Generation of candidate ligands for nicotinic acetylcholine receptors via in situ click chemistry with a soluble acetylcholine binding protein template

Journal of the American Chemical Society

Volumn 134, Issue 15, 2012, Pages 6732-6740

  Grimster, Neil P ^a   Stump, Bernhard ^a   Fotsing, Joseph R ^a   Weide, Timo ^a   Talley, Todd T ^b   Yamauchi, John G ^b   Nemecz, Ákos ^b,c   Kim, Choel ^d   Ho, Kwok Yiu ^b   Sharpless, K Barry ^a   Taylor, Palmer ^b   Fokin, Valery V ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 ,2 ,3-TRIAZOLES; ACETYLCHOLINE-BINDING PROTEINS; ACTIVE CENTER; APLYSIA; AZIDE-ALKYNE CYCLOADDITION; CLICK CHEMISTRY; CYCLOADDITION REACTION; EXTRACELLULAR DOMAINS; IN-SITU; IN-SITU REACTIONS; LIGAND-BINDING SITES; LIGAND-GATED ION CHANNELS; MOLECULAR DETERMINANTS; NICOTINIC ACETYLCHOLINE RECEPTORS; NICOTINIC ACETYLCHOLINE RECEPTORS (NACHRS); OLIGOMERIC PROTEINS; PERIPHERAL NERVOUS SYSTEM; PHYSIOLOGICAL FUNCTIONS; SELECTIVE LIGANDS; SUBUNIT INTERFACES;

ACETYLENE; BINDING SITES; CRYSTAL STRUCTURE; CYCLOADDITION; HYDRAULIC GATES; NITROGEN COMPOUNDS; OLIGOMERS; PROTEINS;

LIGANDS;

1,2,3 TRIAZOLE DERIVATIVE; ACETYLCHOLINE BINDING PROTEIN; ALKYNE; AZIDE; BINDING PROTEIN; BUNGAROTOXIN RECEPTOR; LIGAND; LIGAND GATED ION CHANNEL; NICOTINIC AGENT; NICOTINIC RECEPTOR BLOCKING AGENT; OLIGOMER; RECEPTOR SUBUNIT; TRIAZOLE; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CHEMICAL COMPOSITION; CLICK CHEMISTRY; COMPLEX FORMATION; CRYSTAL STRUCTURE; CYCLOADDITION; DRUG BINDING SITE; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVE SITE; LIGAND BINDING; MOLECULAR INTERACTION; MOLLUSC; PREDICTION; PROTEIN BINDING;

ACETYLCHOLINE; CARRIER PROTEINS; CHOLINERGIC AGENTS; CLICK CHEMISTRY; LIGANDS; RECEPTORS, NICOTINIC;

EID: 84859994538     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja3001858     Document Type: Article

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