메뉴 건너뛰기




Volumn 310, Issue 2, 2011, Pages 232-239

All-trans retinoic acid induces cellular senescence via upregulation of p16, p21, and p27

Author keywords

All trans retinoic acid; Cellular senescence; P16; P21; P27

Indexed keywords

BETA GALACTOSIDASE; GAMMA TUBULIN; PROTEIN P16; PROTEIN P21; PROTEIN P27; RETINOBLASTOMA PROTEIN; RETINOIC ACID; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR E2F1;

EID: 80051703039     PISSN: 03043835     EISSN: 18727980     Source Type: Journal    
DOI: 10.1016/j.canlet.2011.07.009     Document Type: Article
Times cited : (48)

References (38)
  • 1
    • 0029794132 scopus 로고    scopus 로고
    • A decade of molecular biology of retinoic acid receptors
    • Chambon P. A decade of molecular biology of retinoic acid receptors. FASEB J. 1996, 10:940-954.
    • (1996) FASEB J. , vol.10 , pp. 940-954
    • Chambon, P.1
  • 4
    • 79960281507 scopus 로고    scopus 로고
    • Inhibition of estrogen actions in human gynecological malignancies: new aspects of endocrine therapy for endometrial cancer and ovarian cancer
    • Ito K., Utsunomiya H., Niikura H., Yaegashi N., Sasano H. Inhibition of estrogen actions in human gynecological malignancies: new aspects of endocrine therapy for endometrial cancer and ovarian cancer. Mol. Cell. Endocrinol. 2011, 340:161-167.
    • (2011) Mol. Cell. Endocrinol. , vol.340 , pp. 161-167
    • Ito, K.1    Utsunomiya, H.2    Niikura, H.3    Yaegashi, N.4    Sasano, H.5
  • 6
    • 79955037674 scopus 로고    scopus 로고
    • Chemoprevention of hepatocellular carcinoma by acyclic retinoid
    • Shimizu M., Sakai H., Moriwaki H. Chemoprevention of hepatocellular carcinoma by acyclic retinoid. Front Biosci. 2011, 16:759-769.
    • (2011) Front Biosci. , vol.16 , pp. 759-769
    • Shimizu, M.1    Sakai, H.2    Moriwaki, H.3
  • 7
    • 34247245665 scopus 로고    scopus 로고
    • Induction of cell cycle arrest and apoptosis by a combined treatment with 13-cis-retinoic acid, interferon-alpha2a, and alpha-tocopherol in squamous cell carcinoma of the head and neck
    • Zhang X., Chen Z.G., Khuri F.R., Shin D.M. Induction of cell cycle arrest and apoptosis by a combined treatment with 13-cis-retinoic acid, interferon-alpha2a, and alpha-tocopherol in squamous cell carcinoma of the head and neck. Head Neck 2007, 29:351-361.
    • (2007) Head Neck , vol.29 , pp. 351-361
    • Zhang, X.1    Chen, Z.G.2    Khuri, F.R.3    Shin, D.M.4
  • 8
    • 23244452684 scopus 로고    scopus 로고
    • Suppressing cancer: the importance of being senescent
    • Campisi J. Suppressing cancer: the importance of being senescent. Science 2005, 309:886-887.
    • (2005) Science , vol.309 , pp. 886-887
    • Campisi, J.1
  • 10
    • 0037667702 scopus 로고    scopus 로고
    • Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence
    • Narita M., Nunez S., Heard E., Lin A.W., Hearn S.A., Spector D.L., Hannon G.J., Lowe S.W. Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence. Cell 2003, 113:703-716.
    • (2003) Cell , vol.113 , pp. 703-716
    • Narita, M.1    Nunez, S.2    Heard, E.3    Lin, A.W.4    Hearn, S.A.5    Spector, D.L.6    Hannon, G.J.7    Lowe, S.W.8
  • 12
    • 0037085771 scopus 로고    scopus 로고
    • Retinoic acid-induced cell cycle arrest of human myeloid cell lines is associated with sequential down-regulation of c-Myc and cyclin E and posttranscriptional up-regulation of p27(Kip1)
    • Dimberg A., Bahram F., Karlberg I., Larsson L.G., Nilsson K., Oberg F. Retinoic acid-induced cell cycle arrest of human myeloid cell lines is associated with sequential down-regulation of c-Myc and cyclin E and posttranscriptional up-regulation of p27(Kip1). Blood 2002, 99:2199-2206.
    • (2002) Blood , vol.99 , pp. 2199-2206
    • Dimberg, A.1    Bahram, F.2    Karlberg, I.3    Larsson, L.G.4    Nilsson, K.5    Oberg, F.6
  • 13
    • 50649110974 scopus 로고    scopus 로고
    • Epstein-Barr virus latent membrane protein 1 suppresses the growth-inhibitory effect of retinoic acid by inhibiting retinoic acid receptor-beta2 expression via DNA methylation
    • Seo S.Y., Kim E.O., Jang K.L. Epstein-Barr virus latent membrane protein 1 suppresses the growth-inhibitory effect of retinoic acid by inhibiting retinoic acid receptor-beta2 expression via DNA methylation. Cancer Lett. 2008, 270:66-76.
    • (2008) Cancer Lett. , vol.270 , pp. 66-76
    • Seo, S.Y.1    Kim, E.O.2    Jang, K.L.3
  • 14
    • 76249128584 scopus 로고    scopus 로고
    • Hepatitis B virus X protein overcomes the growth-inhibitory potential of retinoic acid by downregulating retinoic acid receptor-beta2 expression via DNA methylation
    • Jung J.K., Park S.H., Jang K.L. Hepatitis B virus X protein overcomes the growth-inhibitory potential of retinoic acid by downregulating retinoic acid receptor-beta2 expression via DNA methylation. J. Gen. Virol. 2010, 91:493-500.
    • (2010) J. Gen. Virol. , vol.91 , pp. 493-500
    • Jung, J.K.1    Park, S.H.2    Jang, K.L.3
  • 15
    • 0032575079 scopus 로고    scopus 로고
    • Functional interplay between p53 and E2F through co-activator p300
    • Lee C.W., Sorensen T.S., Shikama N., La Thangue N.B. Functional interplay between p53 and E2F through co-activator p300. Oncogene 1998, 16:2695-2710.
    • (1998) Oncogene , vol.16 , pp. 2695-2710
    • Lee, C.W.1    Sorensen, T.S.2    Shikama, N.3    La Thangue, N.B.4
  • 16
    • 0347986549 scopus 로고    scopus 로고
    • Direct evidence from siRNA-directed "knock down" that p16(INK4a) is required for human fibroblast senescence and for limiting ras-induced epithelial cell proliferation
    • Bond J., Jones C., Haughton M., DeMicco C., Kipling D., Wynford-Thomas D. Direct evidence from siRNA-directed "knock down" that p16(INK4a) is required for human fibroblast senescence and for limiting ras-induced epithelial cell proliferation. Exp. Cell. Res. 2004, 292:151-156.
    • (2004) Exp. Cell. Res. , vol.292 , pp. 151-156
    • Bond, J.1    Jones, C.2    Haughton, M.3    DeMicco, C.4    Kipling, D.5    Wynford-Thomas, D.6
  • 17
    • 1542720378 scopus 로고    scopus 로고
    • Vitamin D receptor and p21/WAF1 are targets of genistein and 1,25-dihydroxyvitamin D3 in human prostate cancer cells
    • Rao A., Coan A., Welsh J.E., Barclay W.W., Koumenis C., Cramer S.D. Vitamin D receptor and p21/WAF1 are targets of genistein and 1,25-dihydroxyvitamin D3 in human prostate cancer cells. Cancer Res. 2004, 64:2143-2147.
    • (2004) Cancer Res. , vol.64 , pp. 2143-2147
    • Rao, A.1    Coan, A.2    Welsh, J.E.3    Barclay, W.W.4    Koumenis, C.5    Cramer, S.D.6
  • 18
    • 33846997178 scopus 로고    scopus 로고
    • The cyclin-dependent kinase inhibitors p57 and p27 regulate neuronal migration in the developing mouse neocortex
    • Itoh Y., Masuyama N., Nakayama K., Nakayama K., Gotoh Y. The cyclin-dependent kinase inhibitors p57 and p27 regulate neuronal migration in the developing mouse neocortex. J. Biol. Chem. 2007, 282:390-396.
    • (2007) J. Biol. Chem. , vol.282 , pp. 390-396
    • Itoh, Y.1    Masuyama, N.2    Nakayama, K.3    Nakayama, K.4    Gotoh, Y.5
  • 19
    • 0035951791 scopus 로고    scopus 로고
    • 2 stress triggers a release of transforming growth factor-beta 1, which induces biomarkers of cellular senescence of human diploid fibroblasts
    • 2 stress triggers a release of transforming growth factor-beta 1, which induces biomarkers of cellular senescence of human diploid fibroblasts. J. Biol. Chem. 2001, 276:2531-2537.
    • (2001) J. Biol. Chem. , vol.276 , pp. 2531-2537
    • Frippiat, C.1    Chen, Q.M.2    Zdanov, S.3    Magalhaes, J.P.4    Remacle, J.5    Toussaint, O.6
  • 20
    • 34250854122 scopus 로고    scopus 로고
    • Expression of DNA methyltransferase 1 is activated by hepatitis B virus X protein via a regulatory circuit involving the p16INK4a-cyclin D1-CDK 4/6-pRb-E2F1 pathway
    • Jung J.K., Arora P., Pagano J.S., Jang K.L. Expression of DNA methyltransferase 1 is activated by hepatitis B virus X protein via a regulatory circuit involving the p16INK4a-cyclin D1-CDK 4/6-pRb-E2F1 pathway. Cancer Res. 2007, 67:5771-5778.
    • (2007) Cancer Res. , vol.67 , pp. 5771-5778
    • Jung, J.K.1    Arora, P.2    Pagano, J.S.3    Jang, K.L.4
  • 22
    • 0030066105 scopus 로고    scopus 로고
    • Retinoic acid receptor beta mediates the growth-inhibitory effect of retinoic acid by promoting apoptosis in human breast cancer cells
    • Liu Y., Lee M.O., Wang H.G., Li Y., Hashimoto Y., Klaus M., Reed J.C., Zhang X. Retinoic acid receptor beta mediates the growth-inhibitory effect of retinoic acid by promoting apoptosis in human breast cancer cells. Mol. Cell. Biol. 1996, 16:1138-1149.
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 1138-1149
    • Liu, Y.1    Lee, M.O.2    Wang, H.G.3    Li, Y.4    Hashimoto, Y.5    Klaus, M.6    Reed, J.C.7    Zhang, X.8
  • 23
    • 79952439918 scopus 로고    scopus 로고
    • ATRA-induced HL-60 myeloid leukemia cell differentiation depends on the CD38 cytosolic tail needed for membrane localization, but CD38 enzymatic activity is unnecessary
    • Congleton J., Jiang H., Malavasi F., Lin H., Yen A. ATRA-induced HL-60 myeloid leukemia cell differentiation depends on the CD38 cytosolic tail needed for membrane localization, but CD38 enzymatic activity is unnecessary. Exp. Cell. Res. 2011, 317:910-919.
    • (2011) Exp. Cell. Res. , vol.317 , pp. 910-919
    • Congleton, J.1    Jiang, H.2    Malavasi, F.3    Lin, H.4    Yen, A.5
  • 24
    • 0034028836 scopus 로고    scopus 로고
    • Tumor suppressors and oncogenes in cellular senescence
    • Bringold F., Serrano M. Tumor suppressors and oncogenes in cellular senescence. Exp. Gerontol. 2000, 35:317-329.
    • (2000) Exp. Gerontol. , vol.35 , pp. 317-329
    • Bringold, F.1    Serrano, M.2
  • 25
    • 0025043959 scopus 로고
    • The t(15; 17) translocation of acute promyelocytic leukaemia fuses the retinoic acid receptor alpha gene to a novel transcribed locus
    • de The H., Chomienne C., Lanotte M., Degos L., Dejean A. The t(15; 17) translocation of acute promyelocytic leukaemia fuses the retinoic acid receptor alpha gene to a novel transcribed locus. Nature 1990, 347:558-561.
    • (1990) Nature , vol.347 , pp. 558-561
    • de The, H.1    Chomienne, C.2    Lanotte, M.3    Degos, L.4    Dejean, A.5
  • 26
    • 42549124669 scopus 로고    scopus 로고
    • Prevention of bladder cancer recurrence by retinoic acid-ketoconazole: a promising strategy?
    • Lotan Y., Lotan R. Prevention of bladder cancer recurrence by retinoic acid-ketoconazole: a promising strategy?. Cancer Biol. Ther. 2008, 7:101-102.
    • (2008) Cancer Biol. Ther. , vol.7 , pp. 101-102
    • Lotan, Y.1    Lotan, R.2
  • 28
    • 0034212946 scopus 로고    scopus 로고
    • Loss of p16(INK4) protein, alone and together with loss of retinoblastoma protein, correlate with hepatocellular carcinoma progression
    • Hui A.M., Shi Y.Z., Li X., Takayama T., Makuuchi M. Loss of p16(INK4) protein, alone and together with loss of retinoblastoma protein, correlate with hepatocellular carcinoma progression. Cancer Lett. 2000, 154:93-99.
    • (2000) Cancer Lett. , vol.154 , pp. 93-99
    • Hui, A.M.1    Shi, Y.Z.2    Li, X.3    Takayama, T.4    Makuuchi, M.5
  • 30
    • 0029103264 scopus 로고
    • The high levels of p53 present in adenovirus early region 1-transformed human cells do not cause up-regulation of MDM2 expression
    • Grand R.J., Lecane P.S., Owen D., Grant M.L., Roberts S., Levine A.J., Gallimore P.H. The high levels of p53 present in adenovirus early region 1-transformed human cells do not cause up-regulation of MDM2 expression. Virology 1995, 210:323-334.
    • (1995) Virology , vol.210 , pp. 323-334
    • Grand, R.J.1    Lecane, P.S.2    Owen, D.3    Grant, M.L.4    Roberts, S.5    Levine, A.J.6    Gallimore, P.H.7
  • 32
    • 0343953594 scopus 로고    scopus 로고
    • Hypermethylation can selectively silence individual p16ink4A alleles in neoplasia
    • Myohanen S.K., Baylin S.B., Herman J.G. Hypermethylation can selectively silence individual p16ink4A alleles in neoplasia. Cancer Res. 1998, 58:591-593.
    • (1998) Cancer Res. , vol.58 , pp. 591-593
    • Myohanen, S.K.1    Baylin, S.B.2    Herman, J.G.3
  • 33
    • 33847714231 scopus 로고    scopus 로고
    • Tumor-suppressive activity of retinoic acid receptor-beta in cancer
    • Xu X.C. Tumor-suppressive activity of retinoic acid receptor-beta in cancer. Cancer Lett. 2007, 253:14-24.
    • (2007) Cancer Lett. , vol.253 , pp. 14-24
    • Xu, X.C.1
  • 34
    • 35648954161 scopus 로고    scopus 로고
    • P21WAF1/CIP1 is a common transcriptional target of retinoid receptors: pleiotropic regulatory mechanism through retinoic acid receptor (RAR)/retinoid X receptor (RXR) heterodimer and RXR/RXR homodimer
    • Tanaka T., Suh K.S., Lo A.M., De Luca L.M. p21WAF1/CIP1 is a common transcriptional target of retinoid receptors: pleiotropic regulatory mechanism through retinoic acid receptor (RAR)/retinoid X receptor (RXR) heterodimer and RXR/RXR homodimer. J. Biol. Chem. 2007, 282:29987-29997.
    • (2007) J. Biol. Chem. , vol.282 , pp. 29987-29997
    • Tanaka, T.1    Suh, K.S.2    Lo, A.M.3    De Luca, L.M.4
  • 36
    • 0012316186 scopus 로고    scopus 로고
    • Differential ligand-dependent interactions between the AF-2 activating domain of nuclear receptors and the putative transcriptional intermediary factors mSUG1 and TIF1
    • vom Baur E., Zechel C., Heery D., Heine M.J., Garnier J.M., Vivat V., Le Douarin B., Gronemeyer H., Chambon P., Losson R. Differential ligand-dependent interactions between the AF-2 activating domain of nuclear receptors and the putative transcriptional intermediary factors mSUG1 and TIF1. EMBO J. 1996, 15:110-124.
    • (1996) EMBO J. , vol.15 , pp. 110-124
    • vom Baur, E.1    Zechel, C.2    Heery, D.3    Heine, M.J.4    Garnier, J.M.5    Vivat, V.6    Le Douarin, B.7    Gronemeyer, H.8    Chambon, P.9    Losson, R.10
  • 37
    • 0033577059 scopus 로고    scopus 로고
    • Cyclin D1 proteolysis: a retinoid chemoprevention signal in normal, immortalized, and transformed human bronchial epithelial cells
    • Boyle J.O., Langenfeld J., Lonardo F., Sekula D., Reczek P., Rusch V., Dawson M.I., Dmitrovsky E. Cyclin D1 proteolysis: a retinoid chemoprevention signal in normal, immortalized, and transformed human bronchial epithelial cells. J. Natl. Cancer Inst. 1999, 91:373-379.
    • (1999) J. Natl. Cancer Inst. , vol.91 , pp. 373-379
    • Boyle, J.O.1    Langenfeld, J.2    Lonardo, F.3    Sekula, D.4    Reczek, P.5    Rusch, V.6    Dawson, M.I.7    Dmitrovsky, E.8
  • 38
    • 45549096649 scopus 로고    scopus 로고
    • Identification of transcriptional regulatory cascades in retinoic acid-induced growth arrest of HepG2 cells
    • Nakanishi M., Tomaru Y., Miura H., Hayashizaki Y., Suzuki M. Identification of transcriptional regulatory cascades in retinoic acid-induced growth arrest of HepG2 cells. Nucl. Acids Res. 2008, 36:3443-3454.
    • (2008) Nucl. Acids Res. , vol.36 , pp. 3443-3454
    • Nakanishi, M.1    Tomaru, Y.2    Miura, H.3    Hayashizaki, Y.4    Suzuki, M.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.