p34SEI-1 inhibits doxorubicin-induced senescence through a pathway mediated by protein kinase C-δ and c-Jun-NH2-kinase 1 activation in human breast cancer MCF7 cells

Molecular Cancer Research

Volumn 7, Issue 11, 2009, Pages 1845-1853

  Lee, Sae Lo Oom ^a   Hong, Seung Woo ^b   Shin, Jae Sik ^b   Kim, Jin Sun ^a   Ko, Seong Gyu ^c   Hong, Nam Joo ^e   Kim, Dae Jin ^d   Lee, Wang Jae ^b   Jin, Dong Hoon ^b   Lee, Myeong Sok ^a  

^a Sookmyung Women's University   (South Korea)

^b Seoul National University College of Medicine   (South Korea)

^c Kyung Hee University   (South Korea)

^d Chung Ang University   (South Korea)

^e Yeungnam University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

DOXORUBICIN; NUCLEAR PROTEIN; PROTEIN KINASE C DELTA; PROTEIN P34 SEI 1; SMALL INTERFERING RNA; STRESS ACTIVATED PROTEIN KINASE 1; UNCLASSIFIED DRUG; CARRIER PROTEIN; SERTAD1 PROTEIN, HUMAN; TRANSACTIVATOR PROTEIN; TRIM41 PROTEIN, HUMAN;

ARTICLE; BREAST CANCER; CELL STRAIN MCF 7; CONTROLLED STUDY; ENZYME ACTIVITY; FIBROBLAST; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; BIOSYNTHESIS; BREAST TUMOR; CELL AGING; DRUG ANTAGONISM; DRUG EFFECT; ENZYME ACTIVATION; FEMALE; GENETIC TRANSFECTION; GENETICS; METABOLISM; PATHOLOGY; PHOSPHORYLATION;

BREAST NEOPLASMS; CARRIER PROTEINS; CELL AGING; DOXORUBICIN; ENZYME ACTIVATION; FEMALE; HUMANS; MITOGEN-ACTIVATED PROTEIN KINASE 8; NUCLEAR PROTEINS; PHOSPHORYLATION; PROTEIN KINASE C-DELTA; RNA, SMALL INTERFERING; TRANS-ACTIVATORS; TRANSFECTION;

EID: 72449187632     PISSN: 15417786     EISSN: None     Source Type: Journal    
DOI: 10.1158/1541-7786.MCR-09-0086     Document Type: Article

References (39)

1. Sugimoto M, Nakamura T, Ohtani N, et al. Regulation of CDK4 acitivity by a novel CDK4-binding protein, p34(SEI-1). Genes Dev 1999;13:3027-3033
2. Tang TC, Sham JS, Xie D, et al. Identification of a candidate oncogene SEI-1 within a minimal amplified region at 19q13.1 in ovarian cancer cell lines. Cancer Res 2002;62:7157-7161 (Pubitemid 36025229)
3. Thomopson FH, Nelson MA, Trent JM, et al. Amplification of 19q13.1-q13.2 sequences in ovarian cancer: G-band FISH, molecular studies. Cancer Genet Cytogenet 1996;87:55-62.
4. Hoglund M, Gorunova L, Andren-Sandberg A, Dawiskiba S, Mitelman F, Johansson B. Cytogenetic and fluorescence in situ hybridization analyses of chromosome 19 aberrations in pancreatic carcinomas: frequent loss of 19p13.3 and gain of 19q13.1-13.2. Genes Chromosomes Cancer 1998;21:8-16. (Pubitemid 28028103)
5. Tang DJ, Hu L, Xie D, et al. Oncogenic transformation by SEI-1 is associated with chromosomal instability. Cancer Res 2005;65:6504-6508 (Pubitemid 41060682)
6. Li J, Melvin WS, Tsai MD, Muscarella P. The nuclear protein p34SEI-1 regulates the kinase activity of cyclin-dependent kinase 4 in a concentration-dependent manner. Biochemistry 2004;43:4394-4399 (Pubitemid 38445661)
7. Hsu SI-H, Yang CM, Sim KG, Hentschel D, O'Leary E, Bonventre JV. TRIP-Br: a novel family of PHD zinc finger- and bromodomain interacting proteins that regulate the transcriptional activity of E2F-1/DP-1. EMBO J 2001;20:2273-2285 (Pubitemid 32410596)
8. Yin XM, Oltvai ZN, Korsmeyer SJ. BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax. Nature 1994;26:321-323
9. Diaz L, Oltersdorf T, Horne W, et al. A common binding site mediates heterodimerization and homodimerization of Bcl-2 family members. J Biol Chem 1997;25:11350-11355 (Pubitemid 27184138)
10. Reed JC. Dysregulation of apoptosis in cancer. J Clin Oncol 1999;17:2941-2953
11. Kane DJ, Sarafian TA, Anton R, et al. Bcl-2 inhibition of neural death: decreased generation of reactive oxygen species. Science 1993;262:1274-1277 (Pubitemid 24036095)
12. Jung MS, Jin DH, Chae HD, et al. Bcl-xL and E1-19K proteins inhibit p53-induced irreversible growth arrest and senescence by preventing reactive oxygen species-dependent p38 activation. J Biol Chem 2004;279:17765-17771
13. Chang BD, Broude EV, Dokmanovic M, et al. A senescence-like phenotype distinguishes tumor cells that undergo terminal proliferation arrest after exposure to anticancer agents. Cancer Res 1999;59:3761-3767 (Pubitemid 29381884)
14. Hortobagyi GN. Anthracyclines in the treatment of cancer. Drugs 1997;54:1-7.
15. Chang BD, Xuan Y, Broude EV, et al. Role of p53a nd p21waf1/cip1 in senescence-like terminal proliferation arrest induced in human tumor cells by chemotherapeutic drugs. Oncogene 1999;18:4808-4818 (Pubitemid 29423564)
16. Wang Y, Zhu S, Cloughesy TF, Liau LM, Mischel PS. p53 disruption profoundly alters the response of human glioblastoma cells to DNA topoisomerase I inhibition. Oncogene 1999;18:2643-2649
17. Dimri GP, Lee X, Basile G, et al. A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc Natl Acad Sci U S A 1995;92:9363-9367
18. Elmore LW, Rehder CW, McChesney PA, et al. Adriamycin-induced senescence in breast tumor cells involves functional p53 and telomere dysfunction. J Biol Chem 2002;277:35509-35515
19. Han Z, Wei W, Dunaway S, et al. Role of p21 in apoptosis and senescence of human colon cancer cells treated with camptothecin. J Biol Chem 2002;277:17154-17160 (Pubitemid 34967748)
20. Fang L, Igarashi M, Leung J, Sugrue MM, Lee SW, Aaronson SA. p21Waf1/Cip1/Sdi1 induces permanent growth arrest with markers of replicative senescence in human tumor cells lacking functional p53. Oncogene 1999;18:2789-2797 (Pubitemid 29250868)
21. Uhrbom L, Nister M, Westermark B. Induction of senescence in human malignant glioma cells by p16INK4A. Oncogene 1997;15:505-514 (Pubitemid 27384728)
22. Xu HJ, Zhou Y, Ji W, et al. Reexpression of the retinoblastoma protein in tumor cells induces senescence and telomerase inhibition. Oncogene 1997;15:2589-2596 (Pubitemid 27507250)
23. Haq R, Brenton JD, Takahashi M, Finan D, Rottapel R, Zanke BI. Constitutive p38HOG mitogen-activated protein kinase activation induces permanent cell cycle arrest and senescence. Cancer Res 2002;62:5076-5082 (Pubitemid 34987550)
24. Hutter E, Unterluggauer H, Uberall F, Schramek H, Jansen-Durr P. Replicative senescence of human fibroblasts: the role of Ras-dependent signaling and oxidative stress. Exp Gerontol 2002;37:1165-1174 (Pubitemid 35418274)
25. Wheaton K, Riabowol K. Protein kinase Cδ blocks immediate-early gene expression in senescent cells by inactivating serum response factor. Mol Cell Biol 2004;24:7298-7311 (Pubitemid 39014454)
26. Gschwendt M. Protein kinase Cδ. Eur J Biochem 1999;259:555-564
27. Jackson JG, Pereira-Smimth OM. Primary and compensatory roles for RB family members at cell cycle gene promoters that are deacetylated and downregulated in doxorubicin-induced senescence of breast cancer cells. Mol Cell Biol 2006;26:2501-2510
28. Dumont P, Burton M, Chen QM, et al. Induction of replicative senescence biomarkers by sublethal oxidative stresses in normal human fibroblast. Free Radic Biol Med 2000;28:361-373 (Pubitemid 30110651)
29. Ferbeyre G, de Stanchina E, Querido E, Baptiste N, Prives C, Lowe S. PML is induced by oncogenic ras and promotes premature senescence. Genes Dev 2000;14:2015-2027 (Pubitemid 30637352)
30. Pearson M, Carbone R, Sebastiani C, et al. PML regulates p53 acetylation and premature senescence induced by oncogenic Ras. Nature 2000;406:207-210 (Pubitemid 30469006)
31. Chen D, Gould C, Garza R, Gao T, Harmpton RY, Newton AC. Amplitude control of protein kinase C by RINCK, a novel E3 ubiquitin ligase. J Biol Chem 2007;46:33776-33787 (Pubitemid 350159559)
32. Packer L, Fuehr K. Low oxygen concentration extends the lifespan of cultured human diploid cells. Nature 1977;267:423-425 (Pubitemid 8105518)
33. Macip S, Igarashi M, Fang L, Chen A, Pan ZQ, Lee SW, Aaronson SA. Inhibition of p21-mediated ROS accumulation can rescue p21-induced senescence. EMBO J 2004;21:2180-2188 (Pubitemid 34516777)
34. Jasny BR, Pfeffer LM, Tamm I. Effect of β-interferon on human fibroblasts at different population doubling levels. J Exp Med 1984;159:1741-1749
35. Kim NY, Woo AM, Kim JR, Lee CH. Exploration of senescence-associated genes by differential display reverse transcription polymerase chain reaction. Arch Pharm Res 2009;32:737-745
36. Oleinik NV, Krupenko NI, Krupenko SA. Cooperation between JNK1 and JNK2 in activation of p53a poptotic pathway. Oncogene 2007;26:7222-7230
37. Deng R, Li W, Guan Z, et al. Acetylcholinesterase expression mediated by c-Jun-NH2-terminal kinase pathway during anticancer drug-induced apoptosis. Oncogene 2006;25:7070-7077 (Pubitemid 44722074)
38. Hong IK, Jin YJ, Byun HJ, Jeoung DI, Kim YM, Lee HS. Homophilic interactions of Tetraspanin CD151 up-regulate motility and matrix metalloproteinase-9 expression of human melanoma cells through adhesion-dependent c-Jun activation signaling pathways. J Biol Chem 2006;281:24279-24292
39. Cerda SR, Mustafi R, Little H, et al. Protein kinase C δ inhibits Caco-2 cell proliferation by selective changes in cell cycle and cell death regulators. Oncogene 2006;25:3123-3138 (Pubitemid 43881554)