메뉴 건너뛰기




Volumn 40, Issue 6, 2011, Pages 429-438

"Aspirin - resistance"?: A few critical considerations on definition, terminology, diagnosis, clinical value, natural course of atherosclerotic disease, and therapeutic consequences;Aspirinresistenz?

Author keywords

Aspirin resistance; Inflammation; Platelet function; Point of care testing

Indexed keywords

ACETYLSALICYLIC ACID; ADENOSINE DIPHOSPHATE; ADRENALIN; ARACHIDONIC ACID; COLLAGEN; COLLAGEN RECEPTOR; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; FIBRINOGEN RECEPTOR; ISOPROSTANE; NONSTEROID ANTIINFLAMMATORY AGENT; PROSTACYCLIN; PROSTAGLANDIN; PURINERGIC P2Y12 RECEPTOR; THROMBIN; THROMBOXANE A2; VON WILLEBRAND FACTOR;

EID: 83455186014     PISSN: 03011526     EISSN: None     Source Type: Journal    
DOI: 10.1024/0301-1526/a000145     Document Type: Review
Times cited : (13)

References (64)
  • 1
    • 79751499344 scopus 로고    scopus 로고
    • The relationship between inflammation, platelet activation and antiplatelet resistance
    • Acikel S, Akdemir R. The relationship between inflammation, platelet activation and antiplatelet resistance. Inflamm Allergy Drug Targets 2010; 9: 364-81.
    • (2010) Inflamm Allergy Drug Targets , vol.9 , pp. 364-381
    • Acikel, S.1    Akdemir, R.2
  • 2
    • 3042537320 scopus 로고    scopus 로고
    • The antithrombotic profile of aspirin. Aspirin resistance, or simply failure?
    • Altman R, Luciardi H, Muntaner J, Herrera RN. The antithrombotic profile of aspirin. Aspirin resistance, or simply failure? Thromb J 2004; 2: 1-8.
    • (2004) Thromb J , vol.2 , pp. 1-8
    • Altman, R.1    Luciardi, H.2    Muntaner, J.3    Herrera, R.N.4
  • 3
    • 77949543832 scopus 로고    scopus 로고
    • Platelet hyporesponsiveness to acetylsalicylic acid can be transferred by plasma in humans
    • Anger K, Kempfert J, Kostelka M, Mohr FW, Dhein S. Platelet hyporesponsiveness to acetylsalicylic acid can be transferred by plasma in humans. Pharmacology 2010; 85: 241-7.
    • (2010) Pharmacology , vol.85 , pp. 241-247
    • Anger, K.1    Kempfert, J.2    Kostelka, M.3    Mohr, F.W.4    Dhein, S.5
  • 4
    • 73949157474 scopus 로고    scopus 로고
    • Platelet thrombin receptor antagonism and atherothrombosis
    • Angiolillo DJ, Capodanno D, Goto S. Platelet thrombin receptor antagonism and atherothrombosis. Eur Heart J 2010; 31: 17-28.
    • (2010) Eur Heart J , vol.31 , pp. 17-28
    • Angiolillo, D.J.1    Capodanno, D.2    Goto, S.3
  • 5
    • 0037065502 scopus 로고    scopus 로고
    • Collaborative metaanalysis of randomized trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high-risk patients
    • Antithrombotic Trialists Collaboration
    • Antithrombotic Trialists Collaboration. Collaborative metaanalysis of randomized trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high-risk patients. BMJ 2002; 324: 71-86.
    • (2002) BMJ , vol.324 , pp. 71-86
  • 6
    • 80051800551 scopus 로고    scopus 로고
    • Platelet response to aspirin 50 and 100 mg in patients with coronary heart disease over a five-year period
    • Berent R, Auer J, Franklin B, Schmid P, von Duvillard SP. Platelet response to aspirin 50 and 100 mg in patients with coronary heart disease over a five-year period. Am J Cardiol 2011; 108: 644-50.
    • (2011) Am J Cardiol , vol.108 , pp. 644-650
    • Berent, R.1    Auer, J.2    Franklin, B.3    Schmid, P.4    von Duvillard, S.P.5
  • 7
    • 33750924102 scopus 로고    scopus 로고
    • A systematic review and meta-analysis on the hazards of discontinuing or not adhering to aspirin among 50 279 patients at risk for coronary artery disease
    • Biondi-Zoccai GG, Lotrionte M, Agostoni P, Abbate A, Fusaro M, Burzotta F, Testa L, Sheiban I, Sangiorgi G. A systematic review and meta-analysis on the hazards of discontinuing or not adhering to aspirin among 50 279 patients at risk for coronary artery disease. Eur Heart J 2006; 27: 2667-74.
    • (2006) Eur Heart J , vol.27 , pp. 2667-2674
    • Biondi-Zoccai, G.G.1    Lotrionte, M.2    Agostoni, P.3    Abbate, A.4    Fusaro, M.5    Burzotta, F.6    Testa, L.7    Sheiban, I.8    Sangiorgi, G.9
  • 10
    • 0346367328 scopus 로고
    • Aggregation of blood platelets by adenosine diphosphate and its reversal
    • Born GR. Aggregation of blood platelets by adenosine diphosphate and its reversal. Nature 1962; 194: 927-9.
    • (1962) Nature , vol.194 , pp. 927-929
    • Born, G.R.1
  • 13
    • 33747168513 scopus 로고    scopus 로고
    • Effect of enteric coating on antiplatelet activity of low-dose aspirin in healthy volunteers
    • Cox D, Maree AO, Dooley M, Conroy R, Byrne MF, Fitzgerald DJ. Effect of enteric coating on antiplatelet activity of low-dose aspirin in healthy volunteers. Stroke 2006, 37: 2153-8.
    • (2006) Stroke , vol.37 , pp. 2153-2158
    • Cox, D.1    Maree, A.O.2    Dooley, M.3    Conroy, R.4    Byrne, M.F.5    Fitzgerald, D.J.6
  • 14
    • 0037015289 scopus 로고    scopus 로고
    • Effect of low-dose aspirin on vascular inflammation, plaque stability, and atherogenesis in low-density lipoprotein receptordeficient mice
    • Cyrus T, Sung S, Zhao L, Funk CD, Tang S, Praticò D. Effect of low-dose aspirin on vascular inflammation, plaque stability, and atherogenesis in low-density lipoprotein receptordeficient mice. Circulation 2002; 106: 1282-7.
    • (2002) Circulation , vol.106 , pp. 1282-1287
    • Cyrus, T.1    Sung, S.2    Zhao, L.3    Funk, C.D.4    Tang, S.5    Praticò, D.6
  • 15
    • 0037046196 scopus 로고    scopus 로고
    • Aspirinresistant thromboxane biosynthesis and the risk of myocardial infarction, stroke, or cardiovascular death in patients at high risk for cardiovascular events
    • Eikelboom JW, Hirsh J, Weitz JI, Johnston M, Yi Q, Yusuf S. Aspirinresistant thromboxane biosynthesis and the risk of myocardial infarction, stroke, or cardiovascular death in patients at high risk for cardiovascular events. Circulation 2002; 105: 1650-5.
    • (2002) Circulation , vol.105 , pp. 1650-1655
    • Eikelboom, J.W.1    Hirsh, J.2    Weitz, J.I.3    Johnston, M.4    Yi, Q.5    Yusuf, S.6
  • 16
    • 0035875796 scopus 로고    scopus 로고
    • 2 concentrations: A placebo-controlled study using a highly sensitive C-reactive protein assay
    • 2 concentrations: a placebo-controlled study using a highly sensitive C-reactive protein assay. J Am Coll Cardiol 2001; 37: 2036-41.
    • (2001) J Am Coll Cardiol , vol.37 , pp. 2036-2041
    • Feldman, M.1    Jialal, I.2    Devaraj, S.3    Cryer, B.4
  • 17
    • 0020692577 scopus 로고
    • Endogenous biosynthesis of prostacyclin and thromboxane and platelet function during chronic administration of aspirin in man
    • Fitzgerald GA, Brash AR, Oates JA, Pedersen AK. Endogenous biosynthesis of prostacyclin and thromboxane and platelet function during chronic administration of aspirin in man. J Clin Invest 1983; 71: 678-88.
    • (1983) J Clin Invest , vol.71 , pp. 678-688
    • Fitzgerald, G.A.1    Brash, A.R.2    Oates, J.A.3    Pedersen, A.K.4
  • 18
    • 33747088257 scopus 로고    scopus 로고
    • Residual arachidonic acid-induced platelet activation via an adenosine diphosphate-dependent but cyclooxygenase-1-and cyclooxygenase-2-independent pathway: A 700-patient study of aspirin resistance
    • Frelinger AL 3rd, Furman MI, Linden MD, Li Y, Fox ML, Barnard MR, Michelson AD. Residual arachidonic acid-induced platelet activation via an adenosine diphosphate-dependent but cyclooxygenase-1-and cyclooxygenase-2-independent pathway: a 700-patient study of aspirin resistance. Circulation 2006; 113: 2888-96.
    • (2006) Circulation , vol.113 , pp. 2888-2896
    • Frelinger III, A.L.1    Furman, M.I.2    Linden, M.D.3    Li, Y.4    Fox, M.L.5    Barnard, M.R.6    Michelson, A.D.7
  • 20
    • 77953160638 scopus 로고    scopus 로고
    • A comparison of platelet function tests and thromboxane metabolites to evaluate aspirin response in healthy individuals and patients with coronary artery disease
    • Grove EL, Hvas AM, Johnsen HL, Hedegaard SS, Pedersen SB, Mortensen J, Kristensen SD. A comparison of platelet function tests and thromboxane metabolites to evaluate aspirin response in healthy individuals and patients with coronary artery disease. Thromb Haemost 2010; 103: 1245-53.
    • (2010) Thromb Haemost , vol.103 , pp. 1245-1253
    • Grove, E.L.1    Hvas, A.M.2    Johnsen, H.L.3    Hedegaard, S.S.4    Pedersen, S.B.5    Mortensen, J.6    Kristensen, S.D.7
  • 21
    • 78650952436 scopus 로고    scopus 로고
    • Effect of platelet turnover on whole blood platelet aggregation in patients with coronary artery disease
    • Grove EL, Hvas AM, Mortensen SB, Larsen SB, Kristensen SD. Effect of platelet turnover on whole blood platelet aggregation in patients with coronary artery disease. J Thromb Haemost 2011; 9: 185-91.
    • (2011) J Thromb Haemost , vol.9 , pp. 185-191
    • Grove, E.L.1    Hvas, A.M.2    Mortensen, S.B.3    Larsen, S.B.4    Kristensen, S.D.5
  • 23
    • 70350459370 scopus 로고    scopus 로고
    • Mechanisms of platelet activation: Need for new strategies to protect against platelet-mediated atherothrombosis
    • Jennings LK. Mechanisms of platelet activation: need for new strategies to protect against platelet-mediated atherothrombosis. Thromb Haemost 2009; 102: 248-57.
    • (2009) Thromb Haemost , vol.102 , pp. 248-257
    • Jennings, L.K.1
  • 24
    • 0035312545 scopus 로고    scopus 로고
    • The effect of aspirin on C-reactive protein as a marker of risk in unstable angina
    • Kennon S, Price CP, Mills PG, Ranjadayalan K. The effect of aspirin on C-reactive protein as a marker of risk in unstable angina. J Am Coll Cardiol 2001; 37; 1266-70.
    • (2001) J Am Coll Cardiol , vol.37 , pp. 1266-1270
    • Kennon, S.1    Price, C.P.2    Mills, P.G.3    Ranjadayalan, K.4
  • 25
    • 38949119325 scopus 로고    scopus 로고
    • Aspirin "resistance" and the risk of cardiovascular morbidity: Systematic review and meta-analysis
    • Krasopoulos G, Brister SJ, Beattie WS, Buchanan MR. Aspirin "resistance" and the risk of cardiovascular morbidity: systematic review and meta-analysis. BMJ 2008; 336: 195-8.
    • (2008) BMJ , vol.336 , pp. 195-198
    • Krasopoulos, G.1    Brister, S.J.2    Beattie, W.S.3    Buchanan, M.R.4
  • 26
    • 70450189795 scopus 로고    scopus 로고
    • Inflammation in atherosclerosis: From pathophysiology to practice
    • Libby P, Ridker PM, Hansson GK. Inflammation in atherosclerosis: from pathophysiology to practice. J Am Coll Cardiol 2009; 54: 2129-38.
    • (2009) J Am Coll Cardiol , vol.54 , pp. 2129-2138
    • Libby, P.1    Ridker, P.M.2    Hansson, G.K.3
  • 27
    • 34547760330 scopus 로고    scopus 로고
    • A comparison of six major platelet function tests to determine the prevalence of aspirin resistance in patients with stable coronary artery disease
    • Lordkipanidzé M, Pharand C, Schampaert E, Turgeon J, Palisaitis DA, Diodati JG. A comparison of six major platelet function tests to determine the prevalence of aspirin resistance in patients with stable coronary artery disease. Eur Heart J 2007; 28: 1702-08.
    • (2007) Eur Heart J , vol.28 , pp. 1702-1708
    • Lordkipanidzé, M.1    Pharand, C.2    Schampaert, E.3    Turgeon, J.4    Palisaitis, D.A.5    Diodati, J.G.6
  • 29
    • 33746218509 scopus 로고    scopus 로고
    • Platelet inhibition beyond conventional antiplatelet agents: Expanding role of angiotensin receptor blockers, statins and selective serotonin reuptake inhibitors
    • Malinin AI, Ong S, Makarov LM, Petukhova EY, Serebruany VL. Platelet inhibition beyond conventional antiplatelet agents: expanding role of angiotensin receptor blockers, statins and selective serotonin reuptake inhibitors. Int J Clin Pract 2006, 60: 993-1002.
    • (2006) Int J Clin Pract , vol.60 , pp. 993-1002
    • Malinin, A.I.1    Ong, S.2    Makarov, L.M.3    Petukhova, E.Y.4    Serebruany, V.L.5
  • 31
    • 34248371253 scopus 로고    scopus 로고
    • Clinical aspects of platelet inhibitors and thrombus formation
    • Meadows TA, Bhatt DL. Clinical aspects of platelet inhibitors and thrombus formation. Circ Res 2007; 100: 1261-75.
    • (2007) Circ Res , vol.100 , pp. 1261-1275
    • Meadows, T.A.1    Bhatt, D.L.2
  • 32
    • 80053178845 scopus 로고    scopus 로고
    • Aspirin resistance: Fact or fiction? A point of view
    • Mehta JL, Mohandas B. Aspirin resistance: Fact or fiction? A point of view. World J Cardiol 2010; 26: 280-8.
    • (2010) World J Cardiol , vol.26 , pp. 280-288
    • Mehta, J.L.1    Mohandas, B.2
  • 33
    • 17144396926 scopus 로고    scopus 로고
    • Platelet function testing in cardiovascular diseases
    • Michelson AD. Platelet function testing in cardiovascular diseases. Circulation 2004; 110: e489-e93.
    • (2004) Circulation , vol.110
    • Michelson, A.D.1
  • 35
    • 67650756579 scopus 로고    scopus 로고
    • Assessment of aspirin resistance varies on a temporal basis in patients with ischaemic heart disease
    • Muir AR, McMullin MF, Patterson C, McKeown PP. Assessment of aspirin resistance varies on a temporal basis in patients with ischaemic heart disease. Heart 2009; 95: 1225-9.
    • (2009) Heart , vol.95 , pp. 1225-1229
    • Muir, A.R.1    McMullin, M.F.2    Patterson, C.3    McKeown, P.P.4
  • 36
    • 33646761285 scopus 로고    scopus 로고
    • Aspirin resistance detected with aggregometry cannot be explained by cyclooxygenase activity: Involvement of other signaling pathway(s) in cardiovascular events of aspirin-treated patients
    • Ohmori T, Yatomi Y, Nonaka T, Kobayashi Y, Madoiwa S, Mimuro J, Ozaki Y, Sakata Y. Aspirin resistance detected with aggregometry cannot be explained by cyclooxygenase activity: involvement of other signaling pathway(s) in cardiovascular events of aspirin-treated patients. J Thromb Haemost 2006; 4: 1271-8.
    • (2006) J Thromb Haemost , vol.4 , pp. 1271-1278
    • Ohmori, T.1    Yatomi, Y.2    Nonaka, T.3    Kobayashi, Y.4    Madoiwa, S.5    Mimuro, J.6    Ozaki, Y.7    Sakata, Y.8
  • 37
    • 0034739462 scopus 로고    scopus 로고
    • Direct proinflammatory effect of C-reactive protein on human endothelial cells
    • Pasceri V, Willerson JT, Yeh ET. Direct proinflammatory effect of C-reactive protein on human endothelial cells. Circulation 2000; 102: 2165-8.
    • (2000) Circulation , vol.102 , pp. 2165-2168
    • Pasceri, V.1    Willerson, J.T.2    Yeh, E.T.3
  • 38
    • 0019988413 scopus 로고
    • Selective cumulative inhibition of platelet thromboxane production by low-dose aspirin in healthy subjects
    • Patrignani P, Filabozzi P, Patrono C. Selective cumulative inhibition of platelet thromboxane production by low-dose aspirin in healthy subjects. J Clin Invest 1982; 69: 1366-72.
    • (1982) J Clin Invest , vol.69 , pp. 1366-1372
    • Patrignani, P.1    Filabozzi, P.2    Patrono, C.3
  • 39
    • 0141851094 scopus 로고    scopus 로고
    • Aspirin resistance: Definition, mechanism and clinical read-out
    • Patrono C. Aspirin resistance: definition, mechanism and clinical read-out. Thromb Haemost 2003; 1: 1710-3.
    • (2003) Thromb Haemost , vol.1 , pp. 1710-1713
    • Patrono, C.1
  • 42
    • 0022526869 scopus 로고
    • Epinephrine reverses the inhibitory influence of aspirin on platelet-vessel wall interactions
    • Rao GH, Escolar G, White JG. Epinephrine reverses the inhibitory influence of aspirin on platelet-vessel wall interactions. Thromb Res 1986; 44: 65-74.
    • (1986) Thromb Res , vol.44 , pp. 65-74
    • Rao, G.H.1    Escolar, G.2    White, J.G.3
  • 43
    • 18144390229 scopus 로고    scopus 로고
    • Aspirin resistance: A fact or a myth?
    • Rao GH. Aspirin resistance: A fact or a myth? Exp Clin Cardiol 2005; 10: 17-20.
    • (2005) Exp Clin Cardiol , vol.10 , pp. 17-20
    • Rao, G.H.1
  • 44
    • 78649873511 scopus 로고    scopus 로고
    • Inconsistency of different methods for assessing ex-vivo platelet function: Relevance for the detection of aspirin resistance
    • Renda G, Zurro M, Malatesta G, Ruggieri B, De Caterina R. Inconsistency of different methods for assessing ex-vivo platelet function: relevance for the detection of aspirin resistance. Haematologica 2010; 95: 2095-101.
    • (2010) Haematologica , vol.95 , pp. 2095-2101
    • Renda, G.1    Zurro, M.2    Malatesta, G.3    Ruggieri, B.4    de Caterina, R.5
  • 45
    • 0021131707 scopus 로고
    • Inhibition of platelet function by a controlled release acetylsalicylic acid formulation-single and chronic dosing studies
    • Roberts MS, McLeod LJ, Cossum PA, Vial JH. Inhibition of platelet function by a controlled release acetylsalicylic acid formulation-single and chronic dosing studies. Eur J Clin Pharmacol 1984; 27: 67-74.
    • (1984) Eur J Clin Pharmacol , vol.27 , pp. 67-74
    • Roberts, M.S.1    McLeod, L.J.2    Cossum, P.A.3    Vial, J.H.4
  • 47
    • 79960117909 scopus 로고    scopus 로고
    • Randomized, quadruple crossover single-blind study on immediate action of chewed and unchewed low-dose acetylsalicylic acid tablets in healthy volunteers
    • Sai Y, Kusaka A, Imanishi K, Matsumoto M, Takahashi R, Sugimoto N, Sugama J, Anada T, Asakura H, Miyamoto K. Randomized, quadruple crossover single-blind study on immediate action of chewed and unchewed low-dose acetylsalicylic acid tablets in healthy volunteers. J Pharm Sci 2011; 100: 3884-91.
    • (2011) J Pharm Sci , vol.100 , pp. 3884-3891
    • Sai, Y.1    Kusaka, A.2    Imanishi, K.3    Matsumoto, M.4    Takahashi, R.5    Sugimoto, N.6    Sugama, J.7    Anada, T.8    Asakura, H.9    Miyamoto, K.10
  • 51
    • 78649990318 scopus 로고    scopus 로고
    • Redox-generated isoprostanes are associated with residual platelet activity in aspirin-treated patients with stable coronary heart disease
    • Schwedhelm E, Bierend A, Maas R, Trinks R, Kom GD, Tsikas D, Böger RH. Redox-generated isoprostanes are associated with residual platelet activity in aspirin-treated patients with stable coronary heart disease. J Thromb Haemost 2010; 12: 2662-70.
    • (2010) J Thromb Haemost , vol.12 , pp. 2662-2670
    • Schwedhelm, E.1    Bierend, A.2    Maas, R.3    Trinks, R.4    Kom, G.D.5    Tsikas, D.6    Böger, R.H.7
  • 52
    • 79952557680 scopus 로고    scopus 로고
    • Monitoring of antiplatelet therapy. Current limitations, challenges and perspectives
    • Seidel H, Rahman MM, Scharf RE. Monitoring of antiplatelet therapy. Current limitations, challenges and perspectives. Hämostaseologie 2011; 31: 41-51.
    • (2011) Hämostaseologie , vol.31 , pp. 41-51
    • Seidel, H.1    Rahman, M.M.2    Scharf, R.E.3
  • 54
    • 77749264545 scopus 로고    scopus 로고
    • Chronic stable coronary artery disease: Drugs vs. revascularization
    • Simoons ML, Windecker S. Chronic stable coronary artery disease: drugs vs. revascularization. Eur Heart J 2010; 31: 530-41.
    • (2010) Eur Heart J , vol.31 , pp. 530-541
    • Simoons, M.L.1    Windecker, S.2
  • 55
    • 0023816185 scopus 로고
    • Diminished platelet residence time on active human atherosclerotic lesions in-vivo-evidence for an optimal dose of aspirin?
    • Sinzinger H, Kaliman J, Fitscha P, O'Grady J. Diminished platelet residence time on active human atherosclerotic lesions in-vivo-evidence for an optimal dose of aspirin? Prostaglandins Leukot Essent Fatty Acids 1988; 34: 88-93.
    • (1988) Prostaglandins Leukot Essent Fatty Acids , vol.34 , pp. 88-93
    • Sinzinger, H.1    Kaliman, J.2    Fitscha, P.3    O'Grady, J.4
  • 57
    • 34447503098 scopus 로고    scopus 로고
    • Association of laboratory-defined aspirin resistance with a high risk of recurrent cardiovascular events: A systematic review and meta-analysis
    • Snoep JD, Hovens MMC, Eikenboom JC, van der Bom JG, Huisman MV. Association of laboratory-defined aspirin resistance with a high risk of recurrent cardiovascular events: a systematic review and meta-analysis. Arch Intern Med 2007; 167: 1593-9.
    • (2007) Arch Intern Med , vol.167 , pp. 1593-1599
    • Snoep, J.D.1    Hovens, M.M.C.2    Eikenboom, J.C.3    van der Bom, J.G.4    Huisman, M.V.5
  • 58
    • 33645215110 scopus 로고    scopus 로고
    • Endothelial function and inflammation in coronary artery disease
    • Tousoulis D, Charakida M, Stefanadis C. Endothelial function and inflammation in coronary artery disease. Heart 2006; 92: 441-4.
    • (2006) Heart , vol.92 , pp. 441-444
    • Tousoulis, D.1    Charakida, M.2    Stefanadis, C.3
  • 59
    • 79954609254 scopus 로고    scopus 로고
    • The assessment of aspirin resistance by using light transmission and multiple electrode aggregometry
    • Ulehlova J, Slavik L, Krcova V, Hutyra M, Galuszka J, Indrak K. The assessment of aspirin resistance by using light transmission and multiple electrode aggregometry. Int J Lab Hematol 2011; 33: 305-9.
    • (2011) Int J Lab Hematol , vol.33 , pp. 305-309
    • Ulehlova, J.1    Slavik, L.2    Krcova, V.3    Hutyra, M.4    Galuszka, J.5    Indrak, K.6
  • 61
    • 0015237292 scopus 로고
    • Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs
    • Vane JR. Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nature New Biol 1971; 231: 232-5.
    • (1971) Nature New Biol , vol.231 , pp. 232-235
    • Vane, J.R.1
  • 62
    • 0141885287 scopus 로고    scopus 로고
    • C-reactive protein decreases prostacyclin release from human aortic endothelial cells
    • Venugopal SK, Devaraj S, Jialal I. C-reactive protein decreases prostacyclin release from human aortic endothelial cells. Circulation 2003; 108: 1676-8.
    • (2003) Circulation , vol.108 , pp. 1676-1678
    • Venugopal, S.K.1    Devaraj, S.2    Jialal, I.3
  • 63
    • 33644886913 scopus 로고    scopus 로고
    • Aspirin and clopidogrel resistance: An emerging clinical entity
    • Wang TH, Bhatt DL, Topol EJ. Aspirin and clopidogrel resistance: an emerging clinical entity. Eur Heart J 2006; 27: 647-54.
    • (2006) Eur Heart J , vol.27 , pp. 647-654
    • Wang, T.H.1    Bhatt, D.L.2    Topol, E.J.3
  • 64
    • 33746087046 scopus 로고    scopus 로고
    • C-reactive protein promotes platelet adhesion to endothelial cells: A potential pathway in atherothrombosis
    • Yaron G, Brill A, Dashevsky O, Yosef-Levi IM, Grad E, Danenberg HD, Varon D. C-reactive protein promotes platelet adhesion to endothelial cells: a potential pathway in atherothrombosis. Br J Haematol 2006; 134: 426-41.
    • (2006) Br J Haematol , vol.134 , pp. 426-441
    • Yaron, G.1    Brill, A.2    Dashevsky, O.3    Yosef-Levi, I.M.4    Grad, E.5    Danenberg, H.D.6    Varon, D.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.