In the rostral ventrolateral medulla, the 70-kDa heat shock protein (HSP70), but not HSP90, confers neuroprotection against fatal endotoxemia via augmentation of nitric-oxide synthase I (NOS I)/protein kinase G signaling pathway and inhibition of NOS II/peroxynitrite cascade

Molecular Pharmacology

Volumn 68, Issue 1, 2005, Pages 179-192

  Li, Faith C H ^a   Chan, Julie Y H ^b   Chan, Samuel H H ^a   Chang, Alice Y W ^a  

^a NATIONAL SUN YAT SEN UNIVERSITY   (Taiwan)

^b KAOHSIUNG VETERANS GENERAL HOSPITAL   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC GMP DEPENDENT PROTEIN KINASE; CYCLOHEXIMIDE; HEAT SHOCK PROTEIN 70; HEAT SHOCK PROTEIN 90; INDUCIBLE NITRIC OXIDE SYNTHASE; NEURONAL NITRIC OXIDE SYNTHASE; PEROXYNITRITE; PROPOFOL; PROTEIN P70;

ADRENERGIC SYSTEM; ANIMAL CELL; ARTERIAL PRESSURE; ARTICLE; BRADYCARDIA; CARDIOVASCULAR DISEASE; CONTROLLED STUDY; DEPRESSION; DRUG INHIBITION; ENDOTOXEMIA; HYPOTENSION; MALE; MICROINJECTION; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; PROTEOMICS; RAT; REDUCTION; SIGNAL TRANSDUCTION; THALAMUS VENTRAL NUCLEUS;

AMINO ACID SEQUENCE; ANIMALS; CYCLIC GMP-DEPENDENT PROTEIN KINASES; ENDOTOXEMIA; ENZYME INHIBITORS; HSP70 HEAT-SHOCK PROTEINS; HSP90 HEAT-SHOCK PROTEINS; MALE; MEDULLA OBLONGATA; MOLECULAR SEQUENCE DATA; NERVE TISSUE PROTEINS; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE I; NITRIC OXIDE SYNTHASE TYPE II; PEROXYNITROUS ACID; PROTEOMICS; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION;

EID: 22344433164     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.105.011684     Document Type: Article

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