An overview of recent advances in designing orthopedic and craniofacial implants

Journal of Biomedical Materials Research - Part A

Volumn 101, Issue 11, 2013, Pages 3349-3364

  Mantripragada, Venkata P ^a   Lecka Czernik, Beata ^b   Ebraheim, Nabil A ^b   Jayasuriya, Ambalangodage C ^a,b  

^a The University of Toledo   (United States)

^b MEDICAL COLLEGE OF OHIO   (United States)

Author keywords

ceramics; craniofacial; implants; mechanical properties; metal alloys; orthopedic; polymers

Indexed keywords

BIOLOGICAL PROPERTIES; CERAMICS; CRANIOFACIAL; METAL ALLOYS; METALLIC IMPLANTS; NICKEL-FREE STAINLESS STEEL; NONOXIDE CERAMICS; WEAR AND CORROSION RESISTANCE;

ALLOYS; ALUMINA; BIOMATERIALS; CORROSION RESISTANCE; DENTAL PROSTHESES; MECHANICAL PROPERTIES; ORTHOPEDICS; POLYMERS; SILICON CARBIDE; SILICON NITRIDE;

BIOLOGICAL MATERIALS;

BIOMATERIAL; COBALT; MAGNESIUM; NIOBIUM; POLYMER; STAINLESS STEEL; TANTALUM; TITANIUM; ZIRCONIUM;

BIOCOMPATIBILITY; BONE IMPLANT; BONE REGENERATION; CERAMICS; COMPRESSIVE STRENGTH; CRANIOFACIAL IMPLANT; FRACTURE; FRACTURE FIXATION; HARDNESS; HIP ARTHROPLASTY; HUMAN; INTERNAL FIXATOR; INTRAMEDULLARY NAIL; JOINT PROSTHESIS; KNEE ARTHROPLASTY; KNEE IMPLANT; KNEE OSTEOARTHRITIS; METAL IMPLANTATION; ORTHOPEDIC IMPLANT; OSTEOSYNTHESIS; REVIEW; TENSILE STRENGTH; YOUNG MODULUS;

CERAMICS; CRANIOFACIAL; IMPLANTS; MECHANICAL PROPERTIES; METAL ALLOYS; ORTHOPEDIC; POLYMERS;

BIOCOMPATIBLE MATERIALS; FACE; HUMANS; ORTHOPEDICS; PROSTHESES AND IMPLANTS; PROSTHESIS DESIGN; SKULL;

EID: 84884905010     PISSN: 15493296     EISSN: 15524965     Source Type: Journal    
DOI: 10.1002/jbm.a.34605     Document Type: Review

References (200)

1. Hootman JM, Helmick CG, Brady TJ,. A Public Health Approach to Addressing Arthritis in Older Adults: The Most Common Cause of Disability. Am J Pub Health 2012; 102: 426-433.
2. Helmick C, Felson D, Lawrence R, Gabriel S,. Estimates of the prevalence of arthritis and other rhematic conditions in the United States. Arthritis Rheum 2008; 58: 15-25.
3. Lee J, Song J, Hootman JM, Semanik PA, Chang RW, Sharma L, Van Horn L, Bathon JM, Eaton CB, Hochberg MC, Jackson R, Kwoh CK, Mysiw WJ, Nevitt M, Dunlop DD,. Obesity and other modifiable factors for physical inactivity measured by accelerometer in adults with knee osteoarthritis. Arthritis Care Res (Hoboken) 2013; 65: 53-61.
4. Murphy L, Helmick CG,. The impact of osteoarthritis in the United States: A population-health perspective: A population-based review of the fourth most common cause of hospitalization in U.S. adults. Orthop Nurs 2012; 31: 85-91.
5. Kurtz S, Ong K, Lau E, Mowat F, Halpern M,. Projection of primary and revision hip and knee arthroplasty in the United States from 2005-2030. J Bone Joint Surg Am 2007; 89: 780-785.
6. Resnic FS, Normand ST,. Postmarketing surveillance of medical devices-filling in the gaps. N Engl J Med 2012; 366: 875-877.
7. Geetha M, Singh AK, Asokamani R, Gogia AK,. Ti based biomaterials, the ultimate choice for orthopaedic implants-A review. Prog Mat Sci 2009; 54: 397-425.
8. Paxton EW, Fumes O, Namba RS, Inacio MCS, Fenstad AM, Havelin LI,. Comparison of the Norwegian knee anthroplasty register and a United States anthroplasty registry. J Bone Joint Surg Am 2011; 93E: 20-30.
9. Mavrogenis AF, Dimitriou R, Parvizi J, Babis GC,. Biology of implant osseointegration. J Musculoskelet Neuronal Interact 2009; 9: 61-71.
10. Niinomi M,. Metallic biomaterials. J Artif Organs 2008; 11: 105-110.
11. Sakka S, Coulthard P,. Implant failure: Etiology and complications. Med Oral Patol Oral Cir Bucal 2011; 16: 42-44.
12. Hench LL,. Biomaterials. Science 1980; 208: 826-831.
13. Scholz MS, Blanchfield LD, Bloom LD, Coburn BH, Elkington M, Fuller JD, Gilbert ME, Muflahi SA, Pernice MF, Pae SI, Trevarthen JA, White SC, Weaver PM, Bond IP,. The use of composite materials in modern orthopedic medicine and prosthetic devices: A review. Compos Sci Technol 2011; 71: 1791-1803.
14. Taljanovic MS, Jones MD, Ruth JT, Benjamin JB, Sheppard JE, Hunter TB,. Joint arthroplasties and prostheses. Frac Fix Radio. 2003; 23: 1569-1590.
15. Ratner BD, Hoffman AS, Schoen FJ, Lemons JE,. Biomaterials science. An introduction to Materials in Medicine. California: Elsevier Academic Press; 2008. p 864.
16. Manivasagam G, Dhinasekaran D, Rajamanickam A,. biomedical implants: corrosion and its prevention-A review. Rec Pat Corros Sci 2010; 2: 40-54.
17. Amel-Farzad H, Peivandi MT, Yusof-Sani SMR,. In-body corrosion fatigue failure of a stainless steel orthopaedic implant with a rare collection of different damage mechanisms. Eng Fail Anal 2007; 14: 1205-1217.
18. Fini M, Aldini NN, Torricelli P, Giavaresi G, Borsari V, Lenger H,. A new austenitic stainless steel with negligible nickel content: An in vitro and in vivo comparative investigation. Biomaterials 2003; 24: 4929-4939.
19. Lin DJ, Chuang CC, Lin JHC, Lee JW, Ju CP, Yin HS,. Bone formation at the surface of low modulus Ti-7.5Mo implants in rabbit femur. Biomaterials 2007; 28: 2582-2589.
20. Müller R, Abke J, Schnell E, Macionczyk F, Gbureck U, Mehrl R,. Surface engineering of stainless steel materials by covalent collagen immobilization to improve implant biocompatibility. Biomaterials 2005; 26: 6962-6972.
21. Okazaki Y, Gotoh E,. Comparison of metal release from various metallic biomaterials in vitro. Biomaterials 2005; 26: 11-21.
22. Takemoto S, Hattori M, Yoshinari M, Kawada E, Oda Y,. Corrosion behavior and surface characterization of titanium in solution containing fluoride and albumin. Biomaterials 2005; 26: 829-837.
23. Begum Z, Poonguzhali A, Basu R, Sudha C, Shaikh H, Rao RVS,. Studies of the tensile and corrosion fatigue behaviour of austenitic stainless steels. Corros Sci 2011; 53: 1424-1432.
24. Walter MJ,. Stainless Steel for Medical: The high level of nitrogen in BioDur 108 stainless steel provides anhanced mechanical and physical properties for medical implants, Adv mater proc April 2006; 84-86.
25. Braic M, Balaceanu M, Braic V, Vladescu A, Pavelescu G, Albulescu M,. Synthesis and characterization of TiN, TiAIN and TiN/TiAIN biocompatible coatings. Surf Coat Technol. 2005; 200: 1014-1017.
26. Yamamoto A, Kohama Y, Kuroda D, Hanawa T,. Cytocompatibility evaluation of Ni-free stainless steel manufactured by nitrogen adsorption treatment. Mater Sci Eng C 2004; 24: 737-743.
27. Wang P, Ren Y, Zhang B, Yang K,. Effect of nitrogen on blood compatibility of nickel-free high nitrogen stainless steel for biomaterial. Mater Sci Eng C 2010; 30: 1183-1189.
28. Kang CK, Lee YS,. The surface modification of stainless steel and the correlation between the surface properties and protein adsorption. J Mater Sci: Mater in med 2007; 18: 1389-1398.
29. Zhang F, Kang ET, Neoh KG, Wang P, Tan KL,. Surface modification of stainless steel by grafting of poly(ethylene glycol) for reduction in protein adsorption. Biomaterials 2001; 22: 1541-1548.
30. Berry CW, Moore TJ, Safar JA, Henry CA, Wagner MJ,. Antibacterial activity of dental implant metals. Implant Dent 1992; 1: 59-65.
31. Dong Y, Li X, Sammons R, Dong H,. The generation of wear resistant antimicrobial stainless steel surface by active screen plasma alloying with N and nanocrytaslline Ag. J Biomed Mat Res 2010; 93: 185-193.
32. Van Der Borden AJ, Maathuis PG, Engels E, Rakhorst G, Van Der Mei HC, Busscher HJ, Sharma PK,. Prevention of pin tract infection in external stainless steel fixator frames using electric current in a goat model. Biomaterials 2007; 28: 2122-2126.
33. Lin CW, Ju CP, Lin JHC,. A comparison of the fatigue behavior of cast Ti-7.5Mo with c.p. titanium, Ti-6Al-4V and Ti-13Nb-13Zr alloys. Biomaterials 2005; 26: 2899-2907.
34. Long M, Rack HJ,. Titanium alloys in total joint replacement-A materials science perspective. Biomaterials 1998; 19: 1621-1639.
35. Samandari SS, Berndt CC, Gross KA,. Selection of the implant and coating materials for optimized performance by means of nanoindentation. Acta Biomater 2011; 7: 874-881.
36. Kamachi MU, Baldev R,. Corrosion science and technology: Mechanism, mitigation and monitoring. UK: Taylor & Francis. 2008; pp. 283-356.
37. Novikova GE,. Introduction to corrosion of bioimplants. Prot Met Phys Chem Surf. 2011; 47: 372-380.
38. Zhuang L, Langer EW,. Effects of alloy additions on the fatigue properties of cast Co-Cr-Mo alloy used for surgical implants. J Mater Sci 1990; 25: 683-689.
39. Song YC, Park C-H, Moriwaki T,. Mirror finishing of Co-Cr-Mo alloy using elliptical vibration cutting. Precis Eng 2010; 34: 784-789.
40. Williams DF,. Biocompatibility of Clinical Implant Materials. Michigan: CRC Press; 1981; p 288.
41. Navarro M, Michiardi A, Castano O, Planell JA,. Biomaterials in orthopaedics. J R Soc Interf 2008; 5: 1137-1158.
42. Antunes RA, Oliveira MC,. Corrosion fatigue of biomedical metallic alloys: Mechanisms and mitigation. Acta Biomaterialia 2012; 8: 937-962.
43. Anwar HA, Hart AJ, Visuvanathan S, Aldam CH,. The effects of the heavy metals from total hip replacement wear debris on bacterial growth? J Bone Joint Surg Br 2009; 91: 300.
44. Hosman AH, Mei HC, Bulstra SK, Kuijer R, Busscher HJ, Neut D,. Influence of Co-Cr particles and Co-Cr ions on the growth of staphylococcal biofilms. Int J Artif Organs 2011; 34: 759-765.
45. Lhotka C, Szekes T, Stefan I,. Four years study of cobalt and chromium blood levels in patients managed with two different metal-on-metal total hip replacement. J of Orthopedic Res 2003; 21: 189-195.
46. Keegan GM, Leatmonth ID, Case CP,. A systemic comparison of the actual potential and theoretical health effects of cobalt and chromium exposures from industry and surgical implants. Crit Rev Toxicol 2008; 38: 645-674.
47. McAfolaranmi GA, Tettey J, Meek RMD, Grant MH,. Release of chromium from orthopedic anthroplasties. The Open Ortho J 2008; 2: 10-18.
48. Polyzois I, Nikolopoulos D, Michos I, Patsouris E, Theocharis S,. Local and systemic toxicity of nanoscale debris particles in total hip anthroplasty. J Appl Toxicol 2012; 32: 255-269.
49. Mori M, Yamanaka K, Matsumoto H, Chiba A,. Evolution of cold-rolled microstructures of biomedical Co-Cr-Mo alloys with and without N doping. Mater Sci Eng A 2010; 528: 614-621.
50. Yamanaka K, Mori M, Chiba A,. Mechanical properties of as-forged Ni-free Co- 29Cr-6Mo alloys with ultrafine-grained microstructure. Mater Sci Eng A 2011; 528: 5961-5966.
51. Yamanaka K, Mori M, Kurosu S, Matsumoto H, Chiba A,. Ultrafine grain refinement of biomedical Co-29Cr-6Mo alloy during conventional hot-compression deformation. Metall Mater Trans A 2009; 40: 1980-1994.
52. Bhure R, Fattah TM, Bonner C, Hall F, Mahapatro A,. Stability of phosphonic self-assembled monolayers (SAMs) on cobalt chromium (Co-Cr) alloy under oxidative conditions. Appl Surf Sci 2011; 257: 5605-5612.
53. Poh CK, Shi Z, Tan XW, Liang ZC, Foo XM, Tan HC, Neoh KG, Wang W,. Cobalt chromium alloy with immobilized BMP peptide for enhanced bone growth. J Orthop Res 2011; 29: 1424-1430.
54. Levine BR, Sporer S, Poggie RA, Della Valle CJ, Jacobs JJ,. Experimental and clinical performance of porous tantalum in orthopedic surgery. Biomaterials 2006; 27: 4671-4681.
55. Navarro M, Michiardi A, Castano O, Planell JA,. Biomaterials in orthopaedics. J R Soc Inter 2008; 5: 1137-1158.
56. Palmquist A, Jarman T, Emanuelsson L, Branemark R, Engqvist H, Thomsen P,. Forearm bone-anchored amputation prosthesis: a case study on the osseointegration. Acta Orthop 2008; 79: 78-85.
57. Boyer RR,. An overview on the use of titanium in the aerospace industry. Mater Sci Eng A 1996; 213: 103-114.
58. Nag S, Sonia S, Anantha P, Rajarshi B,. Characterization of novel borides in Ti-Nb-Zr-Ta+ 2B metal-matrix composites. Mat charac 2009; 60: 106-113.
59. Brailovski V, Prokoshkin S, Gauthier M, Inaekyan K, Dubinskiy S, Petrzhik M,. Bulk and porous metastable beta Ti-Nb-Zr(Ta) alloys for biomedical applications. Mater Sci Eng C 2011; 31: 643-657.
60. Li JP, De Wijn JR, Van Blitterswijk CA, De Groot K,. Porous Ti6Al4V scaffold directly fabricating by rapid prototyping: preparation and in vitro experiment. Biomaterials 2006; 27:1223- 1235.
61. Van den Dolder J, Farber E, Spauwen PH, Jansen JA,. Bone tissue reconstruction using titanium fiber mesh combined with rat bone marrow stromal cells. Biomaterials 2003; 24:1745- 1750.
62. Mendonca G, Mendonca DBS, Simoes LGP, Araujo AL, Leite ER, Duarte WR, Aragao FJL, Cooper LF,. The effects of implant surface nanoscale features on osteoblast-specific gene expression. Biomaterials 2009; 30: 4053-4062.
63. Muller U, Imwinkelried T, Horst M, Sievers M, Graf- Hausner U,. Do human osteoblasts grow into open-porous titanium? Eur Cells Mater 2006; 11: 8-15.
64. Barradas AMC, Yuan H, Blitterswijk CA, Habibovic P,. Osteoinductive biomaterials: current knowledge of properties, experimental models and biological mechanisms. Eur Cell Mater 2011; 21: 407-429.
65. Perl DP, Brody AR,. Alzheimer's disease: X-ray spectrometer evidence of aluminum accumulation in neurofibrillary tangle-bearing neurons. Science 1980; 208: 297-299.
66. Japan Aluminium Association. Aluminum and health. Tokyo: Japan Aluminium Association; 2002; 1-6.
67. Eisenbarth E, Velten D, Muller M, Thull R, Breme J,. Biocompatibility of beta-stabilizing elements of titanium alloys. Biomaterials 2004; 25: 5705-5713.
68. Semlitsch M,. Classic and new titanium alloys for production of artificial hip joints. Titan 1986; 2: 721-740.
69. Browy K-H, Kramer K-H,. On the properties of a new titanium alloy (TiAl5Fe2.5) as implant material. In:, Lütjering G, Zwicker U, Bunk W, editors. Titanium science and technology, vol. 2. Stuttgart: Deutsche Gesellshaft fur Metallkunde; 1985; 1381-1386.
70. Okazaki Y, Ito Y, Tateishi T, Ito A,. Effect of heat treatment on microstructure and mechanical properties of new titanium alloys for surgical implantation. J Jpn Inst Met 1995; 59: 108-115.
71. Mouhyi J, Dohan Ehrenfest DM, Albrektsson T,. The Peri-implantitis: implant surfaces, microstructure and physico-chemical aspects. Clin Implant Dent Relat Res 2012; 14: 170-183.
72. Boehlert CJ, Cowen CJ, Quast JP, Akahori T, Niinomi M,. Fatigue and wear evaluation of Ti-Al-Nb alloys for biomedical applications. Mater Sci Eng C 2008; 28: 323-330.
73. Ghonem H,. Microstructure and fatigue crack growth mechanisms in high temperature titanium alloys. Int J Fatigue 2010; 32: 1448-1460.
74. Mishra AK, Davidson JA, Poggie RA, Kovacs P, Fitzgerald TJ,. Mechanical and tribological properties and biocompatibility of diffusion hardened Ti-13Nb- 13Zr-a new titanium alloy for surgical implants. In:, Brown SA, Lemons JE, editors. Medical applications of titanium and its alloys, ASTM STP 1272. West Conshohocken, PA: ASTM International; 1996; 96-116.
75. Wang KK, Gustavson LJ, Dumbleton JH,. Micro structure and properties of a new beta titanium alloy, Ti-12Mo-6Zr-2Fe, developed for surgical implants. In:, Brown SA, Lemons JE, editors. Medical applications of titanium and its alloys, ASTM STP 1272. West Conshohocken, PA: ASTM International; 1996; 76-87.
76. Zardiackas LD, Mitchell DW, Disegi JA,. Characterization of Ti-15Mo beta titanium alloy for orthopedic implant. In:, Brown SA, Lemons JE, editors. Medical applications of titanium and its alloys, ASTM STP 1272. West Conshohocken, PA: ASTM International; 1996; 60-75.
77. Hatanaka S, Ueda M, Ikeda M, Niinomi M,. Isothermal aging behavior in Ti- 10Cr-Al alloys for medical applications. Adv Mater Res 2010; 89-91: 232-237.
78. Ikeda M, Ueda M, Kinoshita T, Ogawa M, Niinomi M,. Influence of Fe content of Ti-Mn-Fe alloys on phase constitution and heat treatment behavior. Mater Sci Forum 2012; 706-709: 1893-1898.
79. Ikeda M, Ueda M, Matsunaga R, Niinomi M,. Phase constitution and heat treatment behavior of Ti-7 mass%Mn-Al alloys. Mater Sci Forum 2010; 654-656: 855-858.
80. Kasano Y, Inamura T, Kanetaka H, Miyazaki S, Hosoda H,. Phase constitution and mechanical properties of Ti-(Cr, Mn)-Sn biomedical alloys. Mater Sci Forum 2010; 654-656: 2118-2121.
81. Tane M, Akita S, Nakano T, Hagihara K, Umakoshi Y, Niinomi M, et al,. Peculiar elastic behavior of Ti-Nb-Ta-Zr single crystals. Acta Mater 2008; 56: 2856-2863.
82. Nakai M, Niinomi M, Zhao XF, Zhao XL,. Self-adjustment of Young's modulus in biomedical titanium alloy during orthopaedic operation. Mater Lett 2011; 65:688-690.
83. Zhao XF, Niinomi M, Nakai M, Hieda J,. Beta type Ti-Mo alloys with changeable Young's modulus for spinal fixation applications. Acta Biomater 2012; 8: 1990-1997.
84. Alvarado J, Maldonado R, Marxuach J, Otero R,. Biomechanics of hip and knee prostheses. Appl Eng Mech Med 2003; 1-20.
85. Hosoda H, Hosoda N, Miyazaki S,. Mechanical properties of Ti-Mo-Al biomedical shape memory alloys. Trans MRS-J 2001; 26: 243-246.
86. Ikeda M, Komatsu S, Nakamura Y,. Effects of Sn and Zr additions on phase constitution and aging behavior of Ti-50 mass%Ta alloys quenched from b single phase region. Mater Trans 2004; 45: 1106-1112.
87. Ikeda M, Sugano D, Masuda S, Ogawa M,. The influence of aluminum content on shape memory effect of Ti-7Cr-Al alloys fabricated using low grade sponge titanium. Mater Trans 2005; 46:1604-1609.
88. Borsari V, Fini M, Giavaresi G,. Osteointegration of titanium and hydroxyapatite rough surfaces in healthy and compromised cortical and trabecular bone: in vivo comparative study on young, aged, and estrogen-deficient sheep. J Orthop Res 2007; 25: 1250-1260.
89. Cooper LF, Zhou Y, Takebe J,. Fluoride modification effects on osteoblast behavior and bone formation at TiO2 grit-blasted c.p. titanium endosseous implants. Biomaterials 2006; 27: 926-936.
90. Rupp F, Scheideler L, Olshanska N,. Enhancing surface free energy and hydrophilicity through chemical modification of micro structured titanium implant surfaces. J Biomed Mater Res 2006; 76: 323-334.
91. Morra M,. Biochemical modification of Ti surfaces: peptides and ECM proteins. Eur Cell Mater 2006; 12: 1-15.
92. Rammelt S, Illert T, Bierbaum S,. Coating of titanium implants with collagen, RGD peptide and chondroitin sulphate. Biomaterials 2006; 27: 5561-5572.
93. Kinov P, Leithner A, Radl R, Bodo K, Khoschsorur GA, Schauenstein K, Windhager R,. Role of free radicals in aseptic loosening of hip arthroplasty. J Orthop Res 2006; 24: 55-62.
94. Bucci-Sabattini V, Cassinelli C, Coelho P, Minnici A, Trani A, Ehernfest DD,. Effect of titanium implant surface nanoroughness and calcium phosphate low impregnation on bone cell activity in vitro. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2010; 109: 217-224.
95. McNamara LE, Sjostrom T, Burgess KE, Kim JJ, Liu E, Gordonov S, Moghe PV, Meek RM, Oreffo RO, Su B, Dalby MJ,. Skeletal stem cell physiology on functionally distinct titania nanotopographies. Biomaterials 2011; 32: 7403-7410.
96. Bjursten LM, Rasmusson L, Oh S, Smith GC, Brammer KS, Jin S,. Titanium dioxide nanotubes enhance bone bonding in vivo. J Biomed Mater Res A 2010; 92: 1218-1224.
97. Shalabi MM, Gortemaker A, Van't Hof MA, Jansen JA, Creugers NH,. Implant surface roughness and bone healing: A systematic review. J Dent Res 2006; 85: 496-500.
98. Bourne GH, Herring GM,. The organic matrix of bone. The biochemistry and physiology of bone. New York: Academic Press 1972; 127-189.
99. Porter JR, Ruckh TT, Popat KC,. Bone tissue engineering: a review in bone biomimetics and drug delivery strategies. Biotechnol Prog 2009; 25: 1539-1560.
100. Barbieri D, Renard AJ, de Bruijn JD, Yuan H,. Heterotopic bone formation by nano apatite containing poly(D,L-lactide) composites. Eur Cell Mater 2010; 19: 252-261.
101. Oh S, Daraio C, Chen LH, Pisanic TR, Finones RR, Jin S,. Significantly accelerated osteoblast cell growth on aligned TiO2 nanotubes. J Biomed Mater Res Part A 2006; 78: 97-103.
102. Findlay DM, Welldon K, Atkin GJ, Howie DW, Zannettino ACW, Bobyn D,. The proliferation and phenotypic expression of human osteoblasts on tantalum metal. Biomaterials 2004; 25: 2215-2227.
103. Levine BR, Sporer S, Poggie RA, Valle CJD, Jacobs JJ,. Experimental and clinical performance of porous tantalum in orthopedic surgery. Biomaterials 2006; 27: 4671-4681.
104. Sevilla P, Aparicio C, Planell JA, Gil FJ,. Comparison of the mechanical properties between tantalum and nickel-titanium foams implant materials for bone ingrowth applications. J Alloys Compd 2007; 439: 67-73.
105. Levine B, Della Valle CJ, Jacobs JJ,. Applications of porous tantalum in total hip arthroplasty. J Am Acad Orthop Surg 2006; 14: 646-655.
106. Sheth NP, Lonner JH,. Clinical use of porous tantalum in complex primary total knee anthroplasty. Am J Orthop 2009; 38: 526-530.
107. Bobyn JD, Poggie RA, Krygier JJ, Lewallen DG, Hanssen AD, Lewis RJ, Unger AS, O'Keefe TJ, Christie MJ, Nasser S, Wood JE, Stulberg SD, Tanzer M,. Clinical validation of a structural porous tantalum biomaterial for adult reconstruction. J Bone Joint Surg 2004; 86: 123-129.
108. Rubitschek E, Niendorf T, Karaman I, Maier HJ,. Corrosion fatigue behavior of a biocompatible ultrafine-grained niobium alloy in simulated body fluid. J Mech Behav Biomed Mater 2012; 5:181-192.
109. Kondo R, Nomura N, Suyalatu, Tsutsumi Y, Doi H, Hanawa T,. Microstructure and mechanical properties of as-cast Zr-Nb alloys. Acta Biomater 2011; 7: 4278-4284.
110. Basso A, Roy S, Mermoud A,. Biocompatibility of an xshaped zirconium implant in deep sclerectomy in rabbits. Graefe's Archive for Clinical and Experimental Ophthalmology 2008; 246: 849-855.
111. Suyalatu, Kondo R, Tsutsumi Y, Doi H, Nomura N, Hanawa T,. Effects of phase constitution on magnetic susceptibility and mechanical properties of Zr-rich Zr-Mo alloys. Acta Biomater 2011; 7: 4259-4266.
112. Galetz MC, Fleischmann EW, Konrad CH, Schuetz A, Glatzel U,. Abrasion resistance of oxidized zirconium in comparison with CoCrMo and titanium nitride coatings for artificial knee joints. J Biomed Mater Res B 2010; 93B: 244-251.
113. Niinomi M,. Mechanical biocompatibilities of titanium alloys for biomedical applications. J Mech Behav Biomed Mater 2008; 1: 30-42.
114. Witte F,. The histry of biodegradable magnesium: a review. Acta Biomater 2010; 6: 1680-1692.
115. Gu XN, Li N, Zhou WR, Zheng YF, Zhao X, Cai QZ, et al,. Corrosion resistance and surface biocompatibility of a microarc oxidation coating on a Mg-Ca alloy. Acta Biomater 2011; 7: 1880-1889.
116. Kannan MB, Raman RKS,. Evaluating the stress corrosion cracking susceptibility of Mg-Al-Zn alloy in modified-simulated body fluid for orthopaedic implant application. Scripta Mater 2008; 59: 175-178.
117. Vormann J,. Magnesium: Nutrition and metabolism. Mol Aspects Med 2003; 24: 27-37.
118. Wang J, Tang J, Zhang P, Wang J, Lai Y, Qin L,. Surface modification of magnesium alloys developed for bioabsorbable orthopedic implants: a general review. J Biomed Mat Res Part B 2012; 100B: 1691-1701.
119. Rahaman MN, Yao A,. Ceramics for prosthetic hip and knee joint replacement. J Am Ceram Soc 2007; 90: 1965-1988.
120. Urban A, Garvin KL, Boese CK, Bryson L, Pedersen DR, Callaghan JJ, Miller RK,. Ceramic-on-Polyethylene Bearing Surfaces in Total Hip Arthroplasty. Seventeen to Twenty-One-Year Results. J. Bone Joint Surg Am 2001; 83: 1688-1694.
121. Sarkar R, Banerjee G,. Ceramic based bio-medical implants. Interceram 2010; 59: 98-102.
122. Campbell P, Shen FW, McKellop H,. Biologic and tribologic considerations of alternative bearing surfaces. Clin Orthop 2004; 418: 98-111.
123. Garvie RC, Hannink RH, Pascoe RT,. Ceramic steel? Nature 1975; 258: 703-704.
124. Garvie RC, Nicholson PS,. Structure and thermodynamical properties of partially stabilized zirconia in the CaO-ZrO2 system. J Am Ceram Soc 1972; 55: 152-157.
125. Torricelli P, Verne E, Brovarone CV, Appendino P, Rustichelli F, Krajewski A,. Biological glass coating on ceramic materials: in vitro evaluation using primary osteoblast cultures from healthy and osteopenic rat bone. Biomaterials 2001; 22: 2535-2543.
126. Degidi M, Artese L, Scarano A, Perrotti V, Gehrke P, Piattelli A,. Inflammatory infiltrate, microvessel density, nitric oxide synthase expression, vascular endothelial growth factor expression, and proliferative activity in peri-implant soft tissues around titanium and zirconium oxide healing caps. J Periodont 2006; 77: 73-80.
127. Lohmann CH, Dean DD, Koster G, Casasola D, Buchhorn GH, Fink U,. Ceramic and PMMA particles differentially affect osteoblast phenotype. Biomaterials 2002; 23: 1855-1863.
128. Silva VV, Lameiras FS, Lobato ZI,. Biological reactivity of zirconia-hydroxyapatite composites. J Biomed Mater Research 2002; 63: 583-590.
129. Carinci F, Pezzetti F, Volinia S, Francioso F, Arcelli D, Farina E,. Zirconium oxide: analysis of MG63 osteoblast-like cell response by means of a microarray technology. Biomaterials 2004; 25: 215-228.
130. Chevalier L, Gremillard, Deville S,. Low-Temperature Degradation of Zirconia and Implications for Biomedical Implants. Annu Rev Mater Res 2007; 37: 1-32.
131. Clarke IC, Manaka M, Green DD, Williams P, Pezzotti G, Kim YH, Ries M, Donaldson NT, Gustafson GA,. Current Status of Zirconia Used in Total Hip Implants. J Bone Joint Surg Am 2003; 85: 73-84.
132. Schubert H, Frey F,. Stability of Y-TZP during hydrothermal treatment: neutron experiments and stability considerations. J Eur Ceram Soc 2005; 25: 1597-1602.
133. Willmann G, Fru HJ, Pfaff HG,. Wear Characteristics of Sliding Pairs of Zirconia (Y-TZP) for Hip Endoprostheses. Biomaterials 1996; 17: 2157-2162.
134. El Gannham A,. Bone reconstruction: from bioceramics to tissue engineering. Exp Rev Med Dev 2005; 2: 87-101.
135. Ikawa N, Kimura T, Oumi Y, Sano T,. Amino acid containing amorphous calcium phosphates and the rapid transformation into apatite. J Mater Chem 2009; 19: 4906-4913.
136. Liu Y, de Groot K, Hunziker EB,. BMP-2 liberated from biomimetic implant coatings induces and sustains direct ossification in an ectopic rat model. Bone 2005; 36: 745-757.
137. Weir MD, Xu HH,. High-strength, in situ-setting calcium phosphate composite with protein release. J Biomed Mater Res 2008; 85: 388-396.
138. Jayasuriya AC, Shah C,. Controlled Release of Insulin like Growth Factor-1 and Bone Marrow Stromal Cell Function of Bone-Like Mineral Layers Coated PLGA Scaffolds. J Tissue Eng Regen Med 2008; 2: 43-49.
139. Bandyopadhyay A, Bernard S, Xue W, Bose S,. Calcium phosphate-based resorbable ceramics: influence of MgO, ZnO, and SiO2 dopants. J Am Cer Soc 2006; 89: 2675-2688.
140. Hench LL, Wilson J,. Surface-active biomaterials. Science 1984; 226: 630-636.
141. LeGeros RZ,. Calcium phosphate-based osteoinductive materials. Chem Rev 2008; 108: 4742-4753.
142. Jayasuriya AC, Kibbe S,. Rapid biomineralization of chitosan microparticles to apply in bone regeneration. J Mater Sci Mater Med 2010; 21: 393-398.
143. Jayasuriya AC, Asaad M, Jayatissa AH, Ebraheim NA,. Dissolution Behavior of Biomimetic Minerals on 3D PLGA Scaffold. Surf Coat Tech 2006; 200: 6336-6339.
144. Shin K, Jayasuriya AC, Kohn DH,. Effect of Ionic Activity Products on the Structure and Composition of the Mineral formed on 3-D poly(lactic-co- glycolide) Scaffolds. J Biomed Mater Res A. 2007; 83: 1076-1086.
145. Jayasuriya AC, Shah C, Ebraheim NA, Jayatissa AH,. Acceleration of biomimetic mineralization to apply in bone regeneration. Biomed Mater 2008; 3: 015003.
146. Li Y, Weng W, Tam KC,. Novel highly biodegradable biphasic tricalcium phosphates composed of [alpha]-tricalcium phosphate and [beta]-tricalcium phosphate. Acta Biomater 2007; 3: 251-254.
147. Matsushita N, Terai H, Okada T, Nozaki K, Inoue H, Miyamoto S,. A new bone-inducing biodegradable porous b-tricalcium phosphate. J Biomed Mater Res 2004; 70: 450-458.
148. Yuan H, van Blitterswijk CA, de Groot K, de Bruijn JD,. A comparison of bone Formation in biphasic calcium phosphate (BCP) and hydroxyapatite (HA) implanted in muscle and bone of dogs at different time periods. J Biomed Mater Res A 2006; 78: 139-147.
149. Yuan H, van Blitterswijk CA, de Groot K, de Bruijn JD,. Cross-species comparison of ectopic bone formation in biphasic calcium phosphate (BCP) and hydroxyapatite (HA) scaffolds. Tissue Eng 2006; 12: 1607-1615.
150. Kurashina K, Kurita H, Wu Q, Ohtsuka A, Kobayashi H,. Ectopic osteogenesis with biphasic ceramics of hydroxyapatite and tricalcium phosphate in rabbits. Biomaterials 2002; 23: 407-412.
151. Habibovic P, Juhl MV, Clyens S, Martinetti R, Dolcini L, Theilgaard N, van Blitterswijk CA,. Comparison of two carbonated apatite ceramics in vivo. Acta Biomater 2010; 6: 2219-2226.
152. Klein C, de Groot K, Chen W, Li Y, Zhang X,. Osseous substance formation induced in porous calcium phosphate ceramics in soft tissues. Biomaterials 1994; 15: 31-34.
153. Muschler GF, Nakamoto C, Griffith LG,. Engineering principles of clinical cell-based tissue engineering. J Bone Joint Surg Am 2004; 86: 1541-1558.
154. Yuan H, Fernandes H, Habibovic P, de Boer J, Barradas AM, de Ruiter A, Walsh WR, van Blitterswijk CA, de Bruijn JD,. Osteoinductive ceramics as a synthetic alternative to autologous bone grafting. Proc Natl Acad Sci 2010; 107: 13614-13619.
155. Xynos ID, Hukkanen MVJ, Buttery LDK, Hench LL, Polak JM,. Bioglasss 45S5 stimulates osteoblast turnover and enhances bone formation in vitro: implications and applications for bone tissue engineering. Calcif Tissue Int 2000; 67: 321-329.
156. Yuan H, de Bruijn JD, Zhang X, van Blitterswijk CA, de Groot K,. Bone induction by porous glass ceramic made from bioglass (45s5). J Biomed Mater Res 2001; 58: 270-276.
157. Banchet V, Jallot E, Michel J, Wortham L, Laurent-Maquin D, Balossier G,. X-ray microanalysis in STEM of short-term physicochemical reactions at bioactive glass particle/biological fluid interface. Determination of O/Si atomic ratios. Surf Interface Anal 2004; 36: 658-665.
158. Rokkanen PU,. Bioabsorbable fixation devices in orthopaedics and traumatology. Ann Chir Gyn 1998; 87: 13-20.
159. Mazzocchi M, Bellosi A,. On the possibility of silicon nitride as a ceramic for structural orthopaedic implants. Part I: Processing, microstructure, mechanical properties, cytotoxicity. J Mater Sci Mater Med 2008; 19: 2881-2887.
160. Klemm H,. Silicon nitride for high-temperature applications. J Am Ceram Soc 2010; 93: 1501-1522.
161. Rahaman MN, Yao A, Bal BS, Garino JP, Ries MD,. Ceramics for prosthetic hip and knee joint replacement. J Am Ceram Soc 2007; 90: 1965-1988.
162. Krstic Z, Krstic VD,. Young's modulus, density and phase composition of pressureless sintered self-sealed Si3N4/BN laminated structures. J Eur Ceram Soc 2008; 28: 1723-1730.
163. Neuss S, Jochen S, Rainer T, Ruth K,. Cytocompatibility of high strength non-oxide ceramics. J Biomed Mater Res Part A 2010; 93A: 67-76.
164. Puckett S, Ercan B, Webster TJ, Rahaman M,. Decreased bacteria activity on Si3N4 surfaces compared with PEEK or titanium. Inter J nanomed 2012; 7: 4829-4840.
165. Rezwan K, Chen QZ, Blaker JJ, Boccaccini AR,. Biodegradable and bioactive porous polymer/inorganic composite scaffolds for bone tissue engineering. Biomaterials 2006; 27: 3413-3431.
166. Hasegawa S, Neo M, Tamura J, Fujibayashi S, Takemoto M, Shikinami Y, Okazaki K, Nakamura T,. In vivo evaluation of a porous hydroxyapatite/poly- DLlactide composite for bone tissue engineering. J Biomed Mater Res A 2007; 81: 930-938.
167. Winter GD, Simpson BJ,. Heterotopic bone formed in a synthetic sponge in the skin of young pigs. Nature 1969; 223: 88-90.
168. De Groot K,. Letter: Some considerations about bone-induction. Calcif Tissue Res 1973; 13: 335-337.
169. Bleach NC, Nazhat SN, Tanner KE, Kelloma M,. Effect of filler content on mechanical and dynamic mechanical properties of particulate biphasic calcium phosphate-polylactide composites. Biomaterials 2002; 23: 1579-1585.
170. Dorozhkin SV,. Biocomposites and hybrid biomaterials based on calcium orthophosphates. Biomater. 2011; 1: 3-56.
171. Zhu Y, Gao C, Guan J, Shen J,. Promoting the cytocompatibility of polyurethane scaffolds via surface photo-grafting polymerization of acrylamide. J Mater Sci Mater Med 2004; 15: 283-289.
172. Zhu Y, Gao C, He T, Shen J,. Endothelium regeneration on luminal surface of polyurethane vascular scaffold modified with diamine and covalently grafted with gelatin. Biomaterials 2004; 25: 423-430.
173. Zhu Y, Sun Y,. The influence of polyelectrolyte charges of polyurethane membrane surface on the growth of human endothelial cells. Colloids Surf B 2004; 36: 49-55.
174. Jayasuriya AC, Bhat A,. Fabrication and characterization of novel hybrid organic/inorganic microparticles to apply in bone regeneration. J Biomed Mater Res Part A 2010; 93: 1280-1288.
175. Jayasuriya AC, Bhat A,. Mesenchymal stem cell function on hybrid organic/inorganic microparticles in vitro. J Tissue Eng Regen Med 2010; 4: 340-348.
176. Bhat A, Dreifke M, Gomez C, Kandimalla Y, Ebraheim NA, Jayasuriya AC,. Evaluation of cross-linked chitosan microparticles for bone regeneration. J Tissue Eng Regen Med 2010; 4: 532-542.
177. Kyomoto M, Moro T, Iwasaki Y, Miyaji F, Kawaguchi H, Takatori Y, et al,. Superlubricious surface mimicking articular cartilage by grafting poly(2- methacryloyloxyethyl phosphorylcholine) on orthopaedic metal bearings. J Biomed Mater Res A 2009; 91A: 730-741.
178. Fu T, Zhao J-L, Xu K-W,. The designable elastic modulus of 3-D fabric reinforced biocomposites. Mater Lett 2007; 61: 330-333.
179. Zhou H, Lawrence JG, Bhaduri SB,. Fabrication aspects of PLA-CaP/PLGA=CaP composites for orthopedic applications: A review. Acta Biomat 2012; 8: 1999-2016.
180. Sen N,. Composites: use in saucepan handles, artificial limbs and the AGNI missile. Curr Sci 2004; 86: 372-375.
181. Cifuentes SC, Frutos E, González-Carrasco JL, Muñoz M, Multigner M, Chao J, Benavente R, Lieblich M,. Novel PLLA/magnesium composite for orthopedic applications: A proof of concept. Mat Let 2012; 74: 239-242.
182. Müller WD, Nascimento ML, Zeddies M, Cõrsico M, Gassa LM, Lorenzo de Mele MAF,. Mater Res 2007; 10: 5-10.
183. Lacroix D,. In:, Planell JA, Best SM, Lacroix D, Merolli A, editors. Bone repair biomaterials. Cambridge, UK: Woodhead Publishing Limited 2009. p. 106-118.
184. Yuan H, Van Den Doel M, Li S, Van Blitterswijk CA, De Groot K, De Bruijn JD,. A comparison of the osteoinductive potential of two calcium phosphate ceramics implanted intramuscularly in goats. J Mater Sci Mater Med 2002; 13: 1271-1275.
185. Reddi AH,. Cell biology and biochemistry of endochondral bone development. Coll Relat Res 1981; 1:209- 226.
186. Ohgushi H, Dohi Y, Tamai S, Tabata S,. Osteogenic differentiation of marrow stromal stem cells in porous hydroxyapatite ceramics. J Biomed Mater Res 1993; 27: 1401-1407.
187. Reddi AH,. Regulation of cartilage and bone differentiation by bone morphogenetic proteins. Curr Opin Cell Biol 1992; 4: 850-855.
188. Habibovic P, Yuan H, van der Valk CM, Meijer G, van Blitterswijk CA, de Groot K,. 3D microenvironment as essential element for osteoinduction by biomaterials. Biomaterials 2005; 26: 3565-3575.
189. Habibovic P, Yuan H, van den Doel M, Sees TM, van Blitterswijk CA, de Groot K,. Relevance of osteoinductive biomaterials in critical-sized orthotopic defect. J Orthop Res 2006; 24: 867-876.
190. Ripamonti U, Klar RM, Renton LF, Ferretti C,. Synergistic induction of bone formation by Hop-1, HTGbeta3 and inhibition by zoledronate in macroporous coralderived hydroxyapatites. Biomaterials 2010; 31: 6400-6410.
191. Kato M, Toyoda H, Namikawa T, Hoshino M, Terai H, Miyamoto S, Takaoka K,. Optimized use of a biodegradable polymer as a carrier material for the local delivery of recombinant human bone morphogenetic protein-2 (RHBMP-2). Biomaterials 2006; 27: 2035-2041.
192. Habibovic P, Kruyt MC, Juhl MV, Clyens S, Martinetti R, Dolcini L, Theilgaard N, van Blitterswijk CA,. Comparative in vivo study of six hydroxyapatite-based bone graft substitutes. J Orthop Res 2008; 26: 1363-1370.
193. Le Nihouannen D, Saffarzadeh A, Gauthier O, Moreau F, Pilet P, Spaethe R, Layrolle P, Daculsi G,. Bone tissue formation in sheep muscles induced by a biphasic calcium phosphate ceramic and fi brin glue composite. J Mater Sci Mater Med 2008; 19: 667-675.
194. Yuan H, de Bruijn JD, Zhang X, van Blitterswijk CA, de Groot K,. Use of an osteoinductive biomaterial as a bone morphogenetic protein carrier. J Mater Sci Mater Med 2001; 12: 761-766.
195. Dellinger JG, Eurell JAC, Jamison RD,. Bone response to 3D periodic hydroxyapatite scaffolds with and without tailored microporosity to deliver bone morphogenetic protein 2. J Biomed Mater Res 2006; 76A: 366-376.
196. Lan Levengood SK,. The effect of BMP-2 on micro- and macroscale osteointegration of biphasic calcium phosphate scaffolds with multiscale porosity. Acta Biomater 2010; 6: 3283-3291.
197. Polak SJ, Levengood SKL, Wheeler MB, Maki AJ, Clark SG, Johnson AJW,. Analysis of the roles of microporosity and BMP-2 on multiple measures of bone regeneration and healing in calcium phosphate scaffolds. Acta Biomater 2011; 7: 1760-1771.
198. Woodard JR,. The mechanical properties and osteoconductivity of hydroxyapatite bone scaffolds with multi-scale porosity. Biomaterials 2007; 28: 45-54.
199. Jayasuriya AC, Ebraheim NA,. Evaluation of Bone Matrix and Demineralized Bone Matrix Incorporated PLGA Matrices for Bone Repair. J Mater Sci Mater Med 2009; 20: 1637-1644.
200. Pearse AJ, Hooper GJ, Roothwell A, Frampton C,. Survival and functional outcome after revision of a unicompartmental to a total knee replacement: the New Zealand National Joint Registry. J Bone Joint Surg Br 2010; 92: 508-512.