Suppression of dimerumic acid on hepatic fibrosis caused from carboxymethyl-lysine (CML) by attenuating oxidative stress depends on Nrf2 activation in hepatic stellate cells (HSCs)

Food and Chemical Toxicology

Volumn 62, Issue , 2013, Pages 413-419

  Lee, Bao Hong ^a   Hsu, Wei Hsuan ^a   Hsu, Ya Wen ^b   Pan, Tzu Ming ^a  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^b Sunway Biotechnology Company Limited   (Taiwan)

Author keywords

Advanced glycation end products (AGEs); Carboxymethyl lysine (CML); Dimerumic acid (DMA); Hepatic fibrosis; Nuclear factor erythroid 2 related factor 2 (Nrf2)

Indexed keywords

6 N CARBOXYMETHYLLYSINE; ADVANCED GLYCATION END PRODUCT RECEPTOR; ALLYL ISOTHIOCYANATE; ALPHA SMOOTH MUSCLE ACTIN; COLLAGEN; DIMERUMIC ACID; GLUTAMATE CYSTEINE LIGASE; MESSENGER RNA; NATURAL PRODUCT; PLATELET DERIVED GROWTH FACTOR BETA RECEPTOR; PROCOLLAGEN; PROCOLLAGEN 1A1; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL ACTIVATION; COLLAGEN SYNTHESIS; CONCENTRATION RESPONSE; CONTROLLED STUDY; FERMENTATION; GENE EXPRESSION; LIVER FIBROSIS; MALE; MONASCUS; MOUSE; NONHUMAN; OXIDATIVE STRESS; SIGNAL TRANSDUCTION; STELLATE CELL; TRANSCRIPTION INITIATION;

MONASCUS;

ADVANCED GLYCATION END-PRODUCTS (AGES); CARBOXYMETHYL-LYSINE (CML); DIMERUMIC ACID (DMA); HEPATIC FIBROSIS; NUCLEAR FACTOR-ERYTHROID 2-RELATED FACTOR 2 (NRF2);

ACTINS; ANIMALS; ANTIOXIDANTS; CELLS, CULTURED; COLLAGEN TYPE I; DIKETOPIPERAZINES; GENE EXPRESSION REGULATION; GENE KNOCKDOWN TECHNIQUES; HEPATIC STELLATE CELLS; HYDROXAMIC ACIDS; LIVER CIRRHOSIS; LYSINE; MALE; MICE; MICE, INBRED C57BL; MITOGEN-ACTIVATED PROTEIN KINASES; NF-E2-RELATED FACTOR 2; OXIDATIVE STRESS;

EID: 84884709820     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2013.09.007     Document Type: Article

References (49)

1. Aniya Y., Ohtani I.I., Higa T., Miyagi C., Gibo H., Shimabukuro M., Nakanishi H., Taira J. Dimerumic acid as an antioxidant of the mold Monascus anka. Free Radic. Biol. Med. 2002, 28:999-1004.
2. Basta G., Schmidt A.M., De-Caterina R. Advanced glycation end products and vascular inflammation: implications for accelerated atherosclerosis in diabetes. Cardiovasc. Res. 2004, 63:582-592.
3. Chen H., Zhou Y., Chen K.Q., An G., Ji S.Y., Chen Q.K. Anti-fibrotic effects via regulation of transcription factor Sp1 on hepatic stellate cells. Cell. Physiol. Biochem. 2012, 29:51-60.
4. De-Minicis S., Brenner D.A. NOX in liver fibrosis. Arch. Biochem. Biophys. 2007, 462:266-272.
5. Desai K., Wu L. Methylglyoxal and advanced glycation endproducts: new therapeutic horizons?. Recent Patents Cardiovasc. Drug Discov. 2007, 2:89-99.
6. Disthabanchong S., Radinahamed P., Stitchantrakul W., Hongeng S., Rajatanavin R. Chronic metabolic acidosis alters osteoblast differentiation from human mesenchymal stem cells. Kidney Int. 2007, 71:201-209.
7. Fehrenbach H., Weiskirchen R., Kasper M., Gressner A.M. Up-regulated expression of the receptor for advanced glycation end products in cultured rat hepatic stellate cells during transdifferentiation to myofibroblasts. Hepatology 2001, 34:943-952.
8. Friedman S.L. Mechanisms of hepatic fibrogenesis. Gastroenterology 2008, 134:1655-1669.
9. Guimaraes E.L.M., Empsen C., van-Geerts A. Advanced glyction end products induce production of reactive oxygen species via the actiation of NADPH oxidase in murine hepatic stellate cells. J. Hepatol. 2010, 52:389-397.
10. He C., Sabol J., Mitsuhashi T., Vlassara H. Dietary glycotoxins: inhibition of reactive products by aminoguanidine facilitates renal clearance and reduces tissue sequestration. Diabetes 1999, 48:1308-1315.
11. He X., Wang L., Szklarz G., Bi Y., Ma Q. Resveratrol inhibits paraquat-induced oxidative stress and fibrogenic response by activating the nuclear factor erythroid 2-related factor 2 pathway. J. Pharmacol. Exp. Ther. 2012, 342:81-90.
12. 2-mediated MMP-7 expression via JNK/C-Jun and ERK/C-Fos activation in an AP-1-dependent manner. Int. J. Biol. Sci. 2011, 7:869-880.
13. Ho C.Y., Cheng Y.T., Chau C.F., Yen G.C. Effect of diallyl sulfide on in vitro and in vivo Nrf2-mediated pulmonic antioxidant enzyme expression via activation ERK/p38 signaling pathway. J. Agric. Food Chem. 2012, 60:100-107.
14. Hofmann S.M., Dong H.J., Li Z., Cai W., Altomonte J., Yhung S.N., Zeng F., Fisher E.A., Vlassara H. Improved insulin sensitivity is associated with restricted intake of dietary glycoxidation products in the db/db mouse. Diabetes 2002, 51:2082-2089.
15. Huang S.M., Wu C.H., Yen G.C. Effects of flavonoids on the expression of the pro-inflammatory response in human monocytes induced by ligation of the receptor for AGEs. Mol. Nutr. Food Res. 2006, 50:1129-1139.
16. Hyogo H., Yamagishi S., Iwamoto K., Arihiro K., Takeuchi M., Sato T. Elevated levels of serum advanced glycation end products in patients with non-alcoholic steatohepatitis. J. Gastroenterol. Hepatol. 2007, 22:1112-1119.
17. Keum Y.S., Owuor E.D., Kim B.R., Hu R., Kong A.N. Involvement of Nrf2 and JNK1 in the activation of antioxidant responsive element (ARE) by chemopreventive agent phenethyl isothiocyanate (PEITC). Pharm. Res. 2003, 20:1351-1356.
18. Kobayashi M., Yamamoto M. Molecular mechanisms activating the Nrf2-Keap1 pathway of antioxidant gene regulation. Antioxid. Redox Signal. 2005, 7:385-394.
19. Lee B.H., Hsu W.H., Chang Y.Y., Kuo H.F., Hsu Y.W., Pan T.M. Ankaflavin: a natural novel PPARγ agonist upregulates Nrf2 to attenuate methylglyoxal-induced diabetes in vivo. Free Radic. Biol. Med. 2012, 53:2008-2016.
20. Lee B.H., Hsu W.H., Hsu Y.W., Pan T.M. Dimerumic acid attenuates receptor for advanced glycation endproducts signal to inhibit inflammation and diabetes mediated by Nrf2 activation and promotes methylglyoxal metabolism into D-lactic acid. Free Radic. Biol. Med. 2013, 60:7-16.
21. Lee B.H., Hsu W.H., Hsu Y.W., Pan T.M. Dimerumic acid protects pancreas damage and elevates insulin production in methylglyoxal-treated pancreatic RINm5F cells. J. Funct. Food 2013, 5:642-650.
22. Lin J., Zheng S., Chen A. Curcumin attenuates the effects of insulin on stimulating hepatic stellate cell activation by interrupting insulin signaling and attenuating oxidative stress. Lab. Invest. 2009, 89:1397-1409.
23. Lin J., Tang Y., Kang Q., Feng Y., Chen A. Curcumin inhibites advanced glycation end-products (AGEs)-induced gene expression of receptor for AGEs (RAGE) in hepatic stellate cells in vitro by elevating PPARγ activity and attenuating oxidative stress. Br. J. Pharmacol. 2012, 166:2212-2227.
24. Oh C.J., Kim J.Y., Min A.K., Park K.G., Harris R.A., Kim H.J., Lee I.K. Sulforaphane attenuates hepatic fibrosis via NF-E2-related factor 2-mediated inhibition of transforming growth factor-β/Smad signaling. Free Radic. Biol. Med. 2012, 52:671-682.
25. Ramasamy R., Vannucci S.J., Yan S.S., Herold K., Yan S.F., Schmidt A.M. Advanced glycation end products and RAGE: a common thread in aging, diabetes, neurodegeneration, and inflammation. Glycobiology 2005, 15:16R-28R.
26. San-Martin A., Foncea R., Laurindo F.R., Ebensperger R., Griendling K.K. Nox1-based NADPH oxidase-derived superoxide is required for VSMC activation by advanced glycation end-products. Free Radic. Biol. Med. 2007, 42:1671-1679.
27. Sebekova K., Kupcova V., Schinzel R., Heidland A. Markedly elevated levels of plasma advanced glycation end products in patients with liver cirrhosis - amelioration by liver transplantation. J. Hepatol. 2002, 36:66-71.
28. Shih P.H., Hwang S.L., Yeh C.T., Yen G.C. Synergistic effect of cyanidin and PPAR agonist against nonalcoholic steatohepatitis-mediated oxidative stress-induced cytotoxicity through MAPK and Nrf2 transduction pathways. J. Agric. Food Chem. 2012, 60:2924-2933.
29. Smedsrod B., Melkko J., Araki N., Sano H., Horiuchi S. Advanced glycation end products are eliminated by scavenger-receptor-mediated endocytosis in hepatic sinusoidal Kupffer and endothelial cells. Biochem. J. 1997, 322:567-573.
30. Taira J., Miyagi C., Aniya Y. Dimerumic acid as an antioxidant from the mold, Monascus anka: the inhibition mechanisms against lipid peroxidation and hemeprotein-mediated oxidation. Biochem. Pharmacol. 2002, 63:1019-1026.
31. Tang Y., Zheng S., Chen A. Curcumin eliminates leptin's effects on hepatic stellate cell activation via interrupting leptin signaling. Endocrinology 2009, 150:3011-3020.
32. Urata Y., Yamaguchi M., Higashiyama Y., Ihara Y., Goto S., Kuwano M. Reactive oxygen species accelerate production of vascular endothelial growth factor by advanced glycation end products in RAW264.7 mouse macrophages. Free Radic. Biol. Med. 2002, 32:688-701.
33. Vander-Jagt D., Hunsaker L. Methylglyoxal metabolism and diabetic complications: roles of aldose reductase, glyxalase-I, betaine aldehyde dehydrogenase and oxoaldehyde dehydrogenase. Chem. Biol. Interact. 2003, 143(144):341-351.
34. Vignais P.V. The superoxide-generating NADPH oxidase: structural aspects and activation mechanism. Cell. Mol. Life Sci. 2002, 59:1428-1459.
35. Wang S.H., Chang J.C., Pokkaew R., Lee J.F., Chiou Y.Y. Modified fast procedure for the detection and screening of antiglycative phytochemicals. J. Agric. Food. Chem. 2011, 59:6906-6912.
36. ε-carboxymethyl-lysine accelerates progression of atherosclerotic calcification in diabetes. Food Chem. Toxicol. 2012, 221:387-396.
37. Wautier M.P., Chappey O., Corda S., Stern D.M., Schmidt A.M., Wautier J.L. Activation of NADPH oxidase by AGE links oxidant stress to altered gene expression via RAGE. Am. J. Physiol. Endocrinol. Metab. 2001, 280:E685-E694.
38. Wells R.G. Liver fibrosis: challenges of the new era. Gastroenterology 2009, 136:387-388.
39. Weng C.J., Chen M.J., Yeh C.T., Yen G.C. Hepatoprotection of quercetin against oxidative stress by induction of metallothionein expression through activating MAPK and PI3K pathways and enhancing Nrf2 DNA-binding activity. N. Biotechnol. 2011, 28:767-777.
40. Wu G., Fang Y.Z., Yang S., Lupton J.R., Turner N.D. Glutathione metabolism and its implications for health. J. Nutr. 2004, 134:489-492.
41. Wu C.H., Huang S.M., Lin J.A., Yen G.C. Inhibition of advanced glycation endproduct formation by foodstuffs. Food Funct. 2011, 2:224-234.
42. Wu C.H., Huang S.M., Yen G.C. Silymarin: a novel antioxidant with antiglycation and antiinflammatory properties in vitro and in vivo. Antioxid. Redox Signal. 2011, 14:353-366.
43. Xu J., Fu Y., Chen A. Activation of peroxisome proliferator-activated receptor-gamma contributes to the inhibitory effects of curcumin on rat hepatic stellate cell growth. Am. J. Physiol. Gastrointest. Liver Physiol. 2003, 285:G20-G30.
44. Yagmur E., Tacke F., Weiss C., Lahme B., Manns M.P., Kiefer P., Trautwein C., Gressner A.M. Elevation of Nepsilon-(carboxymethyl)lysine-modified advanced glycation end products in chronic liver disease is an indicator of liver cirrhosis. Clin. Biochem. 2006, 39:39-45.
45. Yamagishi S., Matsui T. Advanced glycation end products, oxidative stress and diabetic nephropathy. Oxid. Med. Cell. Longev. 2010, 3:101-108.
46. Yamashiro J.I., Shiraishi S., Fuwa T., Horie T. Dimerumic acid protected oxidative stress-induced cytotoxicity in isolated rat hepatocytes. Cell. Biol. Toxicol. 2008, 24:283-290.
47. Yano K., Sekine S., Nemoto K., Fuwa T., Horie T. The effect of dimerumic acid on LPS-induced downregulation of Mrp2 in the rat. Biochem. Pharmacol. 2010, 80:533-539.
48. Yeh C.T., Yen G.C. Induction of hepatic antioxidant enzymes by phenolic acids in rats is accompanied by increased levels of multidrug resistance-associated protein 3 mRNA expression. J. Nutr. 2006, 136:11-15.
49. Yeh C.T., Chiu H.F., Yen G.C. Protective effect of sulforaphane on indomethacin-induced cytotoxicity via heme oxygenase-1 expression in human intestinal Int 407 cells. Mol. Nutr. Food Res. 2009, 53:1166-1176.