Oncogenic function of p34SEI-1 via NEDD4-1-mediated PTEN ubiquitination/degradation and activation of the PI3K/AKT pathway

International Journal of Oncology

Volumn 43, Issue 5, 2013, Pages 1587-1595

  Jung, Samil ^a   Li, Chengping ^a   Jeong, Dongjun ^b   Lee, Soonduck ^a   Ohk, Jiyeon ^a   Park, Meeyoung ^a   Han, Songyi ^a   Duan, Jingjing ^a   Kim, Changjin ^b   Yang, Young ^a   Kim, Keun Il ^a   Lim, Jong Seok ^a   Kang, Young Sook ^a   Lee, Myeong Sok ^a  

^a Sookmyung Women's University   (South Korea)

^b Soonchunhyang University   (South Korea)

Author keywords

34 KD protein encoding selected with Ink4a 1 as bait gene; Neuronal precursor cell expressed developmentally downregulated 4 1; Phosphatase and tensin homolog deleted on chromosome ten; Phosphoinositide 3 kinase protein kinase B; Tumorigenesis

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIGASE; NEURONAL PRECURSOR CELL EXPRESSED DEVELOPMENTALLY DOWNREGULATED 4 1; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; UNCLASSIFIED DRUG; ESCRT PROTEIN; MESSENGER RNA; NEDD4 UBIQUITIN PROTEIN LIGASES; NUCLEAR PROTEIN; PTEN PROTEIN, HUMAN; SERTAD1 PROTEIN, HUMAN; SMALL INTERFERING RNA; TRANSACTIVATOR PROTEIN; UBIQUITIN PROTEIN LIGASE;

34 KD PROTEIN ENCODING SEI 1 GENE; ARTICLE; BINDING SITE; BREAST CANCER; CANCER CELL; CANCER CELL CULTURE; CARCINOGENESIS; CELL STRAIN HEK293; CELL SURVIVAL; CELLULAR DISTRIBUTION; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; GENE FUNCTION; GENE OVEREXPRESSION; GENE SILENCING; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MCF7 CELL LINE; NEURONAL PRECURSOR CELL EXPRESSED DEVELOPMENTALLY DOWNREGULATED 4 1 GENE; ONCOGENE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN STABILITY; REGULATOR GENE; REGULATORY MECHANISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION; UBIQUITINATION; WESTERN BLOTTING; APOPTOSIS; BREAST TUMOR; CELL PROLIFERATION; DRUG ANTAGONISM; ENZYME IMMUNOASSAY; FEMALE; GENETICS; METABOLISM; PATHOLOGY; REAL TIME POLYMERASE CHAIN REACTION; TUMOR CELL CULTURE;

APOPTOSIS; BLOTTING, WESTERN; BREAST NEOPLASMS; CELL PROLIFERATION; ENDOSOMAL SORTING COMPLEXES REQUIRED FOR TRANSPORT; FEMALE; HUMANS; IMMUNOENZYME TECHNIQUES; NUCLEAR PROTEINS; PHOSPHATIDYLINOSITOL 3-KINASES; PROTEOLYSIS; PROTO-ONCOGENE PROTEINS C-AKT; PTEN PHOSPHOHYDROLASE; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; RNA, SMALL INTERFERING; TRANS-ACTIVATORS; TUMOR CELLS, CULTURED; UBIQUITIN-PROTEIN LIGASES; UBIQUITINATION;

EID: 84885048125     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo.2013.2064     Document Type: Article

References (38)

1. Morgensztern D and McLeod HL: PI3K/Akt/mTOR pathway as a target for cancer therapy. Anticancer Drugs 16: 797-803, 2005.
2. Cortot A, Armand JP and Soria JC: PI3K-AKT-mTOR pathway inhibitors. Bull Cancer 93: 19-26, 2006 (In French).
3. Yap TA, Garrett MD, Walton MI, Raynaud F, de Bono JS and Workman P: Targeting the PI3K-AKT-mTOR pathway: progress, pitfalls, and promises. Curr Opin Pharmacol 8: 393-412, 2008.
4. LoPiccolo J, Blumenthal GM, Bernstein WB and Dennis PA: Targeting the PI3K/Akt/mTOR pathway: effective combinations and clinical considerations. Drug Resist Updat 11: 32-50, 2008.
5. Yuan TL and Cantley LC: PI3K pathway alterations in cancer: variations on a theme. Oncogene 27: 5497-5510, 2008.
6. Kong D and Yamori T: Advances in development of phosphatidylinositol 3-kinase inhibitors. Curr Med Chem 16: 2839-2854, 2009.
7. Qiao M, Sheng S and Pardee AB: Metastasis and AKT activation. Cell Cycle 7: 2991-2996, 2008.
8. Xue G, Restuccia DF, Lan Q, et al: Akt/PKB-mediated phosphorylation of Twist1 promotes tumor metastasis via mediating cross-talk between PI3K/Akt and TGF-beta signaling axes. Cancer Discov 2: 248-259, 2012.
9. Brader S and Eccles SA: Phosphoinositide 3-kinase signalling pathways in tumor progression, invasion and angiogenesis. Tumori 90: 2-8, 2004.
10. Grille SJ, Bellacosa A, Upson J, et al: The protein kinase Akt induces epithelial mesenchymal transition and promotes enhanced motility and invasiveness of squamous cell carcinoma lines. Cancer Res 63: 2172-2178, 2003.
11. Toker A and Yoeli-Lerner M: Akt signaling and cancer: surviving but not moving on. Cancer Res 66: 3963-3966, 2006.
12. Yoeli-Lerner M and Toker A: Akt/PKB signaling in cancer: a function in cell motility and invasion. Cell Cycle 5: 603-605, 2006.
13. Gagnon V, St-Germain ME, Parent S and Asselin E: Akt activity in endometrial cancer cells: regulation of cell survival through cIAP-1. Int J Oncol 23: 803-810, 2003.
14. Maehama T and Dixon JE: The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate. J Biol Chem 273: 13375-13378, 1998.
15. Stambolic V, Suzuki A, de la Pompa JL, et al: Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN. Cell 95: 29-39, 1998.
16. Akca H, Demiray A, Tokgun O and Yokota J: Invasiveness and anchorage independent growth ability augmented by PTEN inactivation through the PI3K/AKT/NFκB pathway in lung cancer cells. Lung Cancer 73: 302-309, 2011.
17. Carver BS, Chapinski C, Wongvipat J, et al: Reciprocal feedback regulation of PI3K and androgen receptor signaling in PTEN-deficient prostate cancer. Cancer Cell 19: 575-586, 2011.
18. Taylor CJ, Qiao J, Colon NC, Schlegel C, Josifi E and Chung DH: Integrin-linked kinase regulates phosphatase and tensin homologue activity to promote tumorigenesis in neuroblastoma cells. Surgery 150: 162-168, 2011.
19. Tian XX, Pang JC, To SS and Ng HK: Restoration of wild-type PTEN expression leads to apoptosis, induces differentiation, and reduces telomerase activity in human glioma cells. J Neuropathol Exp Neurol 58: 472-479, 1999.
20. McMenamin ME, Soung P, Perera S, Kaplan I, Loda M and Sellers WR: Loss of PTEN expression in paraffin-embedded primary prostate cancer correlates with high Gleason score and advanced stage. Cancer Res 59: 4291-4296, 1999.
21. Chang JG, Chen YJ, Perng LI, et al: Mutation analysis of the PTEN/MMAC1 gene in cancers of the digestive tract. Eur J Cancer 35: 647-651, 1999.
22. Wang X, Trotman LC, Koppie T, et al: NEDD4-1 is a proto-oncogenic ubiquitin ligase for PTEN. Cell 128: 129-139, 2007.
23. Amodio N, Scrima M, Palaia L, et al: Oncogenic role of the E3 ubiquitin ligase NEDD4-1, a PTEN negative regulator, in non-small-cell lung carcinomas. Am J Pathol 177: 2622-2634, 2010.
24. Hayashi R, Goto Y, Ikeda R, Yokoyama KK and Yoshida K: CDCA4 is an E2F transcription factor family-induced nuclear factor that regulates E2F-dependent transcriptional activation and cell proliferation. J Biol Chem 281: 35633-35648, 2006.
25. Hsu SI, Yang CM, Sim KG, Hentschel DM, O'Leary E and Bonventre JV: TRIP-Br: a novel family of PHD zinc finger- and bromodomain-interacting proteins that regulate the transcriptional activity of E2F-1/DP-1. EMBO J 20: 2273-2285, 2001.
26. Hong SW, Kim CJ, Park WS, et al: p34SEI-1 inhibits apoptosis through the stabilization of the X-linked inhibitor of apoptosis protein: p34SEI-1 as a novel target for anti-breast cancer strategies. Cancer Res 69: 741-746, 2009.
27. Li Y, Nie CJ, Hu L, et al: Characterization of a novel mechanism of genomic instability involving the SEI1/SET/NM23H1 pathway in esophageal cancers. Cancer Res 70: 5695-5705, 2010.
28. Tang DJ, Hu L, Xie D, et al: Oncogenic transformation by SEI-1 is associated with chromosomal instability. Cancer Res 65: 6504-6508, 2005.
29. Lee SL, Hong SW, Shin JS, et al: p34SEI-1 inhibits doxorubicin-induced senescence through a pathway mediated by protein kinase C-delta and c-Jun-NH2-kinase 1 activation in human breast cancer MCF7 cells. Mol Cancer Res 7: 1845-1853, 2009.
30. Lin Q, Wang J, Childress C, Sudol M, Carey DJ and Yang W: HECT E3 ubiquitin ligase Nedd4-1 ubiquitinates ACK and regulates epidermal growth factor (EGF)-induced degradation of EGF receptor and ACK. Mol Cell Biol 30: 1541-1554, 2010.
31. Trotman LC, Wang X, Alimonti A, et al: Ubiquitination regulates PTEN nuclear import and tumor suppression. Cell 128: 141-156, 2007.
32. Fouladkou F, Landry T, Kawabe H, et al: The ubiquitin ligase Nedd4-1 is dispensable for the regulation of PTEN stability and localization. Proc Natl Acad Sci USA 105: 8585-8590, 2008.
33. Burow ME, Weldon CB, Melnik LI, et al: PI3-K/AKT regulation of NF-kappaB signaling events in suppression of TNF-induced apoptosis. Biochem Biophys Res Commun 271: 342-345, 2000.
34. Holmes KM, Annala M, Chua CY, et al: Insulin-like growth factor-binding protein 2-driven glioma progression is prevented by blocking a clinically significant integrin, integrin-linked kinase, and NF-kappaB network. Proc Natl Acad Sci USA 109: 3475-3480, 2012.
35. Judge AR, Koncarevic A, Hunter RB, Liou HC, Jackman RW and Kandarian SC: Role for IkappaBalpha, but not c-Rel, in skeletal muscle atrophy. Am J Physiol Cell Physiol 292: C372-C382, 2007.
36. Van Themsche C, Leblanc V, Parent S and Asselin E: X-linked inhibitor of apoptosis protein (XIAP) regulates PTEN ubiquitination, content, and compartmentalization. J Biol Chem 284: 20462-20466, 2009.
37. Sarma SN, Kim YJ and Ryu JC: Gene expression profiles of human promyelocytic leukemia cell lines exposed to volatile organic compounds. Toxicology 271: 122-130, 2010.
38. Du F and Galan JE: Selective inhibition of type III secretion activated signaling by the Salmonella effector AvrA. PLoS Pathog 5: e1000595, 2009.