Poly(ethylene glycol)-block-cationic polylactide nanocomplexes ofdiffering charge density for gene delivery

Biomaterials

Volumn 34, Issue 37, 2013, Pages 9688-9699

  Chen, Chih Kuang ^a   Jones, Charles H ^a   Mistriotis, Panagiotis ^a   Yu, Yun ^a   Ma, Xiaoni ^a   Ravikrishnan, Anitha ^a   Jiang, Ming ^a   Andreadis, Stelios T ^a,b,c   Pfeifer, Blaine A ^a   Cheng, Chong ^a  

^a State University of New York   (United States)

^b University at Buffalo SUNY   (United States)

^c UNIVERSITY AT BUFFALO   (United States)

Author keywords

Cationic polymer; Gene delivery; Nanocomplex; PEGylation; Polylactide

Indexed keywords

CATIONIC POLYMERS; GENE DELIVERY; NANOCOMPLEXES; PEGYLATION; POLY LACTIDE;

BODY FLUIDS; CELL CULTURE; CHARGE DENSITY; NUCLEIC ACIDS; PHYSIOLOGY; POLYESTERS; POLYETHYLENE GLYCOLS; STEM CELLS;

GENE TRANSFER;

ALLYL COMPOUND; CATION; ENHANCED GREEN FLUORESCENT PROTEIN; LUCIFERASE; MACROGOL; NANOCARRIER; PLASMID DNA; POLYLACTIDE; TERTIARY AMINE; THIOL DERIVATIVE;

ADULT; ANIMAL CELL; ARTICLE; BIODEGRADABILITY; BIOPHYSICS; CONTROLLED STUDY; CYTOTOXICITY; EMBRYO; EPITHELIUM CELL; FIBROBLAST; GENE VECTOR; GENETIC TRANSFECTION; HEMOLYSIS; HUMAN; HUMAN CELL; IN VITRO GENE TRANSFER; MACROPHAGE; MALE; MOUSE; NANOFABRICATION; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; PRECURSOR; PRIORITY JOURNAL; STATIC ELECTRICITY; STEM CELL; SURFACE CHARGE;

CATIONIC POLYMER; GENE DELIVERY; NANOCOMPLEX; PEGYLATION; POLYLACTIDE;

ANIMALS; CATIONS; CELL LINE; DNA; GENE TRANSFER TECHNIQUES; HUMANS; PLASMIDS; POLYESTERS; POLYETHYLENE GLYCOLS;

EID: 84884816169     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2013.08.063     Document Type: Article

References (64)

1. Giacca M., Zacchigna S. Virus-mediated gene delivery for human gene therapy. JControl Release 2012, 161:377-388.
2. Vannucci L., Lai M., Chiuppesi F., Ceccherini-Nelli L., Pistello M. Viral vectors: a look back and ahead on gene transfer technology. New Microbiol 2013, 36:1-22.
3. Thomas C.E., Ehrhardt A., Kay M.A. Progress and problems with the use of viral vectors for gene therapy. Nat Rev Genet 2003, 4:346-358.
4. Bouard D., Alazard-Dany D., Cosset F.L. Viral vectors: from virology to transgene expression. Br J Pharmacol 2009, 157:153-165.
5. Felgner P.L., Gadek T.R., Holm M., Roman R., Chan H.W., Wenz M., et al. Lipofection: a highly efficient, lipid-mediated DNA-transfection procedure. Proc Natl Acad Sci U S A 1987, 84:7413-7417.
6. Chen Y., Bathula S.R., Yang Q., Huang L. Targeted nanoparticles deliver siRNA to melanoma. JInvest Dermatol 2010, 130:2790-2798.
7. Zheng M., Pavan G.M., Neeb M., Schaper A.K., Danani A., Klebe G., et al. Targeting the blind spot of polycationic nanocarrier-based siRNA delivery. ACS Nano 2012, 6:9447-9454.
8. Patil M.L., Zhang M., Minko T. Multifunctional triblock nanocarrier (PAMAM-PEG-PLL) for the efficient intracellular siRNA delivery and gene silencing. ACS Nano 2011, 5:1877-1887.
9. Samal S.K., Dash M., Van Vlierberghe S., Kaplan D.L., Chiellini E., van Blitterswijk C., et al. Cationic polymers and their therapeutic potential. Chem Soc Rev 2012, 41:7147-7194.
10. Mintzer M.A., Simanek E.E. Nonviral vectors for gene delivery. Chem Rev 2009, 109:259-302.
11. Benjaminsen R.V., Mattebjerg M.A., Henriksen J.R., Moghimi S.M., Andresen T.L. The possible "proton sponge" effect of polyethylenimine (PEI) does not include change in lysosomal pH. Mol Ther 2013, 21:149-157.
12. Funhoff A.M., van Nostrum C.F., Koning G.A., Schuurmans-Nieuwenbroek N.M., Crommelin D.J., Hennink W.E. Endosomal escape of polymeric gene delivery complexes is not always enhanced by polymers buffering at low pH. Biomacromolecules 2004, 5:32-39.
13. Rehman Z.U., Hoekstra D., Zuhorn I.S. Mechanism of polyplex- and lipoplex-mediated delivery of nucleic acids: real-time visualization of transient membrane destabilization without endosomal lysis. ACS Nano 2013, 7:3767-3777.
14. Lynn D.M., Langer R. Degradable poly(β-amino esters): synthesis, characterization, and self-assembly with plasmid DNA. JAm Chem Soc 2000, 122:10761-10768.
15. Anderson D.G., Lynn D.M., Langer R. Semi-automated synthesis and screening of a large library of degradable cationic polymers for gene delivery. Angew Chem Int Ed 2003, 42:3153-3158.
16. Zugates G.T., Anderson D.G., Little S.R., Lawhorn I.E.B., Langer R. Synthesis of poly(β-amino ester)s with thiol-reactive side chains for DNA delivery. JAm Chem Soc 2006, 128:12726-12734.
17. Tzeng S.Y., Green J.J. Subtle changes to polymer structure and degradation mechanism enable highly effective nanoparticles for siRNA and DNA delivery to human brain cancer. Adv Healthcare Mater 2013, 2:468-480.
18. Lim Y.-b., Choi Y.H., Park J.-s. Aself-destroying polycationic polymer: biodegradable poly(4-hydroxy-l-proline ester). JAm Chem Soc 1999, 121:5633-5639.
19. Putnam D., Langer R. Poly(4-hydroxy-l-proline ester): low-temperature polycondensation and plasmid DNA complexation. Macromolecules 1999, 32:3658-3662.
20. Liu Y., Wenning L., Lynch M., Reineke T.M. New poly(d-glucaramidoamine)s induce DNA nanoparticle formation and efficient gene delivery into mammalian cells. JAm Chem Soc 2004, 126:7422-7423.
21. Zhang Z., Yin L., Xu Y., Tong R., Lu Y., Ren J., et al. Facile functionalization of polyesters through thiol-yne chemistry for the design of degradable, cell-penetrating and gene delivery dual-functional agents. Biomacromolecules 2012, 13:3456-3462.
22. Li J., Yang C., Li H., Wang X., Goh S.H., Ding J.L., et al. Cationic supramolecules composed of multiple oligoethylenimine-grafted β-cyclodextrins threaded on a polymer chain for efficient gene delivery. Adv Mater 2006, 18:2969-2974.
23. Merkel O.M., Kissel T. Nonviral pulmonary delivery of siRNA. Acc Chem Res 2012, 45:961-970.
24. Kulkarni A., DeFrees K., Schuldt R.A., Hyun S.-H., Wright K.J., Yerneni C.K., et al. Cationic α-cyclodextrin:poly(ethylene glycol) polyrotaxanes for siRNA delivery. Mol Pharm 2013, 10:1299-1305.
25. Liu Y., Reineke T.M. Degradation of poly(glycoamidoamine) DNA delivery vehicles: polyamide hydrolysis at physiological conditions promotes DNA release. Biomacromolecules 2010, 11:316-325.
26. Luo X.-h., Liu C.-W., Li Z.-y., Qin S.-y., Feng J., Zhang X.-z., et al. OEI800 polyconjugates linked with ketalized glycolic acid for use as gene vectors. JMater Chem 2011, 21:15305-15315.
27. Tros de Ilarduya C., Sun Y., Duzgunes N. Gene delivery by lipoplexes and polyplexes. Eur J Pharm Sci 2010, 40:159-170.
28. Nicol F., Wong M., MacLaughlin F.C., Perrard J., Wilson E., Nordstrom J.L., et al. Poly-l-glutamate, an anionic polymer, enhances transgene expression for plasmids delivered by intramuscular injection with invivo electroporation. Gene Ther 2002, 9:1351-1358.
29. Schlegel A., Largeau C., Bigey P., Bessodes M., Lebozec K., Scherman D., et al. Anionic polymers for decreased toxicity and enhanced invivo delivery ofsiRNA complexed with cationic liposomes. JControl Release 2011, 152:393-401.
30. Gao X., Yao L., Song Q., Zhu L., Xia Z., Xia H., et al. The association of autophagy with polyethylenimine-induced cytotoxicity in nephritic and hepatic cell lines. Biomaterials 2011, 32:8613-8625.
31. Glodde M., Sirsi S.R., Lutz G.J. Physiochemical properties of low and high molecular weight poly(ethylene glycol)-grafted poly(ethylene imine) copolymers and their complexes with oligonucleotides. Biomacromolecules 2005, 7:347-356.
32. Yang J., Wang H.-Y., Yi W.-J., Gong Y.-H., Zhou X., Zhuo R.-X., et al. PEGylated peptide based reductive polycations as efficient nonviral gene vectors. Adv Healthcare Mater 2013, 2:481-489.
33. Yu Y., Chen C.-K., Law W.-C., Mok J., Zou J., Prasad P.N., et al. Well-defined degradable brush polymer-drug conjugates for sustained delivery of Paclitaxel. Mol Pharm 2013, 10:867-874.
34. Gary D.J., Lee H., Sharma R., Lee J.S., Kim Y., Cui Z.Y., et al. Influence of nano-carrier architecture on invitro siRNA delivery performance and invivo biodistribution: polyplexes vs micelleplexes. ACS Nano 2011, 5:3493-3505.
35. Shim M.S., Kwon Y.J. Acid-transforming polypeptide micelles for targeted nonviral gene delivery. Biomaterials 2010, 31:3404-3413.
36. Qi R.G., Liu S., Chen J., Xiao H.H., Yan L.S., Huang Y.B., et al. Biodegradable copolymers with identical cationic segments and their performance in siRNA delivery. JControl Release 2012, 159:251-260.
37. Chen C.-K., Law W.-C., Aalinkeel R., Nair B., Kopwitthaya A., Mahajan S.D., et al. Well-defined degradable cationic polylactide as nanocarrier for the delivery of siRNA to silence angiogenesis in prostate cancer. Adv Healthcare Mater 2012, 1:751-761.
38. Jones C.H., Chen C.-K., Jiang M., Fang L., Cheng C., Pfeifer B.A. Synthesis of cationic polylactides with tunable charge densities as nanocarriers for effective gene delivery. Mol Pharm 2013, 10:1138-1145.
39. Bajpai V.K., Mistriotis P., Andreadis S.T. Clonal multipotency and effect of long-term invitro expansion on differentiation potential of human hair follicle derived mesenchymal stem cells. Stem Cell Res 2012, 8:74-84.
40. Liu J.Y., Peng H.F., Gopinath S., Tian J., Andreadis S.T. Derivation of functional smooth muscle cells from multipotent human hair follicle mesenchymal stem cells. Tissue Eng Part A 2010, 16:2553-2564.
41. Higgins D.E., Shastri N., Portnoy D.A. Delivery of protein to the cytosol of macrophages using Escherichia coli K-12. Mol Microbiol 1999, 31:1631-1641.
42. Lim Y.-b., Kim S.-M., Lee Y., Lee W.-k., Yang T.-g., Lee M.-j., et al. Cationic hyperbranched poly(amino ester): a novel class of DNA condensing molecule with cationic surface, biodegradable three-dimensional structure, and tertiary amine groups in the Interior. JAm Chem Soc 2001, 123:2460-2461.
43. Zou J., Hew C.C., Themistou E., Li Y., Chen C.K., Alexandridis P., et al. Clicking well-defined biodegradable nanoparticles and nanocapsules by UV-induced thiol-ene cross-linking in transparent miniemulsions. Adv Mater 2011, 23:4274-4277.
44. Jeong J.H., Kim S.W., Park T.G. Molecular design of functional polymers for gene therapy. Prog Polym Sci 2007, 32:1239-1274.
45. Jeong J.H., Christensen L.V., Yockman J.W., Zhong Z.Y., Engbersen J.F.J., Kim W.J., et al. Reducible poly(amido ethylenimine) directed to enhance RNA interference. Biomaterials 2007, 28:1912-1917.
46. Erbacher P., Roche A.C., Monsigny M., Midoux P. The reduction of the positive charges of polylysine by partial gluconoylation increases the transfection efficiency of polylysine/DNA complexes. Biochim Biophys Acta Biomembr 1997, 1324:27-36.
47. Sharma R., Lee J.S., Bettencourt R.C., Xiao C., Konieczny S.F., Won Y.Y. Effects of the incorporation of a hydrophobic middle block into a PEG-polycation diblock copolymer on the physicochemical and cell interaction properties of the polymer-DNA complexes. Biomacromolecules 2008, 9:3294-3307.
48. Kunath K., von Harpe A., Fischer D., Peterson H., Bickel U., Voigt K., et al. Low-molecular-weight polyethylenimine as a non-viral vector for DNA delivery: comparison of physicochemical properties, transfection efficiency and invivo distribution with high-molecular-weight polyethylenimine. JControl Release 2003, 89:113-125.
49. Fife T.H., Singh R., Bembi R. Intramolecular general base catalyzed ester hydrolysis. The hydrolysis of 2-aminobenzoate esters. JOrg Chem 2002, 67:3179-3183.
50. Rehman Zu, Sjollema K.A., Kuipers J., Hoekstra D., Zuhorn I.S. Nonviral gene delivery vectors use syndecan-dependent transport mechanisms in filopodia to reach the cell surface. ACS Nano 2012, 6:7521-7532.
51. Rehman Zu, Hoekstra D., Zuhorn I.S. Protein kinase A inhibition modulates the intracellular routing of gene delivery vehicles in HeLa cells, leading to productive transfection. JControl Release 2011, 156:76-84.
52. El-Sayed A., Harashima H. Endocytosis of gene delivery vectors: from clathrin-dependent to lipid raft-mediated endocytosis. Mol Ther 2013, 21:1118-1130.
53. Sovadinova I., Palermo E.F., Huang R., Thoma L.M., Kuroda K. Mechanism of polymer-induced hemolysis: nanosized pore formation and osmotic lysis. Biomacromolecules 2011, 12:260-268.
54. Fischer D., Li Y., Ahlemeyer B., Krieglstein J., Kissel T. Invitro cytotoxicity testing of polycations: influence of polymer structure on cell viability and hemolysis. Biomaterials 2003, 24:1121-1131.
55. Pochard I., Boisvert J.-P., Persello J., Foissy A. Surface charge, effective charge anddispersion/aggregation properties of nanoparticles. Polym Int 2003, 52:619-624.
56. Putnam D. Polymers for gene delivery across length scales. Nat Mater 2006, 5:439-451.
57. Shmueli R.B., Anderson D.G., Green J.J. Electrostatic surface modifications to improve gene delivery. Expert Opin Drug Delivery 2010, 7:535-550.
58. Grandinetti G., Smith A.E., Reineke T.M. Membrane and nuclear permeabilization by polymeric pDNA vehicles: efficient method for gene delivery or mechanism of cytotoxicity?. Mol Pharm 2012, 9:523-538.
59. Lv H., Zhang S., Wang B., Cui S., Yan J. Toxicity of cationic lipids and cationic polymers in gene delivery. JControl Release 2006, 114:100-109.
60. Rice-Ficht A.C., Arenas-Gamboa A.M., Kahl-McDonagh M.M., Ficht T.A. Polymeric particles in vaccine delivery. Curr Opin Microbiol 2010, 13:106-112.
61. Doshi N., Mitragotri S. Macrophages recognize size and shape of their targets. PLoS One 2010, 5:e10051.
62. Thiele L., Merkle H.P., Walter E. Phagocytosis and phagosomal fate of surface-modified microparticles in dendritic cells and macrophages. Pharm Res 2003, 20:221-228.
63. Gomez J.M.M., Csaba N., Fischer S., Sichelstiel A., Kundig T.M., Gander B., et al. Surface coating of PLGA microparticles with protamine enhances their immunological performance through facilitated phagocytosis. JControl Release 2008, 130:161-167.
64. He X.M., Carter D.C. Atomic structure and chemistry of human serum albumin. Nature 1992, 358:209-215.