Modulation of NF-κB and FOXOs by baicalein attenuates the radiation-induced inflammatory process in mouse kidney

Free Radical Research

Volumn 45, Issue 5, 2011, Pages 507-517

  Lee, Eun Kyeong ^a,b   Kim, Ji Min ^a   Choi, Jehun ^a   Jung, Kyung Jin ^c   Kim, Dae Hyun ^a   Chung, Sang Woon ^a   Ha, Young Mi ^a   Yu, Byung Pal ^d   Chung, Hae Young ^a  

^a Pusan National University   (South Korea)

^b Dongnam Institute of Radiological and Medical Science   (South Korea)

^c Korea Institute of Toxicology   (South Korea)

^d UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

Author keywords

Baicalein; FOXOs; inflammation; ionizing radiation; NF B

Indexed keywords

BAICALEIN; CYCLOOXYGENASE 2; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; SUPEROXIDE DISMUTASE; TRANSCRIPTION FACTOR FOXO; VASCULAR CELL ADHESION MOLECULE 1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME INACTIVATION; INFLAMMATION; IRRADIATION; KIDNEY FUNCTION; MALE; MOUSE; NEPHRITIS; NONHUMAN; RADIATION DOSE; UPREGULATION;

ANIMALS; ANTIOXIDANTS; CATALASE; CREATININE; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FLAVANONES; FORKHEAD TRANSCRIPTION FACTORS; GLUTATHIONE; INFLAMMATION; KIDNEY; LIPID PEROXIDATION; MICE; MICE, INBRED C57BL; NEPHRITIS; NF-KAPPA B; ONCOGENE PROTEIN V-AKT; OXIDATION-REDUCTION; PHOSPHORYLATION; RADIATION INJURIES, EXPERIMENTAL; RADIATION-PROTECTIVE AGENTS; SIGNAL TRANSDUCTION; SUPEROXIDE DISMUTASE; UREA; X-RAYS;

MUS;

EID: 79952667689     PISSN: 10715762     EISSN: 10292470     Source Type: Journal    
DOI: 10.3109/10715762.2011.555479     Document Type: Article

References (47)

1. Myint AS. The role of radiotherapy in the palliative treatment of gastrointestinal cancer. Eur J Gastroenterol Hepatol 2000;12:381-390. (Pubitemid 30218941)
2. Wideł M, Przybyszewski W, Rzeszowska-Wolny J. Radiation-induced bystander effect: the important part of ionizing radiation response. Potential clinical implications. Postepy Hig Med Dosw 2009;63:377-388.
3. Hosseinimehr SJ. Trends in the development of radioprotective agents. Drug Discov Today 2007;12:794-805. (Pubitemid 47539965)
4. Robbins ME, Zhao W, Davis CS, Toyokuni S, Bonsib SM. Radiation-induced kidney injury: a role for chronic oxidative stress? Micron 2002;33:133-141.
5. Huang WH, Lee AR, Chien PY, Chou TC. Synthesis of baicalein derivatives as potential anti-aggregatory and anti-inflammatory agents. J Pharm Pharmacol 2005;57:219-225.
6. Hwang JM, Tseng TH, Tsai YY, Lee HJ. Protective effects of baicalein on tert-butyl hydroperoxide-induced hepatic toxicity in rat hepatocytes. J Biomed Sci 2005;12:389-397.
7. Peng CY, Pan SL, Huang YW, Guh JH. Baicalein attenuates intimal hyperplasia after rat carotid balloon injury through arresting cell-cycle progression and inhibiting ERK, Akt, and NF-kappaB activity in vascular smooth-muscle cells. Naunyn Schmiedebergs Arch Pharmacol 2008;378:579-588.
8. Xiping Z, Jie Z, Qin X, Guanghua F. Influence of baicalin and octreotide on NF-kappaB and p-selectin expression in liver and kidney of rats with severe acute pancreatitis. Inflammation 2009;32:1-11.
9. Tilak JC, Devasagayam TPA. Radioprotective property of baicalein. BARC Newsletter 2003;249:98-104.
10. Mikkelsen RB, Wardman P. Biological chemistry of reactive oxygen and nitrogen and radiation-induced signal transduction mechanisms. Oncogene 2003;22:5734-5754. (Pubitemid 37176697)
11. Ha YM, Chung SW, Kim JM, Kim DH. Molecular activation of NF-kappaB, pro-inflammatory mediators, and signal pathways in gamma-irradiated mice. Biotechnol Lett 2010;32:373-378.
12. Hallahan DE. Radiation-mediated gene expression in the pathogenesis of the clinical radiation response. Semin Radiat Oncol 1996;6:250-267. (Pubitemid 26367392)
13. Quarmby S, Kumar P, Kumar S. Radiation-induced normal tissue injury: role of adhesion molecules in leukocyte-endothelial cell interactions. Int J Cancer 1999;82:385-395. (Pubitemid 29302980)
14. Nozaki Y, Hasegawa Y, Takeuchi A, Fan ZH, Isobe KI, Nakashima I, Shimokata K. Nitric oxide as an inflammatory mediator of radiation pneumonitis in rats. Am J Physiol 1997;272:L651-L658.
15. Liang L, Hu D, Liu W, Williams JP, Okunieff P, Ding I. Celecoxib reduces skin damage after radiation: selective reduction of chemokine and receptor mRNA expression in irradiated skin but not in irradiated mammary tumor. Am J Clin Oncol 2003;26:114-121.
16. von Holzen U, Pataer A, Raju U, Bocangel D. The double-stranded RNA-activated protein kinase mediates radiation resistance in mouse embryo fibroblasts through nuclear factor kappaB and Akt activation. Clin Cancer Res 2007;13:6032-6039. (Pubitemid 350075059)
17. Wang YY, Chen SM, Li H. Hydrogen peroxide stress stimulates phosphorylation of FoxO1 in rat aortic endothelial cells. Acta Pharmacol Sin 2010;31:160-164.
18. Huang H, Tindall DJ. Dynamic FoxO transcription factors. J Cell Sci 2007;120:2479-2487. (Pubitemid 47323857)
19. Marinkovic D, Zhang X, Yalcin S, Luciano JP. Foxo3 is required for the regulation of oxidative stress in erythropoiesis. J Clin Invest 2007;117:2133-2144. (Pubitemid 47219558)
20. Calnan DR, Brunet A. The FoxO code. Oncogene 2008;27:2276-2288. (Pubitemid 351501779)
21. Zhou W, Cao Q, Peng Y, Zhang QJ. FoxO4 inhibits NF-κB and protects mice against colonic injury and inflammation. Gastroenterology 2009;137:1403-1414.
22. Lin L, Hron JD, Peng SL. Regulation of NF-κB, Th activation, and autoinflammation by the Forkhead Transcription Factor Foxo3a. Immunity 2004;21:203-213.
23. Hissin PJ, Hilf R. A fluorometric method for determination of oxidized and reduced glutathione in tissues. Anal Biochem 1976;74:214-226.
24. Aebi H. Catalase i n vitro methods. Enzymology 1984;105:121-126.
25. McCord JM, Fridovich I. Superoxide dismutase. An enzymatic function for erythrocuprein (hemocuperin). J Biol Chem 1969;244:6049-6055.
26. El-Missiry MA, Fayed TA, El-Sawy MR, El-Sayed AA. Ameliorative effect of melatonin against gamma-irradiation-induced oxidative stress and tissue injury. Ecotoxicol Environ Saf 2007;66:278-286. (Pubitemid 44822626)
27. Zhong H, Voll RE, Ghos SH. Phosphorylation of NF-κB p65 by PKA stimulates transcriptional activity by promoting a novel bivalent interaction with the coactivator CBP/p300. Mol Cell 1998;1:661-671. (Pubitemid 128379244)
28. Sakurai H, Chiba H, Miyoshi H, Sugita T, Oriumi WT. IκB kinases phosphorylate NF-κB p65 subunit on serine 536 in the transactivation domain. J Biol Chem 1999;276:30353-30356.
29. Viatour P, Merville MP, Bours V, Chariot A. Phosphorylation of NF-kB and IkB proteins: implications in cancer and inflammation. Trends Biochem Sci 2005;30:43-52. (Pubitemid 40093740)
30. Chen LF, Greene WC. Shaping the nuclear action of NF-κB. Nat Rev Mol Cell Biol 2004;5:392-401.
31. Brunet A, Bonni A, Zigmond MJ, Lin MZ, Juo P, Hu LS, Anderson MJ, Arden KC, Blenis J, Greenberg ME. Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell 1999;96:857-868. (Pubitemid 29165088)
32. Tothova Z, Kollipara R, Huntly BJ, Lee BH. FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress. Cell 2007;128:325-339. (Pubitemid 46137992)
33. Kampkötter A, Gombitang Nkwonkam C, Zurawski RF, Timpel C. Effects of the flavonoids kaempferol and fisetin on thermotolerance, oxidative stress and FoxO transcription factor DAF-16 in the model organism Caenorhabditis elegans. Arch Toxicol 2007;81:849-858. (Pubitemid 350198004)
34. Ganjam GK, Dimova EY, Unterman TG, Kietzmann T. FoxO1 and HNF-4 are involved in regulation of hepatic glucokinase gene expression by resveratrol. J Biol Chem 2009;284:30783-3097.
35. Okuno Y, Matsuda M, Miyata Y, Fukuhara A, Komuro R, Shimabukuro M, Shimomura I. Human catalase gene is regulated by peroxisome proliferator activated receptor-gamma through a response element distinct from that of mouse. Endocr J 2010;57:303-309.
36. Dreger H, Westphal K, Weller A, Baumann G, Stangl V, Meiners S, Stangl K. Nrf2-dependent upregulation of antioxidative enzymes: a novel pathway for proteasome inhibitor-mediated cardioprotection. Cardiovasc Res 2009;83:354-361.
37. Han Y, Son SJ, Akhalaia M, Platonov A. Modulation of radiation-induced disturbances of antioxidant defense systems by ginsan. Evid Based Complement Alternat Med 2005;2:529-536. (Pubitemid 41752490)
38. Harris CA, Derbin KS, Hunte-McDonough B, Krauss MR, Chen KT, Smith DM, Epstein LB. Manganese superoxide dismutase is induced by IFN-gamma in multiple cell types. Synergistic induction by IFN-gamma and tumor necrosis factor or IL-1. J Immunol 1991;147:149-154.
39. Visner GA, Dougall WC, Wilson JM, Burr IA, Nick HS. Regulation of manganese superoxide dismutase by lipopolysaccharide, interleukin-1, and tumor necrosis factor. Role in the acute inflammatory response. J Biol Chem 1990;265:2856-2864.
40. Lands WE, Inoue M, Sugiura Y, Okuyama H. Selective incorporation of polyunsaturated fatty acids into phosphatidylcholine by rat liver microsomes. J Biol Chem 1982;257:14968-1472.
41. Gao Z, Huang K, Yang X, Xu H. Free radical scavenging and antioxidant activities of flavonoids extracted from the radix of Scutellaria baicalensis Georgi. Biochim Biophys Acta 1999;1472:643-650. (Pubitemid 29516652)
42. Jin G, Arai K, Murata Y, Wang S, Stins MF, Lo EH, van Leyen K. Protecting against cerebrovascular injury: contributions of 12/15-lipoxygenase to edema formation after transient focal ischemia. Stroke 2008;39:2538-2543.
43. Panés J, Mollà M, Casadevall M, Salas A, Sans M, Conill C, Anderson DC, Roselló-Catafau J, Granger DN, Piqué JM. Tepoxalin inhibits inflammation and microvascular dysfunction induced by abdominal irradiation in rats. Aliment Pharmacol Ther 2000;14:841-850. (Pubitemid 30352754)
44. Taniguchi H, Yoshida T, Horinaka M, Yasuda T, Goda AE, Konishi M, Wakada M, Kataoka K, Yoshikawa T, Sakai T. Baicalein overcomes tumor necrosis factor-related apoptosis-inducing ligand resistance via two different cell-specific pathways in cancer cells but not in normal cells. Cancer Res 2008;68:8918-8927.
45. Clément MV, Hirpara JL, Chawdhury SH, Pervaiz S. Chemopreventive agent resveratrol, a natural product derived from grapes, triggers CD95 signaling-dependent apoptosis in human tumor cells. Blood 1998;92:996-1002. (Pubitemid 28355484)
46. Hadi SM, Bhat SH, Azmi AS, Hanif S, Shamim U, Ullah MF. Oxidative breakage of cellular DNA by plant polyphenols: a putative mechanism for anticancer properties. Semin Cancer Biol 2007;17:370-376. (Pubitemid 47369169)
47. Ramadan LA, Shouman SA, Sayed-Ahmed MM, El-Habit OH. Modulation of radiation-induced organs toxicity by cremophorel in experimental animals. Pharmacol Res 2001;43:185-191. (Pubitemid 32601449)