Homocysteine is a novel risk factor for suboptimal response of blood platelets to acetylsalicylic acid in coronary artery disease: A randomized multicenter study

Pharmacological Research

Volumn 74, Issue , 2013, Pages 7-22

  Karolczak, Kamil ^a   Kamysz, Wojciech ^b   Karafova, Anna ^b   Drzewoski, Jozef ^a   Watala, Cezary ^a  

^a MEDICAL UNIVERSITY OF LODZ   (Poland)

^b MEDICAL UNIVERSITY OF GDANSK   (Poland)

Author keywords

'Aspirin resistance'; Acetylhomocysteine; Blood platelet reactivity; Coronary artery disease; Homocysteine; Platelet protein acetylation

Indexed keywords

ACETYLSALICYLIC ACID; ARACHIDONIC ACID; C REACTIVE PROTEIN; COLLAGEN; HEMOGLOBIN A1C; HOMOCYSTEINE; LIPID; LOW DENSITY LIPOPROTEIN CHOLESTEROL; THROMBOXANE; TRIACYLGLYCEROL;

ABDOMINAL PAIN; ADULT; AMINO ACID BLOOD LEVEL; ARTICLE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; CORONARY ARTERY DISEASE; DOSE RESPONSE; DRUG DOSE INCREASE; DRUG EFFICACY; DRUG MECHANISM; FATTY ACID METABOLISM; FEMALE; HEADACHE; HUMAN; HYPERHOMOCYSTEINEMIA; HYPERTENSION; IN VITRO STUDY; INTERVENTION STUDY; MAJOR CLINICAL STUDY; MALE; MIGRAINE; MULTICENTER STUDY; NON INSULIN DEPENDENT DIABETES MELLITUS; PLATELET REACTIVITY; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RANDOMIZED CONTROLLED TRIAL; RISK FACTOR; THROMBOCYTE AGGREGATION; THROMBOCYTE FUNCTION; TREATMENT DURATION; TRIACYLGLYCEROL BLOOD LEVEL;

'ASPIRIN-RESISTANCE'; (N-Α-(9-FLUORENYLMETHOXYCARBONYL)-S-TRITYL-L-HOMOCYSTEINE); 1,4-BIS(5-PHENYL-2-OXAZOLYL)BENZENE; 2,5-DIPHENYLOXAZOLE; 5,5′-DITHIOBIS(2-NITROBENZOIC ACID); A(MAX); AA; ACE; ACETYLHOMOCYSTEINE; ACETYLSALICYLIC ACID; ACHTL; ADENOSINE-5′-DIPHOSPHATE; ADMA; ADP; ANGIOTENSIN CONVERTING ENZYME; ARACHIDONIC ACID; AREA UNDER (AGGREGOMETRIC) CURVE; ASA; ASYMMETRIC DIMETHYLARGININE; AUC; BCA; BICINCHONINIC ACID; BLOOD PLATELET REACTIVITY; BMI; BODY MASS INDEX; BOVINE SERUM ALBUMIN; BSA; CABG; CAD; CARDIOVASCULAR DISEASE; CI; COLL; COLLAGEN; COMPREHENSIVE SCORE OF BLOOD PLATELET RESPONSE TO AGONISTS; CONFIDENCE INTERVAL; CORONARY ARTERY BYPASS GRAFTING SURGERY; CORONARY ARTERY DISEASE; COX-1; CS; CVD; CYCLOOXYGENASE-1 (PROSTAGLANDIN G/H SYNTHASE 1); DCM; DICHLOROMETHANE; DIMETHYLSULFOXIDE; DIPEA; DL-HOMOCYSTEINE THIOLACTONE HYDROCHLORIDE; DL-N-ACETYLHOMOCYSTEINE THIOLACTONE; DMF; DMSO; DTNB; F; FAK; FEMALE; FMOC-HCY(TRT)-OH; FOCAL ADHESION KINASE; GLU; GLUTAMIC ACID (GLUTAMATE); GLYCATED HAEMOGLOBIN; HBA(1C); HCY; HDL; HIGH-DENSITY LIPOPROTEINS; HIGH-SENSITIVITY C-REACTIVE PROTEIN; HOMOCYSTEINE; HS-CRP; HTL; INTERQUARTILE RANGE; IQR; LABORATORY ASA (ASPIRIN) RESISTANCE; LAR; LDL; LOW-DENSITY LIPOPROTEINS; M; MALE; MAXIMAL AGGREGATION; ME; MEDIAN; MI; MYOCARDIAL INFARCTION; N,N-DIISOPROPYLETHYLAMINE; N,N-DIMETHYLFORMAMIDE; N.S.; NADPH; NON-SIGNIFICANT; ODDS RATIO; OR; PAFAH I; PAROXONASE; PBS; PCI; PERCUTANEOUS CORONARY INTERVENTION; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR; PHOSPHATE BUFFERED SALINE; PICRYLSULFONIC ACID, 2,4,6-TRINITROBENZENESULFONIC ACID; PLATELET PROTEIN ACETYLATION; PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE I; PON1; POPOP; PPAR; PPO; R(S); RAC1; RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; ROOM TEMPERATURE; RT; SASAR; SD; SDS; SODIUM DODECYL SULFATE; SPEARMAN'S RANK CORRELATION COEFFICIENT; STANDARD DEVIATION; STANDARDIZED VALUE; STD; SUBOPTIMAL ASA RESPONSE; T2DM; TFA; THROMBOXANE (B(2)); TIA; TNBS; TRANSIENT ISCHAEMIC ATTACK; TRIFLUOROACETIC ACID; TX(B(2)); TYPE 2 DIABETES MELLITUS; WBEA; WHOLE BLOOD ELECTRICAL (IMPEDANCE) AGGREGOMETRY;

ADULT; ARACHIDONIC ACID; ASPIRIN; BLOOD PLATELETS; COLLAGEN; CORONARY ARTERY DISEASE; DIABETES MELLITUS, TYPE 2; DRUG RESISTANCE; FEMALE; HOMOCYSTEINE; HUMANS; MALE; MIDDLE AGED; PLATELET AGGREGATION INHIBITORS; RISK FACTORS; YOUNG ADULT;

EID: 84884749444     PISSN: 10436618     EISSN: 10961186     Source Type: Journal    
DOI: 10.1016/j.phrs.2013.04.010     Document Type: Article

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