TRAF6-mediated ubiquitination of APPL1 enhances hepatic actions of insulin by promoting the membrane translocation of Akt

Biochemical Journal

Volumn 455, Issue 2, 2013, Pages 207-216

  Cheng, Kenneth K Y ^a,b   Lam, Karen S L ^a,b   Wang, Yu ^a,b   Wu, Donghai ^c   Zhang, Mingliang ^a   Wang, Baile ^a,b   Li, Xiaomu ^a,b   Hoo, Ruby L C ^a,b   Huang, Zhe ^a,b   Sweeney, Gary ^d   Xu, Aimin ^a,b  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

^b UNIVERSITY OF HONG KONG   (Hong Kong)

^c GUANGZHOU INSTITUTES OF BIOMEDICINE AND HEALTH   (China)

^d YORK UNIVERSITY   (Canada)

Author keywords

Adaptor protein; Gluconeogenesis; Insulin resistance; PH domain and leucine zipper containing 1 (APPL1); Phosphotyrosine interaction; Signal transduction; Ubiquitination

Indexed keywords

ADAPTOR PROTEIN PHOSPHOTYROSINE INTERACTION PLECKSTRIN HOMOLOGY DOMAIN AND LEUCINE ZIPPER CONTAINING 1I; AMPHIPHYSIN; ARGININE; INSULIN; LYSINE; PLECKSTRIN; PROTEIN KINASE B; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 6; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING AFFINITY; CELL FRACTIONATION; CONTROLLED STUDY; ENZYME ACTIVITY; GLUCONEOGENESIS; HUMAN; HUMAN CELL; INSULIN RESISTANCE; LIVER CELL; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; UBIQUITINATION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; CELL MEMBRANE; GLUCOSE; HEPATOCYTES; HUMANS; INSULIN; LIVER; MALE; MICE; MICE, INBRED C57BL; PROTEIN TRANSPORT; PROTO-ONCOGENE PROTEINS C-AKT; TNF RECEPTOR-ASSOCIATED FACTOR 6; UBIQUITINATION;

EID: 84884787995     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20130760     Document Type: Article

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