Comparison of dopamine and norepinephrine in the treatment of shock

New England Journal of Medicine

Volumn 362, Issue 9, 2010, Pages 779-789

  De Backer, Daniel ^a   Biston, Patrick ^d   Devriendt, Jacques ^b   Madl, Christian ^e   Chochrad, Didier ^c   Aldecoa, Cesar ^f   Brasseur, Alexandre ^a   Defrance, Pierre ^d   Gottignies, Philippe ^b   Vincent, Jean Louis ^a  

^a ERASME HOSPITAL   (Belgium)

^b BRUGMANN UNIVERSITY HOSPITAL   (Belgium)

^c Centre Hospitalier Etterbeek Ixelles   (Belgium)

^d Centre Hospitalier Universitaire de Charleroi   (Belgium)

^e MEDICAL UNIVERSITY OF VIENNA   (Austria)

^f HOSPITAL UNIVERSITARIO RÍO HORTEGA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ADRENALIN; DOBUTAMINE; DOPAMINE; DROTRECOGIN; HYDROCORTISONE; LACTIC ACID; NORADRENALIN; VASOPRESSIN; VASOCONSTRICTOR AGENT;

ADULT; AGED; APACHE; ARTERY OCCLUSION; ARTICLE; BLOOD PRESSURE; CARDIOGENIC SHOCK; CENTRAL VENOUS PRESSURE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG DOSE INCREASE; DRUG DOSE REDUCTION; DRUG WITHDRAWAL; FEMALE; HEART ARRHYTHMIA; HEART ATRIUM FIBRILLATION; HEART INDEX; HEART INFARCTION; HEART VENTRICLE FIBRILLATION; HEART VENTRICLE TACHYCARDIA; HUMAN; HYPOVOLEMIC SHOCK; INFECTION; MAJOR CLINICAL STUDY; MALE; MORTALITY; MULTICENTER STUDY; OXYGEN SATURATION; PRIORITY JOURNAL; PROGNOSIS; RANDOMIZED CONTROLLED TRIAL; SEPTIC SHOCK; SHOCK; SKIN DISEASE; SKIN ISCHEMIA; TREATMENT OUTCOME; CHEMICALLY INDUCED DISORDER; COMPARATIVE STUDY; FLUID THERAPY; INTENTION TO TREAT ANALYSIS; KAPLAN MEIER METHOD; MIDDLE AGED; MULTIMODALITY CANCER THERAPY;

AGED; ARRHYTHMIAS, CARDIAC; COMBINED MODALITY THERAPY; DOPAMINE; FEMALE; FLUID THERAPY; HUMANS; INTENTION TO TREAT ANALYSIS; KAPLAN-MEIERS ESTIMATE; MALE; MIDDLE AGED; NOREPINEPHRINE; SHOCK; VASOCONSTRICTOR AGENTS;

EID: 77649282276     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJMoa0907118     Document Type: Article

References (28)

1. Varpula M, Tallgren M, Saukkonen K, Voipio-Pulkki LM, Pettilä V. Hemodynamic variables related to outcome in septic shock. Intensive Care Med 2005;31:1066-71.
2. Marchick MR, Kline JA, Jones AE. The significance of non-sustained hypotension in emergency department patients with sepsis. Intensive Care Med 2009;35:1261-4.
3. Sakr Y, Reinhart K, Vincent JL, et al. Does dopamine administration in shock influence outcome? Results of the Sepsis Occurrence in Acutely Ill Patients (SOAP) Study. Crit Care Med 2006;34:589-97.
4. Bertorello AM, Sznajder JI. The dopamine paradox in lung and kidney epithelia: sharing the same target but operating different signaling networks. Am J Respir Cell Mol Biol 2005;33:432-7.
5. Van den Berghe G, de Zegher F. Anterior pituitary function during critical illness and dopamine treatment. Crit Care Med 1996;24:1580-90.
6. Task Force of the American College of Critical Care Medicine, Society of Critical Care Medicine. Practice parameters for hemodynamic support of sepsis in adult patients in sepsis. Crit Care Med 1999;27:639-60.
7. Antman EM, Anbe DT, Armstrong PW, et al. ACC/AHA guidelines for the management of patients with ST-elevation myocardial infarction: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee to Revise the 1999 Guidelines for the Management of Patients with Acute Myocardial Infarction). Circulation 2004; 110(9):e82-e292. [Errata, Circulation 2005; 111:2013-4, 2007;115(15):e411.]
8. Dellinger RP, Levy MM, Carlet JM, et al. Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008. Intensive Care Med 2008;34:17-60.
9. Martin C, Viviand X, Leone M, Thirion X. Effect of norepinephrine on the outcome of septic shock. Crit Care Med 2000;28:2758-65.
10. Boulain T, Runge I, Bercault N, Benzekri-Lefevre D, Wolf M, Fleury C. Dopamine therapy in septic shock: detrimental effect on survival? J Crit Care 2009;24:575-82.
11. Müllner M, Urbanek B, Havel C, Losert H, Waechter F, Gamper G. Vasopressors for shock. Cochrane Database Syst Rev 2004;3:CD003709.
12. Marik PE, Mohedin M. The contrasting effects of dopamine and norepinephrine on systemic and splanchnic oxygen utilization in hyperdynamic sepsis. JAMA 1994;272:1354-7.
13. De Backer D, Creteur J, Silva E, Vincent JL. Effects of dopamine, norepinephrine, and epinephrine on the splanchnic circulation in septic shock: which is best? Crit Care Med 2003;31:1659-67.
14. Wheeler AP, Bernard GR. Treating patients with severe sepsis. N Engl J Med 1999;340:207-14.
15. Beale RJ, Hollenberg SM, Vincent JL, Parrillo JE. Vasopressor and inotropic support in septic shock: an evidence-based review. Crit Care Med 2004;32:Suppl:S455-S465.
16. Annane D, Vignon P, Renault A, et al. Norepinephrine plus dobutamine versus epinephrine alone for management of septic shock: a randomised trial. Lancet 2007;370:676-84.
17. Garner JS, Jarvis WR, Emori TG, Horan TC, Hughes JM. CDC definitions for nosocomial infections, 1988. Am J Infect Control 1988;16:128-40.
18. Knaus WA, Draper EA, Wagner DP, Zimmerman JE. APACHE II: a severity of disease classification system. Crit Care Med 1985;13:818-29.
19. Vincent JL, Moreno R, Takala J, et al. The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure. Intensive Care Med 1996;22:707-10.
20. Whitehead J. The design and analysis of sequential clinical trials, rev. 2nd ed. New York: Wiley, 2000.
21. Levy B, Dusang B, Annane D, Gibot S, Bollaert PE. Cardiovascular response to dopamine and early prediction of outcome: a prospective multiple-center study. Crit Care Med 2005;33:2172-7.
22. Blanco J, Muriel-Bombín A, Sagredo V, et al. Incidence, organ dysfunction and mortality in severe sepsis: a Spanish multicentre study. Crit Care 2008;12:R158.
23. Annane D, Aegerter P, Jars-Guincestre MC, Guidet B. Current epidemiology of septic shock: the CUB-Réa Network. Am J Respir Crit Care Med 2003;168:165-72.
24. Annane D, Sebille V, Charpentier C, et al. Effect of treatment with low doses of hydrocortisone and fludrocortisone on mortality in patients with septic shock. JAMA 2002;288:862-71.
25. Póvoa PR, Carneiro AH, Ribeiro OS, Pereira AC. Influence of vasopressor agent in septic shock mortality: results from the Portuguese Community-Acquired Sepsis Study (SACiUCI study). Crit Care Med 2009;37:410-6.
26. Loeb HS, Winslow EB, Rahimtoola SH, Rosen KM, Gunnar RM. Acute hemodynamic effects of dopamine in patients with shock. Circulation 1971;44:163-73.
27. Winslow EJ, Loeb HS, Rahimtoola SH, Kamath S, Gunnar RM. Hemodynamic studies and results of therapy in 50 patients with bacteremic shock. Am J Med 1973;54:421-32.
28. Ungar A, Fumagalli S, Marini M, et al. Renal, but not systemic, hemodynamic effects of dopamine are influenced by the severity of congestive heart failure. Crit Care Med 2004;32:1125-9.