-
1
-
-
0036479747
-
Roles of ERBB family receptor tyrosine kinases, and downstream signaling pathways, in the control of cell growth and survival
-
Grant S, Qiao L, Dent P. Roles of ERBB family receptor tyrosine kinases, and downstream signaling pathways, in the control of cell growth and survival. Front Biosci 2002; 7: 376-89.
-
(2002)
Front Biosci
, vol.7
, pp. 376-389
-
-
Grant, S.1
Qiao, L.2
Dent, P.3
-
2
-
-
18144399578
-
mTOR-targeted therapy of cancer with rapamycin derivatives
-
Vignot S, Faivre S, Aguirre D, Raymond E. mTOR-targeted therapy of cancer with rapamycin derivatives. Ann Oncol 2005; 16: 525-37.
-
(2005)
Ann Oncol
, vol.16
, pp. 525-537
-
-
Vignot, S.1
Faivre, S.2
Aguirre, D.3
Raymond, E.4
-
3
-
-
0032493105
-
Akt2 mRNA is highly expressed in embryonic brown fat and the AKT2 kinase is activated by insulin
-
Altomare DA, Lyons GE, Mitsuuchi Y, Cheng JQ, Testa JR. Akt2 mRNA is highly expressed in embryonic brown fat and the AKT2 kinase is activated by insulin. Oncogene 1998; 16: 2407-11.
-
(1998)
Oncogene
, vol.16
, pp. 2407-2411
-
-
Altomare, D.A.1
Lyons, G.E.2
Mitsuuchi, Y.3
Cheng, J.Q.4
Testa, J.R.5
-
4
-
-
0035913188
-
Oncogenic transformation induced by membrane-targeted Akt2 and Akt3
-
Mende I, Malstrom S, Tsichlis PN, Vogt PK, Aoki M. Oncogenic transformation induced by membrane-targeted Akt2 and Akt3. Oncogene 2001; 20: 4419-23.
-
(2001)
Oncogene
, vol.20
, pp. 4419-4423
-
-
Mende, I.1
Malstrom, S.2
Tsichlis, P.N.3
Vogt, P.K.4
Aoki, M.5
-
5
-
-
10744230205
-
MDA-7 negatively regulates the beta-catenin and PI3K signaling pathways in breast and lung tumor cells
-
Mhashilkar AM, Stewart AL, Sieger K, Yang HY, Khimani AH, Ito I, et al. MDA-7 negatively regulates the beta-catenin and PI3K signaling pathways in breast and lung tumor cells. Mol Ther 2003; 8: 207-19.
-
(2003)
Mol Ther
, vol.8
, pp. 207-219
-
-
Mhashilkar, A.M.1
Stewart, A.L.2
Sieger, K.3
Yang, H.Y.4
Khimani, A.H.5
Ito, I.6
-
6
-
-
0029842109
-
Structure of the FKBP12-rapamycin complex interacting with the binding domain of human FRAP
-
Choi J, Chen J, Schreiber SL, Clardy J. Structure of the FKBP12-rapamycin complex interacting with the binding domain of human FRAP. Science 1996; 273: 239-42.
-
(1996)
Science
, vol.273
, pp. 239-242
-
-
Choi, J.1
Chen, J.2
Schreiber, S.L.3
Clardy, J.4
-
7
-
-
0033429554
-
Mammalian target of rapamycin is a direct target for protein kinase B: Identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation
-
Nave BT, Ouwens M, Withers DJ, Alessi DR, Shepherd PR. Mammalian target of rapamycin is a direct target for protein kinase B: identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation. Biochem J 1999; 344: 427-31.
-
(1999)
Biochem J
, vol.344
, pp. 427-431
-
-
Nave, B.T.1
Ouwens, M.2
Withers, D.J.3
Alessi, D.R.4
Shepherd, P.R.5
-
8
-
-
0030881836
-
Phosphorylation of the translational repressor PHAS-I by the mammalian target of rapamycin
-
Brunn GJ, Hudson CC, Sekulic A, Williams JM, Hosoi H, Houghton PJ, et al. Phosphorylation of the translational repressor PHAS-I by the mammalian target of rapamycin. Science 1997; 277: 99-101.
-
(1997)
Science
, vol.277
, pp. 99-101
-
-
Brunn, G.J.1
Hudson, C.C.2
Sekulic, A.3
Williams, J.M.4
Hosoi, H.5
Houghton, P.J.6
-
9
-
-
18444416812
-
Sequential involvement of Cdk1, mTOR and p53 in apoptosis induced by the HIV-1 envelope
-
Castedo M, Roumier T, Blanco J, Ferri KF, Barretina J, Tintignac LA, et al. Sequential involvement of Cdk1, mTOR and p53 in apoptosis induced by the HIV-1 envelope. EMBO J 2002; 21: 4070-80.
-
(2002)
EMBO J
, vol.21
, pp. 4070-4080
-
-
Castedo, M.1
Roumier, T.2
Blanco, J.3
Ferri, K.F.4
Barretina, J.5
Tintignac, L.A.6
-
10
-
-
0035145602
-
Metabolic regulation by leucine of translation initiation through the mTOR-signaling pathway by pancreatic beta-cells
-
Xu G, Kwon G, Cruz WS, Marshall CA, McDaniel ML. Metabolic regulation by leucine of translation initiation through the mTOR-signaling pathway by pancreatic beta-cells. Diabetes 2001; 50: 353-60.
-
(2001)
Diabetes
, vol.50
, pp. 353-360
-
-
Xu, G.1
Kwon, G.2
Cruz, W.S.3
Marshall, C.A.4
McDaniel, M.L.5
-
11
-
-
0032590011
-
PIK3CA is implicated as an oncogene in ovarian cancer
-
Shayesteh L, Lu Y, Kuo WL, Baldocchi R, Godfrey T, Collins C, et al. PIK3CA is implicated as an oncogene in ovarian cancer. Nat Genet 1999; 21: 99-102.
-
(1999)
Nat Genet
, vol.21
, pp. 99-102
-
-
Shayesteh, L.1
Lu, Y.2
Kuo, W.L.3
Baldocchi, R.4
Godfrey, T.5
Collins, C.6
-
12
-
-
11144358645
-
High frequency of mutations of the PIK3CA gene in human cancers
-
Samuels Y, Wang Z, Bardelli A, Silliman N, Ptak J, Szabo S, et al. High frequency of mutations of the PIK3CA gene in human cancers. Science 2004; 304: 554.
-
(2004)
Science
, vol.304
, pp. 554
-
-
Samuels, Y.1
Wang, Z.2
Bardelli, A.3
Silliman, N.4
Ptak, J.5
Szabo, S.6
-
13
-
-
0026667730
-
AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas
-
Cheng JQ, Godwin AK, Bellacosa A, Taguchi T, Franke TF, Hamilton TC, et al. AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas. Proc Natl Acad Sci USA 1992; 89: 9267-71.
-
(1992)
Proc Natl Acad Sci USA
, vol.89
, pp. 9267-9271
-
-
Cheng, J.Q.1
Godwin, A.K.2
Bellacosa, A.3
Taguchi, T.4
Franke, T.F.5
Hamilton, T.C.6
-
14
-
-
16844366148
-
Review of UCN-01 development: A lesson in the importance of clinical pharmacology
-
Fuse E, Kuwabara T, Sparreboom A, Sausville EA, Figg WD. Review of UCN-01 development: a lesson in the importance of clinical pharmacology. J Clin Pharmacol 2005; 45: 394-403.
-
(2005)
J Clin Pharmacol
, vol.45
, pp. 394-403
-
-
Fuse, E.1
Kuwabara, T.2
Sparreboom, A.3
Sausville, E.A.4
Figg, W.D.5
-
15
-
-
3042582607
-
Time to disease progression to evaluate a novel protein kinase C inhibitor, UCN-01, in renal cell carcinoma
-
Rini BI, Weinberg V, Shaw V, Scott J, Bok R, Park JW, et al. Time to disease progression to evaluate a novel protein kinase C inhibitor, UCN-01, in renal cell carcinoma. Cancer 2004; 101: 90-5.
-
(2004)
Cancer
, vol.101
, pp. 90-95
-
-
Rini, B.I.1
Weinberg, V.2
Shaw, V.3
Scott, J.4
Bok, R.5
Park, J.W.6
-
16
-
-
2542547908
-
Perifosine, a novel alkylphospholipid, inhibits protein kinase B activation
-
Kondapaka SB, Singh SS, Dasmahapatra GP, Sausville EA, Roy KK. Perifosine, a novel alkylphospholipid, inhibits protein kinase B activation. Mol Cancer Ther 2003; 2: 1093-103.
-
(2003)
Mol Cancer Ther
, vol.2
, pp. 1093-1103
-
-
Kondapaka, S.B.1
Singh, S.S.2
Dasmahapatra, G.P.3
Sausville, E.A.4
Roy, K.K.5
-
17
-
-
0035872442
-
Inhibition of signal transduction by the Hsp90 inhibitor 17-allylamino-17-demethoxygeldanamycin results in cytostasis and apoptosis
-
Hostein I, Robertson D, DiStefano F, Workman P, Clarke PA. Inhibition of signal transduction by the Hsp90 inhibitor 17-allylamino-17- demethoxygeldanamycin results in cytostasis and apoptosis. Cancer Res 2001; 61: 4003-9.
-
(2001)
Cancer Res
, vol.61
, pp. 4003-4009
-
-
Hostein, I.1
Robertson, D.2
DiStefano, F.3
Workman, P.4
Clarke, P.A.5
-
18
-
-
23044441106
-
Phase I pharmacokinetic and pharmacodynamic study of 17-allylamino, 17-demethoxygeldanamycin in patients with advanced malignancies
-
Banerji U, O'Donnell A, Scurr M, Pacey S, Stapleton S, Asad Y, et al. Phase I pharmacokinetic and pharmacodynamic study of 17-allylamino, 17-demethoxygeldanamycin in patients with advanced malignancies. J Clin Oncol 2005; 23: 4152-61.
-
(2005)
J Clin Oncol
, vol.23
, pp. 4152-4161
-
-
Banerji, U.1
O'Donnell, A.2
Scurr, M.3
Pacey, S.4
Stapleton, S.5
Asad, Y.6
-
19
-
-
0028360374
-
A mammalian protein targeted by G1-arresting rapamycin-receptor complex
-
Brown EJ, Albers MW, Shin TB, Ichikawa K, Keith CT, Lane WS, et al. A mammalian protein targeted by G1-arresting rapamycin-receptor complex. Nature 1994; 369: 756-8.
-
(1994)
Nature
, vol.369
, pp. 756-758
-
-
Brown, E.J.1
Albers, M.W.2
Shin, T.B.3
Ichikawa, K.4
Keith, C.T.5
Lane, W.S.6
-
20
-
-
0029418483
-
Mechanism of action of rapamycin: New insights into the regulation of G1-phase progression in eukaryotic cells
-
Wiederrecht GJ, Sabers CJ, Brunn GJ, Martin MM, Dumont FJ, Abraham RT. Mechanism of action of rapamycin: new insights into the regulation of G1-phase progression in eukaryotic cells. Prog Cell Cycle Res 1995; 1: 53-71.
-
(1995)
Prog Cell Cycle Res
, vol.1
, pp. 53-71
-
-
Wiederrecht, G.J.1
Sabers, C.J.2
Brunn, G.J.3
Martin, M.M.4
Dumont, F.J.5
Abraham, R.T.6
-
21
-
-
20444459116
-
Antitumor activity of rapamycin in a transgenic mouse model of ErbB2-dependent human breast cancer
-
Liu M, Howes A, Lesperance J, Stallcup WB, Hauser CA, Kadoya K, et al. Antitumor activity of rapamycin in a transgenic mouse model of ErbB2-dependent human breast cancer. Cancer Res 2005; 65: 5325-36.
-
(2005)
Cancer Res
, vol.65
, pp. 5325-5336
-
-
Liu, M.1
Howes, A.2
Lesperance, J.3
Stallcup, W.B.4
Hauser, C.A.5
Kadoya, K.6
-
22
-
-
0029794614
-
Rapamycin inhibits constitutive p70s6k phosphorylation, cell proliferation, and colony formation in small cell lung cancer cells
-
Seufferlein T, Rozengurt E. Rapamycin inhibits constitutive p70s6k phosphorylation, cell proliferation, and colony formation in small cell lung cancer cells. Cancer Res 1996; 56: 3895-7.
-
(1996)
Cancer Res
, vol.56
, pp. 3895-3897
-
-
Seufferlein, T.1
Rozengurt, E.2
-
23
-
-
0035870281
-
p53/p21 (CIP1) cooperate in enforcing rapamycin-induced G (1) arrest and determine the cellular response to rapamycin
-
Huang S, Liu LN, Hosoi H, Dilling MB, Shikata T, Houghton PJ. p53/p21 (CIP1) cooperate in enforcing rapamycin-induced G (1) arrest and determine the cellular response to rapamycin. Cancer Res 2001; 61: 3373-81.
-
(2001)
Cancer Res
, vol.61
, pp. 3373-3381
-
-
Huang, S.1
Liu, L.N.2
Hosoi, H.3
Dilling, M.B.4
Shikata, T.5
Houghton, P.J.6
-
24
-
-
0000375616
-
The effect of CCI-779, a novel macrolide anti-tumor agent, on the growth of human tumor cells in vitro and in nude mouse xenograft in vivo
-
Gibbons JJ, Discafani C, Peterson R, Hernandez R, Skotnicki J, Frost J. The effect of CCI-779, a novel macrolide anti-tumor agent, on the growth of human tumor cells in vitro and in nude mouse xenograft in vivo. Proc Am Soc Cancer Res 2000; 40: 301.
-
(2000)
Proc Am Soc Cancer Res
, vol.40
, pp. 301
-
-
Gibbons, J.J.1
Discafani, C.2
Peterson, R.3
Hernandez, R.4
Skotnicki, J.5
Frost, J.6
-
25
-
-
0000183432
-
CCI-779, a rapamycin analog and multifaceted inhibitor of signal transduction: A phase I study
-
abstr.726
-
Hidalgo M, Rowinsky E, Erlichman C, Drengler R, Marshall B, Adjei A, et al. CCI-779, a rapamycin analog and multifaceted inhibitor of signal transduction: a phase I study. Proc Am Soc Clin Onco 2000; 19: 187; (abstr.726).
-
(2000)
Proc Am Soc Clin Onco
, vol.19
, pp. 187
-
-
Hidalgo, M.1
Rowinsky, E.2
Erlichman, C.3
Drengler, R.4
Marshall, B.5
Adjei, A.6
-
26
-
-
2942735384
-
Safety and pharmacokinetics of escalated doses of weekly intravenous infusion of CCI-779, a novel mTOR inhibitor, in patients with cancer
-
Raymond E, Alexandre J, Faivre S, Vera K, Materman E, Boni J, et al. Safety and pharmacokinetics of escalated doses of weekly intravenous infusion of CCI-779, a novel mTOR inhibitor, in patients with cancer. J Clin Oncol 2004; 22: 2336-47.
-
(2004)
J Clin Oncol
, vol.22
, pp. 2336-2347
-
-
Raymond, E.1
Alexandre, J.2
Faivre, S.3
Vera, K.4
Materman, E.5
Boni, J.6
-
28
-
-
0042804378
-
In vivo activity of RAD 001, an orally active rapamycin derivative, in experimental tumor models
-
abstr. 359
-
O'Reilly T, Vaxelaire J, Muller M, Fiebig HH, Hattenberger M, Lane HA. In vivo activity of RAD 001, an orally active rapamycin derivative, in experimental tumor models. Proc Am Assoc Cancer Res 2002: 43; (abstr. 359).
-
(2002)
Proc Am Assoc Cancer Res
, vol.43
-
-
O'Reilly, T.1
Vaxelaire, J.2
Muller, M.3
Fiebig, H.H.4
Hattenberger, M.5
Lane, H.A.6
-
29
-
-
0042303286
-
Antiangiogenetic activity of RAD 001, an orally active anticancer agent
-
abstr. 922
-
Lane H, Schnell C, Theuer A, et al. Antiangiogenetic activity of RAD 001, an orally active anticancer agent. Proc Am Assoc Cancer Res 2002: 43; (abstr. 922).
-
(2002)
Proc Am Assoc Cancer Res
, vol.43
-
-
Lane, H.1
Schnell, C.2
Theuer, A.3
-
30
-
-
0345617103
-
A phase I study of the oral mTOR inhibitor RAD001 as monotherapy to identify the optimal biologically effective dose using toxicity, pharmacokinetic (PK) and pharmacodynamic (PD) endpoints in patients with solid tumours
-
abstr. 803
-
O'Donnell A, Faivre S, Judson I, Delbado C, Brock C, Lane H, et al. A phase I study of the oral mTOR inhibitor RAD001 as monotherapy to identify the optimal biologically effective dose using toxicity, pharmacokinetic (PK) and pharmacodynamic (PD) endpoints in patients with solid tumours. Proc Am Soc Clin Onco 2003; 22: 200; (abstr. 803).
-
(2003)
Proc Am Soc Clin Onco
, vol.22
, pp. 200
-
-
O'Donnell, A.1
Faivre, S.2
Judson, I.3
Delbado, C.4
Brock, C.5
Lane, H.6
-
31
-
-
8344223548
-
Regression of tumor xenografts in mice after oral administration of AP23573, a novel mTOR inhibitor that induces tumor starvation
-
abstr. LB95
-
Clackson T, Metcalf CA, Rozamus LW, Knowles HL, Wardwell SD, Roses JB, et al. Regression of tumor xenografts in mice after oral administration of AP23573, a novel mTOR inhibitor that induces tumor starvation. Proc Am Assoc Cancer Res 2002: 43; (abstr. LB95).
-
(2002)
Proc Am Assoc Cancer Res
, vol.43
-
-
Clackson, T.1
Metcalf, C.A.2
Rozamus, L.W.3
Knowles, H.L.4
Wardwell, S.D.5
Roses, J.B.6
-
32
-
-
17044411266
-
Phase I, pharmacokinetic, and pharmacodynamic study of AP23573, an mTOR Inhibitor, administered IV daily × 5 every other week in patients with refractory or advanced malignancies
-
abstr.
-
Mita M, Rowinsky E, Goldston M, Mita AC, Chu Q, Syedet S, et al. Phase I, pharmacokinetic, and pharmacodynamic study of AP23573, an mTOR Inhibitor, administered IV daily × 5 every other week in patients with refractory or advanced malignancies. Proc Am Soc Clin Onco 2004; 46: 3076; (abstr.).
-
(2004)
Proc Am Soc Clin Onco
, vol.46
, pp. 3076
-
-
Mita, M.1
Rowinsky, E.2
Goldston, M.3
Mita, A.C.4
Chu, Q.5
Syedet, S.6
-
33
-
-
8344238409
-
A phase I trial of a novel mTOR inhibitor AP23573 administered weekly in patients with refractory or advanced malignancies. A pharmacokinetic and pharmacodynamic analysis
-
abstr.
-
Desai AA, Janisch L, Berk LR, Knowles HL, Rivera VM, Bedrosian CL, et al. A phase I trial of a novel mTOR inhibitor AP23573 administered weekly in patients with refractory or advanced malignancies. A pharmacokinetic and pharmacodynamic analysis. Proc Am Soc Clin Onco 2004; 46: 3150; (abstr.).
-
(2004)
Proc Am Soc Clin Onco
, vol.46
, pp. 3150
-
-
Desai, A.A.1
Janisch, L.2
Berk, L.R.3
Knowles, H.L.4
Rivera, V.M.5
Bedrosian, C.L.6
-
34
-
-
1542398693
-
Randomized phase II study of multiple dose levels of CCI-779, a novel mammalian target of rapamycin kinase inhibitor, in patients with advanced refractory renal cell carcinoma
-
Atkins MB, Hidalgo M, Stadler WM, Logan TF, Dutcher JP, Hudes GR, et al. Randomized phase II study of multiple dose levels of CCI-779, a novel mammalian target of rapamycin kinase inhibitor, in patients with advanced refractory renal cell carcinoma. J Clin Oncol 2004; 22: 909-18.
-
(2004)
J Clin Oncol
, vol.22
, pp. 909-918
-
-
Atkins, M.B.1
Hidalgo, M.2
Stadler, W.M.3
Logan, T.F.4
Dutcher, J.P.5
Hudes, G.R.6
-
35
-
-
23944439945
-
Phase II study of temsirolimus (CCI-779), a novel inhibitor of mTOR, in heavily pretreated patients with locally advanced or metastatic breast cancer
-
Chan S, Scheulen ME, Johnston S, Mross K, Cardoso F, Dittrich C, et al. Phase II study of temsirolimus (CCI-779), a novel inhibitor of mTOR, in heavily pretreated patients with locally advanced or metastatic breast cancer. J Clin Oncol 2005; 23: 5314-22.
-
(2005)
J Clin Oncol
, vol.23
, pp. 5314-5322
-
-
Chan, S.1
Scheulen, M.E.2
Johnston, S.3
Mross, K.4
Cardoso, F.5
Dittrich, C.6
-
36
-
-
23844476134
-
CCI-779 in metastatic melanoma: A phase II trial of the California Cancer Consortium
-
Margolin K, Longmate J, Baratta T, Synold T, Christensen S, Weber J, et al. CCI-779 in metastatic melanoma: a phase II trial of the California Cancer Consortium. Cancer 2005; 104: 1045-8.
-
(2005)
Cancer
, vol.104
, pp. 1045-1048
-
-
Margolin, K.1
Longmate, J.2
Baratta, T.3
Synold, T.4
Christensen, S.5
Weber, J.6
-
37
-
-
23944453425
-
Phase II trial of temsirolimus (CCI-779) in recurrent glioblastoma multiforme: A North Central Cancer Treatment Group Study
-
Galanis E, Buckner JC, Maurer MJ, Kreisberg JI, Ballman K, Boni J, et al. Phase II trial of temsirolimus (CCI-779) in recurrent glioblastoma multiforme: a North Central Cancer Treatment Group Study. J Clin Oncol 2005; 23: 5294-304.
-
(2005)
J Clin Oncol
, vol.23
, pp. 5294-5304
-
-
Galanis, E.1
Buckner, J.C.2
Maurer, M.J.3
Kreisberg, J.I.4
Ballman, K.5
Boni, J.6
-
38
-
-
18344370678
-
New therapeutic approaches in glioblastomas
-
Carpentier AF. New therapeutic approaches in glioblastomas. Bull Cancer 2005; 92: 355-9.
-
(2005)
Bull Cancer
, vol.92
, pp. 355-359
-
-
Carpentier, A.F.1
-
39
-
-
23944481410
-
Phase II trial of single-agent temsirolimus (CCI-779) for relapsed mantle cell lymphoma
-
Witzig TE, Geyer SM, Ghobrial I, Inwards DJ, Fonseca R, Kurtin P, et al. Phase II trial of single-agent temsirolimus (CCI-779) for relapsed mantle cell lymphoma. J Clin Oncol 2005; 23: 5347-56.
-
(2005)
J Clin Oncol
, vol.23
, pp. 5347-5356
-
-
Witzig, T.E.1
Geyer, S.M.2
Ghobrial, I.3
Inwards, D.J.4
Fonseca, R.5
Kurtin, P.6
-
40
-
-
27144455334
-
Inhibition of the mammalian target of rapamycin and the induction of cell cycle arrest in mantle cell lymphoma cells
-
Hipp S, Ringshausen I, Oelsner M, Bogner C, Peschel C, Decker T. Inhibition of the mammalian target of rapamycin and the induction of cell cycle arrest in mantle cell lymphoma cells. Haematologica 2005; 90: 1433-4.
-
(2005)
Haematologica
, vol.90
, pp. 1433-1434
-
-
Hipp, S.1
Ringshausen, I.2
Oelsner, M.3
Bogner, C.4
Peschel, C.5
Decker, T.6
-
41
-
-
20144367584
-
Sirolimus for Kaposi's sarcoma in renal-transplant recipients
-
Stallone G, Schena A, Infante B, Di Paolo S, Loverre A, Maggio G, et al. Sirolimus for Kaposi's sarcoma in renal-transplant recipients. N Engl J Med 2005; 352: 1317-23.
-
(2005)
N Engl J Med
, vol.352
, pp. 1317-1323
-
-
Stallone, G.1
Schena, A.2
Infante, B.3
Di Paolo, S.4
Loverre, A.5
Maggio, G.6
-
42
-
-
3142510752
-
Preliminary report of a phase 1 study of intravenous (IV) CCI-779 given in combination with interferon-α (IFN) to patients with advanced renal cell carcinoma
-
abstr. 854
-
Dutcher JP, Hudes G, Motzer R, Ko YJ, Smith JW, Zonno K, et al. Preliminary report of a phase 1 study of intravenous (IV) CCI-779 given in combination with interferon-α (IFN) to patients with advanced renal cell carcinoma. Proc Am Soc Clin Oncol 2003; 22: 213; (abstr. 854).
-
(2003)
Proc Am Soc Clin Oncol
, vol.22
, pp. 213
-
-
Dutcher, J.P.1
Hudes, G.2
Motzer, R.3
Ko, Y.J.4
Smith, J.W.5
Zonno, K.6
-
43
-
-
0038688097
-
Phase I and pharmacokinetic study of CCI-779, a novel cytostatic cell-cycle inhibitor, in combination with 5-fluorouracil and leucovorin in patients with advanced solid tumors
-
Punt CJ, Boni J, Bruntsch U, Peters M, Thielert C. Phase I and pharmacokinetic study of CCI-779, a novel cytostatic cell-cycle inhibitor, in combination with 5-fluorouracil and leucovorin in patients with advanced solid tumors. Ann Oncol 2003; 14: 931-7.
-
(2003)
Ann Oncol
, vol.14
, pp. 931-937
-
-
Punt, C.J.1
Boni, J.2
Bruntsch, U.3
Peters, M.4
Thielert, C.5
-
44
-
-
0041662261
-
Pharmacodynamic evaluation of CCI-779, an inhibitor of mTOR, in cancer patients
-
Peralba JM, DeGraffenried L, Friedrichs W, Fulcher L, Grunwald V, Weiss G, et al. Pharmacodynamic evaluation of CCI-779, an inhibitor of mTOR, in cancer patients. Clin Cancer Res 2003; 9: 2887-92.
-
(2003)
Clin Cancer Res
, vol.9
, pp. 2887-2892
-
-
Peralba, J.M.1
DeGraffenried, L.2
Friedrichs, W.3
Fulcher, L.4
Grunwald, V.5
Weiss, G.6
-
45
-
-
17944377486
-
Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR
-
Neshat MS, Mellinghoff IK, Tran C, Stiles B, Thomas G, Petersen R, et al. Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR. Proc Natl Acad Sci USA 2001; 98: 10314-9.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 10314-10319
-
-
Neshat, M.S.1
Mellinghoff, I.K.2
Tran, C.3
Stiles, B.4
Thomas, G.5
Petersen, R.6
-
46
-
-
0037108682
-
Activated mammalian target of rapamycin pathway in the pathogenesis of tuberous sclerosis complex renal tumors
-
Kenerson HL, Aicher LD, True LD, Yeung RS. Activated mammalian target of rapamycin pathway in the pathogenesis of tuberous sclerosis complex renal tumors. Cancer Res 2002; 62: 5645-50.
-
(2002)
Cancer Res
, vol.62
, pp. 5645-5650
-
-
Kenerson, H.L.1
Aicher, L.D.2
True, L.D.3
Yeung, R.S.4
-
47
-
-
0035870281
-
p53/p21 (CIP1) cooperate in enforcing rapamycin-induced G (1) arrest and determine the cellular response to rapamycin
-
Huang S, Liu LN, Hosoi H, Dilling MB, Shikata T, Houghton PJ. p53/p21 (CIP1) cooperate in enforcing rapamycin-induced G (1) arrest and determine the cellular response to rapamycin. Cancer Res 2001; 61: 3373-81.
-
(2001)
Cancer Res
, vol.61
, pp. 3373-3381
-
-
Huang, S.1
Liu, L.N.2
Hosoi, H.3
Dilling, M.B.4
Shikata, T.5
Houghton, P.J.6
-
48
-
-
1642586272
-
Survival signalling by Akt and eIF4E in oncogenesis and cancer therapy
-
Wendel HG, De Stanchina E, Fridman JS, Malina A, Ray S, Kogan S, et al. Survival signalling by Akt and eIF4E in oncogenesis and cancer therapy. Nature 2004; 428: 332-7.
-
(2004)
Nature
, vol.428
, pp. 332-337
-
-
Wendel, H.G.1
De Stanchina, E.2
Fridman, J.S.3
Malina, A.4
Ray, S.5
Kogan, S.6
-
49
-
-
0029977949
-
Rapamycin resistance tied to defective regulation of p27Kip1
-
Luo Y, Marx SO, Kiyokawa H, Koff A, Massague J, Marks AR. Rapamycin resistance tied to defective regulation of p27Kip1. Mol Cell Biol 1996; 16: 6744-51.
-
(1996)
Mol Cell Biol
, vol.16
, pp. 6744-6751
-
-
Luo, Y.1
Marx, S.O.2
Kiyokawa, H.3
Koff, A.4
Massague, J.5
Marks, A.R.6
-
50
-
-
16444379884
-
Bcl-2 and CCND1/CDK4 expression levels predict the cellular effects of mTOR inhibitors in human ovarian carcinoma
-
Aguirre D, Boya P, Bellet D, Faivre S, Troalen F, Benard J, et al. Bcl-2 and CCND1/CDK4 expression levels predict the cellular effects of mTOR inhibitors in human ovarian carcinoma. Apoptosis 2004; 9: 797-805.
-
(2004)
Apoptosis
, vol.9
, pp. 797-805
-
-
Aguirre, D.1
Boya, P.2
Bellet, D.3
Faivre, S.4
Troalen, F.5
Benard, J.6
-
51
-
-
1842852634
-
Pharmacogenomic profiling of the PI3K/PTEN-AKT-mTOR pathway in common human tumors
-
Xu G, Zhang W, Bertram P, Zheng XF, McLeod H. Pharmacogenomic profiling of the PI3K/PTEN-AKT-mTOR pathway in common human tumors. Int J Oncol 2004; 24: 893-900.
-
(2004)
Int J Oncol
, vol.24
, pp. 893-900
-
-
Xu, G.1
Zhang, W.2
Bertram, P.3
Zheng, X.F.4
McLeod, H.5
|