Development of a lipid particle for β-carotene encapsulation using a blend of tristearin and sunflower oil: Choice of lipid matrix and evaluation of shelf life of dispersions

Food Technology and Biotechnology

Volumn 51, Issue 3, 2013, Pages 383-391

  Gomes, Graziela V L ^a   Simplício, Izabella A S ^a   Souto, Eliana B ^b,c   Cardoso, Lisandro P ^d   Pinho, Samantha C ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b UNIVERSIDADE FERNANDO PESSOA   (Portugal)

^c UNIVERSITY OF TRÁS OS MONTES AND ALTO DOURO   (Portugal)

^d UNIVERSITY OF CAMPINAS   (Brazil)

Author keywords

carotene; Encapsulation; Solid lipid particles

Indexed keywords

AVERAGE PARTICLE SIZE; COLLOIDAL CARRIERS; CRYSTALLINITIES; LIPID PARTICLES; MICROSTRUCTURAL ALTERATIONS; PHARMACEUTICAL FIELDS; THERMAL BEHAVIOURS; WIDE ANGLE XRAY DIFFRACTION;

BIOCHEMISTRY; DIFFERENTIAL SCANNING CALORIMETRY; DISPERSIONS; ENCAPSULATION; MIXTURES; X RAY DIFFRACTION;

OILS AND FATS;

EID: 84885024451     PISSN: 13309862     EISSN: 13342606     Source Type: Journal    
DOI: None     Document Type: Article

References (44)

1. J. Parada, J.M. Aguilera, Food microstructure affects the bioavailability of several nutrients, J. Food Sci. 72 (2007) R21-R32.
2. S.J. Hur, B.O. Lim, E.A. Decker, D.J. McClements, In vitro human digestion models for food applications, Food Chem. 125 (2011) 1-12.
3. C.J.H. Porter, C.W. Pouton, J.F. Cuine, W.N. Charman, Enhancing intestinal drug solubilization using lipid-based delivery systems, Adv. Drug Deliv. Rev. 60 (2008) 673-691.
4. W.N. Charman, Lipids, lipophilic drugs, and oral drug delivery - Some emerging concepts, J. Pharm. Sci. 89 (2000) 967-978.
5. P.D. Fraser, P.M. Bramley, The biosynthesis and nutritional uses of carotenoids, Prog. Lipid Res. 43 (2004) 228-265.
6. W. Stahl, H. Sies: Carotenoids: Occurrence, Biochemical Activities and Bioavailability. In: Antioxidant Food Suplements in Human Health, L. Packer, M. Hiramatsu, T. Yoshikawa (Eds.), Academic Press, San Diego, CA, USA (1999) pp. 183-198.
7. D.J. McClements, Design of nano-laminated coatings to control bioavailability of lipophilic food components, J. Food Sci. 75 (2010) 30-42.
8. D.J. McClements, Y. Li, Structured emulsion-based delivery systems: Controlling the digestion and release of lipophilic food components, Adv. Coll. Interface Sci. 159 (2010) 213-228.
9. A.M. Nik, S. Langmaid, A.J. Wright, Nonionic surfactant and interfacial structure impact crystallinity and stability of b-carotene loaded lipid nanodispersions, J. Agric. Food Chem. 60 (2012) 4126-4135.
10. H.D. Silva, M.A. Cerqueira, B.W.S. Souza, C. Ribeiro, M.C. Avides, M.A.C. Quintas et al., Nanoemulsions of b-carotene using a high energy emulsification-evaporation technique, J. Food Eng. 102 (2011) 130-135.
11. L. Cornacchia, Y.H. Roos, Stability of b-carotene in protein- stabilised oil-in-water delivery systems, J. Agric. Food Chem. 59 (2011) 7013-7020.
12. A.M. Nik, M. Corredig, A.J. Wright, Release of lipophilic molecules during in vitro digestion of soy protein-stabilized emulsions. Mol. Nutr. Food Res. (Suppl. 2), 55 (2011) 278-289.
13. L. Mao, D. Xu, J. Yang, F. Yuan, Y. Gao, Effects of homogenization models and emulsifiers on the physicochemical properties of b-carotene nanoemulsions, J. Disp. Sci. Technol. 31 (2010) 986-993.
14. L. Mao, D. Xu, J. Yang, F. Yuan, Y. Gao, J. Zhao, Effects of small and large molecule emulsifiers on the characteristics of b-carotene nanoemulsions prepared by high pressure homogenization, Food Technol. Biotechnol. 47 (2009) 336-342.
15. T. Helgason, T.S. Awad, K. Kristbergsson, E.A. Decker, D.J. McClements, J. Weiss, Impact of surfactant properties on oxidative stability of b-carotene encapsulated within solid lipid nanoparticles, J. Agric. Food Chem. 57 (2009) 8033-8040.
16. A. Hentschel, S. Gramdorf, R.H. Muller, T. Kurz, b-Carotene- loaded nanostructured lipid carriers, J. Food Sci. 73 (2008) 1-6.
17. Y. Yuan, Y. Gao, J. Zhao, L. Mao, Characterization and stability evaluation of b-carotene nanoemulsions produced by high pressure homogenization under various emulsifying conditions, Food Res. Int. 41 (2008) 61-68.
18. C.P. Tan, M. Nakajima, b-Carotene nanodispersions: Preparation, characterization and stability evaluation, Food Chem. 92 (2005) 661-671.
19. S.H. Jeong, J.H. Park, K. Park: Formulation Issues Around Lipid-Based Oral and Parenteral Delivery Systems. In: Role of Lipid Excipients in Modifying Oral and Parenteral Drug Delivery. Basic Principles and Biological Examples, K.M. Wasan (Ed.), Wiley-Interscience, Hoboken, NJ, USA (2007) pp. 32-47.
20. R.H. Müller, M. Radtke, S.A. Wissing, Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) in cosmetic and dermatological preparations, Adv. Drug Deliv. Rev. 54 (2002) S131-S155.
21. K.K. Sawant, S.S. Dodiya, Recent advances and patents on solid lipid nanoparticles, Rec. Pat. Drug Deliv. Formul. 2 (2008) 120-135.
22. R.H. Müller, K. Mäder, S. Gohla, Solid lipid nanoparticles (SLN) for controlled drug delivery: A review of the state of the art, Eur. J. Pharm. Biopharm. 50 (2000) 161-177.
23. W. Mehnert, K. Mäder, Solid lipid nanoparticles: Production, characterization and applications, Adv. Drug Del. Rev. 47 (2001) 165-169.
24. E.M.B. Souto, SLN and NLC for topical delivery of antifungals, PhD Thesis, Free University of Berlin, Berlin, Germany (2005) (in English).
25. K.R. Kuhn, R.L. Cunha, Flaxseed oil - Whey protein isolate emulsions: Effect of high pressure homogenization, J. Food Eng. 111 (2012) 449-457.
26. J. Weiss, E.A. Decker, D.J. McClements, K. Kristbergsson, T. Helgason, T. Awad, Solid lipid nanoparticles as delivery systems for bioactive food components, Food Biophys. 3 (2008) 146-154.
27. A.A. Attama, B.C. Schicke, C.C. Müller-Goymann, Further characterization of theobroma oil-beeswax admixtures as lipid matrices for improved drug delivery systems, Eur. J. Pharm. Biopharm. 64 (2006) 294-306.
28. A.A. Attama, C.C. Müller-Goymann, A critical study of novel physically structured lipid matrices composed of homolipid from Capra hircus and theobroma oil, Int. J. Pharm. 322 (2006) 67-78.
29. P. Severino, S.C. Pinho, E.B. Souto, M.H.A. Santana, Crystallinity of Dynasan 114® and Dynasan 118ä matrices for the production of stable Miglyol®-loaded nanoparticles, J. Therm. Anal. Calor. 108 (2012) 101-108.
30. P. Severino, S.C. Pinho, E.B. Souto, M.H.A. Santana, Polymorphism, crystallinity and hydrophilic-hydrophobic balance of stearic acid and stearic acid-capric/caprylic triglyceride matrices for production of stable nanoparticles, Coll. Surf. B: Biointerfaces, 86 (2011) 125-130.
31. T.A.B. Sanders, Fat and fatty acid intake and metabolic effects in the human body, Annals Nutr. Metab. 55 (2009) 162-172.
32. H.T. Osborn, C.C. Akoh, Structured lipids - Novel fats with medical, nutraceutical and food applications, Compreh. Rev. Food Sci. Food Safety, 1 (2002) 93-103.
33. H. Bunjes, M.H.J. Koch, Saturated phospholipids promote crystallization but slow down polymorphic transitions in trygliceride nanoparticles, J. Contr. Rel. 107 (2005) 229-243.
34. H. Bunjes, M.H.J. Koch, K. Westesen, Influence of emulsifiers on the crystallization of solid lipid nanoparticles, J. Pharm. Sci. 92 (2003) 1509-1520.
35. K. Westesen, B. Siekmann, Investigation of gel formation of phospholipid-stabilized solid lipid nanoparticles, Int. J. Pharm. 151 (1997) 35-45.
36. S.C. Cunha, M.B.P.P. Oliveira, Discrimination of vegetable oils by triacylglycerols evaluation of profile using HPLC/ELSD, Food Chem. 95 (2006) 518-524.
37. L.C. Hung, M. Basri, B.A. Tejo, R. Ismail, H.L.L. Nang, H.A. Hassan, C.Y. May, An improved method for the preparation of nanostructured lipid carriers containing heat-sensitive bioactives, Coll. Surf. B: Biointerfaces, 87 (2011) 180-186.
38. S. Trombino, R. Cassano, R. Muzzalupo, A. Pingitore, N. Picci, Stearyl ferulate-based solid lipid nanoparticles for the encapsulation and stabilization of β-carotene and a-tocopherol, Coll. Surf. B: Biointerfaces, 72 (2009) 181-187.
39. M.D. Triplett II, J.F. Rathman, Optimization of b-carotene loaded solid lipid nanoparticles preparation using a high shear homogenization technique, J. Nanopart. Res. 11 (2009) 601-614.
40. R.V. Tikekar, N. Nitin, Effect of physical state (solid vs. liquid) of lipid core on the rate of transport of oxygen and free radicals in solid lipid nanoparticles and emulsion, Soft Matter, 7 (2011) 8149-8157.
41. C. Hinawan, V.M. Starov, A.G.F. Stapley, Thermodynamic and kinetic aspects of fat crystallization, Adv. Coll. Interface Sci. 122 (2006) 3-33.
42. R.E. Timms, Phase behaviour of fats and their mixtures, Prog. Lip. Res. 23 (1984) 1-38.
43. H.M.D.N. Lida, K. Sundram, W.L. Siew, A. Aminah, S. Mamot, TAG composition and solid fat content of palm oil, sunflower oil, and palm kernel olein blends before and after chemical interesterification, J. Am. Oil Chem. Soc. 79 (2002) 1137-1144.
44. P.A. Yoshida, D. Yokota, M.A. Foglio, R.A.F. Rodrigues, S.C. Pinho, (Liposomes incorporating essential oil of Brazilian cherry (Eugenia uniflora L.): Characterization of aqueous dispersions and lyophilized formulations, J. Microencapsul. 27 (2010) 416-425.