DNA sequences in the rat parathyroid hormone-related peptide gene responsible for 1,25-dihydroxyvitamin D3-mediated transcriptional repression

Molecular Endocrinology

Volumn 10, Issue 6, 1996, Pages 672-681

  Falzon, Miriam ^a,b  

^a University of Texas Medical Branch School of Medicine   (United States)

^b UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; CALCITRIOL; CHLORAMPHENICOL ACETYLTRANSFERASE; DNA; MESSENGER RNA; PARATHYROID HORMONE RELATED PROTEIN; VITAMIN RECEPTOR;

ANIMAL CELL; ARTICLE; AUTORADIOGRAPHY; CONTROLLED STUDY; DNA SEQUENCE; DOWN REGULATION; ELECTROPHORETIC MOBILITY; GENE; GENE EXPRESSION; GENETIC TRANSCRIPTION; HYPERCALCEMIA; MONKEY; NONHUMAN; NORTHERN BLOTTING; PRIORITY JOURNAL; RAT;

ANIMALS; BASE SEQUENCE; BINDING SITES; CALCITRIOL; DOWN-REGULATION; ELECTROPHORESIS; GENE EXPRESSION REGULATION; PARATHYROID HORMONE-RELATED PROTEIN; PROTEINS; RATS; RECEPTORS, CALCITRIOL; SEQUENCE HOMOLOGY, NUCLEIC ACID; TRANSCRIPTION, GENETIC; VITAMIN D;

EID: 0029969905     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/me.10.6.672     Document Type: Article

References (47)

1. Moseley JM, Kubota M, Diefenbach-Jagger H, Wettenhall REH, Kemp BE, Suva LJ, Rodda CP, Ebeling PR, Hudson PJ, Zajac JD, Martin TJ 1987 Parathyroid hormone-related protein purified from a human lung cancer cell line. Proc Natl Acad Sci USA 84:5048-5052
2. Burtis WJ, Wu T, Bunch C, Wysolmerski JJ, Insogna KL, Weir EC, Broadus AE, Stewart AF 1987 Identification of a novel 17,000-dalton parathyroid hormone-like adenylate cyclase-stimulating protein from a tumor associated with humoral hypercalcemia of malignancy. J Biol Chem 262: 7151-7156
3. Suva LJ, Winslow GA, Wettenhall REH, Hammonds RG, Moseley JM, Diefenbach-Jagger H, Rodda CP, Kemp BE, Rodriguez H, Chen, EY, Hudson, PJ, Martin TJ, Wood WI 1987 A parathyroid hormone-related protein implicated in malignant hypercalcemia: cloning and expression. Science 237:893-896
4. Broadus AE, Mangin M, Ikeda K, Insogna KL, Weir EC, Burtis WJ, Stewart AF 1988 Humoral hypercalcemia of cancer. N Engl J Med 319:556-563
5. Yasuda T, Banville D, Hendy GN, Goltzman D 1989 Characterization of the human parathyroid hormone-like peptide gene. J Biol Chem 264:7720-7725
6. Martin TJ, Moseley JM, Gillespie MT 1991 Parathyroid hormone-related protein: biochemistry and molecular biology. Crit Rev Biochem Mol Biol 26:377-395
7. Stewart AF, Wu T, Goumas D, Burtis WJ, Broadus AE 1987 N-terminal amino-acid sequence of two novel tumor-derived adenylate cyclase-stimulating proteins: identification of parathyroid hormone-like and -unlike domains. Biochem Biophys Res Commun 146:672-678
8. Strewler GJ, Stern PH, Jacobs JW, Eveloff J, Klein RF, Leung SC, Rosenblatt M, Nissenson RA 1987 Parathyroid hormone-like protein from human renal carcinoma cells. Structural and functional homology with parathyroid hormone. J Clin Invest 80:1803-1807
9. Jüppner H, Abou-Samra A-B, Uneno S, Gu W-X, Potts Jr JT, Segre GV 1988 The parathyroid hormone-like peptide associated with humoral hypercalcemia of malignancy and parathyroid hormone bind to the same receptor on the plasma membrane of ROS 17/2.8 cells. J Biol Chem 263:8557-8560
10. Nissenson RA, Diep D, Strewler GJ 1988 Synthetic peptides comprising the amino-terminal sequence of a parathyroid hormone-like protein from human malignancies. Binding to parathyroid hormone receptors and activation of adenylate cyclase in bone cells and kidney. J Biol Chem 263:12866-12871
11. Jüppner H, Abou-Samra A-B, Freeman M, Kong XF, Schipani E, Richards J, Kolakowski Jr LF, Hock J, Potts Jr JT, Kronenberg HM, Segre GV 1991 A G protein-linked receptor for parathyroid hormone and parathyroid hormone-related peptide. Science 254:1024-1026
12. Abou-Samra A-B, Jüppner H, Force T, Freeman MW, Kong X-F, Schipani E, Urena P, Richards J, Bonventre JV, Potts JT, Kronenberg HM, Segre GV 1992 Expression cloning of a common receptor for parathyroid hormone and parathyroid hormone-related peptide from rat osteoblast-like cells: a single receptor stimulates intracellular accumulation of both cAMP and inositol triphosphates and increases intracellular free calcium. Proc Natl Acad Sci USA 89:2732-2736
13. 3 on gene expression and secretion. J Clin Invest 87:884-893
14. Ikeda K, Lu C, Weir EC, Mangin M, Broadus AE 1989 Transcriptional regulation of the parathyroid hormone-related peptide by glucocorticoids and vitamin D in a human C-cell line. J Biol Chem 264:15743-15746
15. Reichel H, Koeffler HP, Norman AW 1989 The role of the vitamin D endocrine system in health and disease. N Engl J Med 320:980-991
16. Naveh-Many T, Silver J 1988 Regulation of calcitonin gene transcription by vitamin D metabolites in vivo in the rat. J Clin Invest 81:270-273
17. Peleg S, Abruzzesse RV, Cooper CW, Gagel RF 1993 Down-regulation of calcitonin gene transcription by vitamin D requires two widely separated enhancer sequences. Mol Endocrinol 7:999-1008
18. Haussler MR, Terpening CM, Komm BS, Whitfield GK, Haussler CA 1988 Vitamin D hormone receptors: structure, regulation and molecular function. In: Norman AW, Schaefer K, Grigoleit H-G, Herrath DV (eds) Vitamin D: Molecular, Cellular and Clinical Endocrinology. de Gruyter, Berlin, pp 205-214
19. Ozono K, Liao J, Kerner SA, Scott RA, Pike JW 1990 The vitamin D-responsive element in the human osteocalcin gene. J Biol Chem 265:21881-21888
20. MacDonald PN, Haussler CA, Terpening CM, Galligan MA, Reeder MC, Whitfield GK, Haussler MR 1991 Baculovirus-mediated expression of the human vitamin D receptor. Functional characterization, vitamin D response element interactions and evidence for a receptor auxiliary factor. J Biol Chem 266:18808-18813
21. 3. Proc Natl Acad Sci USA 86:4455-4459
22. 3. Proc Natl Acad Sci USA 87:369-373
23. 3 enhancement of mouse secreted phosphoprotein 1 (Spp-1 or osteopontin) gene expression. Proc Natl Acad Sci USA 87:9995-9999
24. 3 receptors. Cell 65:1255-1266
25. 3. J Bone Miner Res 6:1021-1027
26. Yu VC, Delsert C, Andersen B, Holloway JM, Devary OV, Naar AM, Kim SY, Boutin JM, Glass CK, Rosenfeld MG 1991 RXRβ: a coregulator that enhances binding of retinoic acid, thyroid hormone, and vitamin D receptors to their cognate response elements. Cell 67:1251-1266
27. Leid M, Kastner P, Nakshatri H, Saunders M, Zacharewski T, Chen J-Y, Staub A, Garnier J-M, Mader S, Chambon P 1992 Purification, cloning, and RXR identity of the HeLa cell factor with which RAR or TR heterodimerizes to bind target sequences efficiently. Cell 68:377-395
28. 3. Proc Natl Acad Sci USA 89: 8097-8101
29. MacDonald PN, Dowd DR, Nakajima S, Galligan MA, Reeder MC, Haussler CA, Ozato K, Haussler MR 1993 Retinoid X receptors stimulate and 9-cis retinoic acid inhibits 1,25-dihydroxyvitamin D activated expression of the rat osteocalcin gene. Mol Cell Biol 13:5907-5917
30. 3. J Biol Chem 269:2971-2981
31. Akerblom IE, Slater EP, Beato M, Baxter JD, Mellon PL, 1988 Negative regulation by glucocorticoids through interference with a cAMP responsive enhancer. Science 241:350-353
32. Yang-Yen H-F, Chambard J-C, Sun Y-L, Smeal T, Schmidt TJ, Drouin J, Karin M 1990 Transcriptional interference between c-jun and the glucocorticoid receptor: mutual inhibition of DNA binding due to direct protein-protein interaction. Cell 62:1205-1215
33. Adler SL, Waterman ML, He X, Rosenfeld MG 1988 Steroid receptor-mediated inhibition of rat prolactin gene expression does not require the receptor DNA-binding domain. Cell 52:685-695
34. 3 increases synthesis of the vitamin K-dependent bone protein by osteosarcoma cells. J Biol Chem 255:11660-11663
35. 3 24-hydroxylase gene. J Biol Chem 269:10545-10550
36. Parker CS, Topol J 1984 A Drosophila RNA polymerase Il transcription factor contains a promoter-region-specific DNA-binding activity. Cell 36:357-369
37. Ohlsson H, Edlund T 1986 Sequence-specific interactions of nuclear factors with the insulin gene enhancer. Cell 45:35-44
38. Coen DM 1995 The polymerase chain reaction. In: Ausubel FM, Brent R, Kingston RE, Moore DD, Seidman JG, Smith JA, Struhl K (eds) Current Protocols in Molecular Biology. John Wiley & Sons, Inc., New York, unit 15
39. 3 receptor. Proc Natl Acad Sci USA 85:9499-9502
40. Maniatis T, Fritsch EF, Sambrook J (eds) 1989 Molecular Cloning: A Laboratory Manual, ed. 2. Cold Spring Harbor Laboratory, NY
41. Lieberman HB, Lin P-F, Yeh D-B, Ruddle FH 1988 Transcriptional and posttranscriptional mechanisms regulate murine thymidine kinase gene expression in serum-stimulated cells. Mol Cell Biol 8:5280-5291
42. Mahajan PB, Thompson Jr EA 1987 Cyclosporin A inhibits rDNA transcription in lymphosarcoma P1798 cells. J Biol Chem 262:16150-16156
43. Bradford MM 1976 A rapid and sensitive method for the quantitation of microgram quantities of protein using the principle of protein-dye binding. Anal Biochem 72:248-253
44. Gorman CM, Moffat LF, Howard BH 1982 Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells. Mol Cell Biol 2:1044-1051
45. Feenstra A, Fewell J, Lueders K, Kuff EL 1986 In vitro methylation inhibits the promoter activity of a cloned intracisternal A-particle LTR. Nucleic Acids Res 14:4343-4352
46. Falzon M, Kuff EL 1988 Multiple protein-binding sites in an intracisternal A-particle long terminal repeat. J Virol 62:4070-4077
47. Falzon M, Kuff EL 1989 Isolation and characterization of a protein fraction that binds to enhancer core sequences in intracisternal A-particle long terminal repeats. J Biol Chem 264:21915-21922