Azathioprine desensitizes liver cancer cells to insulin-like growth factor 1 and causes apoptosis when it is combined with bafilomycin A1

Toxicology and Applied Pharmacology

Volumn 272, Issue 3, 2013, Pages 568-578

  Hernández Breijo, Borja ^a   Monserrat, Jorge ^a   Román, Irene D ^a   González Rodríguez, Águeda ^a   Fernández Moreno, Ma Dolores ^a   Lobo, Ma Val T ^b   Valverde, Ángela M ^a   Gisbert, Javier P ^c   Guijarro, Luis G ^a  

^a UNIVERSITY OF ALCALÁ   (Spain)

^b INSTITUTO DE SALUD CARLOS III   (Spain)

^c Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas   (Spain)

Author keywords

Apoptosis; Autophagy; Cancer; Desensitization; Senescence; Thiopurine

Indexed keywords

AZATHIOPRINE; BAFILOMYCIN A1; BETA GALACTOSIDASE; INSULIN RECEPTOR SUBSTRATE 1; LACTATE DEHYDROGENASE; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN P85; RAF PROTEIN; RAS PROTEIN; SERINE; SOMATOMEDIN C; TRANSCRIPTION FACTOR E2F; TUBERIN;

ANIMAL CELL; APOPTOSIS; ARTICLE; AUTOPHAGY; CELL CYCLE; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME ACTIVATION; FLOW CYTOMETRY; HEPATOBLASTOMA; IMMUNOPRECIPITATION; LIVER CANCER; LIVER CELL CARCINOMA; MOUSE; NONHUMAN; ONCOGENE C FOS; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION;

3-MA; 3-METHYLADENINE; AKT; APOPTOSIS; AUTOPHAGY; BAF; BAFILOMYCIN A1; CANCER; DESENSITIZATION; E2F; E2F TRANSCRIPTION FACTOR; EC50; ERK; EXTRACELLULAR SIGNAL-REGULATED KINASE; FORKHEAD BOX O1; FOXO1; GLUTATHIONE S TRANSFERASE; GST; GTPΓS; GUANOSINE 5′-O-[GAMMA-THIO]TRIPHOSPHATE; HALF MAXIMAL EFFECTIVE CONCENTRATION; INSULIN RECEPTOR SUBSTRATE; IRS; LC3; MAMMALIAN TARGET OF RAPAMYCIN; MAPK; MICROTUBULE-ASSOCIATED PROTEIN LIGHT CHAIN 3; MITOGEN-ACTIVATED PROTEIN KINASE; MTOR; N-ACETYLCYSTEINE; NAC; PARP; PHOSPHOINOSITIDE-3-KINASE; PI3K; POLY (ADP-RIBOSE) POLYMERASE; PROTEIN KINASE B; RB; RETINOBLASTOMA PROTEIN; SENESCENCE; THIOPURINE; TSC-2; TUBEROUS SCLEROSIS 2 PROTEIN;

ANTIMETABOLITES, ANTINEOPLASTIC; APOPTOSIS; AZATHIOPRINE; CELL LINE, TUMOR; DRUG THERAPY, COMBINATION; ENZYME INHIBITORS; HEP G2 CELLS; HUMANS; INSULIN-LIKE GROWTH FACTOR I; LIVER NEOPLASMS; MACROLIDES;

EID: 84884721977     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2013.07.024     Document Type: Article

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