5,14-HEDGE, a 20-HETE mimetic, reverses hypotension and improves survival in a rodent model of septic shock: Contribution of soluble epoxide hydrolase, CYP2C23, MEK1/ERK1/2/IKKβ/IκB-α/NF-κB pathway, and proinflammatory cytokine formation

Prostaglandins and Other Lipid Mediators

Volumn 102-103, Issue , 2013, Pages 31-41

  Tunctan, Bahar ^a   Korkmaz, Belma ^a   Sari, Ayse Nihal ^a   Kacan, Meltem ^a   Unsal, Demet ^a   Serin, Mehmet Sami ^a   Buharalioglu, C Kemal ^a   Sahan Firat, Seyhan ^a   Cuez, Tuba ^a   Schunck, Wolf Hagen ^b   Falck, John R ^c   Malik, Kafait U ^d  

^a MERSIN UNIVERSITY   (Turkey)

^b MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^c UNIVERSITY OF TEXAS AT DALLAS   (United States)

^d UNIVERSITY OF TENNESSEE COLLEGE OF MEDICINE   (United States)

Author keywords

CYP2C23; Endotoxin; Hypotension; Inflammation; Mortality; NF B; Soluble epoxide hydrolase

Indexed keywords

20 HYDROXYEICOSA 6,15 DIENOIC ACID; 20 HYDROXYICOSATETRAENOIC ACID; CYP2C23 PROTEIN; EPOXIDE HYDROLASE; I KAPPA B ALPHA; I KAPPA B KINASE BETA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 8; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; N [20 HYDROXYEICOSA 5,14 DIENOYL]GLYCINE; SOLUBLE EPOXIDE HYDROLASE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD PRESSURE; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENDOTOXEMIA; ENZYME ACTIVITY; FEMALE; HEART RATE; HYPOTENSION; INFLAMMATION; MALE; MORTALITY; MOUSE; NONHUMAN; PROTEIN EXPRESSION; RAT; SEPTIC SHOCK; SURVIVAL RATE; TACHYCARDIA; VASOCONSTRICTION;

ANIMALS; BLOOD PRESSURE; CYTOCHROME P-450 ENZYME SYSTEM; DISEASE MODELS, ANIMAL; EPOXIDE HYDROLASES; GENE EXPRESSION REGULATION; HEART RATE; HUMANS; HYDROXYEICOSATETRAENOIC ACIDS; HYPOTENSION; INFLAMMATION; LIPOPEPTIDES; MAP KINASE SIGNALING SYSTEM; MICE; NF-KAPPA B; RATS; SHOCK, SEPTIC; SURVIVAL;

EID: 84877075478     PISSN: 10988823     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.prostaglandins.2013.01.005     Document Type: Article

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