Platelet kainate receptor signaling promotes thrombosis by stimulating cyclooxygenase activation

Circulation Research

Volumn 105, Issue 6, 2009, Pages 595-603

  Sun, Henry ^a   Swaim, Anne Marie ^a   Herrera, Jesus Enrique ^a   Becker, Diane ^a   Becker, Lewis ^a   Srivastava, Kalyan ^a,c   Thompson, Laura E ^a   Shero, Michelle R ^a   Perez Tamayo, Alita ^a   Suktitipat, Bhoom ^a   Mathias, Rasika ^a   Contractor, Anis ^b   Faraday, Nauder ^a   Morrell, Craig N ^a,c  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

^c UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

Author keywords

Cyclooxygenase; Glutamate; Kainate; Mitogen activated kinase; P38; Platelet; Thrombosis; Thromboxane

Indexed keywords

GLUTAMATE RECEPTOR 5; GLUTAMATE RECEPTOR 6; GLUTAMIC ACID; KAINIC ACID RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; PROSTAGLANDIN SYNTHASE; PROTEIN SUBUNIT; AMINO ACID RECEPTOR STIMULATING AGENT; GLUR6 KAINATE RECEPTOR; KAINIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; GENETIC VARIABILITY; INTRON; KNOCKOUT MOUSE; MOUSE; NERVE CELL; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR BINDING; SIGNAL TRANSDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM; THROMBOCYTE ACTIVATION; THROMBOSIS; ANIMAL; GENETICS; HUMAN; METABOLISM; MOUSE MUTANT; THROMBOCYTE;

ANIMALS; BLOOD PLATELETS; EXCITATORY AMINO ACID AGONISTS; HUMANS; KAINIC ACID; MICE; MICE, KNOCKOUT; PLATELET ACTIVATION; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; RECEPTORS, KAINIC ACID; THROMBOSIS;

EID: 70349239136     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.109.198861     Document Type: Article

References (33)

1. Morrell CN, Sun H, Ikeda M, Beique JC, Swaim AM, Mason E, Martin TV, Thompson LE, Gozen O, Ampagoomian D, Sprengel R, Rothstein J, Faraday N, Huganir R, Lowenstein CJ. Glutamate mediates platelet activation through the AMPA receptor. J Exp Med. 2008;205:575-584.
2. Graham GJ, Stevens JM, Page NM, Grant AD, Brain SD, Lowry PJ, Gibbins JM. Tachykinins regulate the function of platelets. Blood. 2004;104:1058-1065.
3. Walther DJ, Peter JU, Winter S, Holtje M, Paulmann N, Grohmann M, Vowinckel J, Alamo-Bethencourt V, Wilhelm CS, Ahnert-Hilger G, Bader M. Serotonylation of small GTPases is a signal transduction pathway that triggers platelet alpha-granule release. Cell. 2003;115:851-862.
4. Fukata Y, Tzingounis AV, Trinidad JC, Fukata M, Burlingame AL, Nicoll RA, Bredt DS. Molecular constituents of neuronal AMPA receptors. J Cell Biol. 2005;169:399-404.
5. Lerma J. Kainate receptor physiology. Curr Opin Pharmacol. 2006;6:89-97.
6. Contractor A, Heinemann SF. Glutamate receptor trafficking in synaptic plasticity. Sci STKE. 2002;2002: RE14.
7. Hinoi E, Takarada T, Ueshima T, Tsuchihashi Y, Yoneda Y. Glutamate signaling in peripheral tissues. Eur J Biochem. 2004;271:1-13.
8. Ganor Y, Besser M, Ben-Zakay N, Unger T, Levite M. Human T cells express a functional ionotropic glutamate receptor GluR3, and glutamate by itself triggers integrin-mediated adhesion to laminin and fibronectin and chemotactic migration. J Immunol. 2003;170:4362-4372.
9. Hitchcock IS, Skerry TM, Howard MR, Genever PG. NMDA receptormediated regulation of human megakaryocytopoiesis. Blood. 2003;102:1254-1259.
10. Pacheco-Dominguez RL, Palma-Nicolas JP, Lopez E, Lopez-Colome AM. The activation of MEK-ERK1/2 by glutamate receptor-stimulation is involved in the regulation of RPE proliferation and morphologic transformation. Exp Eye Res. 2008;86:207-219.
11. Chen K, Febbraio M, Li W, Silverstein RL. A specific CD36-dependent signaling pathway is required for platelet activation by oxidized lowdensity lipoprotein. Circ Res. 2008;102:1512-1519.
12. Begonja AJ, Geiger J, Rukoyatkina N, Rauchfuss S, Gambaryan S, Walter U. Thrombin stimulation of p38 MAP kinase in human platelets is mediated by ADP and thromboxane A2 and inhibited by cGMP/cGMP-dependent protein kinase. Blood. 2007;109:616-618.
13. Shankar H, Garcia A, Prabhakar J, Kim S, Kunapuli SP. P2Y12 receptormediated potentiation of thrombin-induced thromboxane A2 generation in platelets occurs through regulation of Erk1/2 activation. J Thromb Haemost. 2006;4:638-647.
14. Canobbio I, Reineri S, Sinigaglia F, Balduini C, Torti M. A role for p38 MAP kinase in platelet activation by von Willebrand factor. Thromb Haemost. 2004;91:102-110.
15. Fitzgerald DJ. Vascular biology of thrombosis: the role of platelet-vessel wall adhesion. Neurology. 2001;57: S1-S4.
16. Egan K, Fitz Gerald GA. Eicosanoids and the vascular endothelium. Handb Exp Pharmacol. 2006:189-211.
17. Cheng Y, Austin SC, Rocca B, Koller BH, Coffman TM, Grosser T, Lawson JA, Fitz Gerald GA. Role of prostacyclin in the cardiovascular response to thromboxane. A2. Science. 2002;296:539-541.
18. Yoshikawa K, Kita Y, Kishimoto K, Shimizu T. Profiling of eicosanoid production in the rat hippocampus during kainic acid-induced seizure: dual phase regulation and differential involvement of COX-1 and COX-2. J Biol Chem. 2006;281:14663-14669.
19. Strauss KI, Marini AM. Cyclooxygenase-2 inhibition protects cultured cerebellar granule neurons from glutamate-mediated cell death. J Neurotrauma. 2002;19:627-638.
20. Kim EJ, Lee JE, Kwon KJ, Lee SH, Moon CH, Baik EJ. Differential roles of cyclooxygenase isoforms after kainic acid-induced prostaglandin E (2) production and neurodegeneration in cortical and hippocampal cell cultures. Brain Res. 2001;908:1-9.
21. Chen J, Li C, Pei DS, Han D, Liu XM, Jiang HX, Wang XT, Guan QH, Wen XR, Hou XY, Zhang GY. GluR6-containing KA receptor mediates the activation of p38 MAP kinase in rat hippocampal CA1 region during brain ischemia injury. Hippocampus. 2009;19:79-89.
22. Ferrer I, Blanco R, Carmona M, Puig B, Dominguez I, Vinals F. Active, phosphorylation-dependent MAP kinases, MAPK/ERK, SAPK/JNK and p38, and specific transcription factor substrates are differentially expressed following systemic administration of kainic acid to the adult rat. Acta Neuropathol. 2002;103:391-407.
23. Fitz Gerald GA, Austin S, Egan K, Cheng Y, Pratico D. Cyclo-oxygenase products and atherothrombosis. Ann Med. 2000;32 Suppl 1:21-26.
24. Canobbio I, Bertoni A, Lova P, Paganini S, Hirsch E, Sinigaglia F, Balduini C, Torti M. Platelet activation by von Willebrand factor requires coordinated signaling through thromboxane A2 and Fc gamma IIA receptor. J Biol Chem. 2001;276:26022-26029.
25. Dunlop ME, Muggli EE. Hyaluronan increases glomerular cyclooxygenase-2 protein expression in a p38 MAP-kinase-dependent process. Kidney Int. 2002;61:1729-1738.
26. Dangelmaier C, Jin J, Daniel JL, Smith JB, Kunapuli SP. The P2Y1 receptor mediates ADP-induced p38 kinase-activating factor generation in human platelets. Eur J Biochem. 2000;267:2283-2289.
27. Hackeng CM, Franke B, Relou IA, Gorter G, Bos JL, van Rijn HJ, Akkerman JW. Low-density lipoprotein activates the small GTPases Rap1 and Ral in human platelets. Biochem J. 2000;349:231-238.
28. Hackeng CM, Relou IA, Pladet MW, Gorter G, van Rijn HJ, Akkerman JW. Early platelet activation by low density lipoprotein via p38MAP kinase. Thromb Haemost. 1999;82:1749-1756.
29. Ohmori T, Yatomi Y, Nonaka T, Kobayashi Y, Madoiwa S, Mimuro J, Ozaki Y, Sakata Y. Aspirin resistance detected with aggregometry cannot be explained by cyclooxygenase activity: involvement of other signaling pathway (s) in cardiovascular events of aspirin-treated patients. J Thromb Haemost. 2006;4:1271-1278.
30. Eikelboom JW, Hankey GJ, Thom J, Bhatt DL, Steg PG, Montalescot G, Johnston SC, Steinhubl SR, Mak KH, Easton JD, Hamm C, Hu T, Fox KA, Topol EJ. Incomplete inhibition of thromboxane biosynthesis by acetylsalicylic acid: determinants and effect on cardiovascular risk. Circulation. 2008;118:1705-1712.
31. Eikelboom JW, Hirsh J, Weitz JI, Johnston M, Yi Q, Yusuf S. Aspirinresistant thromboxane biosynthesis and the risk of myocardial infarction, stroke, or cardiovascular death in patients at high risk for cardiovascular events. Circulation. 2002;105:1650-1655.
32. Relou AM, Gorter G, van Rijn HJ, Akkerman JW. Platelet activation by the apoB/E receptor-binding domain of LDL. Thromb Haemost. 2002;87:880-887.
33. Maurer-Spurej E. Serotonin reuptake inhibitors and cardiovascular diseases: a platelet connection. Cell Mol Life Sci. 2005;62:159-170.