Role of B 12 and Homocysteine Status in Determining BMD and Bone Turnover in Young Indians

Journal of Clinical Densitometry

Volumn 15, Issue 3, 2012, Pages 366-373

  Haroon, Nisha Nigil ^a   Marwaha, Raman K ^b   Godbole, Madan M ^c   Gupta, Sushil K ^c  

^a TORONTO GENERAL HOSPITAL   (Canada)

^b INSTITUTE OF NUCLEAR MEDICINE AND ALLIED SCIENCES   (India)

^c SANJAY GANDHI POSTGRADUATE INSTITUTE OF MEDICAL SCIENCES   (India)

Author keywords

B 12; Homocysteine; Peak bone mass

Indexed keywords

ALKALINE PHOSPHATASE; CREATININE; CYANOCOBALAMIN; FOLIC ACID; HOMOCYSTEINE; OSTEOCALCIN; PHOSPHORUS; VITAMIN D;

ADULT; ARTICLE; BODY HEIGHT; BODY MASS; BODY WEIGHT; BONE DENSITY; BONE TURNOVER; CREATININE BLOOD LEVEL; CYANOCOBALAMIN DEFICIENCY; DIETARY INTAKE; DISEASE ASSOCIATION; DUAL ENERGY X RAY ABSORPTIOMETRY; FEMALE; FOLIC ACID BLOOD LEVEL; HUMAN; HYPERHOMOCYSTEINEMIA; INDIAN; MAJOR CLINICAL STUDY; MALE; PHOSPHATE BLOOD LEVEL; PRIORITY JOURNAL; SUN EXPOSURE; VITAMIN D DEFICIENCY; BONE; CAUCASIAN; CROSS-SECTIONAL STUDY; INDIA; METABOLISM; NUTRITIONAL STATUS; PATHOPHYSIOLOGY; PHYSIOLOGY;

ADULT; BONE AND BONES; BONE DENSITY; CROSS-SECTIONAL STUDIES; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; HUMANS; HYPERHOMOCYSTEINEMIA; INDIA; MALE; NUTRITIONAL STATUS; VITAMIN B 12 DEFICIENCY; YOUNG ADULT;

EID: 84864303243     PISSN: 10946950     EISSN: 15590747     Source Type: Journal    
DOI: 10.1016/j.jocd.2012.01.006     Document Type: Article

References (57)

1. Shatrugna V., Kulkarni B., Kumar P.A., et al. Bone status of Indian women from a low-income group and its relationship to the nutritional status. Osteoporos Int 2005, 16:1827.
2. Handa R, 2003 Action plan osteoporosis: Consensus statement of the expert group meeting, Osteoporosis Society of India. New Delhi. 1-40. Available at: Accessed on August 26, 2011. http://www.osteofound.org/press_centre/fact_sheet.html.
3. Tandon N., Marwaha R.K., Kalra S., et al. Bone mineral parameters in healthy young Indian adults with optimal vitamin D availability. Natl Med J India 2003, 16:298-302.
4. Kadam N., Khadilkar A., Chiplonkar S., et al. Variation in lumbar spine bone mineral content by age and gender in apparently healthy Indians. J Bone Miner Metab 2009, 27:705-712.
5. Vupputuri M.R., Goswami R., Gupta N., et al. Prevalence and functional significance of 25-hydroxyvitamin D deficiency and vitamin D receptor gene polymorphisms in Asian Indians. Am J Clin Nutr 2006, 83:1411-1419.
6. Arya V., Bhambri R., Godbole M.M., Mithal A. Vitamin D status and its relationship with bone mineral density in healthy Asian Indians. Osteoporos Int 2004, 15:56-61.
7. Sachan A., Gupta R., Das V., et al. High prevalence of vitamin D deficiency among pregnant women and their newborns in northern India. Am J Clin Nutr 2005, 81:1060-1064.
8. Harinarayan C.V. Prevalence of vitamin D insufficiency in postmenopausal south Indian women. Osteoporos Int 2005, 16:397-402.
9. Paul T.V., Thomas N., Seshadri M.S., et al. Prevalence of osteoporosis in ambulatory postmenopausal women from a semiurban region in Southern India: relationship to calcium nutrition and vitamin D status. Endocr Pract 2008, 14:665-671.
10. Marwaha R.K., Tandon N., Shivaprasad C., et al. Peak bone mineral density of physically active healthy Indian men with adequate nutrition and no known current constraints to bone mineralization. J Clin Densitom 2009, 12:314-321.
11. Roy D., Swarbrick C., King Y., et al. Differences in peak bone mass in women of European and South Asian origin can be explained by differences in body size. Osteoporos Int 2005, 16:1254-1262.
12. 12 is associated with lower BMD: the Framingham Osteoporosis Study. J Bone Miner Res 2005, 20:152-158.
13. 12 status relate to bone turnover markers, broadband ultrasound attenuation, and fractures in healthy elderly people. J Bone Miner Res 2005, 6:921-929.
14. Dhonukshe-Rutten R.A., van Dusseldorp M., Schneede J., et al. Low bone mineral density and bone mineral content are associated with low cobalamin status in adolescents. Eur J Nutr 2005, 6:341-347.
15. Morris M.S., Jacques P.F., Selhub J. Relation between homocysteine and B-vitamin status indicators and bone mineral density in older Americans. Bone 2005, 37:234-242.
16. 12 to bone mineral density of postmenopausal women. Bone 2003, 33:956-999.
17. Golbahar J., Hamidi A., Aminzadeh M.A., Omrani G.R. Association of plasma folate, plasma total homocysteine, but not methylenetetrahydrofolate reductase C667T polymorphism, with bone mineral density in postmenopausal Iranian women: a cross-sectional study. Bone 2004, 35:760-765.
18. Gjesdal C.G., Vollset S.E., Ueland P.M., et al. Plasma total homocysteine level and bone mineral density: the Hordaland Homocysteine Study. Arch Intern Med 2006, 1:88-94.
19. 12 and homocysteine to vertebral bone mineral density change in postmenopausal women. A five-year longitudinal evaluation. Bone 2008, 42:314-320.
20. Gerdhem P., Ivaska K.K., Isaksson A., et al. Associations between homocysteine, bone turnover, BMD, mortality, and fracture risk in elderly women. J Bone Miner Res 2007, 22:127-134.
21. Zhu K., Beilby J., Dick I.M., et al. The effects of homocysteine and MTHFR genotype on hip bone loss and fracture risk in elderly women. Osteoporos Int 2009, 7:1183-1191.
22. Krivosíková Z., Krajcovicová-Kudlácková M., Spustová V., et al. The association between high plasma homocysteine levels and lower bone mineral density in Slovak women: the impact of vegetarian diet. Eur J Nutr 2010, 49:147-153.
23. Ravaglia G., Forti P., Maioli F., et al. Folate, but not homocysteine, predicts the risk of fracture in elderly persons. J Gerontol A Biol Sci Med Sci 2005, 60:1458-1462.
24. LeBoff M.S., Narweker R., LaCroix A., et al. Homocysteine levels and risk of hip fracture in postmenopausal women. J Clin Endocrinol Metab 2009, 94:1207-1213.
25. Sakamoto W., Isomura H., Fujie K., et al. Homocysteine attenuates the expression of osteocalcin but enhances osteopontin in MC3T3-E1 preosteoblastic cells. Biochim Biophys Acta 2005, 1740:12-16.
26. Koh J.M., Lee Y.S., Kim Y.S., et al. Homocysteine enhances bone resorption by stimulation of osteoclast formation and activity through increased intracellular ROS generation. J Bone Miner Res 2006, 21:1003-1011.
27. Kim D.J., Koh J.M., Lee O., et al. Homocysteine enhances apoptosis in human bone marrow stromal cells. Bone 2006, 39:582-590.
28. Vaes B.L., Lute C., Blom H.J., et al. Vitamin B (12) deficiency stimulates osteoclastogenesis via increased homocysteine and methylmalonic acid. Calcif Tissue Int 2009, 84:413-422.
29. Herrmann M., Umanskaya N., Wildemann B., et al. Stimulation of osteoblast activity by homocysteine. J Cell Mol Med 2008, 12:1205-1210.
30. Herrmann M., Tami A., Wildemann B., et al. Hyperhomocysteinemia induces a tissue specific accumulation of homocysteine in bone by collagen binding and adversely affects bone. Bone 2009, 44:467-475.
31. Herrmann M., Wildemann B., Claes L., et al. Experimental hyperhomocysteinemia reduces bone quality in rats. Clin Chem 2007, 53:1455-1461.
32. 12 deficiency does not alter bone quality in rats. J Bone Miner Res 2009, 24:589-596.
33. 12 in urban North India. Eur J Clin Nutr 2002, 41:68-77.
34. Khanduri U., Sharma A., Joshi A. Occult cobalamin and folate deficiency in Indians. Natl Med J India 2005, 18:182-183.
35. 12 and folate concentrations during pregnancy and insulin resistance in the offspring: the Pune Maternal Nutrition Study. Diabetologia 2008, 51:29-38.
36. Misra U.K., Kalita J., Srivastava A.K., Agarwal S. MTHFR gene polymorphism and its relationship with plasma homocysteine and folate in a North Indian population. Biochem Genet 2010, 48:229-235.
37. Refsum H., Yajnik C.S., Gadkari M., et al. Hyperhomocysteinemia and elevated methylmalonic acid indicate a high prevalence of cobalamin deficiency in Asian Indians. Am J Clin Nutr 2001, 74:233-241.
38. 12 and vegetarianism in India. Acta Haematol 1975, 53:90-97.
39. Mathan V.I. Tropical sprue in southern India. Trans R Soc Trop Med Hyg 1988, 82:10-14.
40. Ulrich C.M., Georgiou C.C., Snow-Harter C.M., Gillis D.E. Bone mineral density in mother-daughter pairs: relations to lifetime exercise, lifetime milk consumption, and calcium supplements. Am J Clin Nutr 1996, 63:72-79.
41. Kumar N., Shekhar C., Kumar P., Kundu A.S. Kuppuswamy's socioeconomic status scale-updating for 2007. Indian J Pediatr 2007, 12:1131-1132.
42. Dawson-Hughes B., Heaney R.P., Holick M.F., et al. Estimates of optimal vitamin D status. Osteoporos Int 2005, 16:713-716.
43. Hollis B.W. Circulating 25-hydroxyvitamin D levels indicative of vitamin D sufficiency: implications for establishing a new effective dietary intake recommendation for vitamin D. J Nutr 2005, 135:317-322.
44. Dietary supplement fact sheet: vitamin B12. Office of dietary supplements. Available at: Accessed: March 28, 2010. http://ods.od.nih.gov/factsheets/vitaminb12.asp%23h3.
45. Gopalan C, Rama Sastri BV, Balasubramanian SC, eds. 2007 Nutritive Value of Indian Foods. Delhi, India: Indian Council of Medical Research.
46. Nutrient requirements and recommended dietary allowances for Indians 1990, Expert Group of ICMR, Indian Council of Medical Research, New Delhi, India.
47. Leifke E., Gorenoi V., Wichers C., et al. Age-related changes of serum sex hormones, insulin-like growth factor-1 and sex-hormone binding globulin levels in men: cross-sectional data from a healthy male cohort. Clin Endocrinol (Oxf) 2000, 53:689-695.
48. Riancho J.A., Valero C., Zarrabeitia M.T. MTHFR polymorphism and bone mineral density: meta-analysis of published studies. Calcif Tissue Int 2006, 79:289-293.
49. Abrahamsen B., Jørgensen H.L., Nielsen T.L., et al. MTHFR c0.677C > T polymorphism as an independent predictor of peak bone mass in Danish men-results from the Odense Androgen Study. Bone 2006, 38:215-219.
50. McLean R.R., Jacques P.F., Selhub J., et al. Homocysteine as a predictive factor for hip fracture in older persons. N Engl J Med 2004, 350:2042.
51. 12 levels in postmenopausal women. Archiv Gynecol Obstet 2010, 281:663-668.
52. Bhupathiraju S.N., Alekel D.L., Stewart J.W., et al. Relationship of circulating total homocysteine and C-reactive protein to trabecular bone in postmenopausal women. J Clin Densitom 2007, 10:395-403.
53. van Meurs J.B.J., Dhonukshe-Rutten R.A.M., Pluijm S.M.F., et al. Homocysteine levels and the risk of osteoporotic fracture. N Engl J Med 2004, 350:2033-2041.
54. McLean R.R., Jacques P.F., Selhub J., et al. Plasma B vitamins, homocysteine, and their relation with bone loss and hip fracture in elderly men and women. J Clin Endocrinol Metab 2008, 93:2206-2212.
55. Carmel R., Lau K.H., Baylink D.J., et al. Cobalamin and osteoblast-specific proteins. N Engl J Med 1988, 2:70-75.
56. Herrmann M., Umanskaya N., Traber L., et al. The effect of B-vitamins on biochemical bone turnover markers and bone mineral density in osteoporotic patients-a one year double blind placebo controlled trial. Clin Chem Lab Med 2007, 45:1785-1792.
57. Green T.J., McMahon J.A., Skeaff C.M., et al. Lowering homocysteine with B vitamins has no effect on biomarkers of bone turnover in older persons: a 2-y randomized controlled trial. Am J Clin Nutr 2007, 85:460-464.