in endotoxemic rats, FASEB J. 23 (2009) 932-935.
47. +-ATPase in the aorta from rats with endotoxic shock Shock 23 2005 179 185
48. (+)-ATPase catalytic isoforms in rat arteries: gender differences in activity mediated by nitric oxide donors Am. J. Physiol. 286 2004 H1793 1800
49. R. Moreau, E. Barrire, K.A. Tazi, B. Lardeux, D. Dargre, W. Urbanowicz, O. Poirel, L. Chauvelot-Moachon, M.C. Guimont, D. Bernuau, and D. Lebrec Terlipressin inhibits in vivo aortic iNOS expression induced by lipopolysaccharide in rats with biliary cirrhosis Hepatology 36 2002 1070 1078 (Pubitemid 35253422)
50. C.C. Wu, M.H. Liao, S.J. Chen, and M.H. Yen Pentoxifylline improves circulatory failure and survival in murine models of endotoxaemia Eur. J. Pharmacol. 373 1999 41 49
51. C.C. Wu, M.H. Liao, S.J. Chen, and M.H. Yen Tetramethylpyradizine prevents inducible NO synthase expression and improves survival in rodent models of endotoxic shock Naunyn Schmiedebergs Arch. Pharmacol. 360 1999 435 444
52. A. Gupta, and A.C. Sharma Despite minimal hemodynamic alterations endotoxemia modulates NOS and p38-MAPK phosphorylation via metalloendopeptidases Mol. Cell. Biochem. 265 2004 47 56 (Pubitemid 41461863)
53. A. Gupta, and A.C. Sharma Metalloendopeptidase inhibition regulates phosphorylation of p38-mitogen-activated protein kinase and nitric oxide synthase in heart after endotoxemia Shock 20 2003 375 381
54. G. Mazzocchi, G. Albertin, and G.G. Nussdorfer Adrenomedullin (ADM), acting through ADM(22-52)-sensitive receptors, is involved in the endotoxin-induced hypotension in rats Life Sci. 66 2000 1445 1450 (Pubitemid 30152315)
55. A.C. Sharma, A.D. Sam, K.J. Alden, S.L. Moore, W.R. Law, and J.L. Ferguson Central versus peripheral mediation of naloxone's perfusion effects in endotoxic rats Shock 14 2000 441 446
56. T. Cuez, B. Korkmaz, C.K. Buharalioglu, S. Sahan-Firat, J. Falck, K.U. Malik, and B. Tunctan A synthetic analog of 20-HETE, 5, 14-HEDGE, reverses endotoxin-induced hypotension via increased 20-HETE levels associated with decreased iNOS protein expression and vasodilator prostanoid production in rats Basic Clin. Pharmacol. 106 2010 378 388
57. B. Tunctan, B. Korkmaz, C.K. Buharalioglu, S. Sahan Firat, S. Anjaiah, J. Falck, R.J. Roman, and K.U. Malik A 20-HETE agonist, N-[20-hydroxyeicosa-5(Z), 14(Z)-dienoyl]glycine, opposes the fall in blood pressure and vascular reactivity in endotoxin-treated rats Shock 30 2008 329 335
58. P. Komalavilas, P.K. Shah, H. Jo, and T.M. Lincoln Activation of mitogen-activated protein kinase pathways by cyclic GMP and cyclic GMP-dependent protein kinase in contractile vascular smooth muscle cells J. Biol. Chem. 274 1999 34301 34309 (Pubitemid 129511772)
59. R.B. Pilz, and K.E. Broderick Role of cyclic GMP in gene regulation Front. Biosci. 10 2005 1239 1268
60. H. Schindler, and C. Bogdan NO as a signaling molecule: effects on kinases Int. Immunopharmacol. 1 2001 1443 1455 (Pubitemid 32622789)
61. F.M. Martens, B. Demeilliers, D. Girardot, C. Daigle, H.H. Dao, D. deBlois, and P. Moreau Vessel-specific stimulation of protein synthesis by nitric oxide synthase inhibition: role of extracellular signal-regulated kinases 1/2 Hypertension 39 2002 16 21 (Pubitemid 34098082)
62. J. Stoclet, I. Fleming, G. Gray, G. Julou-Schaeffer, F. Schneider, C. Schott, and J. Parratt Nitric oxide and endotoxemia Circulation 87 1993 V77 V80
63. A. Kleschyov, B. Muller, C. Schott, and J. Stoclet Role of adventitial nitric oxide in vascular hyporeactivity induced by lipopolysaccharide in rat aorta Br. J. Pharmacol. 124 1998 623 626 (Pubitemid 28276797)
64. H. Zhang, Y. Du, R. Cohen, A. Chobanian, and P. Brecher Adventitia as a source of inducible nitric oxide synthase in rat aorta Am. J. Hypertens. 12 1999 467 475 (Pubitemid 29238408)
65. S. Cuzzocrea, E. Mazzon, R. Di Paola, E. Esposito, H. Macarthur, G.M. Matuschak, and D. Salvemini A role for nitric oxide-mediated peroxynitrite formation in a model of endotoxin-induced shock J. Pharmacol. Exp. Ther. 319 2006 73 81 (Pubitemid 44455112)
66. R. Bianca, S. d'Emmanuele di Villa Marzocco, R. Di Paola, G. Autore, A. Pinto, S. Cuzzocrea, and R. Sorrentino Melatonin prevents lipopolysaccharide- induced hyporeactivity in rat J. Pineal Res. 36 2004 146 154 (Pubitemid 38429279)
67. K. Takakura, W. Xiaohong, K. Takeuchi, Y. Yasuda, and S. Fukuda Deactivation of norepinephrine by peroxynitrite as a new pathogenesis in the hypotension of septic shock Anesthesiology 98 2003 928 934 (Pubitemid 36373228)