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Volumn 43, Issue 5, 2013, Pages 1652-1658

Baicalein, an active component of Scutellaria baicalensis Georgi, induces apoptosis in human colon cancer cells and prevents AOM/DSS-induced colon cancer in mice

Author keywords

Apoptosis; Azoxymethane dextran sulfate sodium model; Baicalein; Colon cancer

Indexed keywords

AZOXYMETHANE; BAICALEIN; CASPASE 3; CASPASE 8; CASPASE 9; DEXTRAN SULFATE; GELATINASE A; GELATINASE B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA;

EID: 84885042534     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo.2013.2086     Document Type: Article
Times cited : (89)

References (30)
  • 1
    • 67349245787 scopus 로고    scopus 로고
    • New insights into the aetiology of colorectal cancer from genome-wide association studies
    • Tenesa A and Dunlop MG: New insights into the aetiology of colorectal cancer from genome-wide association studies. Nat Rev Genet 10: 353-358, 2009.
    • (2009) Nat Rev Genet , vol.10 , pp. 353-358
    • Tenesa, A.1    Dunlop, M.G.2
  • 2
    • 84867103263 scopus 로고    scopus 로고
    • Chronic intestinal inflammation: Inflammatory bowel disease and colitis-associated colon cancer
    • Rubin DC, Shaker A and Levin MS: Chronic intestinal inflammation: inflammatory bowel disease and colitis-associated colon cancer. Front Immunol 3: 107, 2012.
    • (2012) Front Immunol , vol.3 , pp. 107
    • Rubin, D.C.1    Shaker, A.2    Levin, M.S.3
  • 3
    • 2442563304 scopus 로고    scopus 로고
    • Clinical epidemiology of inflammatory bowel disease: Incidence, prevalence, and environmental influences
    • Loftus EV Jr: Clinical epidemiology of inflammatory bowel disease: Incidence, prevalence, and environmental influences. Gastroenterology 126: 1504-1517, 2004.
    • (2004) Gastroenterology , vol.126 , pp. 1504-1517
    • Loftus Jr., E.V.1
  • 4
    • 77949867613 scopus 로고    scopus 로고
    • Inflammatory bowel disease in korea: Epidemiological, genomic, clinical, and therapeutic characteristics
    • Kim ES and Kim WH: Inflammatory bowel disease in Korea: epidemiological, genomic, clinical, and therapeutic characteristics. Gut Liver 4: 1-14, 2010.
    • (2010) Gut Liver , vol.4 , pp. 1-14
    • Kim, E.S.1    Kim, W.H.2
  • 6
    • 33747777758 scopus 로고    scopus 로고
    • PPARgamma as a new therapeutic target in inflammatory bowel diseases
    • Dubuquoy L, Rousseaux C, Thuru X, et al: PPARgamma as a new therapeutic target in inflammatory bowel diseases. Gut 55: 1341-1349, 2006.
    • (2006) Gut , vol.55 , pp. 1341-1349
    • Dubuquoy, L.1    Rousseaux, C.2    Thuru, X.3
  • 7
    • 4444280899 scopus 로고    scopus 로고
    • Activation of ppar gamma and delta by conjugated linoleic acid mediates protection from experimental inflammatory bowel disease
    • Bassaganya-Riera J, Reynolds K, Martino-Catt S, et al: Activation of PPAR gamma and delta by conjugated linoleic acid mediates protection from experimental inflammatory bowel disease. Gastroenterology 127: 777-791, 2004.
    • (2004) Gastroenterology , vol.127 , pp. 777-791
    • Bassaganya-Riera, J.1    Reynolds, K.2    Martino-Catt, S.3
  • 8
    • 33846852961 scopus 로고    scopus 로고
    • A clinical trial of rosiglitazone and 5-aminosalicylate combination for ulcerative colitis
    • (In Chinese)
    • Liang HL and Ouyang Q: A clinical trial of rosiglitazone and 5-aminosalicylate combination for ulcerative colitis. Zhonghua Nei Ke Za Zhi 45: 548-551, 2006 (In Chinese).
    • (2006) Zhonghua Nei Ke Za Zhi , vol.45 , pp. 548-551
    • Liang, H.L.1    Ouyang, Q.2
  • 9
    • 80555143144 scopus 로고    scopus 로고
    • Activation of ppargamma and delta by dietary punicic acid ameliorates intestinal inflammation in mice
    • Bassaganya-Riera J, DiGuardo M, Climent M, et al: Activation of PPARgamma and delta by dietary punicic acid ameliorates intestinal inflammation in mice. Br J Nutr 106: 878-886, 2011.
    • (2011) Br J Nutr , vol.106 , pp. 878-886
    • Bassaganya-Riera, J.1    Diguardo, M.2    Climent, M.3
  • 10
    • 34547603895 scopus 로고    scopus 로고
    • PPARs and molecular mechanisms of transrepression
    • Ricote M and Glass CK: PPARs and molecular mechanisms of transrepression. Biochim Biophys Acta 1771: 926-935, 2007.
    • (2007) Biochim Biophys Acta , vol.1771 , pp. 926-935
    • Ricote, M.1    Glass, C.K.2
  • 11
    • 58749114381 scopus 로고    scopus 로고
    • New therapeutic aspects of flavones: The anticancer properties of scutellaria and its main active constituents wogonin, baicalein and baicalin
    • Li-Weber M: New therapeutic aspects of flavones: the anticancer properties of Scutellaria and its main active constituents Wogonin, Baicalein and Baicalin. Cancer Treat Rev 35: 57-68, 2009.
    • (2009) Cancer Treat Rev , vol.35 , pp. 57-68
    • Li-Weber, M.1
  • 12
    • 56549127848 scopus 로고    scopus 로고
    • Baicalein attenuates intimal hyperplasia after rat carotid balloon injury through arresting cell-cycle progression and inhibiting erk, akt, and nf-kappab activity in vascular smooth-muscle cells
    • Peng CY, Pan SL, Huang YW, Guh JH, Chang YL and Teng CM: Baicalein attenuates intimal hyperplasia after rat carotid balloon injury through arresting cell-cycle progression and inhibiting ERK, Akt, and NF-kappaB activity in vascular smooth-muscle cells. Naunyn Schmiedebergs Arch Pharmacol 378: 579-588, 2008.
    • (2008) Naunyn Schmiedebergs Arch Pharmacol , vol.378 , pp. 579-588
    • Peng, C.Y.1    Pan, S.L.2    Huang, Y.W.3    Guh, J.H.4    Chang, Y.L.5    Teng, C.M.6
  • 13
    • 79952667689 scopus 로고    scopus 로고
    • Modulation of nf-kappab and foxos by baicalein attenuates the radiation-induced inflammatory process in mouse kidney
    • Lee EK, Kim JM, Choi J, et al: Modulation of NF-kappaB and FOXOs by baicalein attenuates the radiation-induced inflammatory process in mouse kidney. Free Radic Res 45: 507-517, 2011.
    • (2011) Free Radic Res , vol.45 , pp. 507-517
    • Lee, E.K.1    Kim, J.M.2    Choi, J.3
  • 14
    • 77958570942 scopus 로고    scopus 로고
    • Inhibition of growth and induction of alkaline phosphatase in colon cancer cells by flavonols and flavonol glycosides
    • Lea MA, Ibeh C, Deutsch JK, Hamid I and desBordes C: Inhibition of growth and induction of alkaline phosphatase in colon cancer cells by flavonols and flavonol glycosides. Anticancer Res 30: 3629-3635, 2010.
    • (2010) Anticancer Res , vol.30 , pp. 3629-3635
    • Lea, M.A.1    Ibeh, C.2    Deutsch, J.K.3    Hamid, I.4    Desbordes, C.5
  • 15
    • 0036570319 scopus 로고    scopus 로고
    • Mechanisms controlling cell cycle arrest and induction of apoptosis after 12-lipoxygenase inhibition in prostate cancer cells
    • Pidgeon GP, Kandouz M, Meram A and Honn KV: Mechanisms controlling cell cycle arrest and induction of apoptosis after 12-lipoxygenase inhibition in prostate cancer cells. Cancer Res 62: 2721-2727, 2002.
    • (2002) Cancer Res , vol.62 , pp. 2721-2727
    • Pidgeon, G.P.1    Kandouz, M.2    Meram, A.3    Honn, K.V.4
  • 16
    • 36749022239 scopus 로고    scopus 로고
    • Baicalein induces cancer cell death and proliferation retardation by the inhibition of cdc2 kinase and survivin associated with opposite role of p38 mitogen-activated protein kinase and akt
    • Chao JI, Su WC and Liu HF: Baicalein induces cancer cell death and proliferation retardation by the inhibition of CDC2 kinase and survivin associated with opposite role of p38 mitogen-activated protein kinase and AKT. Mol Cancer Ther 6: 3039-3048, 2007.
    • (2007) Mol Cancer Ther , vol.6 , pp. 3039-3048
    • Chao, J.I.1    Su, W.C.2    Liu, H.F.3
  • 17
    • 38449116664 scopus 로고    scopus 로고
    • Baicalein inhibits il-1beta- and tnf-alpha-induced inflammatory cytokine production from human mast cells via regulation of the nf-kappab pathway
    • Hsieh CJ, Hall K, Ha T, Li C, Krishnaswamy G and Chi DS: Baicalein inhibits IL-1beta- and TNF-alpha-induced inflammatory cytokine production from human mast cells via regulation of the NF-kappaB pathway. Clin Mol Allergy 5: 5, 2007.
    • (2007) Clin Mol Allergy , vol.5 , pp. 5
    • Hsieh, C.J.1    Hall, K.2    Ha, T.3    Li, C.4    Krishnaswamy, G.5    Chi, D.S.6
  • 18
    • 79959364228 scopus 로고    scopus 로고
    • Baicalein, a component of scutellaria baicalensis, induces apoptosis by mcl-1 down-regulation in human pancreatic cancer cells
    • Takahashi H, Chen MC, Pham H, et al: Baicalein, a component of Scutellaria baicalensis, induces apoptosis by Mcl-1 down-regulation in human pancreatic cancer cells. Biochim Biophys Acta 1813: 1465-1474, 2011.
    • (2011) Biochim Biophys Acta , vol.1813 , pp. 1465-1474
    • Takahashi, H.1    Chen, M.C.2    Pham, H.3
  • 19
    • 20144387818 scopus 로고    scopus 로고
    • Baicalein, a component of scutellaria radix from huang-lian-jie-du-tang (hljdt), leads to suppression of proliferation and induction of apoptosis in human myeloma cells
    • Ma Z, Otsuyama K, Liu S, et al: Baicalein, a component of Scutellaria radix from Huang-Lian-Jie-Du-Tang (HLJDT), leads to suppression of proliferation and induction of apoptosis in human myeloma cells. Blood 105: 3312-3318, 2005.
    • (2005) Blood , vol.105 , pp. 3312-3318
    • Ma, Z.1    Otsuyama, K.2    Liu, S.3
  • 20
    • 43049090780 scopus 로고    scopus 로고
    • Role of p53, puma, and bax in wogonin-induced apoptosis in human cancer cells
    • Lee DH, Kim C, Zhang L and Lee YJ: Role of p53, PUMA, and Bax in wogonin-induced apoptosis in human cancer cells. Biochem Pharmacol 75: 2020-2033, 2008.
    • (2008) Biochem Pharmacol , vol.75 , pp. 2020-2033
    • Lee, D.H.1    Kim, C.2    Zhang, L.3    Lee, Y.J.4
  • 21
    • 84871585110 scopus 로고    scopus 로고
    • Baicalein induces apoptosis in esophageal squamous cell carcinoma cells through modulation of the pi3k/akt pathway
    • Zhang HB, Lu P, Guo QY, Zhang ZH and Meng XY: Baicalein induces apoptosis in esophageal squamous cell carcinoma cells through modulation of the PI3K/Akt pathway. Oncol Lett 5: 722-728, 2013.
    • (2013) Oncol Lett , vol.5 , pp. 722-728
    • Zhang, H.B.1    Lu, P.2    Guo, Q.Y.3    Zhang, Z.H.4    Meng, X.Y.5
  • 22
    • 84872386900 scopus 로고    scopus 로고
    • Effects of baicalein on apoptosis, cell cycle arrest, migration and invasion of osteosarcoma cells
    • Zhang Y, Song L, Cai L, Wei R, Hu H and Jin W: Effects of baicalein on apoptosis, cell cycle arrest, migration and invasion of osteosarcoma cells. Food Chem Toxicol 53: 325-333, 2013.
    • (2013) Food Chem Toxicol , vol.53 , pp. 325-333
    • Zhang, Y.1    Song, L.2    Cai, L.3    Wei, R.4    Hu, H.5    Jin, W.6
  • 23
    • 18844437520 scopus 로고    scopus 로고
    • Characterization of chemical constituents in scutellaria baicalensis with antiandrogenic and growth-inhibitory activities toward prostate carcinoma
    • Bonham M, Posakony J, Coleman I, Montgomery B, Simon J and Nelson PS: Characterization of chemical constituents in Scutellaria baicalensis with antiandrogenic and growth-inhibitory activities toward prostate carcinoma. Clin Cancer Res 11: 3905-3914, 2005.
    • (2005) Clin Cancer Res , vol.11 , pp. 3905-3914
    • Bonham, M.1    Posakony, J.2    Coleman, I.3    Montgomery, B.4    Simon, J.5    Nelson, P.S.6
  • 24
    • 38549123294 scopus 로고    scopus 로고
    • Therapeutic potential of aif-mediated caspase-independent programmed cell death
    • Lorenzo HK and Susin SA: Therapeutic potential of AIF-mediated caspase-independent programmed cell death. Drug Resist Updat 10: 235-255, 2007.
    • (2007) Drug Resist Updat , vol.10 , pp. 235-255
    • Lorenzo, H.K.1    Susin, S.A.2
  • 25
    • 54049158576 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor ligand mcc-555 suppresses intestinal polyps in apcmin/+ mice via extracellular signal-regulated kinase and peroxisome proliferator-activated receptor-dependent pathways
    • Yamaguchi K, Cekanova M, McEntee MF, et al: Peroxisome proliferator-activated receptor ligand MCC-555 suppresses intestinal polyps in ApcMin/+ mice via extracellular signal-regulated kinase and peroxisome proliferator-activated receptor-dependent pathways. Mol Cancer Ther 7: 2779-2787, 2008.
    • (2008) Mol Cancer Ther , vol.7 , pp. 2779-2787
    • Yamaguchi, K.1    Cekanova, M.2    McEntee, M.F.3
  • 26
    • 46049085866 scopus 로고    scopus 로고
    • NF-kappa b and nrf2 as potential chemopreventive targets of some anti-inflammatory and antioxidative phytonutrients with anti-inflammatory and antioxidative activities
    • Surh YJ: NF-kappa B and Nrf2 as potential chemopreventive targets of some anti-inflammatory and antioxidative phytonutrients with anti-inflammatory and antioxidative activities. Asia Pac J Clin Nutr 17 (Suppl 1): 269-272, 2008.
    • (2008) Asia Pac J Clin Nutr , vol.17 , Issue.SUPPL. 1 , pp. 269-272
    • Surh, Y.J.1
  • 27
    • 43949145241 scopus 로고    scopus 로고
    • Chemoprevention by white currant is mediated by the reduction of nuclear beta-catenin and nf-kappab levels in min mice adenomas
    • Rajakangas J, Misikangas M, Paivarinta E and Mutanen M: Chemoprevention by white currant is mediated by the reduction of nuclear beta-catenin and NF-kappaB levels in Min mice adenomas. Eur J Nutr 47: 115-122, 2008.
    • (2008) Eur J Nutr , vol.47 , pp. 115-122
    • Rajakangas, J.1    Misikangas, M.2    Paivarinta, E.3    Mutanen, M.4
  • 28
    • 80052376690 scopus 로고    scopus 로고
    • Baicalein inhibits the migration and invasive properties of human hepatoma cells
    • Chiu YW, Lin TH, Huang WS, et al: Baicalein inhibits the migration and invasive properties of human hepatoma cells. Toxicol Appl Pharmacol 255: 316-326, 2011.
    • (2011) Toxicol Appl Pharmacol , vol.255 , pp. 316-326
    • Chiu, Y.W.1    Lin, T.H.2    Huang, W.S.3
  • 29
    • 77957356424 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gamma 2 mutation may cause a subset of ulcerative colitis
    • Aoyagi Y, Nagata S, Kudo T, et al: Peroxisome proliferator-activated receptor gamma 2 mutation may cause a subset of ulcerative colitis. Pediatr Int 52: 729-734, 2010.
    • (2010) Pediatr Int , vol.52 , pp. 729-734
    • Aoyagi, Y.1    Nagata, S.2    Kudo, T.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.