Target Genes: PTHrP

Vitamin D

Volumn 1, Issue , 2005, Pages 737-749

  Goltzman, David ^a   Kremer, Richard ^a  

^a MCGILL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84884861012     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-012252687-9/50046-2     Document Type: Chapter

References (108)

1. Martin TJ, Moseley J, Williams D Parathyroid hormone-related protein: hormone and cytokine. J Endocrinol 1997, 154:523-537.
2. Martin TJ, Moseley J, Gillespie MT Parathyroid hormone-related protein: biochemistry and molecular biology. Crit Rev Biochem Mol Biol 1991, 26:377-395.
3. Karaplis AC, Yasuda J, Hendy GN, Goltzman D, Banville D Gene-encoding parathyroid hormone-like peptide: nucleotide sequence of the rat gene and comparison with the human homolog. Mol Endocrinol 1990, 4:441-446.
4. Mangin M, Ikeda K, Broadus AE Structure of the mouse gene encoding parathyroid hormone-related peptide. Gene 1990, 95:195-202.
5. Thiede MA, Rutledge SJ Nucleotide sequence of a parathyroid hormone-related peptide expressed by the 10-day chicken embryo. Nucleic Acids Res 1990, 18:3062.
6. Mangin M, Ikeda K, Dreyer BE, Broadus AE Identification of an upstream promoter of the human parathyroid hormone-related peptide gene. Mol Endocrinol 1990, 4:851-858.
7. Yasuda T, Banville D, Hendy GN, Goltzman D Characterization of the human parathyroid hormone-like peptide gene: Functional and evolutionary aspects. J Biol Chem 1989, 13:7720-7725.
8. Vasavada RC, Wysolmerski JJ, Broadus AE, Philbrick WM Identification and characterization of a GC-rich promoter of the human PTHrP gene. Mol Endocrinol 1993, 7:273-282.
9. Moseley JM, Gillespie MT Parathyroid hormone-related protein. Crit Rev Clin Lab Sciences 1995, 32:299-343.
10. 3 gene expression and secretion. J Clin Invest 1991, 87:884-893.
11. Sebag M, Henderson JE, Goltzman D, Kremer R Regulation of parathyroid hormone-related peptide production in normal human mammary epithelial cells in vitro. Am J Physiol 1994, 267(3):C723-C730.
12. Glatz JA, Heath JK, Southby J, L'Keefe LM, Kiriyama T, Moseley JM, Martin TJ, Gillespie MT Dexamethasone regulation of PTHrP expression in a squamous cancer cell line. Mol Cell Endocrinol 1994, 101:295-308.
13. Liu B, Goltzman D, Rabbani SA Regulation of parathyroid hormone related protein production in vitro by the rat hypercalcemic leydig tumor H500. Endocrinology 1993, 132:1658-1664.
14. Orloff JJ, Reddy D, de Papp AE, Yang KH, Soifer NE, Stewart AF Parathyroid hormone-related protein as a prohormone. Post-translational processing and receptor interactions. Endocr Reviews 1994, 15:40-60.
15. Kemp BE, Moseley JM, Rodda CP, Ebeling PR, Wettenhall RE, Stapleton D, Diefenback-Jagger H, Ure F, Michelangeli VP, Simmons HA, et al. Parathyroid hormone-related protein of malignancy: active synthetic fragments. Science 1987, 238:1568-1570.
16. Stewart AF, Broadus AE PTHrP: coming of age in the 1990s. J Clin Endocrinol Metab 1991, 71:1410-1414.
17. Soifer NE, Dee KE, Insogna KL, Burtis WJ, Matovcik LM, Wu TL, Milstone LM, Broadus AE, Philbrick WM, Stewart AF PTHrP: Evidence of secretion of a novel mid region fragment by three different cell lines in culture. J Biol Chem 1992, 267:18236-18243.
18. Kovacs CS, Lanske B, Hunzelman JL, Guo J, Karaplis AC, Kroninberg HM Parathyroid hormone related peptide (PTHrP) regulates fetal-placental calcium transport through a receptor distinct from the PTH/PTHrP receptor. Proc Natl Acad Sci USA 1996, 93:15233-15238.
19. Cornish J, Callon KE, Nicholson GC, Reid IR Parathyroid hormone-related protein (107-139) inhibits bone resorption in vivo. Endocrinology 1997, 138:1299-1304.
20. Cornish J, Callon KE, Lin C, Xiao C, Moseley JM, Reid IR Stimulation of osteoblast proliferation by C-terminal fragments of parathyroid hormone-related protein. J Bone Min Res 1999, 14:915-922.
21. Wu TL, Soifer NE, Burtis WJ, Milstone LM, Stewart AF Glycosylation of PTHrP secreted by human epidermal keratinocytes. J Clin Endocrinol Metab 1991, 73:1002-1007.
22. Burtis WJ, Brady TG, Orloff JJ, Ersbak BJ, Warrell RP, Olson BR, Wu TL, Mitnick ME, Broadus AE, Stewart AF Immunochemical characterization of circulating parathyroid hormone-related protein in patients with humoral hypercalcemia. N Engl J Med 1990, 322:1106-1112.
23. Orloff JJ, Soifer NE, Fodero JP, Dann P, Burtis WJ Accumulation of carboxyterminal fragments of PTHrP in renal failure. Kidney Int 1993, 43:1371-1376.
24. Chorev M, Rosenblatt M Structure-function analysis of parathyroid hormone and parathyroid hormone-related protein. The Parathyroids: Basic and Clinical Concepts 1994, 139. Raven Press, New York. J.P. Bilezekian, R. Marcus, M.D. Levine (Eds.).
25. Jüppner H Functional properties of the PTH/PTHrP receptor. Bone 1995, (Suppl. 17):39S-42S.
26. Jüppner H Molecular cloning and characterization of a PTH/PTHrP receptor: a member of an ancient family of G protein coupled receptors. Curr Opin Nephrol Hypertens 1994, 3:371-378.
27. Abou-Samra AB, Juppner H, Force T, Freeman MW, Kong XF, Schipani E, Urena P, Richards J, Bonventre JV, Potts JT, et al. Expression cloning of a common receptor for PTH and PTHrP from rat osteoblast-like cells: A single receptor stimulates intracellular accumulation of both camp and inositol triphosphates and increases intracellular free calcium. Proc Natl Acad Sci USA 1992, 89:2732-2736.
28. Verheijen MH, Defize LH Parathyroid hormone related peptide activates mitogen-activated protein kinase via a cAMP-mediated pathway independent of Ras. J Biol Chem 1997, 272:3423-3429.
29. Henderson JE, Amizuka N, Warshawsky H, Biasotto D, Lanske BM, Goltzman D, Karaplis AC Nucleolar localization of parathyroid hormone-related peptide enhances survival of chondrocytes under conditions that promote apoptotic cell death. Mol Cell Biol 1995, 15:4064-4075.
30. Jans DA, Hubner S Regulation of protein transport to the nucleus: central role of phosphorylation. Physiol Rev 1996, 76:651-685.
31. Jans DA, Xiao CY, Lam MH Nuclear targeting signal recognition: A key control point in nuclear transport?. Bioessays 2000, 22:532-544.
32. Lam MH, Olsen SL, Rankin WA, Ho PW, Martin TJ, Gillespie MT, Moseley JM PTHrP and cell division: expression and localization of PTHrP in a keratinocyte cell line (HaCaT) during the cell cycle. J Cell Physiol 1997, 173:433-446.
33. Massfelder T, Dann P, Wu TL, Vasavaba R, Helwig JJ, Stewart AF Opposing mitogenic and antimitogenic actions of parathyroid hormone related protein in vascular smooth muscle cells: a critical role for nuclear targeting. Proc Natl Acad Sci USA 1997, 94:13630-13635.
34. Bouvet M, Nardin SR, Burton DW, Behling C, Carethers JM, Moossa AR, Deftos LJ Human pancreatic adenocarci-nomas express parathyroid hormone-related protein. J Clin Endocrinol Metab 2001, 86:310-316.
35. Yeung SC, Eton O, Burton DW, Deftos LJ, Vassilopoulou-Sellin R, Gagel RF Hypercalcemia due to parathyroid hormone-related protein secretion by melanoma. Horm Res 1998, 49:288-291.
36. Bucht E, Rong H, Pernow Y, Nordqvist AC, Eriksson E, Rankin W, von Schoultz EW, Burtis WJ, Granberg B, Falkmer UG, Burton DW, Deftos LJ Parathyroid hormone-related protein in patients with primary breast cancer and eucalcemia. Cancer Res 1998, 58:4113-4116.
37. Henderson JE, He B, Goltzman D, Karaplis AC Constitutive expression of parathyroid hormone-related peptide (PTHrP) stimulates growth and inhibits differentiation of CFK2 chondrocytes. J Cell Physiol 1996, 169:33-41.
38. Jans DA, Hassan G Nuclear targeting by growth factors, cytokines and their receptors: A role in signaling?. Bioessays 1998, 20:400-411.
39. Lam MH, Briggs LJ, Hu W, Martin TJ, Gillespie MT, Jans DA Importin beta recognizes parathyroid hormone-related protein with high affinity and mediates its nuclear import in the absence of importin alpha. J Biol Chem 1999, 274:7391-7398.
40. Watson PH, Fraher LJ, Natale BV, Kisiel M, Hendy GN, Hodsman AB Nuclear localization of the type 1 parathyroid hormone/parathyroid hormone-related peptide receptor in MC3T3-E1 cells: Association with serum-induced proliferation. Bone 2000, 26:221-225.
41. Aarts MM, Rix A, Guo J, Bringhurst R, Henderson JE The nucleolar targeting signal of parathyroid hormone-related protein mediates endocytosis and nucleolar translocation. J Bone Min Res 1999, 14:1493-1503.
42. Kopito RR ER quality control: The cytoplasmic connection. Cell 1997, 88:427-430.
43. Meerovitch K, Wing S, Goltzman D Pre-proparathyroid hormone-related protein, a secreted peptide is a substrate for the ubiquitin proteolytic system. J Biol Chem 1997, 272:6707.
44. Fujihara SM, Nadler SG Modulation of nuclear protein import: a novel means of regulating gene expression. Biochem Pharmacol 1998, 56:157-161.
45. Stewart AF, Horst R, Deftos LJ, Camden EC, Lang R, Broadus AE Biochemical evaluation of patients with cancer-associated hypercalcemia. Evidence for humoral and non-humoral groups. N Engl J Med 1980, 303:1377-1383.
46. Kaiser SM, Laneuville P, Bernier SM, Rhim JS, Kremer R, Goltzman D Enhanced growth of a human keratinocyte cell line induced by antisense RNA for parathyroid hormone-related peptide. J Biol Chem 1992, 267:13623-13628.
47. Burton PB, Moniz C, Quirke P, Malik A, Bui TD, Juppner H, Segre GV, Knight DE Parathyroid hormone-related peptide: expression in fetal and neonatal development. J Pathol 1992, 167:291-296.
48. Benitezverguizas J, Esbrit P Proliferative effect of parathyroid hormone-related protein on the hypercalcemic walker 256 carcinoma cell line. Biochem Biophys Res Commun 1994, 198:1281-1289.
49. Rabbani SA, Gladu J, Liu B, Goltzman D Regulation in vivo of the growth of Leydig cell tumors by antisense ribonucleic acid for parathyroid hormone related peptide. Endocrinology 1995, 136:5416-5422.
50. Huang D, Kremer R Inhibition of metastasis in melanoma following targeted disruption of the PTHrP gene: Enhanced visualization of the invasive process with green fluorescence protein. Proceedings of the 24th Annual Meeting of the ASBMR 2002.
51. Bouizar Z, Spyratos F, Deytieux S, de Vernejoul MC, Jullienne A Polymerase chain reaction analysis of parathyroid hormone-related protein gene expression in breast cancer patients and occurrence of bone metastases. Cancer Res 1993, 53:5076-5078.
52. Truong NU, deB Edwardes MD, Papavasiliou V, Goltzman D, Kremer R Parathyroid hormone-related peptide and survival of patients with cancer and hypercalcemia. Am J Med 2003, 115:115-121.
53. Kremer R, Shustik C, Tabak T, Papavasiliou V, Goltzman D Parathyroid-hormone-related peptide in hematologic malignancies. Am J Med 1996, 100:406-411.
54. Henderson JE, Sebag M, Rhim J, Goltzman D, Kremer R Dysregulation of parathyroid hormone-like peptide expression and secretion in a keratinocyte model of tumor expression. Cancer Res 1991, 51:6521-6528.
55. Merryman JI, De Wille J, Wermeister JR, Capen CL, Rosol TJ Effects of transforming growth factors on parathyroid hormone-related protein production and ribonucleic acid expression by a squamous carcinoma cell line in vitro. Endocrinology 1994, 134:2424-2430.
56. Casey ML, Mike M, Erk A, MacDonald PC Transforming growth factor β, stimulation of parathyroid hormone related protein expression in human uterine cells in culture: mRNA levels and protein secretion. J Clin Endocrinol Metab 1992, 74:950-952.
57. Ikeda K, Lu C, Weir EC, Mangin M, Broadus AE Transcriptional regulation of the parathyroid hormone related peptide gene by glucocorticoids and vitamin D in a human C-cell line. J Biol Chem 1989, 264:15743-15746.
58. 3. Brit J Dermatol 1998, 138:944-951.
59. 3 and 9- cis-retinoic acid on parathyroid hormone-related protein expression by oral cancer cells (NSC-3). J Endocrinol 1998, 156:349-357.
60. Yu J, Papavasiliou V, Rhim J, Goltzman D, Kremer R Vitamin D analogs: New therapeutic agents for the treatment of squamous cancer and its associated hypercalcemia. Anticancer Drugs 1995, 6:101-108.
61. Inoue D, Matsumoto T, Ogata E, Ikeda K 22-Oxacalcitriod, a noncalcemic analogue of calcitriol, suppresses both cell proliferation and parathyroid hormone-related peptide gene expression in human T cell lymphotrophic virus, type I-infected T cells. J Biol Chem 1993, 268:16730-16736.
62. 3-responsive repressor sequences in the rat parathyroid hormone-related peptide gene. J Biol Chem 1996, 271:16310-16316.
63. Nishishita T, Okazaki T, Ishikawa T, Igarashi T, Hata K, Ogata E, Fujita T A negative vitamin D response. DNA element in the human parathyroid hormone-related peptide gene binds to vitamin D receptor along with Ku antigen to mediate negative gene regulation by vitamin D. J Biol Chem 1998, 273(18):10901-10907.
64. Falzon M, Zhong J The non-calcemic vitamin D analogs EB 1089 and 22-oxacalcitriol suppress serum-induced parathyroid hormone-related peptide gene expression in a lung cancer cell line. Endocrinology 1998, 139:1046-1053.
65. Hongo T, Kupfer J, Enomoto H, Sharifi B, Giannella-Neto D, Forrester JS, Singer FR, Goltzman D, Hendy GN, Pirola C, et al. Abundant expression of parathyroid hormone related protein in primary aortic smooth muscle cells accompanies serum-induced proliferation. J Clin Invest 1991, 88:1841-1847.
66. Streutker C, Drucker DJ Rapid induction of parathyroid hormone-like peptide gene expression by sodium butyrate in a rat islet cell line. Mol Endocrinol 1991, 5:703-708.
67. Kremer R, Woodworth CD, Goltzman D Expression and action of parthyroid hormone-related peptide in human cervical epithelial cells. Am J Physiol 1996, 271:C164-C171.
68. Cros M, Silve C, Graulet AM, Morieux C, Urena P, de Vernejoul MC, Bouizar Z Estrogen stimulates PTHrP but not PTHPTHrP receptor gene expression in the kidney of ovariectomized rat. J Cell Biochem 1998, 70:84-93.
69. Chilco PJ, Gerardi JM, Kaczmarczyk SJ, Chu S, Leopold V, Zajac JD Calcitonin invreases transcription of parathyroid hormone related protein via cAMP. Mol Cell Endocrinol 1993, 94:1-7.
70. Rodan SB, Wesolowski G, Ianacone J, Thiede MA, Rodan GA Production of parathyroid hormone-like peptide in a human osteosarcoma cell line: Stimulation by phorbol esters and epidermal growth factor. J Endocrinol 1989, 122:219-227.
71. Lu C, Ikeda K, Deftos LJ, Cazdar AF, Mangin M, Broadus AE Glucocorticoid regulation of PTHrP gene transcription in a human neuroendocrine cell line. Mol Endocrinol 1989, 3:2034-2040.
72. Deftos LJ, Hogue-Angeletti R, Chalberg C, Su T PTHrP secretion is stimulated by CT and inhibited by chromogranin A peptides. Endocrinology 1989, 125:563-565.
73. Eto M, Akishita M, Ishikawa M, Kozaki K, Yoshizumi M, Hashimoto M, Ako J, Sugimoto N, Nagano K, Sudoh N, Roba K, Ouchi Y Cytokine-induced expression of parathyroid hormone-related peptide in cultured human vascular endothelial cells. Biochem Biophys Res Commun 1998, 249:339-343.
74. Funk JL, Wei H Regulation of parathyroid hormone-related protein expression in MCF-7 breast carcinoma cells by estrogen and antiestrogens. Biochem Biophys Res Commun 1998, 251:849-854.
75. Heath JK, Southby J, Fukumoto S, O'Keefe LM, Martin TJ, Gillespie MT Epidermal growth factor-stimulated parathyroid hormone-related protein expression involves increased gene transcription and mRNA stability. Biochem J 1995, 307:159-167.
76. Rizzoli R, Feyen JHM, Grau G, Wohlwend A, Sappino AP, Bonjour JP Regulation of parathyroid hormone-related protein production in a human lung squamous cell carcinoma line. J Endocrinol 1994, 143:333-342.
77. Kremer R, Goltzman D, Amizuka N, Webber MM, Rhim JS ras Activation of human prostate epithelial cells induces overexpression of parathyroid hormone-related peptide. Clin Cancer Res 1997, 3:855-859.
78. Aklilu F, Park M, Goltzman D, Rabbani SA Increased PTHrP production by a tyrosine kinase oncogene, TRP-MET: role of the ras signaling pathway. Am J Physiol 1996, 271:E277-E283.
79. Broadus AE, Stewart AF Parathyroid hormone related protein. Structure, processing and physiological actions. The Parathyroids 1994, 259-294. Raven Press, New York. J.P. Bilezikian, M.A. Levine, R. Marcus (Eds.).
80. Sidler B, Alpert L, Henderson JE, Deckelbaum R, Amizuka N, Silva E, Goltzman D, Karaplis AC Amplification of the parathyroid hormone-related peptide (PTHrP) gene amplification in a colonic carcinoma. J Clin Endocrinol 1996, 81:2841-2847.
81. 3-dependent signal transduction by phosphorylating human retinoid X receptor alpha. J Clin Invest 1999, 103:1729-1735.
82. Powell GJ, Southby J, Danks JA, Stillwell RG, Hayman JA, Henderson MA, Bennett RC, Martin TJ Localization of parathyroid hormone-related protein in breast cancer metastases: increased incidence in bone compared with other sites. Cancer Res 1991, 51:3059-3061.
83. Southby J, Kissin MW, Danks JA, Hayman JA, Moseley JM, Henderson MA, Bennett RC, Martin TJ Immuno-histochemical localization of parathyroid hormone-related protein in human breast cancer. Cancer Res 1990, 50:7710-7716.
84. Vargas SJ, Gillespie MT, Powell GJ, Southby J, Danks JA, Moseley JM, Martin TJ Localization of parathyroid hormone-related protein mRNA expression in breast cancer and metastatic lesions by in situ hybridization. J Bone Miner Res 1992, 7:971-979.
85. Bundred NJ, Walder RA, Ratcliffe WA, Wguuck J, Morisson JM, Ratcliffe JG Parathyroid hormone related protein and skeletal morbidity in breast cancer. Eur J Cancer 1992, 28(213):690-692.
86. Kissin MW, Henderson MA, Danks JA, Hayman JA, Bennett RC, Martin TJ Parathyroid hormone related protein in breast cancers of widely varying prognosis. Eur J Surg Oncol 1993, 19:134-142.
87. Grill V, Ho P, Body JJ, Johanson N, Lee SC, Krukeja SC, Moseley JM, Martin TJ Parathyroid hormone-related protein: elevated levels in both humoral hypercalcemia of malignancy and hypercalcemia complicating metastatic breast cancer. J Clin Endocrinol Metab 1991, 73:1309-1315.
88. Guise TA Parathyroid hormone-related protein and bone metastases. Cancer 1997, 80:1572-1580.
89. Guise TA, Yin JJ, Taylor SD, Kumagai Y, Dallas M, Boyce BF, Yoneda T, Mundy GR Evidence for a causal role of parathyroid hormone-related protein in the pathogenesis of human breast cancer mediated osteolysis. J Clin Invest 1996, 98:1544-1549.
90. Sato K Does PTHrP mediate cancer-associated cachexia as well as humoral hypercalcemia of malignancy?. 7th Int Forum on Calcified Tissue and Bone Metabolism 1999, 32-37.
91. Sato K, Yamakawa Y, Shimuze K, Satoh T, Mohojomi K, Demura H, Akatsu T, Nagata N, Kasahara T, Ohkawa H, Ohsumi K Passive immunization with antiparathyroid hormone-related protein antibody markedly prolongs survival time of hypercalcemia nude mice bearing transplanted human PTHrP-producing tumors. J Bone Min Res 1993, 8:859-860.
92. Stein CA, Cheng YC Antisense oligonucleotides as therapeutic agents. Is the bullet really magical?. Science 1993, 261:1004-1012.
93. Armentano D, Yu SF, Kantoff PW, Von Ruden T, Anderson WF, Gilboa E Effects of internal viral sequences on the utility of retroviral vectors. J Virol 1987, 61:1047-1050.
94. Palmer JD, Rosman GJ, Osborne WRA, Miller AD Genetically modified skin fibroblasts persist long after transplantation but gradually inactivate introduced genes. Proc Natl Acad Sci USA 1991, 88:1330-1334.
95. Aklilu F, Park M, Goltzman D, Rabbani SA Induction of parathyroid hormone-related peptide by the Ras oncogene: role of Ras farnesylvation inhibitors as potential therapeutic agents for hypercalcemia of malignancy. Cancer Res 1997, 57:4517-4522.
96. 3-mediated transcriptional repression. Mol Endocrinol 1996, 10:672-681.
97. Binderup L, Brammn E Effect of a novel vitamin D analog MC903 on cell proliferation and differentiation in vitro and on calcium metabolism in vivo. Biochem Pharmacol 1988, 37:889-895.
98. 3. Biochem Pharmacol 1991, 41:1601-1606.
99. Kragballe K, Gjertsen BT, de Hoop D, Karlsmark T, van de Kerkhof PC, Larko O, Nieboer C, Roed-Petersen J, Strand A, Tikjob G Double-blind, right/left comparison of calcipotriol and betamethasone valerate in treatment of psoriasis vulgaris. Lancet 1991, 337:193-196.
100. Haq M, Kremer R, Goltzman D, Rabbani SA A vitamin D analogue (EB 1089) inhibits parathyroid hormone-related peptide production and prevents the development of malignancy-associated hypercalcemia in vivo. J Clin Invest 1993, 91:2416-2422.
101. El Abdaimi K, Papavasiliou V, Rabbani SA, Rhim JS, Goltzman D, Kremer R Reversal of hypercalcemia with the vitamin D analogue EB 1089 in a human model of squamous cancer. Cancer Res 1999, 59:3325-3328.
102. El Abdaimi K, Dion N, Papavasiliou V, Cardinal PE, Binderup L, Goltzman D, Ste-Marie LG, Kremer R The vitamin D analogue EB 1089 prevents skeletal metastasis and prolongs survival time in nude mice transplanted with human breast cancer cells. Cancer Res 2000, 60:4412-4418.
103. Sasaki A, Boyce BF, Story B, Wright KR, Chapman M, Boyce R, Mundy GR, Yoneda T Bisphosphonate residronate reduces metastatic human breast cancer burden in bone in nude mice. Cancer Res 1995, 55:3551-3557.
104. 3 suppresses growth and induces differentiation in an autocrine fashion. Mol Cancer Res 2002, 1:56-67.
105. Thiede MA, Harm SC, Hasson DM, Gardner RM In vivo regulation of parathyroid hormone-related peptide messenger ribonucleic acid in the rat uterus by 17β-estradiol. Endocrinology 1991, 128:2317-2323.
106. El Abdaimi K, Papavasiliou V, Goltzman D, Kremer R Expression and regulation of parathyroid hormone-related peptide in normal and malignancy melanocytes. Am J Physiol Cell Physiol 2000, 279:C1230-C1238.
107. Thiede MA The mRNA encoding a parathyroid hormone-like peptide is produced in mammary tissue in response to elevations in serum prolactin. Mol Endocrinol 1989, 3:1443-1447.
108. Huang DC, Papavasiliou V, Rhim JS, Horst RL, Kremer R Mol Cancer Res 2002, 1:1-12.