메뉴 건너뛰기




Volumn 305, Issue 7, 2013, Pages

Protein C and acute inflammation: A clinical and biological perspective

Author keywords

ARDS; Histone; Protein C; Sepsis; Trauma

Indexed keywords

ACTIVATED PROTEIN C; ENZYME PRECURSOR; PROTEIN C;

EID: 84884933962     PISSN: 10400605     EISSN: 15221504     Source Type: Journal    
DOI: 10.1152/ajplung.00093.2013     Document Type: Article
Times cited : (60)

References (110)
  • 2
    • 80052395881 scopus 로고    scopus 로고
    • Extracellular histones increase plasma thrombin generation by impairing thrombomodulin-dependent protein C activation
    • Ammollo CT, Semeraro F, Xu J, Esmon NL, Esmon CT. Extracellular histones increase plasma thrombin generation by impairing thrombomodulin-dependent protein C activation. J Thromb Haemost 9: 1795-1803, 2011.
    • (2011) J Thromb Haemost , vol.9 , pp. 1795-1803
    • Ammollo, C.T.1    Semeraro, F.2    Xu, J.3    Esmon, N.L.4    Esmon, C.T.5
  • 6
    • 84555189890 scopus 로고    scopus 로고
    • Efficacy of therapy with recombinant human activated protein C of critically ill surgical patients with infection complicated by septic shock and multiple organ dysfunction syndrome
    • Barie PS, Hydo LJ, Shou J, Eachempati SR. Efficacy of therapy with recombinant human activated protein C of critically ill surgical patients with infection complicated by septic shock and multiple organ dysfunction syndrome. Surg Infect (Larchmt) 12: 443-449, 2011.
    • (2011) Surg Infect (Larchmt) , vol.12 , pp. 443-449
    • Barie, P.S.1    Hydo, L.J.2    Shou, J.3    Eachempati, S.R.4
  • 10
    • 33847361454 scopus 로고    scopus 로고
    • Use of Drotrecogin alfa (activated) in Italian intensive care units: The results of a nationwide survey
    • Bertolini G, Rossi C, Anghileri A, Livigni S, Addis A, Poole D. Use of Drotrecogin alfa (activated) in Italian intensive care units: the results of a nationwide survey. Intensive Care Med 33: 426-434, 2007.
    • (2007) Intensive Care Med , vol.33 , pp. 426-434
    • Bertolini, G.1    Rossi, C.2    Anghileri, A.3    Livigni, S.4    Addis, A.5    Poole, D.6
  • 13
    • 35848943443 scopus 로고    scopus 로고
    • Acute coagulopathy of trauma: Mechanism, identification and effect
    • Brohi K, Cohen MJ, Davenport RA. Acute coagulopathy of trauma: mechanism, identification and effect. Curr Opin Crit Care 13: 680-685, 2007.
    • (2007) Curr Opin Crit Care , vol.13 , pp. 680-685
    • Brohi, K.1    Cohen, M.J.2    Davenport, R.A.3
  • 16
    • 34247388903 scopus 로고    scopus 로고
    • Recombinant human activated protein C inhibits local and systemic activation of coagulation without influencing inflammation during Pseudomonas aeruginosa pneumonia in rats
    • Choi G, Hofstra JJ, Roelofs JJ, Florquin S, Bresser P, Levi M, van der Poll T, Schultz MJ. Recombinant human activated protein C inhibits local and systemic activation of coagulation without influencing inflammation during Pseudomonas aeruginosa pneumonia in rats. Crit Care Med 35: 1362-1368, 2007.
    • (2007) Crit Care Med , vol.35 , pp. 1362-1368
    • Choi, G.1    Hofstra, J.J.2    Roelofs, J.J.3    Florquin, S.4    Bresser, P.5    Levi, M.6    van der Poll, T.7    Schultz, M.J.8
  • 17
    • 84859802851 scopus 로고    scopus 로고
    • Tissue factor, blood coagulation, and beyond: An overview
    • Chu AJ. Tissue factor, blood coagulation, and beyond: an overview. Int J Inflam 2011: 367284, 2011.
    • (2011) Int J Inflam , vol.2011 , pp. 367284
    • Chu, A.J.1
  • 18
    • 84855826297 scopus 로고    scopus 로고
    • Critical role of activated protein C in early coagulopathy and later organ failure, infection and death in trauma patients
    • Cohen MJ, Call M, Nelson M, Calfee CS, Esmon CT, Brohi K, Pittet JF. Critical role of activated protein C in early coagulopathy and later organ failure, infection and death in trauma patients. Ann Surg 255: 379-385, 2012.
    • (2012) Ann Surg , vol.255 , pp. 379-385
    • Cohen, M.J.1    Call, M.2    Nelson, M.3    Calfee, C.S.4    Esmon, C.T.5    Brohi, K.6    Pittet, J.F.7
  • 19
    • 84872088511 scopus 로고    scopus 로고
    • Coagulation system changes associated with susceptibility to infection in trauma patients
    • discussion 57-58
    • Cole E, Davenport R, De'Ath H, Manson J, Brockamp T, Brohi K. Coagulation system changes associated with susceptibility to infection in trauma patients. J Trauma Acute Care Surg 74: 51-57; discussion 57-58, 2013.
    • (2013) J Trauma Acute Care Surg , vol.74 , pp. 51-57
    • Cole, E.1    Davenport, R.2    De'Ath, H.3    Manson, J.4    Brockamp, T.5    Brohi, K.6
  • 21
    • 0034648757 scopus 로고    scopus 로고
    • Thrombin signalling and protease-activated receptors
    • Coughlin SR. Thrombin signalling and protease-activated receptors. Nature 407: 258-264, 2000.
    • (2000) Nature , vol.407 , pp. 258-264
    • Coughlin, S.R.1
  • 24
    • 0038128677 scopus 로고    scopus 로고
    • Activation of protein C following infusion of protein C concentrate in children with severe meningococcal sepsis and purpura fulminans: A randomized, double-blinded, placebo-controlled, dose-finding study
    • de Kleijn ED, de Groot R, Hack CE, Mulder PG, Engl W, Moritz B, Joosten KF, Hazelzet JA. Activation of protein C following infusion of protein C concentrate in children with severe meningococcal sepsis and purpura fulminans: a randomized, double-blinded, placebo-controlled, dose-finding study. Crit Care Med 31: 1839-1847, 2003.
    • (2003) Crit Care Med , vol.31 , pp. 1839-1847
    • de Kleijn, E.D.1    de Groot, R.2    Hack, C.E.3    Mulder, P.G.4    Engl, W.5    Moritz, B.6    Joosten, K.F.7    Hazelzet, J.A.8
  • 28
    • 13444283302 scopus 로고    scopus 로고
    • Dynamic evolution of coagulopathy in the first day of severe sepsis: Relationship with mortality and organ failure
    • Dhainaut JF, Shorr AF, Macias WL, Kollef MJ, Levi M, Reinhart K, Nelson DR. Dynamic evolution of coagulopathy in the first day of severe sepsis: relationship with mortality and organ failure. Crit Care Med 33: 341-348, 2005.
    • (2005) Crit Care Med , vol.33 , pp. 341-348
    • Dhainaut, J.F.1    Shorr, A.F.2    Macias, W.L.3    Kollef, M.J.4    Levi, M.5    Reinhart, K.6    Nelson, D.R.7
  • 29
    • 77957663762 scopus 로고    scopus 로고
    • Nebulized heparin is associated with fewer days of mechanical ventilation in critically ill patients: A randomized controlled trial
    • Dixon B, Schultz MJ, Smith R, Fink JB, Santamaria JD, Campbell DJ. Nebulized heparin is associated with fewer days of mechanical ventilation in critically ill patients: a randomized controlled trial. Crit Care 14: R180, 2010.
    • (2010) Crit Care , vol.14
    • Dixon, B.1    Schultz, M.J.2    Smith, R.3    Fink, J.B.4    Santamaria, J.D.5    Campbell, D.J.6
  • 30
    • 33846654603 scopus 로고    scopus 로고
    • Timing of drotrecogin alfa (activated) initiation in treatment of severe sepsis: A database cohort study of hospital mortality, length of stay, and costs
    • Ernst FR, Johnston JA, Pulgar S, He J, Ball DE, Young JK, Cooper LM. Timing of drotrecogin alfa (activated) initiation in treatment of severe sepsis: a database cohort study of hospital mortality, length of stay, and costs. Curr Med Res Opin 23: 235-244, 2007.
    • (2007) Curr Med Res Opin , vol.23 , pp. 235-244
    • Ernst, F.R.1    Johnston, J.A.2    Pulgar, S.3    He, J.4    Ball, D.E.5    Young, J.K.6    Cooper, L.M.7
  • 31
    • 84874784306 scopus 로고    scopus 로고
    • Molecular circuits in thrombosis and inflammation
    • Esmon CT. Molecular circuits in thrombosis and inflammation. Thromb Haemost 109: 416-420, 2013.
    • (2013) Thromb Haemost , vol.109 , pp. 416-420
    • Esmon, C.T.1
  • 32
    • 0029119879 scopus 로고
    • An update on clinical and basic aspects of the protein C anticoagulant pathway
    • Esmon CT, Schwarz HP. An update on clinical and basic aspects of the protein C anticoagulant pathway. Trends Cardiovasc Med 5: 141-148, 1995.
    • (1995) Trends Cardiovasc Med , vol.5 , pp. 141-148
    • Esmon, C.T.1    Schwarz, H.P.2
  • 34
    • 20444443508 scopus 로고    scopus 로고
    • Activated protein C mediates novel lung endothelial barrier enhancement: Role of sphingosine 1-phosphate receptor transactivation
    • Finigan JH, Dudek SM, Singleton PA, Chiang ET, Jacobson JR, Camp SM, Ye SQ, Garcia JG. Activated protein C mediates novel lung endothelial barrier enhancement: role of sphingosine 1-phosphate receptor transactivation. J Biol Chem 280: 17286-17293, 2005.
    • (2005) J Biol Chem , vol.280 , pp. 17286-17293
    • Finigan, J.H.1    Dudek, S.M.2    Singleton, P.A.3    Chiang, E.T.4    Jacobson, J.R.5    Camp, S.M.6    Ye, S.Q.7    Garcia, J.G.8
  • 35
    • 0042167223 scopus 로고    scopus 로고
    • Combined antithrombin and protein C supplementation in meningococcal purpura fulminans: A pharmacokinetic study
    • Fourrier F, Leclerc F, Aidan K, Sadik A, Jourdain M, Tournoys A, Noizet O. Combined antithrombin and protein C supplementation in meningococcal purpura fulminans: a pharmacokinetic study. Intensive Care Med 29: 1081-1087, 2003.
    • (2003) Intensive Care Med , vol.29 , pp. 1081-1087
    • Fourrier, F.1    Leclerc, F.2    Aidan, K.3    Sadik, A.4    Jourdain, M.5    Tournoys, A.6    Noizet, O.7
  • 36
    • 0030053131 scopus 로고    scopus 로고
    • Time course of procoagulant activity and D dimer in bronchoalveolar fluid of patients at risk for or with acute respiratory distress syndrome
    • Fuchs-Buder T, de Moerloose P, Ricou B, Reber G, Vifian C, Nicod L, Romand JA, Suter PM. Time course of procoagulant activity and D dimer in bronchoalveolar fluid of patients at risk for or with acute respiratory distress syndrome. Am J Respir Crit Care Med 153: 163-167, 1996.
    • (1996) Am J Respir Crit Care Med , vol.153 , pp. 163-167
    • Fuchs-Buder, T.1    de Moerloose, P.2    Ricou, B.3    Reber, G.4    Vifian, C.5    Nicod, L.6    Romand, J.A.7    Suter, P.M.8
  • 37
    • 0034661942 scopus 로고    scopus 로고
    • The autolysis loop of activated protein C interacts with factor Va and differentiates between the Arg506 and Arg306 cleavage sites
    • Gale AJ, Heeb MJ, Griffin JH. The autolysis loop of activated protein C interacts with factor Va and differentiates between the Arg506 and Arg306 cleavage sites. Blood 96: 585-593, 2000.
    • (2000) Blood , vol.96 , pp. 585-593
    • Gale, A.J.1    Heeb, M.J.2    Griffin, J.H.3
  • 38
    • 4644240503 scopus 로고    scopus 로고
    • A protein C deficiency exacerbates inflammatory and hypotensive responses in mice during polymicrobial sepsis in a cecal ligation and puncture model
    • Ganopolsky JG, Castellino FJ. A protein C deficiency exacerbates inflammatory and hypotensive responses in mice during polymicrobial sepsis in a cecal ligation and puncture model. Am J Pathol 165: 1433-1446, 2004.
    • (2004) Am J Pathol , vol.165 , pp. 1433-1446
    • Ganopolsky, J.G.1    Castellino, F.J.2
  • 39
    • 59649104743 scopus 로고    scopus 로고
    • Adverse outcomes associated with the use of drotrecogin alfa (activated) in patients with severe sepsis and baseline bleeding precautions
    • Gentry CA, Gross KB, Sud B, Drevets DA. Adverse outcomes associated with the use of drotrecogin alfa (activated) in patients with severe sepsis and baseline bleeding precautions. Crit Care Med 37: 19-25, 2009.
    • (2009) Crit Care Med , vol.37 , pp. 19-25
    • Gentry, C.A.1    Gross, K.B.2    Sud, B.3    Drevets, D.A.4
  • 42
    • 84862906006 scopus 로고    scopus 로고
    • Protein C anticoagulant and cytoprotective pathways
    • Griffin JH, Zlokovic BV, Mosnier LO. Protein C anticoagulant and cytoprotective pathways. Int J Hematol 95: 333-345, 2012.
    • (2012) Int J Hematol , vol.95 , pp. 333-345
    • Griffin, J.H.1    Zlokovic, B.V.2    Mosnier, L.O.3
  • 46
    • 0027404562 scopus 로고
    • Binding of protein S to factor Va associated with inhibition of prothrombinase that is independent of activated protein C
    • Heeb MJ, Mesters RM, Tans G, Rosing J, Griffin JH. Binding of protein S to factor Va associated with inhibition of prothrombinase that is independent of activated protein C. J Biol Chem 268: 2872-2877, 1993.
    • (1993) J Biol Chem , vol.268 , pp. 2872-2877
    • Heeb, M.J.1    Mesters, R.M.2    Tans, G.3    Rosing, J.4    Griffin, J.H.5
  • 47
    • 30944442628 scopus 로고    scopus 로고
    • Drotrecogin alfa (activated) in sepsis: Initial experience with patient selection, cost, and clinical outcomes
    • Higgins TL, Steingrub JS, Tereso GJ, Tidswell MA, McGee WT. Drotrecogin alfa (activated) in sepsis: initial experience with patient selection, cost, and clinical outcomes. J Intensive Care Med 20: 339-345, 2005.
    • (2005) J Intensive Care Med , vol.20 , pp. 339-345
    • Higgins, T.L.1    Steingrub, J.S.2    Tereso, G.J.3    Tidswell, M.A.4    McGee, W.T.5
  • 53
    • 84865278685 scopus 로고    scopus 로고
    • Effectiveness and safety of drotrecogin alfa (activated) for severe sepsis: A meta-analysis and metaregression
    • Kalil AC, LaRosa SP. Effectiveness and safety of drotrecogin alfa (activated) for severe sepsis: a meta-analysis and metaregression. Lancet Infect Dis 12: 678-686, 2012.
    • (2012) Lancet Infect Dis , vol.12 , pp. 678-686
    • Kalil, A.C.1    LaRosa, S.P.2
  • 54
    • 33847422269 scopus 로고    scopus 로고
    • Evaluating the use of Drotrecogin alfa (activated) in adult severe sepsis: A Canadian multicenter observational study
    • Kanji S, Perreault MM, Chant C, Williamson D, Burry L. Evaluating the use of Drotrecogin alfa (activated) in adult severe sepsis: a Canadian multicenter observational study. Intensive Care Med 33: 517-523, 2007.
    • (2007) Intensive Care Med , vol.33 , pp. 517-523
    • Kanji, S.1    Perreault, M.M.2    Chant, C.3    Williamson, D.4    Burry, L.5
  • 57
    • 84871196677 scopus 로고    scopus 로고
    • Extracellular histone release in response to traumatic injury: Implications for a compensatory role of activated protein C
    • Kutcher ME, Xu J, Vilardi RF, Ho C, Esmon CT, Cohen MJ. Extracellular histone release in response to traumatic injury: implications for a compensatory role of activated protein C. J Trauma Acute Care Surg 73: 1389-1394, 2012.
    • (2012) J Trauma Acute Care Surg , vol.73 , pp. 1389-1394
    • Kutcher, M.E.1    Xu, J.2    Vilardi, R.F.3    Ho, C.4    Esmon, C.T.5    Cohen, M.J.6
  • 58
    • 0038115187 scopus 로고    scopus 로고
    • Aggravation of endotoxin-induced disseminated intravascular coagulation and cytokine activation in heterozygous protein-C-deficient mice
    • Levi M, Dorffler-Melly J, Reitsma P, Buller H, Florquin S, van der Poll T, Carmeliet P. Aggravation of endotoxin-induced disseminated intravascular coagulation and cytokine activation in heterozygous protein-C-deficient mice. Blood 101: 4823-4827, 2003.
    • (2003) Blood , vol.101 , pp. 4823-4827
    • Levi, M.1    Dorffler-Melly, J.2    Reitsma, P.3    Buller, H.4    Florquin, S.5    van der Poll, T.6    Carmeliet, P.7
  • 59
    • 2942545798 scopus 로고    scopus 로고
    • Bidirectional relation between inflammation and coagulation
    • Levi M, van der Poll T, Buller HR. Bidirectional relation between inflammation and coagulation. Circulation 109: 2698-2704, 2004.
    • (2004) Circulation , vol.109 , pp. 2698-2704
    • Levi, M.1    van der Poll, T.2    Buller, H.R.3
  • 63
    • 67949120336 scopus 로고    scopus 로고
    • The international PROGRESS registry of patients with severe sepsis: Drotrecogin alfa (activated) use and patient outcomes
    • Martin G, Brunkhorst FM, Janes JM, Reinhart K, Sundin DP, Garnett K, Beale R. The international PROGRESS registry of patients with severe sepsis: drotrecogin alfa (activated) use and patient outcomes. Crit Care 13: R103, 2009.
    • (2009) Crit Care , vol.13
    • Martin, G.1    Brunkhorst, F.M.2    Janes, J.M.3    Reinhart, K.4    Sundin, D.P.5    Garnett, K.6    Beale, R.7
  • 64
    • 17144403820 scopus 로고    scopus 로고
    • Activated protein C treatment: Experience about 23 patients in the operative period
    • Maurice A, Seguin P, Aguillon D, Chanavaz C, Malledant Y. [Activated protein C treatment: experience about 23 patients in the operative period]. Ann Fr Anesth Reanim 24: 343-346, 2005.
    • (2005) Ann Fr Anesth Reanim , vol.24 , pp. 343-346
    • Maurice, A.1    Seguin, P.2    Aguillon, D.3    Chanavaz, C.4    Malledant, Y.5
  • 65
    • 62549129433 scopus 로고    scopus 로고
    • Influence of nebulized unfractionated heparin and N-acetylcysteine in acute lung injury after smoke inhalation injury
    • Miller AC, Rivero A, Ziad S, Smith DJ, Elamin EM. Influence of nebulized unfractionated heparin and N-acetylcysteine in acute lung injury after smoke inhalation injury. J Burn Care Res 30: 249-256, 2009.
    • (2009) J Burn Care Res , vol.30 , pp. 249-256
    • Miller, A.C.1    Rivero, A.2    Ziad, S.3    Smith, D.J.4    Elamin, E.M.5
  • 66
  • 67
    • 34147119744 scopus 로고    scopus 로고
    • The cytoprotective protein C pathway
    • Mosnier LO, Zlokovic BV, Griffin JH. The cytoprotective protein C pathway. Blood 109: 3161-3172, 2007.
    • (2007) Blood , vol.109 , pp. 3161-3172
    • Mosnier, L.O.1    Zlokovic, B.V.2    Griffin, J.H.3
  • 68
    • 33847687731 scopus 로고    scopus 로고
    • Drotrecogin alfa (activated) in children with severe sepsis: A multicentre phase III randomised controlled trial
    • REsearching severe Sepsis and Organ dysfunction in children: a gLobal perspective (RESOLVE) study group
    • Nadel S, Goldstein B, Williams MD, Dalton H, Peters M, Macias WL, Abd-Allah SA, Levy H, Angle R, Wang D, Sundin DP, Giroir B; REsearching severe Sepsis and Organ dysfunction in children: a gLobal perspective (RESOLVE) study group. Drotrecogin alfa (activated) in children with severe sepsis: a multicentre phase III randomised controlled trial. Lancet 369: 836-843, 2007.
    • (2007) Lancet , vol.369 , pp. 836-843
    • Nadel, S.1    Goldstein, B.2    Williams, M.D.3    Dalton, H.4    Peters, M.5    Macias, W.L.6    Abd-Allah, S.A.7    Levy, H.8    Angle, R.9    Wang, D.10    Sundin, D.P.11    Giroir, B.12
  • 69
    • 70350129236 scopus 로고    scopus 로고
    • Protective mechanisms of activated protein C in severe inflammatory disorders
    • Neyrinck AP, Liu KD, Howard JP, Matthay MA. Protective mechanisms of activated protein C in severe inflammatory disorders. Br J Pharmacol 158: 1034-1047, 2009.
    • (2009) Br J Pharmacol , vol.158 , pp. 1034-1047
    • Neyrinck, A.P.1    Liu, K.D.2    Howard, J.P.3    Matthay, M.A.4
  • 73
    • 77953504483 scopus 로고    scopus 로고
    • Regulation of the protein C anticoagulant and antiinflammatory pathways
    • Rezaie AR. Regulation of the protein C anticoagulant and antiinflammatory pathways. Curr Med Chem 17: 2059-2069, 2010.
    • (2010) Curr Med Chem , vol.17 , pp. 2059-2069
    • Rezaie, A.R.1
  • 78
    • 0028958909 scopus 로고
    • Treatment of purpura fulminans in meningococcemia with protein C concentrate
    • Rivard GE, David M, Farrell C, Schwarz HP. Treatment of purpura fulminans in meningococcemia with protein C concentrate. J Pediatr 126: 646-652, 1995.
    • (1995) J Pediatr , vol.126 , pp. 646-652
    • Rivard, G.E.1    David, M.2    Farrell, C.3    Schwarz, H.P.4
  • 79
    • 33645774438 scopus 로고    scopus 로고
    • Intravenous administration of activated protein C in Pseudomonas-induced lung injury: Impact on lung fluid balance and the inflammatory response
    • Robriquet L, Collet F, Tournoys A, Prangere T, Neviere R, Fourrier F, Guery BP. Intravenous administration of activated protein C in Pseudomonas-induced lung injury: impact on lung fluid balance and the inflammatory response. Respir Res 7: 41, 2006.
    • (2006) Respir Res , vol.7 , pp. 41
    • Robriquet, L.1    Collet, F.2    Tournoys, A.3    Prangere, T.4    Neviere, R.5    Fourrier, F.6    Guery, B.P.7
  • 81
    • 44249085375 scopus 로고    scopus 로고
    • Drotrecogin alfa (activated): Real-life use and outcomes for the UK
    • Rowan KM, Welch CA, North E, Harrison DA. Drotrecogin alfa (activated): real-life use and outcomes for the UK. Crit Care 12: R58, 2008.
    • (2008) Crit Care , vol.12
    • Rowan, K.M.1    Welch, C.A.2    North, E.3    Harrison, D.A.4
  • 82
    • 65549087489 scopus 로고    scopus 로고
    • Caveolae are required for protease-selective signaling by protease-activated receptor-1
    • Russo A, Soh UJ, Paing MM, Arora P, Trejo J. Caveolae are required for protease-selective signaling by protease-activated receptor-1. Proc Natl Acad Sci USA 106: 6393-6397, 2009.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 6393-6397
    • Russo, A.1    Soh, U.J.2    Paing, M.M.3    Arora, P.4    Trejo, J.5
  • 86
    • 80051884192 scopus 로고    scopus 로고
    • Extracellular histones promote thrombin generation through platelet-dependent mechanisms: Involvement of platelet TLR2 and TLR4
    • Semeraro F, Ammollo CT, Morrissey JH, Dale GL, Friese P, Esmon NL, Esmon CT. Extracellular histones promote thrombin generation through platelet-dependent mechanisms: involvement of platelet TLR2 and TLR4. Blood 118: 1952-1961, 2011.
    • (2011) Blood , vol.118 , pp. 1952-1961
    • Semeraro, F.1    Ammollo, C.T.2    Morrissey, J.H.3    Dale, G.L.4    Friese, P.5    Esmon, N.L.6    Esmon, C.T.7
  • 89
    • 21644443327 scopus 로고    scopus 로고
    • Use of protein C concentrate in pediatric patients with sepsis
    • Silvani P, Camporesi A, Licari E, Wolfler A. Use of protein C concentrate in pediatric patients with sepsis. Minerva Anestesiol 71: 373-378, 2005.
    • (2005) Minerva Anestesiol , vol.71 , pp. 373-378
    • Silvani, P.1    Camporesi, A.2    Licari, E.3    Wolfler, A.4
  • 90
    • 33750979835 scopus 로고    scopus 로고
    • Inhalation of activated protein C inhibits endotoxin-induced pulmonary inflammation in mice independent of neutrophil recruitment
    • Slofstra SH, Groot AP, Maris NA, Reitsma PH, Cate HT, Spek CA. Inhalation of activated protein C inhibits endotoxin-induced pulmonary inflammation in mice independent of neutrophil recruitment. Br J Pharmacol 149: 740-746, 2006.
    • (2006) Br J Pharmacol , vol.149 , pp. 740-746
    • Slofstra, S.H.1    Groot, A.P.2    Maris, N.A.3    Reitsma, P.H.4    Cate, H.T.5    Spek, C.A.6
  • 91
    • 85080851973 scopus 로고    scopus 로고
    • Infectious purpura fulminans: Caution needed in the use of protein c
    • Smith OP, White B. Infectious purpura fulminans: caution needed in the use of protein c. Br J Haematol 106: 253-254, 1999.
    • (1999) Br J Haematol , vol.106 , pp. 253-254
    • Smith, O.P.1    White, B.2
  • 92
    • 84055182505 scopus 로고    scopus 로고
    • Activated protein C promotes protease-activated receptor-1 cytoprotective signaling through beta-arrestin and dishevelled-2 scaffolds
    • Soh UJ, Trejo J. Activated protein C promotes protease-activated receptor-1 cytoprotective signaling through beta-arrestin and dishevelled-2 scaffolds. Proc Natl Acad Sci USA 108: E1372-E1380, 2011.
    • (2011) Proc Natl Acad Sci USA , vol.108
    • Soh, U.J.1    Trejo, J.2
  • 94
    • 29244446219 scopus 로고    scopus 로고
    • The effects of supra-normal protein C levels on markers of coagulation, fibrinolysis and inflammation in a human model of endotoxemia
    • Spiel AO, Firbas C, Mayr FB, Leitner JM, Schmidt B, Knobl P, Varadi K, Jilma B. The effects of supra-normal protein C levels on markers of coagulation, fibrinolysis and inflammation in a human model of endotoxemia. Thromb Haemost 94: 1148-1155, 2005.
    • (2005) Thromb Haemost , vol.94 , pp. 1148-1155
    • Spiel, A.O.1    Firbas, C.2    Mayr, F.B.3    Leitner, J.M.4    Schmidt, B.5    Knobl, P.6    Varadi, K.7    Jilma, B.8
  • 97
    • 78649445694 scopus 로고    scopus 로고
    • A prospective, observational study of Xigris Use in the United States (XEUS)
    • XEUS Investigators
    • Steingrub JS, Cheatham ML, Woodward B, Wang HT, Effron MB; XEUS Investigators. A prospective, observational study of Xigris Use in the United States (XEUS). J Crit Care 25: 660. e9-16, 2010.
    • (2010) J Crit Care , vol.25
    • Steingrub, J.S.1    Cheatham, M.L.2    Woodward, B.3    Wang, H.T.4    Effron, M.B.5
  • 99
    • 77955685646 scopus 로고    scopus 로고
    • Human protein C concentrate in the treatment of purpura fulminans: A retrospective analysis of safety and outcome in 94 pediatric patients
    • Veldman A, Fischer D, Wong FY, Kreuz W, Sasse M, Eberspacher B, Mansmann U, Schosser R. Human protein C concentrate in the treatment of purpura fulminans: a retrospective analysis of safety and outcome in 94 pediatric patients. Crit Care 14: R156, 2010.
    • (2010) Crit Care , vol.14
    • Veldman, A.1    Fischer, D.2    Wong, F.Y.3    Kreuz, W.4    Sasse, M.5    Eberspacher, B.6    Mansmann, U.7    Schosser, R.8
  • 104
    • 0034548822 scopus 로고    scopus 로고
    • An open-label study of the role of adjuvant hemostatic support with protein C replacement therapy in purpura fulminans-associated meningococcemia
    • White B, Livingstone W, Murphy C, Hodgson A, Rafferty M, Smith OP. An open-label study of the role of adjuvant hemostatic support with protein C replacement therapy in purpura fulminans-associated meningococcemia. Blood 96: 3719-3724, 2000.
    • (2000) Blood , vol.96 , pp. 3719-3724
    • White, B.1    Livingstone, W.2    Murphy, C.3    Hodgson, A.4    Rafferty, M.5    Smith, O.P.6
  • 106
    • 0033525831 scopus 로고    scopus 로고
    • Reconstitution of the human endothelial cell protein C receptor with thrombomodulin in phosphatidylcholine vesicles enhances protein C activation
    • Xu J, Esmon NL, Esmon CT. Reconstitution of the human endothelial cell protein C receptor with thrombomodulin in phosphatidylcholine vesicles enhances protein C activation. J Biol Chem 274: 6704-6710, 1999.
    • (1999) J Biol Chem , vol.274 , pp. 6704-6710
    • Xu, J.1    Esmon, N.L.2    Esmon, C.T.3
  • 107
    • 65349138302 scopus 로고    scopus 로고
    • Endogenous activated protein C signaling is critical to protection of mice from lipopolysaccaride-induced septic shock
    • Xu J, Ji Y, Zhang X, Drake M, Esmon CT. Endogenous activated protein C signaling is critical to protection of mice from lipopolysaccaride-induced septic shock. J Thromb Haemost 7: 851-856, 2009.
    • (2009) J Thromb Haemost , vol.7 , pp. 851-856
    • Xu, J.1    Ji, Y.2    Zhang, X.3    Drake, M.4    Esmon, C.T.5
  • 109
    • 2942703851 scopus 로고    scopus 로고
    • Effect of factor V Leiden polymorphism in severe sepsis and on treatment with recombinant human activated protein C
    • Yan SB, Nelson DR. Effect of factor V Leiden polymorphism in severe sepsis and on treatment with recombinant human activated protein C. Crit Care Med 32: S239-S246, 2004.
    • (2004) Crit Care Med , vol.32
    • Yan, S.B.1    Nelson, D.R.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.