Induction of parathyroid hormone-related peptide by the Ras oncogene: Role of Ras farnesylation inhibitors as potential therapeutic agents for hypercalcemia of malignancy

Cancer Research

Volumn 57, Issue 20, 1997, Pages 4517-4522

  Aklilu, Fasika ^a   Park, Morag ^a   Goltzman, David ^a   Rabbani, Shafaat Ahmed ^a  

^a ROYAL VICTORIA HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

PARATHYROID HORMONE;

ANIMAL CELL; ARTICLE; CANCER; CELL PROLIFERATION; FEMALE; GENE INDUCTION; HYPERCALCEMIA; MOUSE; NONHUMAN; ONCOGENE RAS; PRIORITY JOURNAL; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ALKYL AND ARYL TRANSFERASES; ANIMALS; ANTINEOPLASTIC AGENTS; CELL DIVISION; CELL LINE; CELL TRANSFORMATION, NEOPLASTIC; ENZYME INHIBITORS; FEMALE; GENES, RAS; HYPERCALCEMIA; METHIONINE; MICE; MICE, NUDE; MUTAGENESIS, SITE-DIRECTED; NEOPLASMS, EXPERIMENTAL; PARATHYROID HORMONE; PARATHYROID HORMONE-RELATED PROTEIN; PROTEIN BIOSYNTHESIS; PROTEIN ISOPRENYLATION; RATS; RATS, INBRED F344; TRANSFECTION;

EID: 0030774564     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (45)

1. Moseley, J. M., Kubota, M., Diefenbach-Jagger, H. D., Wettenhall, R. E. H., Kemp, B. E., Suva, L. J., Rodda, C. P., Ebeling, P. R., Hudson, P. J., Zajac, J. D., and Martin, T. J. Parathyroid hormone-related protein purified from a human lung cancer cell line. Proc. Natl. Acad. Sci. USA. 84: 5048-5052, 1987.
2. Stewart, A. F., Wu, T., Goumas, D., Burtis, W. J., and Broadus, A. E. N-termmal amino acid sequence of two novel tumor-derived adenylate cyclase-stimulating proteins: identification of parathyroid hormone-like and parathyroid hormone-unlike domains. Biochem. Biophys. Res. Commun., 146: 672-678, 1987.
3. Strewler, G. J., Stern, P. H., Jacobs, J. W., Eveloff, J., Klein, R. F., Leung, S. C., Rosenblatt, M., and Nissenson, R. A. Parathyroid hormone like protein from human renal carcinoma cells. Structural and functional homology with parathyroid hormone. J. Clin. Invest., 80: 1803-1807, 1987.
4. Rabbani, S. A., Mitchell, J., Roy, D. R., Kremer, Bennett, H. P. J., and Goltzman, D. Purification of peptides with parathyroid hormone-like bioactivity from human and rat malignancies associated with hypercalcemia. Endocrinology, 118: 1200-1210, 1986.
5. Li, X., and Drucker, D. J. Growth factor-like properties of parathyroid hormone-related peptide in transfected rodent cell lines. Cancer Res., 53: 2980-2986, 1994.
6. Rabbani, S. A., Mitchell, J., Roy, D. R., Hendy, G. N., and Goltzman, D. Influence of the amino-terminus on in vitro and in vivo biological activity of synthetic parathyroid hormone-like peptides of malignancy. Endocrinology, 123: 2709-2716, 1988.
7. Jüppner, H., Abou-Samra, A., Freeman, M., Kong, X. F., Schipani, E., Richards, J., Kolakowski, L. F., Hock, J., Potts, J. T., Kronenberg, H. M., and Segre, G. V. A G-protein linked receptor for parathyroid hormone and parathyroid hormone-related peptide. Science (Washington DC), 254: 1024-1026, 1991.
8. McAuley, P., Asa, S. L., Chiu, B., Henderson, J., Goltzman, D., and Drucker, D. J. Parathyroid hormone-like peptide in normal and neoplastic mesothelial cells. Cancer (Phila.), 66: 1975-1979, 1990.
9. Burton, P. B., Moniz, C., and Knight, D. Parathyroid hormone related peptide can function as an autocrine growth factor in human renal cell carcinoma. Biochem. Biophys. Res. Commun., 167: 1134-1138, 1990.
10. Rabbani, S. A., Gladu, J., Liu, B., and Goltzman, D. Regulation in vivo of the growth of Leydig cell tumors by antisense ribonucleic acid for parathyroid hormone-related peptide. Endocrinology. 136: 5416-5422, 1995.
11. Kremer, R., Karaplis, A. C., Henderson, J., Gulliver, W., Banville, D., Hendy, G. N., and Goltzman, D. Regulation of parathyroid hormone-like peptide in cultured normal human keratinocytes. Effect of growth factors and 1,25 dihydroxyvitamin D3 on gene expression and secretion. J. Clin. Invest., 87: 884-893, 1991.
12. Karaplis, A. C., Luz, A., Glowacki, J., Bronson, R. T., Tybulewicz, V. L., Kronenberg, H. M., and Mulligan, R. C. Lethal skeletal dysplasia from targeted disruption of the parathyroid hormone-related peptide gene. Genes Dev., 8: 277-289, 1994.
13. Thiede, M. A., and Rodan, G. A. Expression of a calcium-mobilizing parathyroid hormone-like peptide in lactating mammary tissue. Science (Washington DC), 242: 278-280, 1988.
14. Sebag, M., Henderson, J., Goltzman, D., and Kremer, R. Regulation of parathyroid hormone-related peptide production in normal human mammary epithelial cells in vitro. Am. J. Physiol., 267: C723-C730, 1994.
15. Soifer, N. E., Van Why, S. K., Ganz, M. B., Kashgarian, M., Seigel, N. J., and Stewart, A. F. Expression of parathyroid hormone-related protein in the rat glomerulus and tubule during recovery from renal ischemia. J. Clin. Invest., 92: 2850-2857, 1993.
16. Abbas, S. K., Pickard, D. W., Illingworth, D., Storer, J., Purdie, D. W., Moniz, C., Dixit, M., Caple, I. W., Ebeling, P. R., Rodda, C. P., Martin, T. J., and Care, A. D. Measurement of parathyroid hormone related protein in extracts of fetal parathyroid glands and placental membranes. J. Endocrinol., 124: 319-325, 1990.
17. Mok, L. L. S., Nickols, G. A., Thompson, J. C., and Cooper, C. W. Parathyroid hormone as a smooth muscle relaxant. Endocr. Rev., 10: 420-436, 1989.
18. Philbrick, W. M., Wysolmerski, J. J., Galbraith, S., Holt, E., Orloff, J. J., Yang, K. H., Vasavada, R. C., Weir, E. C., Broadus, A. E., and Stewart, A. F. Defining the roles of parathyroid hormone-related protein in normal physiology. Physiol. Rev., 76: 127-170, 1996.
19. Guise, T. A., Yoneda, T., Yates, A. J., and Mundy, G. R. The combined effect of tumor-produced parathyroid hormone-related protein and transforming growth factor-alpha enhance hypercalcemia in vivo and bone resorption in vitro. J. Clin. Endocrinol. Metab., 77: 40-45, 1993.
20. Burtis, W. J., Brady, T. G., Orloff, J. J., Ersbak, J. B., Warrell, R. P., Jr., Olson, B. R., Wu, T. L., Mitnick, M. E., Broadus, A. E., and Stewart, A. F. Immunochemical characterization of circulating parathyroid hormone-related protein in patients with humoral hypercalcemia of cancer. N. Engl. J. Med., 322: 1106-1112, 1990.
21. Stewart, A. F., Horst, R., Deftos, L. J., Cadman, E. C., Lang, R., and Broadus, A. E. Biochemical evaluation of patients with cancer-associated hypercalcemia: evidence for humoral and non-humoral groups. N. Engl. J. Med., 303: 1377-1383, 1980.
22. Aklilu, F., Park, M., Goltzman, D., and Rabbani, S. A. Increased PTHRP production by a tyrosine kinase oncogene, Tpr-Met: role of the Ras signaling pathway. Am. J. Physiol., 271: E277-E283, 1996.
23. Bos, J. L. Ras oncogenes in human cancer: a review. Cancer Res., 49: 4682-4689, 1989.
24. Casey, P. J., Solski, P. A., Der, C. J., and Buss, J. E. p21ras is modified by a farnesyl isoprenoid. Proc. Natl. Acad. Sci. USA, 86: 8323-8327, 1989.
25. Kato, K., Cox, A. D., Hisaka, M. M., Graham, S. M., Buss, J. E., and Der, C. J. Isoprenoid addition to Ras protein is the critical modification for its membrane association and transforming activity. Proc. Natl. Acad. Sci. USA, 89: 6403-6407, 1992.
26. Boguski, M. S., and McCormick, F. Proteins regulating Ras and its relatives. Nature (Lond.), 366: 643-654, 1993.
27. Barbacid, M. ras genes. Annu. Rev. Biochem., 56: 779-827, 1987.
28. Kohl, N. E., Conner, M. W., Gibbs, J. B., Graham, S. L., Hartman, G. D., and Oliff, A. Development of inhibitors of protein farnesylation as potential chemotherapeutic agents. J. Cell. Biochem., 22: 145-150, 1995.
29. Nagasu, T., Yoshimatsu, K., Rowell, C., Lewis, M. D., Garcia, A. M. Inhibition of human tumor xenograft growth by treatment with the farnesyl transferase inhibitor B956. Cancer Res., 55: 5310-5314, 1995.
30. Gibbs, J. B., Pompliano, D. L., Mosser, S. D., Rands, E., Lingham, R. B., Singh, S. B., Scolnick, E. M., Kohl, N. E., and Oliff, A. Selective inhibition of farnesyl-protein transferase blocks ras processing in vivo. J. Biol. Chem., 268: 7617-7620, 1993.
31. Sepp-Lorenzino, L., Ma, Z., Rands, E., Kohl, N. E., Gibbs, J. B., Oliff, A., and Rosen, N. A peptidomimetic inhibitor of farnesyl: protein transferase blocks the anchorage-dependent and -independent growth of human tumor cell lines. Cancer Res., 55: 5302-5309, 1995.
32. Rabbani, S. A., Haq, M., and Goltzman, D. Biosynthesis and processing of endogenous parathyroid hormone related peptide (PTHRP) by rat Leydig cell tumor H-500. Biochemistry, 32: 4931-4937, 1993.
33. Thomas, P. S. Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose. Proc. Natl. Acad. Sci. USA, 77: 5201-5205, 1980.
34. Henderson, J., Shustik, C., Kremer, R., Rabbani, S. A., Hendy, G. N., and Goltzman, D. Circulating concentrations of parathyroid hormone-like peptide in malignancy and in hyperparathyroidism. J. Bone Miner. Res., 5: 105-113, 1989.
35. Glantz, S. A. Primer of Biostatistics. New York: McGraw-Hill, 1981.
36. 2+ stimulate accumulation of inositol phosphates in bovine parathyroid cells. FEBS Lett., 218: 113-118, 1987.
37. Henderson, J. E., Sebag, M., Rhim, J. S., Golizman, D., and Kremer, R. Dysregulation of parathyroid hormone-like peptide expression and secretion in a keratinocyte model of tumor progression. Cancer Res., 51: 6521-6528, 1991.
38. Wysolmerski, J. J., Vasavada, R., Foley, J., Weir, E. C., Burtis, W. J., Kukreja, S. C., Guise, T. A., Broadus, A. E., and Philbrick, W. M. Transaction of the PTHrP gene in squamous carcinomas predicts the occurrence of hypercalcemia in athymic mice. Cancer Res., 56: 1043-1049, 1996.
39. Kremer, R., Sebag, M., Champigny, C., Meerovitch, K., Hendy, G. N., White, J., and Goltzman, D. Identification and characterization of 1,25-dihydroxyvitamin D3-responsive repressor sequences in the rat parathyroid hormone-related peptide gene. J. Biol. Chem., 271: 16310-16316, 1996.
40. Haq, M., Kremer, R., Goltzman, D., and Rabbani, S. A. A vitamin D analogue (EB1089) inhibits parathyroid hormone-related peptide production and prevents the development of malignancy-associated hypercalcemia in vivo. J. Clin. Invest., 91: 2416-2422, 1993.
41. Liu, B., Amizuka, N., Goltzman, D., and Rabbani, S. A. Inhibition of processing of parathyroid hormone-related peptide by anti-sense furin: effect in vitro and in vivo on rat Leydig (H-500) tumor cells. Int. J. Cancer, 63: 276-281, 1995.
42. Liu, B., Goltzman, D., and Rabbani, S. A. Processing of pro-PTHRP by the prohormone convertase, furin: effect on biological activity. Am. J. Physiol., 268: E832-E838, 1995.
43. Khosravi-Far, R., White, M. A., Westwick, J. K., Solski, P. A., Chrzanowska-Wodnicka, M., Van Aeist, L., Wigler, M. H., and Der, C. J. Oncogenic Ras activation of Raf/mitogen-activated protein kinase-independent pathways is sufficient to cause tumorigenic transformation. Mol. Cell. Biol., 16: 3923-3933, 1996.
44. Cowley, S., Paterson, H., Kemp, P., and Marshall, C. J. Activation of MAP kinase kinase is necessary and sufficient for PC 12 differentiation and for transformation of NIH 3T3 cells. Cell. 77: 841-852, 1994.
45. Davis, R. J. The mitogen-activated protein kinase signal transduction pathway. J. Biol. Chem., 268: 14553-14556, 1993.