Modulation of nuclear protein import. A novel means of regulating gene expression

Biochemical Pharmacology

Volumn 56, Issue 2, 1998, Pages 157-161

  Fujihara, Sheri M ^a   Nadler, Steven G ^a  

^a BRISTOL MYERS SQUIBB   (United States)

Author keywords

Karyopherin ; NLS; Nuclear transport; Peptides

Indexed keywords

15 DEOXYSPERGUALIN; CYCLOSPORIN; NUCLEAR PROTEIN; PEPTIDE; STEROID; TACROLIMUS; TRANSCRIPTION FACTOR;

ARTICLE; EUKARYOTE; GENE EXPRESSION; NONHUMAN; PRIORITY JOURNAL; PROTEIN TRANSPORT;

ANIMALS; BIOLOGICAL TRANSPORT; GENE EXPRESSION REGULATION, VIRAL; NUCLEAR PROTEINS;

EID: 0031787639     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(98)00049-5     Document Type: Article

References (40)

1. Görlich D, Nuclear protein import. Curr Opin Cell Biol 9: 412-419, 1997.
2. Panté N and Aebi U, Toward the molecular dissection of protein import into nuclei. Curr Opin Cell Biol 8: 397-406, 1996.
3. Görlich D and Mattaj IW, Nucleocytoplasmic transport. Science 271: 1513-1518, 1996.
4. Pandey S and Parnaik VK, Identification and characterization of nuclear location signal-binding proteins in nuclear envelopes. Biochim Biophys Acta 1063: 81-89, 1991.
5. Adam SA, Lobl TJ, Mitchell MA and Gerace L, Identification of specific binding proteins for a nuclear location sequence. Nature 337: 276-279, 1989.
6. Stochaj U, Osborne M, Kurihara T and Silver P, A yeast protein that binds nuclear localization signals: Purification localization, and antibody inhibition of binding activity. J Cell Biol 113: 1243-1254, 1991.
7. Yamasaki L, Kanda P and Lanford RE, Identification of four nuclear transport signal-binding proteins that interact with diverse transport signals. Mol Cell Biol 9: 3028-3036, 1989.
8. Radu A, Blobel G and Moore MS, Identification of a protein complex that is required for nuclear protein import and mediates docking of import substrate to distinct nucleoporins. Proc Nad Acad Sci USA 92: 1769-1773, 1995.
9. Chelsky D, Ralph R and Jonak G, Sequence requirements for synthetic peptide-mediated translocation to the nucleus. Mol Cell Biol 9: 2487-2492, 1989.
10. Lanford RE, Kanda P and Kennedy RC, Induction of nuclear transport with a synthetic peptide homologous to the SV40 T antigen transport signal. Cell 46: 575-582, 1986.
11. Michaud N and Goldfarb DS, Most nuclear proteins are imported by a single pathway. Exp Cell Res 208: 128-136, 1993.
12. Lanford RE, Feldherr CM, White RG, Dunham RG and Kanda P, Comparison of diverse transport signals in synthetic peptide-induced nuclear transport. Exp Cell Res 186: 32-38, 1990.
13. Goldfarb DS, Gariépy J, Schoolnik G and Kornberg RD, Synthetic peptides as nuclear localization signals. Nature 322: 641-644, 1986.
14. Boulikas T, Nuclear localization signals (NLS). Crit Rev Eukaryot Gene Exp 3: 193-227, 1993.
15. Adam SA, Sterne-Marr R and Gerace L, Nuclear protein import in permeabilized mammalian cells requires soluble cytoplasmic factors. J Cell Biol 111: 807-816, 1990.
16. Görlich D, Prehn S, Laskey RA and Hartmann E, Isolation of a protein that is essential for the first step of nuclear protein import. Cell 79: 767-778, 1994.
17. Nadler SG, Tritschler D, Haffar OK, Blake J, Bruce AG and Cleaveland JS, Differential expression and sequence-specific interaction of karyopherin a with nuclear localization sequences. J Biol Chem 272: 4310-4315, 1997.
18. Shulga N, Roberts P, Gu Z, Spitz L, Tabb MM, Nomura M and Goldfarb DS, In vivo nuclear transport kinetics in Saccharomyces cerevisiae: A role for heat shock protein 70 during targeting and translocation. J Cell Biol 135: 329-339, 1996.
19. Koepp DM and Silver PA, A GTPase controlling nuclear trafficking: Running the right way or walking RANdomly? Cell 87: 1-4, 1996.
20. Barnes PJ and Karin M, Nuclear factor-κB - A pivotal transcription factor in chronic inflammatory diseases. N Engl J Med 336: 1066-1071, 1997.
21. Grilli M, Chiu JJ-S and Lenardo MJ, NF-κB and Rel: Participants in a multiform transcriptional regulatory system. Int Rev Cytol 143: 1-62, 1993.
22. Vosshall LB, Price JL, Sehgal A, Saez L and Young MW, Block in nuclear localization of period protein by a second clock mutation, timeless. Science 263: 1606-1609, 1994.
23. Norris JL and Manley JL, Selective nuclear transport of the Drosophila morphogen dorsal can be established by a signaling pathway involving the transmembrane protein Toll and protein kinase A. Genes Dev 6: 1654-1667, 1992.
24. Mercurio F, Zhu H, Murray BW, Shevchenko A, Bennett BL, Li JW, Young DB, Barbosa M, Mann M, Manning A and Rao A, IKK-1 and IKK-2: Cytokine-activated IκB kinases essential for NF-κB activation. Science 278: 860-866, 1997.
25. Woronicz JD, Gao X, Cao Z, Rothe M and Goeddel DV, IκB kinase-β: NF-κB activation and complex formation with IκB kinase-α and NIK. Science 278: 866-869, 1997.
26. Palombella VJ, Rando OJ, Goldberg AL and Maniatis T, The ubiquitin-proteasome pathway is required for processing the NF-κB1 precursor protein and the activation of NF-κB. Cell 78: 773-785, 1994.
27. Tagawa T, Kuroki T, Vogt PK and Chida K, The cell cycle-dependent nuclear import of v-Jun is regulated by phosphorylation of a serine adjacent to the nuclear localization signal. J Cell Biol 130: 255-263, 1995.
28. Moll T, Tebb G, Surana U, Robirsch H and Nasmyth K, The role of phosphorylation and the CDC28 protein kinase in cell cycle-regulated nuclear import of the S. cerevisiae transcription factor SW15, Cell 66: 743-758, 1991.
29. Rao A, NF-ATp: A transcription factor required for the co-ordinate induction of several cytokine genes. Immunol Today 15: 274-281, 1994.
30. Schreiber SL, Chemistry and biology of the immunophilins and their immunosuppressive ligands. Science 251: 283-287, 1991.
31. Scheinman RI, Cogswell PC, Lofquist AK and Baldwin AS Jr, Role of transcriptional activation of IκBα in mediation of immunosuppression by glucocorticoids. Science 270: 283-290, 1995.
32. Dubrovsky L, Ulrich P, Nuovo GJ, Manogue KR, Cerami A and Bukrinsky M, Nuclear localization signal of HIV-1 as a novel target for therapeutic intervention. Mol Med 1: 217-230, 1995.
33. Popov S, Dubrovsky L, Lee MA, Pennathur S, Haffar O, aL-Abed Y, Tonge P, Ulrich P, Rexach M, Blobel G, Cerami A and Bukrinsky M, Critical role of reverse transcriptase in the inhibitory mechanism of CNI-H0294 on HIV-1 nuclear translocation. Proc Natl Acad Sci USA 93: 11859-11864, 1996.
34. Gulizia J, Dempsey MP, Sharova N, Bukrinsky MI, Spitz L, Goldfarb D and Stevenson M, Reduced nuclear import of human immunodeficiency virus type 1 preintegration complexes in the presence of a prototypic nuclear targeting signal. J Virol 68: 2021-2025, 1994.
35. Burton PS, Conradi RA, Ho NFH, Hilgers AR and Borchard RT, How structural features influence the biomembrane permeability of peptides. J Pharm Sci 85: 1336-1340, 1996.
36. Lin Y-Z, Yao S, Veach RA, Torgeson TR and Hawiger J, Inhibition of nuclear translocation of transcription factor NF-κB by a synthetic peptide containing a cell membrane-permeable motif and nuclear localization sequence. J Biol Chem 270: 14255-14258, 1995.
37. Cleves AE, Protein transport: The nonclassical ins and outs. Curr Biol 7: R318-R320, 1997.
38. Tepper MA, Nadler SG, Esselstyn JM and Sterbenz KG, Deoxyspergualin inhibits K light chain expression in 70Z/3 pre-B cells by blocking lipopolysaccharide-induced NF-κB activation. J Immunol 155: 2427-2436, 1995.
39. Yang J and DeFranco DB, Differential roles of heat shock protein 70 in the in vitro nuclear import of glucocorticoid receptor and simian virus 40 large tumor antigen. Mol Cell Biol 14: 5088-5098, 1994.
40. Her L-S, Lund E and Dahlberg JE, Inhibition of Ran guanosine triphosphatase-dependent nuclear transport by the matrix protein of vesicular stomatitis virus. Science 276: 1845-1848, 1997.